scholarly journals Animal Research In Diabetes And Ethical Consideration

1970 ◽  
Vol 1 (2) ◽  
pp. 20-23
Author(s):  
Shamima Parvin Lasker ◽  
Rishad Raihan
Keyword(s):  
Human Subjects ◽  
Alternative Methods ◽  
Decision Making Process ◽  
Potential Importance ◽  
Ethical Aspects ◽  
Benefit Ratio ◽  
Human Diabetes ◽  
Prevention Of Diabetes ◽  
Clear Statement ◽  
Insight Into

Research must have a clear statement that is the hypothesis. This hypothesis may involve a clinical question or pathophysiologic mechanism that cannot be tested ethically or appropriately using human subjects or alternative methods. Therefore, numerous animal models have been developed that mimic to human diabetes. They provide additional knowledge about and insight into disease processes and hopefully better methods for treatment or prevention of diabetes in humans. All scientific research involving the use of animals should begin with an ethical focus by examining the risk-benefit ratio (i.e., morbidity or mortality to the animal versus the potential importance of the knowledge acquired). The aim of this paper is to discuss these ethical aspects within the context of research on diabetes and form a framework for the decision-making process. DOI: http://dx.doi.org/10.3329/bioethics.v1i2.9625 Bangladesh Journal of Bioethics 2010; 1(2): 20-23

Understanding Health Behavior: An Integrated Model for Social Marketers

2008 ◽  
Vol 14 (2) ◽  
pp. 2-32 ◽  
Author(s):  
Magdalena Cismaru ◽  
Anne M. Lavack ◽  
Heather Hadjistavropoulos ◽  
Kim D. Dorsch
Keyword(s):  
Health Behavior ◽  
Social Marketing ◽  
Transtheoretical Model ◽  
Process Model ◽  
Decision Making Process ◽  
Extended Parallel Process Model ◽  
Behavioral Theories ◽  
Health Related ◽  
Social Marketing Campaigns ◽  
Insight Into

Many effective social marketing campaigns seek to change health-related behavior by utilizing various health-protective behavioral theories. In this article, we review and integrate three such theories: protection motivation theory (PMT), the extended parallel process model (EPPM), and the transtheoretical model (TTM). We highlight how EPPM and TTM can be used to refine PMT by adding insight into the decision-making process involved when consumers consider whether or not to follow a particular recommended health behavior. Specifically, the development of an integrated PMT model can provide insight into the characteristics of people more or less likely to change, what happens when persuasion fails, and what can be done to increase persuasion. Developing an integrated PMT model opens new avenues of research that have the potential to increase our understanding of behavior and assist in creating more persuasive social marketing campaigns.

Analogy Models for Prediction of Human Toxicity

1990 ◽  
Vol 18 (1_part_1) ◽  
pp. 103-116
Author(s):  
Sven Hellberg ◽  
Lennart Eriksson ◽  
Jörgen Jonsson ◽  
Fredrik Lindgren ◽  
Michael Sjöström ◽  
...  
Keyword(s):  
Human Subjects ◽  
Toxicity Testing ◽  
In Vitro Cytotoxicity ◽  
Alternative Methods ◽  
Laboratory Animals ◽  
In Vitro Tests ◽  
Human Toxicity ◽  
Efficient Data ◽  
Basal Cytotoxicity

Estimating the toxicity to humans of chemicals by testing on human subjects is not considered to be ethically acceptable, and toxicity testing on laboratory animals is also questionable. Therefore, there is a need for alternative methods that will give estimates of various aspects of human toxicity. Batteries of in vitro tests, together with physicochemical and toxicokinetic data, analysed by efficient data analytical methods, may enable analogy models to be constructed that can predict human toxicity. It may be possible to model non-specific toxicity relating to lipophilicity, or basal cytotoxicity, for a series of diverse compounds with large variation in chemical structure and physicochemical properties. However, local models for a series of similar compounds are generally expected to be more accurate, as well as being capable of modelling more-specific interactions. Analogy models for the prediction of human toxicity are discussed and exemplified with physicochemical and cytotoxicity data from the first ten chemicals in the multicenter evaluation of in vitro cytotoxicity (MEIC) project.

