Evaluation of vitamin D levels and body mass indexes of university employees

Objective: Vitamin D is known to have important effects on human health. The existence of a relationship between obesity and vitamin D levels, which have been shown to cause a number of health problems with various studies, is certain. In this study, the relationship between vitamin D levels and body mass indexes(BMI) of individuals was evaluated. The study is unique for being the only research on literature that carried out with university employees. Materials and methods: Blood samples, anthropometric measurement (BMI) was obtained from 87 volunteer working at Haliç University. The questionnaire form covering the basic questions applied by means of face-to-face method. Quantification of the analytes for 25-hydroxyvitamin-D was carried out using LC-MS/MS. The relationship between 25-hydroxyvitamin-D values and BMI was evaluated with Tukey HSD multiple comparison test. 95% confidence and 80% power sampling were applied to the predictions of a minimum0.50 connection coefficient between 2 quantitative variables.The necessity of 30 cases was determined by using the N = [(Zα+Zβ)/C]2 + 3formula.Considering the losses, the work will be carried out over 80 people. Results and Discussion: There’s significant difference between 25-hydroxyvitamin-D2 and 25-hydroxyvitamin-D3 and the BMI levels of the subjects(p:0.028<0.05-p:0.000<0.05). The average 25-hydroxyvitamin-D3 and 25-hydroxyvitamin-D2 levels of overweight participants were significantly higher than the mean levels of underweight participants’. No significant relationship was found between 25-hydroxyvitamin-D3 and 25-hydroxyvitamin-D2 levels and the time spent outdoors during summer and winter. Conclusion: To prevent vitamin D deficiency and insufficiency is to obtain some sensible sun exposure, ingest foods that contain vitamin D, and take supplement. Bangladesh Journal of Medical Science Vol.19(2) 2020 p.229-236

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To screen or not to screen? Vitamin D deficiency in chronic mental illness

Australasian Psychiatry ◽

10.1177/1039856217726717 ◽

2017 ◽

Vol 26 (1) ◽

pp. 56-59

Author(s):

Ivana Goluza ◽

Jay Borchard ◽

Nalin Wijesinghe ◽

Kishan Wijesinghe ◽

Nagesh Pai

Keyword(s):

Vitamin D ◽

Length Of Stay ◽

P Value ◽

Hydroxyvitamin D ◽

Psychiatric Setting ◽

Retrospective Audit ◽

Vitamin D Levels ◽

Significant Difference ◽

25 Hydroxyvitamin D ◽

The Mean

Objectives: The objective of the current study was to examine the pathology test utilisation of 25-hydroxyvitamin D (25(OH)D) within an Australian inpatient psychiatric setting. Method: A retrospective audit of 300 random hospital files of those admitted as inpatients between Nov 2014 and Nov 2015 was undertaken. Data was quantitatively analysed and described. Results: The number of inpatients who had a vitamin D determination during their admission was 37/300 (12.33%). The mean vitamin D level of those tested was 51.63 nmol/l. Of those that were tested, 18/37 (48.6%) were mildly to moderately deficient. There was a statistically significant difference in age and length of stay between those that were and were not tested for vitamin D levels, p-value <0.001 and 0.017, respectively. In addition, a simple linear regression indicated a weak association between length of stay and vitamin D levels. Conclusion: This audit highlights vitamin D screening inadequacy. More research is recommended to establish tangible benefits of supplementation, while local practice provides valuable data for education and policy purposes.

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Vitamin D status in children with autoimmune thyroiditis

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20173125 ◽

2017 ◽

Vol 4 (5) ◽

pp. 1595

Author(s):

Gomathi Priya J ◽

Seenivasan Venkatasamy ◽

Karamath S Pyarejan ◽

Jayachandran K.

