scholarly journals Newly onset: sudden & severe headache in a patient who overused analgesic

2015 ◽  
Vol 14 (4) ◽  
pp. 399-401 ◽  
Author(s):  
Khairi Che Mat ◽  
Rohayah Husain ◽  
Nasir Mohamad
Keyword(s):  
Medical Science ◽  
Severe Headache ◽  
Increased Intracranial Pressure ◽  
Provisional Diagnosis ◽  
Early Management ◽  
Progressive Development ◽  
Acute Headache ◽  
First Time ◽  
Space Occupying Lesion ◽  
New Onset

This case report presented a rare cause of severe headache in a patient who developed episodes of acute severe headache for the first time. The earliest accurate provisional diagnosis is crucial for a new onset severe headache in adult. A good history taking and high index of suspicious are remained the most important clinical component in managing severe first time headache in adult. The differential diagnosis of subarachnoid hemorrhage, space-occupying lesion with increased intracranial pressure, acute intoxication, meningo-encephalitis and others must be ruled out as these conditions are benefited in early management. In this patient, progressive development of headache is masked by severe intense headache, which later will be described as acute headache. The causes of newly onset severe intense headache will be discussed in the discussion.Bangladesh Journal of Medical Science Vol.14(4) 2015 p.399-401

New-onset systemic sclerosis and scleroderma renal crisis under docetaxel

2021 ◽  
pp. 239719832110076
Author(s):  
Véronique Debien ◽  
Arthur Petitdemange ◽  
Dorothée Bazin ◽  
Carole Ederle ◽  
Benoit Nespola ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Rna Polymerase Iii ◽  
Systemic Autoimmune Disease ◽  
Scleroderma Renal Crisis ◽  
Prostate Cancers ◽  
Poor Outcomes ◽  
Induced Changes ◽  
First Time ◽  
Lung And Kidney ◽  
New Onset

Systemic sclerosis is a rare systemic autoimmune disease characterized by microvascular impairment and fibrosis of the skin and other organs with poor outcomes. Toxic causes may be involved. We reported the case of a 59-year-old woman who developed an acute systemic sclerosis after two doses of adjuvant chemotherapy by docetaxel and cyclophosphamide for a localized hormone receptor + human epithelial receptor 2—breast cancer. Docetaxel is a major chemotherapy drug used in the treatment of breast, lung, and prostate cancers, among others. Scleroderma-like skin-induced changes (morphea) have been already described for taxanes. Here, we report for the first time a case of severe lung and kidney flare with thrombotic microangiopathy after steroids for acute interstitial lung disease probably induced by anti-RNA polymerase III + systemic sclerosis after docetaxel.

History of Headache Research in Denmark

Cephalalgia ◽  
2001 ◽  
Vol 21 (7) ◽  
pp. 748-752 ◽  
Author(s):  
P Tfelt-Hansen
Keyword(s):  
Migraine With Aura ◽  
Tension Type Headache ◽  
Regional Cerebral Blood ◽  
Danish Population ◽  
Genetic Studies ◽  
History Of ◽  
Headache Clinic ◽  
Type Headache ◽  
Acute Headache ◽  
First Time

Headache research in Denmark started with the description in 1949 by Dalsgaard-Nielsen of the percutaneous nitroglycerin test. In 1976 Jes Olesen started The Copenhagen Acute Headache Clinic and from that time modern headache research began in Denmark. Specific changes in regional cerebral blood flow during attacks of migraine with aura, spreading oligaemia, were described for the first time in 1980. The first headache classification with operational diagnostic criteria was published in 1988 and used in a Danish population study from 1989. The lifetime prevalence of migraine was 8% in men and 25% in women. An intravenous nitroglycerin test was introduced in 1989 and has been developed as an experimental headache model. In 1993 it was suggested by Jes Olesen et al. that NO supersensitivity could be a possible molecular mechanism of migraine pain. Recent genetic studies have supported the distinction between migraine with aura and migraine without aura. From the middle of the 1980s the pathophysiology of tension-type headache has been investigated and recent results indicate central sensitization in patients with chronic tension-type headache.

