scholarly journals Effects of Repeatedly Heated Palm Oil on Serum Lipid Profile, Lipid Peroxidation and Homocysteine Levels in a Post-Menopausal Rat Model

2020 ◽  
Vol 11 (2) ◽  
Author(s):  
Siti Khadijah Adam ◽  
Ima Nirwana Soelaiman ◽  
Nor Aini Umar ◽  
Norhayati Mokhtar ◽  
Norazlina Mohamed ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Lipid Profile ◽  
Palm Oil ◽  
Serum Lipid ◽  
Unsaturated Fatty Acids ◽  
Thiobarbituric Acid ◽  
Serum Lipid Profile ◽  
Control Group ◽  
Cholesterol Diet ◽  
Sprague Dawley

Oxidized unsaturated fatty acids may contribute to the pathogenesis of atherosclerosis. In the present study, we examined the effects of heated palm oil mixed with 2% cholesterol diet on serum lipid profile, homocysteine and thiobarbituric acid reactive substances (TBARS) levels in estrogen-deficient rats. Twenty-four female Sprague Dawley rats were ovariectomized and then were divided equally into four groups. The control group was given 2% cholesterol diet only throughout the study period. The three treatment groups received 2% cholesterol diet fortified with fresh, once-heated or five-times-heated palm oil,respectively. Serum TBARS, lipid profile and homocysteine levels were measured prior to ovariectomy and at the end of four months of the study. Five-times-heated palm oil caused a significant increase in TBARS and total cholesterol (TC) compared to control (F = 22.529, p < 0.05). There was a significant increase in serum homocysteine in the control as well as five-times heated palm oil group compared to fresh and once-heated palm oil groups (F = 4.432, p < 0.05). The findings suggest that repeatedly heated palm oil increase lipid peroxidation and TC. Ovariectomy increases the development of atherosclerosis as seen in this study. Feeding with fresh and once-heated palm oil does not cause any deleterious effect but repeatedly heated oil may be harmful because it causes oxidative damage thereby predisposing to atherosclerosis.

scholarly journals Effect of Ethanol Extract of Glycine Max (Soy Bean) on Serum Lipid Profile of Fat-Fed Hyperlipidemic Rats

2018 ◽  
Vol 10 (1) ◽  
pp. 21-26
Author(s):  
K Sharmin ◽  
R Ahmed ◽  
A Momtaz ◽  
SA Chowdhury ◽  
NA Maya ◽  
...  
Keyword(s):  
Glycine Max ◽  
Lipid Profile ◽  
Serum Lipid ◽  
Serum Lipid Profile ◽  
Lipid Lowering ◽  
Control Group ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Experimentally Induced

Hypercholesterolemia is one of the important causes of cardiovascular disease related mortality and morbidity and recently it has become a significant issue in public health problem of developing countries. The purpose of the study was to see the effect of glycine max (soy bean) on serum lipid profile of experimentally induced hyperlipidemic rats. Hypercholesterolemia was induced by high cholesterol diet containing 1% cholesterol in olive oil. This study was done on 24 long Norwegian rats (Rattus norvegicus) weighing about 200-210 gram. For convenience, the study was divided into Experiment I and Experiment II. In experiment I, 12 rats were divided into two groups- Group A (n = 6, control group) fed on laboratory diet and Group B (n=6) fed on laboratory diet and soy bean extract for 35 days. In experiment II, the remaining 12 rats were divided into 2 groups, Group C (n=6) were fed on laboratory diet and high cholesterol diet (HCD) for 35 days and Group D (n=6) were fed laboratory diet and high cholesterol diet on initial 10 days and soy bean extract was added along with high cholesterol diet for next 25 days. Serum TC, TG, LDL-C and HDL-C were measured after 35 days. HCD increased TG, TC and LDL-C significantly in group C. Glycine max (soy bean) treated group showed that it decreased plasma TC, TG and LDL-C in experimentally induced hyperlipidemic rats but Glycine max (soy bean) did not show any significant lipid lowering effect in normolipidemic rats. The results of this experimental study indicate that Glycine max can act as a cholesterol lowering agent and thereby can improve cardiovascular functions.Bangladesh J Med Biochem 2017; 10(1): 21-26

scholarly journals Canavalia ensiformis Protein Extract Effect Toward Serum Lipid Profile of Hypercholesterolemic Sprague Dawley Rat

2018 ◽  
Vol 14 (1) ◽  
pp. 49-55
Author(s):  
Mira Dian Naufalina ◽  
Muchlis AU Sofro ◽  
Gemala Anjani
Keyword(s):  
Lipid Profile ◽  
Serum Lipid ◽  
Ldl Cholesterol ◽  
Serum Lipid Profile ◽  
Control Group ◽  
Sprague Dawley ◽  
Protein Extract ◽  
Jack Bean ◽  
Sprague Dawley Rat ◽  
Experimental Group