Keyword(s):

Vitamin D ◽

Alkaline Phosphatase ◽

Serum Calcium ◽

Autoimmune Thyroiditis ◽

Causal Factor ◽

Vitamin D Status ◽

Hydroxyvitamin D ◽

Vitamin D Levels ◽

Significant Difference ◽

25 Hydroxyvitamin D

Background: Deficiency of 25 hydroxyvitamin D has been linked with predisposition to autoimmune disorders. Also, vitamin D has been found to be a causal factor in many autoimmune diseases. Objective of the study was to investigate vitamin D status in children with autoimmune thyroiditis attending endocrinology OPD at a tertiary centre in southern India.Methods: It is a case control study done in which 75 children (70 female, 5 male) with age and sex matched healthy controls were chosen. Free thyroxine, TSH, anti TPOAb, anti TGAb, 25 hydroxyvitamin D, serum calcium, phosphorus, alkaline phosphatase levels were estimated in both cases and control subjects. Children with anti TPO or anti TG positivity were divided into four groups based on their level of antibody titers.Results: The mean age in cases was 9.8±0.34 years. 25(OH)D levels were significantly lower in cases (15.07±1.14 ng/ml) compared to controls (17.82±1.13 ng/ml) (p<0.0006). Mean serum calcium levels in cases (9.35±0.16 mg/dl) were significantly lower when compared to controls (9.73±0.14 mg/dl) (p<0.0005). Similarly mean serum alkaline phosphatase level in cases (184.97±11.10 IU/L) were significantly elevated when compared with controls (122.37±6.82 IU/L) (p<0.0001). However, there was no significant difference in serum phosphorus levels between cases (4.42±0.10 mg/dl) and controls (4.43±0.14 mg/dl) (p=0.83). There was no significant difference in vitamin D level among the groups in both anti TPO (p< 0.283) and anti TG (p<0.148).Conclusions: The significant decrease in vitamin D levels in cases signifies that 25(OH)D may be an independent causal factor related to the autoimmunity in thyroid diseases.

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Relationship Between Level of Serum 25-Hydroxyvitamin D and Risk of Squamous Cell Carcinoma in an Iranian Population

Dermatology Practical & Conceptual ◽

10.5826/dpc.0904a06 ◽

2019 ◽

pp. 278-282

Author(s):

Mahboobeh-Sadat Hosseini ◽

Fereshteh Salarvand ◽

Amir Houshang Ehsani ◽

Pedram Noormohammadpour ◽

Shadi Azizzadeh ◽

...

Keyword(s):

Vitamin D ◽

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Outdoor Environment ◽

Hydroxyvitamin D ◽

Vitamin D Levels ◽

History Of ◽

25 Hydroxyvitamin D ◽

The Relationship

Background: The relationship between vitamin D and skin squamous cell carcinoma (SCC) is not well defined. Objective: To investigate the relationship between vitamin D levels and the incidence of skin SCC for the first time in Iran. Methods and Study Design: In this case-control study, 126 subjects were enrolled (63 in each group) out of referents to Razi Skin Hospital in Tehran in 2014. The risk factors for cancer gathered by self-reported questionnaires and blood samples were obtained to measure the level of 25-hydroxyvitamin D. Multivariate logistic regression was used to neutralize the effect of confounding factors. Results: Cases of SCC were more likely to be in men, older than 49 years and working in an outdoor environment, and with longtime exposure to sunlight and a personal history of skin cancers. Family history of skin cancer and of cigarette smoking were not significantly related to SCC. In the SCC and control groups, 69.8% and 31.7%, respectively, had sufficient levels of vitamin D (P < 0.001). Mean level of 25-hydroxyvitamin D was 40.99 ng/mL in the SCC group and 26.34 ng/mL in the control group (P < 0.05). In the unadjusted model, the level of vitamin D as a continuous variable was positively related to SCC risk. In the adjusted model, vitamin D did not independently predict the likelihood of SCC. Conclusion: Vitamin D level and SCC risk are directly related, although not in an independent fashion. Indeed, this relation is severely confounded by exposure to sunlight, which was evidenced by an increased vitamin D level in the people working outside and the higher prevalence of SCC in the same population.

