scholarly journals Comparison of the Risk of Mortality from Solid Cancers after Radiation Incidents and Occupational Exposures

2021 ◽  
pp. 34-41
Author(s):  
A.N. Koterov ◽  
◽  
L.N. Ushenkova ◽  
M.V. Kalinina ◽  
A.P. Biryukov ◽  
...  
Keyword(s):  
Cancer Mortality ◽  
Occupational Exposures ◽  
The United States ◽  
Pooled Analysis ◽  
Disaster Medicine ◽  
Nuclear Industry ◽  
Chronic Radiation ◽  
Techa River ◽  
Risk Of Mortality ◽  
Study Results

The purpose of the study was to compare the excess relative risk of mortality (ERR per 1 Sv) from solid cancers during acute — catastrophic or accidental and occupational, fractionated or chronic — exposure. Study materials and methods. Materials of the study: maintained database (source database) on nuclear industry workers from about 40 countries, based on which a pooled analysis of data was conducted to determine the integral value of ERR per 1 Gy for mortality from solid cancers; indicators of cohorts exposed to catastrophic and accidental radiation: the cohort LSS victims of the atomic bombings in Japan; residents of the Techa River — radioactive contamination resulting from releases from "Mayak" production association; Russian liquidators of the Chernobyl nuclear accident. Study results and analysis. Comparison of the ERR of 1 Sv deaths from solid cancers for workers in the global nuclear industry (pooling analysis of data from 37 studies) with those of the LSS cohort; Techa River residents and Chernobyl accident liquidators showed no logical and principled differences, with the risks for the latter two cohorts being the highest. Although the findings partly support the approach of the UN Scientific Committee on the Effects of Atomic Radiation that the carcinogenic effects of acute (catastrophic or accidental) and occupational (fractionated or chronic) radiation exposure are independent of the dose rate factor (DDREF), this issue cannot be considered unequivocally resolved, given the biological mechanisms and radiobiological experimental data. Based on the ERR per 1 Sv, the average external dose, and the annual background cancer mortality rates in Russia and the United States, the expected cancer mortality increase for 100,000 workers in the nuclear industry would be an average of 32-69 people over 10 years — 0.032-0.069% of the group. Such risks, due to multiple carcinogenic non-radiation factors of life and work, as well as fluctuating background values, cannot be taken into account in the practice of disaster medicine and public health.

Comparing the risk of mortality from solid cancer after radiation incidents and occupational radiation exposure

2021 ◽  
Vol 61 (9) ◽  
pp. 580-587
Author(s):  
Aleksey N. Koterov ◽  
Liliya N. Ushenkova ◽  
Mariya V. Kalinina ◽  
Aleksandr P. Biryukov
Keyword(s):  
Radiation Exposure ◽  
Chernobyl Accident ◽  
Cancer Mortality ◽  
The United States ◽  
Nuclear Industry ◽  
Solid Cancer ◽  
Nuclear Workers ◽  
Chronic Radiation ◽  
Techa River ◽  
The Many

The purpose of the study is to compare the excess relative risk (ERR per 1 Sv) of solid cancer mortality in acute - catastrophic or emergency, and occupational - fractionated or chronic exposure. Materials and research methods. A maintained database (database of sources) on nuclear workers from about 40 countries, on the basis of it a combined data analysis was carried out to determine the integral ERR value per 1 Gy for cancer mortality for comparison with parameters of cohorts exposed to catastrophic and emergency exposure: the LSS cohort victims of the atomic bombings in Japan, residents of the Techa River (radioactive contamination due to emissions from the Mayak plant) and Russian liquidators of the Chernobyl accident. Results. Comparison of the ERR per 1 Sv for cancer mortality for workers in the global nuclear industry (combining analysis of data from 37 studies) with the parameters of the LSS cohort, residents on the Techa River and liquidators of the Chernobyl accident showed the absence of logical and principial differences, and the risks for the last two cohorts were the highest. Although the data obtained partly confirm the approach of recent years by the United Nations Scientific Committee on the Effects of Atomic Radiation, according to which the carcinogenic effects of acute, accidental, and fractionated or chronic radiation exposure do not depend on the dose rate factor (DDREF), nevertheless, taking into account biological mechanisms and data radiobiological experiments, this issue cannot be considered unambiguously resolved. Conclusion. Based on the ERR per 1 Sv, the average external dose, and the annual background cancer mortality in Russia and the United States, the expected increase in cancer mortality for 100,000 nuclear workers will average 32-69 people over 10 years (0.032-0.069% of the group). Such risks, due to the many carcinogenic non-radiation factors of life and work, as well as fluctuations in the background value, cannot be taken into account in the practice of medicine and health care.

