scholarly journals C - reactive protein levels in women with pregnancy induced hypertension

1970 ◽  
Vol 10 (3) ◽  
pp. 159-162 ◽  
Author(s):  
TK Ghosh ◽  
S Ghosh ◽  
D Bhattacharjee
Keyword(s):  
Normal Control ◽  
Hematological Parameter ◽  
Adult Women ◽  
Pregnancy Induced Hypertension ◽  
C Reactive Protein ◽  
Medical College ◽  
Protein Levels ◽  
Reactive Protein ◽  
Induced Hypertension ◽  
Pregnant Mothers

Objective: The main objective of this study is to determine the level of C- reactive protein in pregnancy induced hypertension (PIH) along its relation with normal pregnant mothers and also to compare it with different grades of pregnancy. C-reactive protein and inflammation are interrelated. Another objective of this study is to find out the relationship of C- reactive protein, biochemical and hematological parameter in PIH as well as its clinical correlation. Materials and Methods: The study was conducted in the department of Gynaecology and department of Pathology in Burdwan Medical College West Bengal India after taking permission from ethical committee. 50 cases of PIH mothers and age and gestational matched 50 cases of normal control pregnant mothers and 50 normal healthy non pregnant adult women were included in this present study. CRP was estimated by turbidometric method. Serum Uric acid, SGPT, Serum Creatinine were estimated by semi auto analyzer, Serum ß HCG was estimated by ELISA technique. The total leukocytes count, absolute Neutrophils count, Platelet counts were done in hematological cell counter with correlation from peripheral direct smear and manual counting. Urine protein was detected by dipstick method. Results: Serum C- reactive protein was positively correlated with severity of in PIH. Results shows a significantly increased C-reactive protein in PIH (Mean SD 42.02 mg/L±18 .01 mg/L, P<0.001) in comparison to normal control mother (Mean SD 4.2 ±0.93 mg/L). Conclusion: Serum C-reactive protein levels can be used as marker for early diagnosis and intervention of PIH and can be reduced maternal as well as fetal morbidity and mortality. Key words: C - reactive protein, pregnancy induced hypertension. DOI: http://dx.doi.org/ 10.3329/bjms.v10i3.8358 BJMS 2011; 10(3): 159-162

Serum Uric Acid Level as a Predictive Biomarker of Gestational Hypertension Severity; A Prospective Observational Case-Control Study

2020 ◽  
Vol 15 (3) ◽  
pp. 227-239 ◽  
Author(s):  
Hader I. Sakr ◽  
Akef A. Khowailed ◽  
Reham S. Al-Fakharany ◽  
Dina S. Abdel-Fattah ◽  
Ahmed A. Taha
Keyword(s):  
Blood Pressure ◽  
Pregnant Women ◽  
Case Control Study ◽  
Serum Urate ◽  
Interleukin 1Β ◽  
Pregnancy Induced Hypertension ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Induced Hypertension ◽  
Control Study

Background: Pre-eclampsia poses a significant potential risk of hypertensive disorders during pregnancy, a leading cause of maternal deaths. Hyperuricemia is associated with adverse effects on endothelial function, normal cellular metabolism, and platelet aggregation and adhesion. This study was designed to compare serum urate levels in normotensive pregnant women to those with pregnancy-induced hypertension, and to evaluate its value as a potential predictive marker of hypertension severity during pregnancy. Methods: A prospective, observational, case-control study conducted on 100 pregnant women in their third trimester. Pregnant women were classified into two groups (n=50) according to arterial blood pressure measurements: group I had normal blood pressure, and group II had a blood pressure of ≥ 140/90, which was further subdivided according to hypertension severity into IIa (pregnancy- induced hypertension, IIb (mild pre-eclampsia), and IIc (severe pre-eclampsia). Blood samples were obtained on admission. Serum urate, high sensitive C-reactive protein, and interleukin-1β levels, and lipid profile were compared among the groups. Results: A significant increase in the mean values of serum urate, C-reactive protein, and interleukin- 1β levels was detected in gestational hypertensives. In addition, there was a positive correlation between serum urate levels and C-reactive protein and interleukin-1β, as well as between serum urate levels and hypertension severity. Conclusion: Hyperuricemia and increased C-reactive protein and interleukin-1β serum levels correlate with the severity of pregnancy-induced hypertension, and these biomarkers may play a role in the pathogenesis of pre-eclampsia. Serum urate measurement is sensitive, reliable markers that correlate well with the severity of hypertension in pregnant females with pre-eclampsia.