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Association between Vitamin D Level and Acne, and Correlation with Disease Severity: A Meta-Analysis

Dermatology ◽

10.1159/000517514 ◽

2021 ◽

pp. 1-8

Author(s):

Yusuf Hasamoh ◽

Kunlawat Thadanipon ◽

Premjit Juntongjin

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Meta Analysis ◽

Inverse Association ◽

Hydroxyvitamin D ◽

Vitamin D Levels ◽

Newcastle Ottawa Scale ◽

25 Hydroxyvitamin D ◽

The Relationship ◽

Ottawa Scale

Background: Vitamin D deficiency is frequently associated with several medical conditions. However, a comprehensive meta-analysis assessing the association between vitamin D level and acne is lacking. Objective: To determine the relationship between vitamin D level and acne, and to assess the association between vitamin D level and acne severity. Methods: This meta-analysis was assessed by using the PubMed, EMBASE, Cochrane, and Scopus databases following the PRISMA guidelines. Serum/plasma 25-hydroxyvitamin D (25[OH]D) level, vitamin D deficiency, and the severity association between acne patients and healthy controls (HCs) were evaluated. The quality assessment was performed by using the Newcastle-Ottawa Scale. Results: Thirteen articles with a total of 1,362 acne patients and 1,081 HCs were included. The circulating 25(OH)D levels were significantly lower in patients with acne than in HCs (pooled MD = –9.02 ng/mL, 95% CI = –13.22 to –4.81, p < 0.0001). Vitamin D deficiency was more prevalent in acne patients than in HCs (pooled OR = 2.97, 95% CI = 1.68–5.23, I2 = 72%). Also, vitamin D levels were negatively correlated with acne severity. Conclusion: This meta-analysis demonstrated the significantly low vitamin D levels in acne patients. Also, there was evidence of an inverse association between vitamin D levels and acne severity. Therefore, vitamin D might be involved in the pathogenesis of acne.

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Correlation between vitamin D levels and hard-to-heal wounds: a systematic review

Journal of Wound Care ◽

10.12968/jowc.2020.29.sup7.s24 ◽

2020 ◽

Vol 29 (Sup7) ◽

pp. S24-S30 ◽

Cited By ~ 1

Author(s):

Karen Smith ◽

Susan Hewlings

Keyword(s):

Vitamin D ◽

Financial Burden ◽

Vitamin D Supplementation ◽

Nutritional Deficiencies ◽

Vitamin D Status ◽

Hydroxyvitamin D ◽

Venous Ulcers ◽

Vitamin D Levels ◽

25 Hydroxyvitamin D ◽

The Relationship

Objective: Hard-to-heal wounds are a major biological, psychological, social and financial burden on both individual patients and the broader health system. They are associated with a variety of comorbidities and have a complex aetiology, but are typically associated with nutritional deficiencies, such as low vitamin D levels. This systematic literature review evaluates the current research regarding the connection between inadequate vitamin D status and wound healing. Method: PubMed and EBSCO databases were searched following PRISMA guidelines for primary research studies relating to pressure ulcers, diabetic ulcers or venous ulcers and vitamin D status. Results: A total of 10 studies, involving 2359 participants, met the inclusion criteria. There was a strong correlation between low levels of 25-hydroxyvitamin D and the presence of all three types of hard-to-heal wounds. Conclusion: Research suggests a correlation between low vitamin D levels and hard-to-heal wounds. However, it is not clear if the relationship is causal or only correlational. There is also emerging evidence on the use of vitamin D supplementation for the treatment of hard-to-heal wounds. More research is needed to understand the correlation between vitamin D and hard-to-heal wounds.