scholarly journals Health status and cancer related mortality among nuclear plant workers exposed to ionizing radiation

2021 ◽  
Author(s):  
Ali Javinaani ◽  
Hasan Abolghasemi ◽  
Hadi Hamidi
Keyword(s):  
Ionizing Radiation ◽  
Cancer Mortality ◽  
Occupational Exposures ◽  
Nuclear Plant ◽  
Nuclear Industry ◽  
Cancer Development ◽  
Adverse Health Effects ◽  
Health Registry ◽  
Risk Of Cancer ◽  
Occupational Radiation

AbstractBackgroundThe investigation of potential adverse health effects of occupational exposures to ionizing radiation, on nuclear plant workers, is an important area of research. In this study, we aimed to calculate the incidence and risk of cancer development and mortality during last five years (2015-2019).Material and Methods456 nuclear industry workers were included into this study (39 cancer patients and 417 healthy. For this cohort, the cancer mortality has been assessed by data obtained from national health registry excluded for the probability of known causes of death. The associations between cumulative occupational radiation exposures (radon, gamma radiation and long-lived radionuclides) and cancer mortality were calculated.ResultsRadon and Gamma exposure was significantly higher among workers who developed cancer [8.4 (0; 3,224.5) vs 19.7 (0; 128.4), p=0.03] and [12.0 (2.1; 110.0) vs 24.5 (0; 470.1), p=0.02]. However, no significant association was found between long-lived radionuclides and risk of cancer (p=0.07).ConclusionIn conclusion, significant association has been observed between the risk of cancer development and radon and gamma exposure among nuclear industry workers, but no association was found between cancer and long-live nucleoids exposure.

Racial and Sex Disparities in Trauma Outcomes Based on Geographical Region

2020 ◽  
pp. 000313482096006
Author(s):  
William Q. Duong ◽  
Areg Grigorian ◽  
Cyrus Farzaneh ◽  
Jeffry Nahmias ◽  
Theresa Chin ◽  
...  
Keyword(s):  
United States ◽  
The United States ◽  
Trauma Patients ◽  
Improvement Program ◽  
Trauma Outcomes ◽  
Risk Of Death ◽  
Hospital Access ◽  
Risk Of Mortality ◽  
Sex Disparities ◽  
Male Patients

Objectives Disparities in outcomes among trauma patients have been shown to be associated with race and sex. The purpose of this study was to analyze racial and sex mortality disparities in different regions of the United States, hypothesizing that the risk of mortality among black and Asian trauma patients, compared to white trauma patients, will be similar within all regions in the United States. Methods The Trauma Quality Improvement Program (2010-2016) was queried for adult trauma patients, separating by U.S. Census regions. Multivariable logistic regression analyses were performed for each region, controlling for known predictors of morbidity and mortality in trauma. Results Most trauma patients were treated in the South (n = 522 388, 40.7%). After risk adjustment, black trauma patients had a higher associated risk of death in all regions, except the Northeast, compared to white trauma patients. The highest associated risk of death for blacks (vs. whites) was in the Midwest (odds ratio [OR] 1.30, P < .001). Asian trauma patients only had a higher associated risk of death in the West (OR 1.39, P < .001). Male trauma patients, compared to women, had an increased associated risk of mortality in all four regions. Discussion This study found major differences in outcomes among different races within different regions of the United States. There was also both an increased rate and associated risk of mortality for male patients in all regions. Future prospective studies are needed to identify what regional differences in trauma systems including population density, transport times, hospital access, and other trauma resources explain these findings.

Role Stress and Sense of Control Predict Using Food to Cope With Stress in Midlife Women

2021 ◽  
pp. 089826432110110
Author(s):  
Dana R. Riedy ◽  
Ashley MacPherson ◽  
Natalie D. Dautovich
Keyword(s):  
Work Stress ◽  
Underlying Mechanism ◽  
The United States ◽  
Role Stress ◽  
Work And Family ◽  
Midlife Women ◽  
Sense Of Control ◽  
Study Results ◽  
Using Data ◽  
Significant Mediator