scholarly journals Fibronectin and C-reactive protein in pregnancy induced hypertension

2003 ◽  
Vol 22 (4) ◽  
pp. 325-328
Author(s):  
Svetlana Djuricic ◽  
Marina Stojanov ◽  
Ivana Obradovic ◽  
Aleksandar Glisic ◽  
Darko Plecas
Keyword(s):  
Normal Pregnancy ◽  
Medical Complication ◽  
Pregnancy Induced Hypertension ◽  
Plasma Fibronectin ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Nephelometric Method ◽  
Induced Hypertension ◽  
The One ◽  
In Pregnancy

Hypertension is the most common medical complication in pregnancy. Of the varying forms of hypertension that can effect pregnancy pre-eclampsia is the one specific to pregnant women. The differential diagnosis between pre-eclampsia and pregnancy induced hypertension (PIH) is essential to proper management of pregnancy. The aim of this study was to examine the effect of hypertension on plasma fibronectin and C-reactive protein (CRP) during gestatation. The examined groups comprised 37 patients with normal pregnancy and 30 with PIH between 24 and 36 weeks of gestation. Plasma fibronectin and CRP were both assayed by nephelometric method. The obtained results for both examined parameters were significantly higher in PIH group than in controls (p < 0.05). A positive correlation was found between fibronectin, CRP and weeks of gestation (p < 0.05). Therefore, we can conclude that plasmatic fibronectin and CRP are among useful screening parameters for estimation of the endothelial injury in hypertensive disorders of pregnancy.

scholarly journals C-reactive protein levels in children with uncomplicated malaria

2017 ◽  
Vol 4 (2) ◽  
pp. 573
Author(s):  
Dipthi Nishal Castelino ◽  
K. Shreedhara Avabratha
Keyword(s):  
Parasite Density ◽  
Uncomplicated Malaria ◽  
Malaria Parasite ◽  
Clinical Signs ◽  
C Reactive Protein ◽  
Major Health Problem ◽  
Medical College ◽  
Protein Levels ◽  
Reactive Protein ◽  
Paediatric Age

Background: Malaria is one of the biggest burden in terms of morbidity and mortality among all infectious diseases and continues to be a major health problem in India. The objective of this study was to study the levels of C-reactive protein in children with uncomplicated Malaria. To correlate C-reactive protein levels with malaria parasite density and species of Malaria.Methods: Retrospective study was done in Father Muller Medical College, Mangalore, Karnataka. 50 patients below 15 years of age malaria parasite positive by fluorescent test (MPFT) and by Peripheral smear formed the subjects and CRP levels and parasite densities was noted down into the proforma.Results: The age group predominantly was children more than 10 years. Plasmodium vivax was the type of malaria in 60% children. Most common symptoms were fever (100%), chills and rigors (41%), vomiting (48%) and headache (24%). Clinical signs observed were hepatomegaly (30%) and splenomegaly (64%). Mean levels of C reactive protein (CRP) were 42.91%with standard deviation of 31.62. Mean CRP levels were high in children with Falciparum malaria (44.51±34.19).58% had CRP levels ranging from 6-50 mg/l. 50% children with CRP levels >50 mg/L had parasite density of (++++) which is 100 parasites per 1 field of quantitative buffy coat.Conclusions: C-reactive protein levels are markedly elevated in acute malarial infection in paediatric age group.It correlates well with disease severity.

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