scholarly journals Boehmeria glomerulifera Miq. Exhibits in vivo Antidepressant and Antidiarrheal Activities

2019 ◽  
Vol 22 (2) ◽  
pp. 181-184
Author(s):  
Muhammed Mahfuzur Rahman ◽  
Sharmin Khandker Shampa ◽  
Md Abdul Bari ◽  
Mohammad Kaisarul Islam ◽  
Mohammad A Rashid
Keyword(s):  
Crude Extract ◽  
Castor Oil ◽  
Methanolic Extract ◽  
Antidepressant Activity ◽  
Pharmaceutical Journal ◽  
The Other ◽  
Mice Model ◽  
Rural People ◽  
The Family

Boehmeria glomerulifera Miq., is medicinal herb belongs to the family Urticaceae. It is used for treating various diseases by folk practitioners and rural people. The CNS antidepressant and antidiarrhoeal activities of the crude extract were investigated at 200 and 400 mg/kg bw in Swiss Albino mice model. The crude methanolic extract revealed significant (p < 0.05) antidepressant activity in mice at 400 mg/kg bw. On the other hand, in the castor oil-induced antidiarrheal assay, the extract demonstrated significant (p < 0.05) antidiarrhoeal activity at 400 mg/kg bw. Bangladesh Pharmaceutical Journal 22(2): 181-184, 2019

scholarly journals Analgesic and Antidiarrheal Activities of Leaf of Podocarpus neriifolius D. Don

2016 ◽  
Vol 19 (2) ◽  
pp. 215-218
Author(s):  
Md Rahatullah Razan ◽  
Muhammed Mahfuzur Rahman ◽  
Faiza Tahia ◽  
Md Khalid Hossain ◽  
Mohammad A Rashid
Keyword(s):  
Body Weight ◽  
Acetic Acid ◽  
Analgesic Activity ◽  
Castor Oil ◽  
Methanol Extract ◽  
Methanolic Extract ◽  
Pharmaceutical Journal ◽  
Activity Assay ◽  
Swiss Albino Mice

The methanol extract of leaf of Podocarpus neriifolius D. Don exhibited in vivo peripheral analgesic and antidiarrheal activities in Swiss Albino mice. In the peripheral analgesic activity assay, the methanolic extract showed 50.00 ± 8.57% and 70.25 ± 1.18% inhibition of acetic acid-induced writhing at 200 and 400 mg/kg body weight, respectively. In addition, the extract also revealed a dose dependant inhibition of castor oil- induced diarrhea with 43.77 ± 3.13% and 56.23 ± 6.49% inhibition of feces at 200 and 400 mg/kg body weight, respectivelyBangladesh Pharmaceutical Journal 19(2): 215-218, 2016

scholarly journals Analgesic, Anti-diarrheal, Anti-depressant, Membrane Stabilizing and Cytotoxic Activities of Bridelia verrucosa Haines

2019 ◽  
Vol 22 (1) ◽  
pp. 50-55
Author(s):  
Tasmia Tabassum ◽  
Md Abdul Bari ◽  
Md Ruhul Kuddus ◽  
Mohammad A. Rashid
Keyword(s):  
Acetylsalicylic Acid ◽  
Plant Extract ◽  
Crude Extract ◽  
Castor Oil ◽  
Methanol Extract ◽  
Antidepressant Activity ◽  
Pharmaceutical Journal ◽  
Cytotoxic Activities ◽  
Vincristine Sulphate ◽  
Time Test

The present study was aimed for the evaluation of analgesic, anti-diarrheal and anti-depressant activities of methanol crude extract of Bridelia verrucosa leaves in Swiss albino mice. The analgesic activity was assessed by formalin-induced paw licking method, where the crude extract of B. verrucosa (400 mg/kg, b.w.) exhibited 54.55% reduction of licking response in mice as compared to 69.09% reduction exhibited by standard acetylsalicylic acid. In the castor oil-induced diarrhea in mice, the plant extract at the dose of 400 mg/kg, b.w., demonstrated 57.67% reduction of diarrheal feces in mice. The antidepressant activity of the plant extract was evaluated through phenobarbitone-Na induced sleeping time test. The methanol extract of B. verrucosa and its different Kupchan fractions were also subjected to screenings for membrane stabilizing and cytotoxic activities using acetylsalicylic acid and vincristine sulphate as standard, respectively. Bangladesh Pharmaceutical Journal 22(1): 50-55, 2019

scholarly journals Fagonia: A potential medicinal desert plant

2015 ◽  
Vol 27 (1) ◽  
pp. 28-33 ◽  
Author(s):  
Dinesh Puri ◽  
Anil Bhandari
Keyword(s):  
Skin Diseases ◽  
Methanolic Extract ◽  
Radical Scavenging ◽  
The Other ◽  
Flavonoid Glycosides ◽  
Desert Plant ◽  
Desert Plants ◽  
Whole Plant ◽  
The Family ◽  
Radical Scavenging Properties