Riskesdas 2013 showed the prevalence of abnormal total cholesterol levels in Indonesia is 35.9%, low HDL cholesterol is 22.9%, high LDL cholesterol is 15.9%, and high triglyceride is 11.9%. This study aimed to prove the effect of jack bean protein extract toward serum lipid profile of a hypercholesterolemic rat. This was a true experimental study conducted in September 2016 with post-only control group design. Twenty four male Sprague Dawley rats were randomly classified into 4 different groups; control negative group (C-), control positive group (C+), first experimental group (X1) which was given jack bean extract 4g/200g of body weight of the rat per day, and second experimental group (X2) which was given jack bean extracts 6g/200g of body weight of the rat per day. Treatment for 2 weeks showed a significant effect. Total cholesterol, LDL cholesterol, and triglycerides levels of groups with protein jack bean extract administration were lower than the positive control group (p <0.05). Increasing doses of jack bean extracts was linear with serum lipid profile improvement of Sprague Dawley Rat. These result indicated the positive effect of jack bean protein extract toward serum lipid profile of hypercholesterolemic Sprague Dawley Rat.

scholarly journals Omega-3 polyunsaturated fatty acids-enriched hen eggs consumption enhances microvascular reactivity in young healthy individuals

2018 ◽  
Vol 43 (10) ◽  
pp. 988-995 ◽  
Author(s):  
Ana Stupin ◽  
Lidija Rasic ◽  
Anita Matic ◽  
Marko Stupin ◽  
Zlata Kralik ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Lipid Profile ◽  
Serum Lipid ◽  
Serum Lipid Profile ◽  
Control Group ◽  
Omega 3 ◽  
Healthy Individuals ◽  
Microvascular Reactivity ◽  
Significant Difference

The beneficial effect of omega-3 polyunsaturated fatty acids (PUFA) supplementation on the cardiovascular (CV) system is well supported in CV patients; however, the effect of the consumption of omega-3 PUFA-enriched functional food in healthy individuals is still not fully elucidated. This study aimed to determine the effect of the consumption of omega-3 PUFA-enriched hen eggs on the microvascular reactivity (primary outcome), blood pressure (BP), and serum lipid profile in young healthy individuals. The control group (N = 16) ate 3 ordinary hen eggs (277 mg of omega-3 PUFAs/day), and the OMEGA-3 group (N = 20) ate 3 omega-3 PUFA-enriched eggs containing 259 mg of omega-3 PUFAs/egg daily (α-linolenic acid (ALA), 167 mg/egg; eicosapentaenoic acid (EPA), 7 mg/egg; docosahexaenoic acid (DHA), 84 mg/egg) for 3 weeks (777 mg of omega-3 PUFA/day). Postocclusive reactive hyperemia (PORH) in skin microcirculation assessed by laser Doppler flowmetry, serum lipid profile, fasting blood glucose, high-sensitivity C-reactive protein (hsCRP), and arterial BP were measured in all subjects before and after the protocol. PORH was significantly enhanced, and triglycerides, hsCRP, and BP were significantly decreased in the OMEGA-3 group compared with baseline measurements, whereas there was no significant difference in the control group after the protocol when compared with baseline. To the best of our knowledge, this is the first study to demonstrate that consumption of a mixture of omega-3 PUFA (ALA + EPA + DHA), provided via enriched hen eggs, elicits changes in the microvascular reactivity, BP, and triglyceride level in healthy subjects that are associated with CV benefits, thus suggesting that daily consumption of omega-3 PUFA-enriched eggs in healthy individuals may potentially contribute to CV risk factor attenuation and disease prevention.

scholarly journals Estimation of Serum Lipid Profile and Its Correlation with Alveolar Bone Height in Chronic Periodontitis

2019 ◽  
pp. 1-6
Author(s):  
Avadhut Kamble ◽  
Mukta Motwani ◽  
Naman Shah
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Chronic Periodontitis ◽  
Serum Lipid ◽  
Fasting Blood Glucose ◽  
Screening Method ◽  
Serum Lipid Profile ◽  
Control Group ◽  
Group I ◽  
Significant Difference

Aim: Numerous studies have been previously carried out to find out any correlation between lipid profile and periodontitis but existence of an association does not establish whether periodontitis causes an elevation in serum lipid level or elevation in serum lipid profile predispose to periodontitis. The aim of the present study was to find any significant correlation between HDL, LDL, VLDL and cholesterol with periodontitis. Material and Methods: 100 patients with chronic periodontitis (group I) and 50 healthy patients (group II) were selected. The levels of serum lipid, including HDL, LDL, VLDL, and TOTAL CHOLESTEROL along with fasting blood glucose were assessed. The relationship between severity of periodontitis based on clinical and radiographic finding with serum lipid correlated. Results: There was no significant difference found between mean values of total cholesterol, LDL and VLDL among study and control group. Only HDL showed a highly significant difference (p< 0.00) between healthy and patient with chronic periodontitis. Conclusion: Estimation of serum lipid profile, especially HDL levels in subjects with periodontitis can be considered as a screening method for early diagnosis of atherosclerosis to avoid further progression of cardiovascular changes in early age of the life.