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Study on the relationship between serum 25-hydroxyvitamin D levels and vascular calcification in hemodialysis patients with consideration of seasonal variation in vitamin D levels

Atherosclerosis ◽

10.1016/j.atherosclerosis.2011.11.028 ◽

2012 ◽

Vol 220 (2) ◽

pp. 563-568 ◽

Cited By ~ 8

Author(s):

Jae Hyun Chang ◽

Han Ro ◽

Sejoong Kim ◽

Hyun Hee Lee ◽

Wookyung Chung ◽

...

Keyword(s):

Vitamin D ◽

Seasonal Variation ◽

Vascular Calcification ◽

Hemodialysis Patients ◽

Hydroxyvitamin D ◽

Vitamin D Levels ◽

25 Hydroxyvitamin D ◽

The Relationship

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Correlation between vitamin D levels and hard-to-heal wounds: a systematic review

Journal of Wound Care ◽

10.12968/jowc.2021.30.sup6.s4 ◽

2021 ◽

Vol 30 (Sup6) ◽

pp. S4-S10

Author(s):

Karen Smith ◽

Susan Hewlings

Keyword(s):

Vitamin D ◽

Financial Burden ◽

Vitamin D Supplementation ◽

Nutritional Deficiencies ◽

Vitamin D Status ◽

Hydroxyvitamin D ◽

Venous Ulcers ◽

Vitamin D Levels ◽

25 Hydroxyvitamin D ◽

The Relationship

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Circulating Vitamin D Levels and Risk of Vitiligo: Evidence From Meta-Analysis and Two-Sample Mendelian Randomization

Frontiers in Nutrition ◽

10.3389/fnut.2021.782270 ◽

2021 ◽

Vol 8 ◽

Author(s):

Jie Song ◽

Ke Liu ◽

Weiwei Chen ◽

Bin Liu ◽

Hong Yang ◽

...

Keyword(s):

Vitamin D ◽

Observational Studies ◽

Mendelian Randomization ◽

Meta Analysis ◽

Sensitivity Analyses ◽

Genome Wide Association Studies ◽

Hydroxyvitamin D ◽

Vitamin D Levels ◽

Significant Difference ◽

25 Hydroxyvitamin D

Background: The association between circulating vitamin D levels and risk of vitiligo was inconsistent among observational studies, and whether these observed associations were causal remained unclear. Therefore, we aimed to evaluate the effect of vitamin D on the risk of vitiigo using meta-analysis and Mendelian randomization (MR).Methods: At the meta-analysis stage, literature search was performed in PubMed and Web of Science to identify eligible observational studies examining the association of circulating 25-hydroxyvitamin D [25(OH)D] or 25-hydroxyvitamin D3 [25(OH)D3] levels with risk of vitiligo up to April 30, 2021. Standardized mean differences (SMDs) with 95% confidence intervals (CIs) of 25(OH)D and 25(OH)D3 in patients with vitiligo relative to controls were pooled. Then at the MR stage, genetic instruments for circulating 25(OH)D (N = 120,618) and 25(OH)D3 (N = 40,562) levels were selected from a meta-analysis of genome-wide association studies (GWAS) of European descent, and summary statistics of vitiligo were obtained from a meta-analysis of three GWASs including 4,680 cases and 39,586 controls. We used inverse-variance weighted (IVW) as main method, followed by weighted-median and likelihood-based methods. Pleiotropic and outlier variants were assessed by MR-Egger regression and MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO) test.Results: In the meta-analysis, patients with vitiligo had a lower level of circulating 25(OH)D compared with controls [SMD = −1.40; 95% confidence interval (CI): −1.91, −0.89; P < 0.001], while no statistically significant difference of 25(OH)D3 between vitiligo cases and controls was found (SMD = −0.63; 95% CI: −1.29, 0.04; P = 0.064). However, in the MR analyses, genetically predicted 25(OH)D [odds ratio (OR) = 0.93, 95% CI = 0.66–1.31, P = 0.66] and 25(OH)D3 levels (OR = 0.95, 95% CI = 0.80–1.14, P = 0.60) had null associations with risk of vitiligo using the IVW method. Sensitivity analyses using alternative MR methods and instrumental variables (IV) sets obtained consistent results, and no evidence of pleiotropy or outliers was observed.Conclusion: Our study provided no convincing evidence for a causal effect of 25(OH)D or 25(OH)D3 levels on the risk of vitiligo. Further longitudinal and experimental studies, as well as functional studies are warranted to elucidate the role of vitamin D in the development of vitiligo.