Perbandingan Interpretasi Analisis Data Page View dan Click Related Post Pada Website Edukasi Sebagai Implisit Feedback Dengan Hasil Interpretasi Penggunaan Teknologi EyeTracking

2021 ◽  
Vol 3 (2) ◽  
pp. 66-72
Author(s):  
Riad Taufik Lazwardi ◽  
Khoirul Umam
Keyword(s):  
Decision Process ◽  
Recommendation System ◽  
User Behavior ◽  
Implicit Feedback ◽  
Decision Making Process ◽  
Learning Material ◽  
Relative Preferences ◽  
Insight Into ◽  
Explicit Feedback ◽  
Data Page

The analysis used in this study uses the help of Google Analytics to understand how the user's behavior on the Calculus learning material educational website page. Are users interested in recommendation articles? The answer to this question provides insight into the user's decision process and suggests how far a click is the result of an informed decision. Based on these results, it is hoped that a strategy to generate feedback from clicks should emerge. To evaluate the extent to which feedback shows relevance, versus implicit feedback to explicit feedback collected manually. The study presented in this study differs in at least two ways from previous work assessing the reliability of implicit feedback. First, this study aims to provide detailed insight into the user decision-making process through the use of a recommendation system with an implicit feedback feature. Second, evaluate the relative preferences that come from user behavior (user behavior). This differs from previous studies which primarily assessed absolute feedback. 

Publishing quantitative careers research: challenges and recommendations

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Bert Schreurs ◽  
Angus Duff ◽  
Pascale M. Le Blanc ◽  
Thomas H. Stone
Keyword(s):  
Design Methodology ◽  
Team Member ◽  
Research Question ◽  
Editorial Team ◽  
Board Members ◽  
Decision Making Process ◽  
Cross Sectional ◽  
Content Type ◽  
Insight Into

Purpose This article aims to provide prospective authors guidelines that will hopefully enable them to submit more competitive manuscripts to journals publishing careers research.Design/methodology/approach Based on their experience as an author, reviewer and editorial team member, the authors identify the main criteria that a quantitative study must meet to be considered for publication in international peer-reviewed journals covering career-related topics. They emphasize the importance of contributing to the careers literature and of designing the study in accordance with the research question.Findings Manuscripts are rejected because they are insufficiently innovative, and/or because sample, instruments and design are not appropriate to answer the research question at hand. Cross-sectional designs cannot be used to answer questions of mediation but should not be discarded automatically since they can be used to address other types of questions, including questions about nesting, clustering of individuals into subgroups, and to some extent, even causality.Originality/value The manuscript provides an insight into the decision-making process of reviewers and editorial board members and includes recommendations on the use of cross-sectional data.

Exploring ethical aspects of elective surgery patients’ decision-making experiences

2012 ◽  
Vol 20 (6) ◽  
pp. 672-683 ◽  
Author(s):  
Mei-Ling Lin ◽  
Chuen-Teng Huang ◽  
Hsien-Hsien Chiang ◽  
Ching-Huey Chen
Keyword(s):  
Decision Making ◽  
Informed Consent ◽  
Healthcare Professionals ◽  
Elective Surgery ◽  
Phenomenological Approach ◽  
Healthcare Personnel ◽  
Decision Making Process ◽  
Ethical Aspects ◽  
Southern Taiwan ◽  
Colaizzi's Method

The practice of respecting patients’ autonomy is rooted in the healthcare professionals’ empathy for patients’ situations, without which appropriate supports to the patients during the informed consent process may be remarkably moderated. The purpose of this study was to explore elective surgery patients’ experiences during their decision-making process. This research was conducted using a phenomenological approach, and the data analysis was guided by Colaizzi’s method. A total of 17 participants were recruited from a hospital in southern Taiwan. Two major themes emerged from the analyses: (a) a voluntary yet necessary alternative—to undergo a surgery and (b) alternatives compelled by the unalterable decision—the surgery. It was concluded that unless healthcare professionals can empathize with the distressed situation of their patients who are facing elective surgery, the practice of informed consent may become merely a routine. Nurses can be the best advocates for patients and facilitators to enhance communication between patients and healthcare personnel.

scholarly journals Automated Biomarker Candidate Discovery in Imaging Mass Spectrometry Data Through Spatially Localized Shapley Additive Explanations