scholarly journals The Protective Role of Coenzyme Q10 in Metallothionein-3 Expression in Liver and Kidney Upon Rats’ Exposure to Lead Acetate

2021 ◽  
Author(s):  
Ardeshir Afshar Mazandaran ◽  
Parvin Khodarahmi
Keyword(s):  
Lipid Profile ◽  
Serum Lipid ◽  
Lead Acetate ◽  
Protective Role ◽  
Serum Lipid Profile ◽  
Control Group ◽  
Cytotoxic Effects ◽  
Cyt C ◽  
Renal Expression

Abstract Metallothionein-3 (MT3) is an antioxidant protein that alters after exposure to heavy metals. In this study, we investigated the hepatic and renal expression of MT3 gene following exposure to lead acetate (PbAc) alone and PbAc plus CoQ10 as an adjuvant antioxidant. Twenty-four rats were allocated into three groups, including control, PbAc (free access to drinking water contaminated with PbAc at 1g/100ml), and PbAc plus CoQ10 (10 mg/kg/day Oral). After 28 consecutive days of treatment, the mRNA expression of MT3 and Cyt-c genes and MT3 protein levels were assessed using real-time PCR and immunosorbent assay. The serum lipid profile was also monitored in the three groups. PbAc exposure significantly reduced the hepatic and renal MT3 mRNA and protein expression compared to the control group. This reduction was significantly increased with addition of CoQ10 to levels near those of the control group. The hepatic and renal expression of Cyt-c mRNA increased after treatment with PbAc, while such effect was reversed after addition of CoQ10. Alteration in lipid profile including increased cholesterol and low-density lipoprotein levels were observed after PbAc exposure which were counteracted by CoQ10. Our results confirm the cytotoxic effects of acute lead exposure manifested as changes in the serum lipid profile and cellular levels of Cyt-c mRNA. These cytotoxic effects may have been caused by decreased MT3 gene expression and be reduced by the protective role of CoQ10.

Comparative Effect of Garden Egg Fruit, Oat and Apple on Serum Lipid Profile in Rats Fed a High Cholesterol Diet

2005 ◽  
Vol 4 (4) ◽  
pp. 245-249 ◽  
Author(s):  
James Karho Edijala . ◽  
Samuel Ogheneovo Asa . ◽  
George Edaghogho Eri . ◽  
Uzezi Atomatofa .
Keyword(s):  
Lipid Profile ◽  
Serum Lipid ◽  
Serum Lipid Profile ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Comparative Effect

Antihypercholesterolemia Effect of Acalypha indica L. to Serum Lipid Profile and Histopathology Liver on Sprague Dawley Rats: Focused on Gemfibrozil as a Control

2017 ◽  
Vol 23 (7) ◽  
pp. 6966-6969 ◽  
Author(s):  
Rani Wardani Hakim ◽  
Melisa Leviana ◽  
Desak Gede Budi Krisnamurti ◽  
Taufik Budianto ◽  
Hardya Gustada ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Serum Lipid ◽  
Serum Lipid Profile ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Acalypha Indica

scholarly journals Effect of Stellaria media Tea on Lipid Profile in Rats

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Virág Demján ◽  
Tivadar Kiss ◽  
Andrea Siska ◽  
Márton Richárd Szabó ◽  
Márta Sárközy ◽  
...  
Keyword(s):  
Body Weight ◽  
Lipid Profile ◽  
Serum Lipid ◽  
Serum Lipid Profile ◽  
Control Group ◽  
Stellaria Media ◽  
Experimental Proof ◽  
Cardiac Morphology ◽  
Liver And Kidney ◽  
And Function

Background. In folk medicine, common chickweed (Stellaria media) has traditionally been applied for the treatment of hypercholesterolemia; however, there is no firm experimental proof to support the rationale of this practice. Therefore, we aimed to assess the efficacy and safety of Stellaria media tea in hypercholesterolemic rats. Materials and Methods. Adult male Wistar rats were divided into 3 groups. The (i) control group received standard laboratory chow, the (ii) hypercholesterolemic group received cholesterol-enriched diet, and the (iii) chickweed-treated hypercholesterolemic group received cholesterol-enriched diet and 100 mg/kg body weight Stellaria media tea lyophilizate for 8 weeks. Blood samples were collected to determine serum lipid profile as well as liver and kidney function, and echocardiography was performed to assess cardiac morphology and function. Results. Cholesterol-enriched diet significantly increased serum total cholesterol, LDL- and HDL-cholesterol levels, but did not affect triacylglycerol concentrations. The addition of chickweed to the diet did not cause any significant change in serum lipid profile or body weight increase. Liver and kidney functions were unaltered and cardiac morphology and function were not changed due to Stellaria media tea lyophilizate. Conclusion. Although chickweed does not seem to be toxic, our results do not support the rationale of its use in the treatment of hypercholesterolemia.

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