Objective: The current study examined the association between role stress and using food to cope with stress in midlife women and examined sense of control as a potential underlying mechanism. Methods: An archival analysis was performed using data from 638 midlife women from the Midlife in the United States II study. Results: Hierarchical linear regression analyses demonstrated that work stress (β = .180, p < .001) and family stress (β = .138, p < .05) significantly predicted using food to cope with stress. Sense of control was a significant mediator between work stress and using food to cope with stress ( b = 0.02, 95% CI [.0014, .0314]). Discussion: Midlife women with higher role stress related to work and family are more likely to use food to cope with stress, and sense of control seems to be the link between work stress and using food to cope.

scholarly journals Outcomes for Children and Adolescents With Cancer: Challenges for the Twenty-First Century

2010 ◽  
Vol 28 (15) ◽  
pp. 2625-2634 ◽  
Author(s):  
Malcolm A. Smith ◽  
Nita L. Seibel ◽  
Sean F. Altekruse ◽  
Lynn A.G. Ries ◽  
Danielle L. Melbert ◽  
...  
Keyword(s):  
United States ◽  
Childhood Cancer ◽  
Cancer Mortality ◽  
Lymphoblastic Leukemia ◽  
The United States ◽  
Mortality Rates ◽  
Mortality Data ◽  
Childhood Cancers ◽  
Essential Information ◽  
The Impact

Purpose This report provides an overview of current childhood cancer statistics to facilitate analysis of the impact of past research discoveries on outcome and provide essential information for prioritizing future research directions. Methods Incidence and survival data for childhood cancers came from the Surveillance, Epidemiology, and End Results 9 (SEER 9) registries, and mortality data were based on deaths in the United States that were reported by states to the Centers for Disease Control and Prevention by underlying cause. Results Childhood cancer incidence rates increased significantly from 1975 through 2006, with increasing rates for acute lymphoblastic leukemia being most notable. Childhood cancer mortality rates declined by more than 50% between 1975 and 2006. For leukemias and lymphomas, significantly decreasing mortality rates were observed throughout the 32-year period, though the rate of decline slowed somewhat after 1998. For remaining childhood cancers, significantly decreasing mortality rates were observed from 1975 to 1996, with stable rates from 1996 through 2006. Increased survival rates were observed for all categories of childhood cancers studied, with the extent and temporal pace of the increases varying by diagnosis. Conclusion When 1975 age-specific death rates for children are used as a baseline, approximately 38,000 childhood malignant cancer deaths were averted in the United States from 1975 through 2006 as a result of more effective treatments identified and applied during this period. Continued success in reducing childhood cancer mortality will require new treatment paradigms building on an increased understanding of the molecular processes that promote growth and survival of specific childhood cancers.

scholarly journals Contrast Associated Acute Kidney Injury and Mortality in Older Adults with Acute Coronary Syndrome: A Pooled Analysis of the FRASER and HULK Studies

2021 ◽  
Vol 10 (10) ◽  
pp. 2151
Author(s):  
Rita Pavasini ◽  
Matteo Tebaldi ◽  
Giulia Bugani ◽  
Elisabetta Tonet ◽  
Roberta Campana ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Renal Function ◽  
Multivariable Analysis ◽  
Kidney Injury ◽  
Coronary Intervention ◽  
Pooled Analysis ◽  
Coronary Syndrome ◽  
Risk Of Mortality ◽  
Increased Risk ◽  
Short Term Mortality

Whether contrast-associated acute kidney injury (CA-AKI) is only a bystander or a risk factor for mortality in older patients undergoing percutaneous coronary intervention (PCI) is not well understood. Data from FRASER (NCT02386124) and HULK (NCT03021044) studies have been analysed. All patients enrolled underwent coronary angiography. The occurrence of CA-AKI was defined based on KDIGO criteria. The primary outcome of the study was to test the relation between CA-AKI and 3-month mortality. Overall, 870 older ACS adults were included in the analysis (mean age 78 ± 5 years; 28% females). CA-AKI occurred in 136 (16%) patients. At 3 months, 13 (9.6%) patients with CA-AKI died as compared with 13 (1.8%) without it (p < 0.001). At multivariable analysis, CA-AKI emerged as independent predictor of 3-month mortality (HR 3.51, 95%CI 1.05–7.01). After 3 months, renal function returned to the baseline value in 78 (63%) with CA-AKI. Those without recovered renal function (n = 45, 37%) showed an increased risk of mortality as compared to recovered renal function and no CA-AKI subgroups (HR 2.01, 95%CI 1.55–2.59, p = 0.009 and HR 2.71, 95%CI 1.45–5.89, p < 0.001, respectively). In conclusion, CA-AKI occurs in a not negligible portion of older MI patients undergoing invasive strategy and it is associated with short-term mortality.

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