2020 ◽  
Author(s):  
Leonoor E.M. Tideman ◽  
Lukasz G. Migas ◽  
Katerina V. Djambazova ◽  
Nathan Heath Patterson ◽  
Richard M. Caprioli ◽  
...  
Keyword(s):  
Machine Learning ◽  
Mass Spectrometry ◽  
Molecular Species ◽  
Imaging Mass Spectrometry ◽  
Mass Spectrometry Data ◽  
Decision Making Process ◽  
Spatial Specificity ◽  
The Relationship ◽  
Insight Into ◽  
Imaging Mass Spectrometry Data

AbstractThe search for molecular species that are differentially expressed between biological states is an important step towards discovering promising biomarker candidates. In imaging mass spectrometry (IMS), performing this search manually is often impractical due to the large size and high-dimensionality of IMS datasets. Instead, we propose an interpretable machine learning workflow that automatically identifies biomarker candidates by their mass-to-charge ratios, and that quantitatively estimates their relevance to recognizing a given biological class using Shapley additive explanations (SHAP). The task of biomarker candidate discovery is translated into a feature ranking problem: given a classification model that assigns pixels to different biological classes on the basis of their mass spectra, the molecular species that the model uses as features are ranked in descending order of relative predictive importance such that the top-ranking features have a higher likelihood of being useful biomarkers. Besides providing the user with an experiment-wide measure of a molecular species’ biomarker potential, our workflow delivers spatially localized explanations of the classification model’s decision-making process in the form of a novel representation called SHAP maps. SHAP maps deliver insight into the spatial specificity of biomarker candidates by highlighting in which regions of the tissue sample each feature provides discriminative information and in which regions it does not. SHAP maps also enable one to determine whether the relationship between a biomarker candidate and a biological state of interest is correlative or anticorrelative. Our automated approach to estimating a molecular species’ potential for characterizing a user-provided biological class, combined with the untargeted and multiplexed nature of IMS, allows for the rapid screening of thousands of molecular species and the obtention of a broader biomarker candidate shortlist than would be possible through targeted manual assessment. Our biomarker candidate discovery workflow is demonstrated on mouse-pup and rat kidney case studies.HighlightsOur workflow automates the discovery of biomarker candidates in imaging mass spectrometry data by using state-of-the-art machine learning methodology to produce a shortlist of molecular species that are differentially expressed with regards to a user-provided biological class.A model interpretability method called Shapley additive explanations (SHAP), with observational Shapley values, enables us to quantify the local and global predictive importance of molecular species with respect to recognizing a user-provided biological class.By providing spatially localized explanations for a classification model’s decision-making process, SHAP maps deliver insight into the spatial specificity of biomarker candidates and enable one to determine whether (and where) the relationship between a biomarker candidate and the class of interest is correlative or anticorrelative.

The implications of the decision in Helen Suzman Foundation v Judicial Service Commission 2018 (7) BCLR 763 (CC) 8 on the functioning of the South African Judicial Service Commission

2020 ◽  
Vol 24 ◽  
Author(s):  
Nomthandazo Ntlama
Keyword(s):  
South Africa ◽  
Decision Making ◽  
Human Rights ◽  
South African ◽  
Rule Of Law ◽  
Decision Making Process ◽  
Constitutional Court ◽  
Service Commission ◽  
Insight Into ◽  
Future Management

ABSTRACT The article examines the implications of the judgment of the Constitutional Court in Helen Suzman Foundation v Judicial Service Commission 2018 (7) BCLR 763 (CC) 8 on the functioning of the Judicial Service Commission (JSC). The judgment has brought to the fore a new lease of life relating to the JSC's post-interview deliberations as a disclosable record in terms of Rule 53(1)(b) of the Uniform Rules of Court. The disclosure seeks to provide an insight into the decision-making process of the JSC in the appointment of judicial officers in South Africa. It is argued that the judgment is two-pronged: first, the disclosure of the post-interview record enhances the culture of justification for decisions taken, which advances the foundational values of the new democratic dispensation; secondly, it creates uncertainty about the future management and protection of the JSC processes in the undertaking of robust debates on the post-interview deliberations. It then questions whether the JSC members will be privileged in their engagement with the suitability of the candidates to be recommended for appointment by the President. The question is raised against the uncertainty about which decision of the JSC will be challenged that will need the disclosure of the record because the judgment does not entail the national disclosure of the record in respect of each candidate but applies only when there is an application for review of the JSC decision. Key words: Judicial Service Commission, appointments, discretion, judiciary, independence, rule of law, discretion, accountability, transparency, human rights.