 Desert plants are unique adaptation from environmental conditions. Fagonia is a genus of plant in the family zygophyllaceae with about 20 species around Mediterranean to India, S. Africa, California, Chili. The local name of fagonia is dhamasa. They are traditionally well known for the treatment of hemorrhoids, inflammation, sores, leprosy, open wounds and fever in the form of internal and external conventional formulation. When the powder that is made up of the whole plant of F. schweinfurthii is dusted on boils and skin eruptions, it causes healing, when the whole plant is boiled in water, its bath is useful for allergies and other skin diseases and decoction is given orally as blood purifier. The other species like Fagonia bruguieri its aqueous extract is claimed for anti-allergy. Methanolic extract of Fagonia cretica is claimed for good antimicrobial potential and it exhibited strong free radical scavenging properties against reactive oxygen and nitrogen species. The other effects of Fagonia species include anti-inflammatory, analgesic, antipyretic and thrombolytic activities are observed. Many chemical constituent's, such as triterpenoids, saponins, flavonoid glycosides, etc., have already been reported in different Fagonia spp. DOI: http://dx.doi.org/10.3126/jnpa.v27i1.12147 Journal of Nepal Pharmaceutical Association 2014 Vol.XXVII: 28-33

scholarly journals In vivo Analgesic activity of methanolic extract of Helianthus annuus seeds

2016 ◽  
Vol 5 (4) ◽  
pp. 38-40 ◽  
Author(s):  
Rubab Tarannum Islam ◽  
Ahmed Tanjimul Islam ◽  
Mir Monir Hossain ◽  
Kishor Mazumder
Keyword(s):  
Body Weight ◽  
Acetic Acid ◽  
Helianthus Annuus ◽  
Analgesic Activity ◽  
Latency Period ◽  
Pharmaceutical Journal ◽  
Mice Model ◽  
Hot Plate ◽  
Writhing Test

The sunflower seed is the seed of the sunflower (Helianthus annuus). The methanol extract of seeds of Helianthus annuus were screened for analgesic activity in mice model to systematically explore the medicinal values of the plant. Acetic acid induced writhing and hot plate methods were used to confirm the central and peripheral analgesic action. In case of acetic acid-induced writhing test the extract showed significant (P <0.05) analgesic potential at doses 100 and 200 mg/kg body weight (50.35 and 57.85% inhibition, respectively). In the hot plate method, increase (p < 0.05) of latency period was also observed in comparison to standard aspirin. At 60 minutes, the latency period of two different doses (100 and 200 mg/kg body weight) was found at 13 ± 0.91 and 16.5 ± 1.55 second. The results obtained support the use of Helianthus annuus seeds in painful conditions acting both centrally and peripherally.Islam et al., International Current Pharmaceutical Journal, March 2016, 5(4): 38-40http://www.icpjonline.com/documents/Vol5Issue4/02.pdf

scholarly journals Antidiarrhoeal activity of rind of Punica granatum

2013 ◽  
Vol 2 (5) ◽  
pp. 101-104 ◽  
Author(s):  
Saleha Akter ◽  
Amit Sarker ◽  
Md. Sanowar Hossain
Keyword(s):  
Body Weight ◽  
Animal Models ◽  
Magnesium Sulfate ◽  
Castor Oil ◽  
Methanolic Extract ◽  
Punica Granatum ◽  
Pharmaceutical Journal ◽  
Phytochemical Screening ◽  
Traditional Use ◽  
Standard Drug

Punica granatum (Family: Punicaceae) is a widely consumed fruit in Bangladesh locally known as Anar or Bedana. Traditionally the plant is used to treat diarrhoea, dysentery, hemorrhage, tuberculosis and chronic periodontitis. The present study was undertaken in order to justify and authenticate the traditional use of rind of P. granatum fruit in diarrhoea. Methanolic extract of the rind of the fruit was tested in castor oil- and magnesium sulfate-induced diarrhoea in mice at the doses of 200 and 400 mg/kg body weight. The results of the present study revealed significant antidiarrhoeal activity (p<0.001) in both animal models. The extract inhibited 31.25% defaecation at the dose of 200 mg/kg and 53.75% at the dose of 400 mg/kg in castor oil-induced diarrhoea while standard drug loperamide inhibited 71.25% defaecation. In magnesium sulfate-induced diarrhoea the inhibition of defaecation was 45.71 and 57.14% at the doses of 200 and 400 mg/kg respectively while loperamide inhibited 64.29% defaecation. The antidiarrhoeal effect of the extract was concentration dependent in both castor oil-induced diarrhoea and magnesium sulfate-induced diarrhoea. Phytochemical screening of the extract revealed the presence of flavonoids and alkaloids that may play key role in its antidiarrhoeal activity. The results of the present study validate the folkloric use of the rind of P. granatum in the treatment of diarrhoea.DOI: http://dx.doi.org/10.3329/icpj.v2i5.14437 International Current Pharmaceutical Journal, April 2013, 2(5): 101-104

scholarly journals Ethnopharmacological evaluation of Cenchrus ciliaris for multiple gastrointestinal disorders