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Relationship of vitamin D, BMI and BMD in age and gender linked population

International Journal of Research in Orthopaedics ◽

10.18203/issn.2455-4510.intjresorthop20181439 ◽

2018 ◽

Vol 4 (3) ◽

pp. 406

Author(s):

Ritwik Ganguli ◽

Priyanka Pahari

Keyword(s):

Vitamin D ◽

Vitamin D Insufficiency ◽

Healthy Individuals ◽

Mineral Density ◽

Hydroxyvitamin D ◽

Vitamin D Levels ◽

25 Hydroxyvitamin D ◽

And Gender ◽

Relationship Of ◽

The Relationship

Background: Vitamin D insufficiency prevalence has been related to low bone mineral density (BMD). However, controversial results have been reported for the relationship between serum 25-hydroxyvitamin D [25(OH)D] levels and BMD. This study was done to investigate whether serum 25(OH)D levels were associated with BMD in different age group and sex link population.Methods: This study involved, aged 40-70 yr, who is consecutively selected from KPCMCH, BMD camp. BMD was measured at the lumbar spine and femoral neck. The correlation between serum 25(OH)D levels and BMD was investigated.Results: Vitamin D levels for healthy and patients individuals at hospital. The age of 40 healthy subjects ranged from 40 to 70 years with the average of 55.30±10.30 years and body mass index (BMI) ranged from 18 to 37 kg/m2, with the of average of 28.90±5.20 kg/m2. Comparison between healthy and patients based on BMI and vitamin D level for the overweight BMI healthy individuals was 29.78±9.40 ng/ml, and that of hyperlipidemic patients was 24.47±8.78 ng/ml.Conclusions: In this study, there is significant different between healthy and patients group in vitamin D3level.BMD significantly decreased in patients group more elderly.

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Prevalence of Vitamin D Deficiency among Patients Attending a General Otolaryngology Clinic in South Auckland

Annals of Otology Rhinology & Laryngology ◽

10.1177/000348940911800502 ◽

2009 ◽

Vol 118 (5) ◽

pp. 326-328 ◽

Cited By ~ 5

Author(s):

Jim Bartley ◽

David Reid ◽

Randall P. Morton

Keyword(s):

Vitamin D ◽

Statistical Analysis ◽

Vitamin D Deficiency ◽

Prospective Observational Study ◽

Vitamin D Status ◽

Hydroxyvitamin D ◽

Vitamin D Levels ◽

25 Hydroxyvitamin D ◽

Relationship Of ◽

The Relationship

Objectives: We performed a prospective observational study to estimate the prevalence of vitamin D deficiency in patients attending a general otolaryngology clinic in South Auckland, New Zealand. Methods: From July 21, 2008, to August 7, 2008, all new patients presenting to otolaryngology clinics at which one of the authors (D.R.) was present had their vitamin D status assessed by measurement of their plasma 25-hydroxyvitamin D [25(OH)D] level. Results: Of 48 patients, 2% had 25(OH)D levels of 17.5 nmol/L or less (a level associated with osteomalacia), 58% had 25(OH)D levels of 50 nmol/L or less (a level associated with vitamin D deficiency), and 100% had 25(OH)D levels of 80 nmol/L or less. Conclusions: Most of the patients attending a general otolaryngology clinic in South Auckland are vitamin D–deficient. It is unclear whether low vitamin D levels are associated more directly with otolaryngological disorders or skin type, because the small size of this study and the broad range of conditions seen precluded a meaningful statistical analysis. Further research into the relationship of vitamin D to specific otolaryngological presentations is required.

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