scholarly journals Importance of Ethical Aspects for Decision-Making

2020 ◽  
Vol 10 (3) ◽  
pp. 35
Author(s):  
Zdenek Dytrt ◽  
Radomir Serek
Keyword(s):  
Decision Making ◽  
Sustainable Growth ◽  
Educational Institutions ◽  
Decision Making Process ◽  
Ethical Aspects ◽  
Quantitative Management ◽  
Complex Decision Making ◽  
Effective Decision ◽  
Complex Decision ◽  
Effective Decision Making

The management theory did not develop equally with the changes in technologies. The consequence of this shortcoming is a prevalence of quantitative management which puts an emphasis on the quantitative values. This represents a risk for the sustainable growth. Therefore, the managerial ethics, which biases qualitative values and attitudes, is important for the managers' decision-making. The effective decision-making process is further based not only on the manager's experience, which may lead to a certain routine, but also on the cooperation among the other departments and educational institutions. Furthermore, the successful innovations, which are often an outcome of the systemic and complex decision-making, require to follow certain rules during their implementation. A person may become an initiator, leader, subject or a consumer of the innovation and should be adequately prepared for all these roles. Despite the abrupt development in the technical areas there is not such progress in the humanities. Education is still more focused on the content and form (thus quantity) rather than on the applications and relations (quality).

scholarly journals Structural analysis of urinary glycosaminoglycans from healthy human subjects

Glycobiology ◽  
2019 ◽  
Vol 30 (3) ◽  
pp. 143-151
Author(s):  
Xiaorui Han ◽  
Patience Sanderson ◽  
Sara Nesheiwat ◽  
Lei Lin ◽  
Yanlei Yu ◽  
...  
Keyword(s):  
Electron Transfer Dissociation ◽  
Human Subjects ◽  
Health Condition ◽  
Healthy Human ◽  
Zone Electrophoresis ◽  
Capillary Zone ◽  
Males And Females ◽  
Negative Electron Transfer Dissociation ◽  
Urinary Glycosaminoglycans ◽  
Insight Into

Abstract Urinary glycosaminoglycans (GAGs) can reflect the health condition of a human being, and the GAGs composition can be directly related to various diseases. In order to effectively utilize such information, a detailed understanding of urinary GAGs in healthy individuals can provide insight into the levels and structures of human urinary GAGs. In this study, urinary GAGs were collected and purified from healthy males and females of adults and young adults. The total creatinine-normalized urinary GAG content, molecular weight distribution and disaccharide compositions were determined. Using capillary zone electrophoresis (CZE)–mass spectrometry (MS) and CZE–MS/MS relying on negative electron transfer dissociation, the major components of healthy human urinary GAGs were determined. The structures of 10 GAG oligosaccharides representing the majority of human urinary GAGs were determined.

scholarly journals Ethics in Research with Human Subjects - A Brief Review

1970 ◽  
pp. 24-26
Author(s):  
Md Uzire Azam Khan ◽  
Md Ruhul Amin ◽  
Firoza Begum ◽  
Momotaz Begum
Keyword(s):  
Human Subjects ◽  
Basic Research ◽  
Research Protocol ◽  
Research Subjects ◽  
Nuremberg Code ◽  
Benefit Ratio ◽  
Subject Selection ◽  
Independent Review ◽  
Ethics In Research ◽  
Guide Lines

Ethics in research involving humans were first codified in 1946 as Nuremberg code. Subsequently other ethical declarations and guide lines were developed to protect the research participants as well as the researchers. The basic research bioethics includes three principles-respects for person, beneficence, and justice. To make a research with human subjects ethically sound the research protocol should have social and scientific values, fair subject selection, favorable risk benefit ratio, independent review, and informed consent of and respect for the participants. Above all the researcher should be honest and responsible enough to safeguard the rights and welfare of the research subjects. DOI: 10.3329/bjpp.v24i1.5734Bangladesh J Physiol Pharmacol 2008; 24(1&2) : 24-26

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