Seizure Disorders

2016 ◽  
pp. 633-638
Author(s):  
Lily C. Wong-Kisiel
Keyword(s):  
Intracranial Pressure ◽  
Brain Tumors ◽  
Behavioral Changes ◽  
Increased Intracranial Pressure ◽  
Primary Brain Tumors ◽  
Seizure Disorders ◽  
Neurologic Deficits ◽  
New Onset

Brain tumors may manifest with focal progressive neurologic deficits, increased intracranial pressure (causing headache, vomiting, and papilledema), new-onset seizures, or progressive cognitive and behavioral changes. The most common primary brain tumors in adults are meningioma, astrocytoma, oligodendroglioma, and lymphoma.

scholarly journals Cyclopropenium Nanoparticles and Gene Transfection in Cells

Pharmaceutics ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 768
Author(s):  
Noam Y. Steinman ◽  
Luis M. Campos ◽  
Yakai Feng ◽  
Abraham J. Domb ◽  
Hossein Hosseinkhani
Keyword(s):  
Viral Vectors ◽  
Gene Transfection ◽  
Medical Science ◽  
Genetic Material ◽  
Mouse Fibroblast ◽  
Ethylene Imine ◽  
Efficient Gene ◽  
Poly Ethylene ◽  
First Time

Non-viral vectors for the transfection of genetic material are at the frontier of medical science. In this article, we introduce for the first time, cyclopropenium-containing nanoparticles as a cationic carrier for gene transfection, as an alternative to the common quaternary ammonium transfection agents. Cyclopropenium-based cationic nanoparticles were prepared by crosslinking poly(ethylene imine) (PEI) with tetrachlorocyclopropene. These nanoparticles were electrostatically complexed with plasmid DNA into nanoparticles (~50 nm). Their cellular uptake into F929 mouse fibroblast cells, and their eventual expression in vitro have been described. Transfection is enhanced relative to PEI with minimal toxicity. These cyclopropenium nanoparticles possess efficient gene transfection capabilities with minimal cytotoxicity, which makes them novel and promising candidates for gene therapy.

Bevacizumab used for the treatment of severe, refractory perilesional edema due to an arteriovenous malformation treated with stereotactic radiosurgery

2012 ◽  
Vol 116 (5) ◽  
pp. 972-977 ◽  
Author(s):  
Brian J. Williams ◽  
Deric M. Park ◽  
Jason P. Sheehan
Keyword(s):  
Pain Management ◽  
Arteriovenous Malformation ◽  
Stereotactic Radiosurgery ◽  
Gamma Knife ◽  
Corticosteroid Therapy ◽  
Severe Headache ◽  
Central Sulcus ◽  
Intracranial Arteriovenous Malformation ◽  
Perilesional Edema ◽  
First Time

The authors present a case of an arteriovenous malformation of the central sulcus treated with Gamma Knife surgery. The patient developed perilesional edema 9 months after treatment and experienced severe headache and hemiparesis. Her symptoms were refractory to corticosteroid therapy and pain management. She was subsequently treated with bevacizumab with striking improvement in her symptoms and results of neuroimaging studies. This is the first time that bevacizumab has been used to control severe refractory perilesional edema related to an intracranial arteriovenous malformation.

The Need for Schools of Psychiatry

1920 ◽  
Vol 66 (272) ◽  
pp. 10-23
Author(s):  
C. Hubert Bond
Keyword(s):  
Public Health ◽  
Mental Disorder ◽  
Annual Report ◽  
Medical Profession ◽  
Medical Science ◽  
Medical Schools ◽  
Public Institutions ◽  
Extended Form ◽  
First Time ◽  
Important Branch

In their fourth Annual Report, published in 1918, the Board of Control drew attention—not for the first time, but in more extended form than hitherto—to deficiencies in the arrangements, as at present organised, for the treatment of persons suffering from mental disorder, especially in its incipient and early stages; to the insufficiency of attention paid at medical schools to this important branch of medical science with its consequent ill-effects both to patients and to the medical profession; and to the absence of any special qualification in psychiatry, as a requirement for the higher medical posts in public institutions for the insane, such as is demanded in public health of medical officers of health of areas of above a stated size.

scholarly journals Uncommon Presentation of Idiopathic Intracranial Hypertension in a Patient with Polycystic Ovary Syndrome: A Case Report

2017 ◽  
Vol 9 (1) ◽  
pp. 49-53
Author(s):  
Anas Mohammad Albarrak ◽  
Suleiman Kojan
Keyword(s):  
Intracranial Pressure ◽  
Polycystic Ovary Syndrome ◽  
Intracranial Hypertension ◽  
Idiopathic Intracranial Hypertension ◽  
Polycystic Ovary ◽  
Fluid Composition ◽  
Increased Intracranial Pressure ◽  
Ovary Syndrome ◽  
Early Management ◽  
Uncommon Presentation

Introduction: Idiopathic intracranial hypertension is a rare condition characterized by increased intracranial pressure without clinical, laboratory, or radiological evidence of intracranial pathology. Early management could prevent irreversible outcomes. Case Presentation: A 17-year-old single Arabian female of Arab origin presented with a 2-day complaint of horizontal diplopia and transient visual obscurations. She denied any history of headache or decreased vision. The patient was diagnosed with polycystic ovary syndrome a year prior to presentation. Examination revealed bilateral moderate papilledema and limited left eye abduction. However, visual acuity and fields were normal. Increased intracranial pressure was confirmed by lumbar puncture opening pressure (550 mm H<Sub>2</Sub>O). The cerebrospinal fluid composition and imaging of brain and cerebral venous system were normal. The diagnosis of idiopathic intracranial hypertension was confirmed and the patient was treated with acetazolamide 500 mg twice per day. The symptoms totally resolved within 3 days and the papilledema disappeared after 2 months. Conclusion: Awareness of such uncommon presentation of idiopathic intracranial hypertension emphasizes the critical importance of detailed ophthalmic examination and shows the good prognosis of early management.

scholarly journals Assessment of socio-economic risks by method of extremely critical (threshold) indicators

POPULATION ◽  
2021 ◽  
Vol 24 (3) ◽  
pp. 8-17
Author(s):  
Vyacheslav Lokosov
Keyword(s):  
Social System ◽  
Risk Indicators ◽  
Critical Threshold ◽  
Past Century ◽  
Russian Society ◽  
Progressive Development ◽  
Transitional State ◽  
First Time ◽  
Economic Risks

Method of extremely critical (threshold) indicators of social development, including assessment of socio-economic risks, has been developed in the national sociology, economics, and other social sciences about three decades. For the first time development of the method as a scientific problem was stated in 1994, and there was made an attempt to construct such scale of indicators. Development of the method is going productively. There have been published a series of research works, dissertations that directly or indirectly develop or apply this method, propose different variants of constructing a scale of indicators. We have three basic components of situation diagnosis: the existing social system, the risks (challenges, threats) hampering progressive development of this system, and the extremely critical values of the risk indicators, a certain "red line", going beyond which means an increase in the probability of radical changes and further— collapse of the existing system, its transitional state and reorganization. The research and management tasks are to counteract such risks and to prevent entry of the society into the critical zone; or vice versa, to stimulate transformation of the system. The article provides an assessment of the socio-economic risks by method of extremely critical (threshold) indicators that leads to conclusion about a certain, far from complete and sufficient departure of the Russian society from the critical line of the 90s of the past century, and therefore about a tendency to reduction of the risk of another dismantlement of the existing social system. Along with these positive changes, dangerous disproportions and critical risks remain in many socio-economic indicators, primarily related to demography, population health, standards and quality of life.

scholarly journals Comparison of CDC Bottle Bioassay with WHO Standard Method for Assessment Susceptibility Level of Malaria Vector, Anopheles stephensi to Three Imagicides

2019 ◽  
Author(s):  
Hassan Vatandoost ◽  
Mohammad Reza Abai ◽  
Morteza Akbari ◽  
Ahmad Raeisi ◽  
Hemn Yousefi ◽  
...  
Keyword(s):  
Insecticide Resistance ◽  
Anopheles Stephensi ◽  
Medical Science ◽  
Natural Populations ◽  
Standard Test ◽  
Test Method ◽  
Significant Difference ◽  
Anopheles Vectors ◽  
Susceptibility Tests ◽  
First Time

Background: The detection of insecticide resistance in natural populations of Anopheles vectors is absolutely necessary for malaria control. CDC bottle bioassay as a new tools has been employed for detecting the insecticide resistance. For a limit number of mosquito vectors, diagnostic doses and diagnostic times for some insecticides have already been deter­mined using this new assay. For the first time in the area, susceptibility levels of Anopheles stephensi was done with DDT, deltamethrin, and bendiocarb using CDC bottle bioassay and compared results with WHO standard test method. Methods: Anopheles stephensi were collected in larvae stage from the cisterns of drinking water in Chabahar port which considered as old malaria foci, Sistan and Baluchistan province. The field collected larvae were colonized at the insectary of School of Public Health (SPH), Tehran University of Medical Science. The susceptibility tests were carried out on sugar fed female mosquitoes aged 2–3 days, against DDT 4%, bendiocarb 1% and deltamethrin 0.05% using WHO and CDC susceptibility methods. The mortality and knockdown rates, as well as the parameters of regression analysis, includ­ing LT50 and LT90, was calculated separately for the WHO and CDC methods.  Results: The 24h mortality rates of An. stephensi were 28.6% and 25.6% for DDT, 60.8% and 64.6% for bendiocarb and 100% for deltamethrin using both WHO and CDC assay at 30 and 60min respectively. The 50% lethal times (LT50) were estimated 44.9 and 66.2min, 38.9 and 81.8min and 0.7 and 15.0min respectively using both WHO and CDC susceptibility tests. Conclusion: The similar results of susceptibility levels were shown for DDT, bendiocarb and deltamethrin. The lethal times (LT50) showed significant difference using both WHO and CDC bioassay methods.

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