2017 ◽  
Vol 12 (2) ◽  
pp. 15 ◽  
Author(s):  
Ambreen Aleem ◽  
Khalid Hussain Janbaz
Keyword(s):  
Crude Extract ◽  
Castor Oil ◽  
Ex Vivo ◽  
Video Clip ◽  
Scientific Basis ◽  
Gastrointestinal Disorders ◽  
Cenchrus Ciliaris ◽  
Traditional Uses ◽  
Full Screen

<p class="Abstract">This study was conducted to rationalize the traditional uses of <em>Cenchrus ciliaris</em> in gastrointestinal disorders using <em>in vivo</em> and <em>ex vivo</em> assays. The antidiarrheal effect was evaluated in rats by the castor oil-induced diarrheal model. <em>C. ciliaris</em> (100, 300 and 500 mg/kg) reduced the castor oil-induced diarrhea significantly. Another study carried out in mice to determine the intestinal transit rate showed that <em>C. ciliaris</em> (100 and 200 mg/kg) inhibited the transit rate significantly. <em>Ex vivo</em> assay demonstrated that <em>C. ciliaris</em> (0.01–1 mg/mL) relaxed the spontaneous and K<sup>+ </sup>(80 mM)-induced contractions, like verapamil. The crude extract (75, 100 and 150 mg/kg) also exhibited significant anti-emetic activity in chicks. These results indicate the presence of antispasmodic, antidiarrheal and antiemetic activities in <em>C. ciliaris</em>, thus providing the scientific basis for its traditional uses.</p><p class="Abstract"><strong>Video Clip of Methodology</strong>: 56 sec  <a href="https://www.youtube.com/v/FwQ01gHJaGk">Full Screen</a>   <a href="https://www.youtube.com/watch?v=FwQ01gHJaGk">If Failed</a></p>

scholarly journals Sodium Arsenite Induced Systemic Organ Damage and Changes in Various Blood Parameters in Mice

2013 ◽  
Vol 11 (2) ◽  
pp. 169-172 ◽  
Author(s):  
Rim Sabrina Jahan Sarker ◽  
Nazmul Ahsan ◽  
Anwarul Azim Akhand
Keyword(s):  
Sodium Arsenite ◽  
Organ Damage ◽  
Blood Parameters ◽  
The Other ◽  
Toxic Effects ◽  
Spleen Weight ◽  
Mice Model ◽  
Model Animal ◽  
Remediation Process

In this study, we examined the toxic effects of arsenic in vivo taking mice as a model animal. Swiss albino mice with similar weights were divided into two groups. The mice belonging to the first group were used as the control, while the other group was exposed to sodium arsenite (SA) through drinking water. Compared to control, the level of hemoglobin in SA-exposed mice was decreased while the number of neutrophils and monocytes were increased. In addition, SA also induced increase in liver and spleen weight within 8 weeks of exposure. In contrast, the weight of the kidney was found to decrease. These findings in mice model might be useful for better understanding of the toxic effects of arsenic in order to develop effective remediation process against arsenicmediated effects on human health. DOI: http://dx.doi.org/10.3329/dujps.v11i2.14576 Dhaka Univ. J. Pharm. Sci. 11(2): 169-172, 2012 (December)

scholarly journals Cruciglanis, a new genus of Pseudopimelodid catfish (Ostariophysi: Siluriformes) with description of a new species from the Colombian Pacific coast

2006 ◽  
Vol 4 (2) ◽  
pp. 147-156 ◽  
Author(s):  
Armando Ortega-Lara ◽  
Pablo Lehmann A.
Keyword(s):  
New Genus ◽  
The Other ◽  
Dark Spot ◽  
Phylogenetic Position ◽  
Caudal Fin ◽  
Sensory Canal ◽  
The Pacific ◽  
The Family ◽  
Pacific Slope

Cruciglanis pacifici, gen. et sp. nov., is described from the Dagua and Anchicaya Rivers on the Pacific slope of Colombia. The new genus is differentiated from the other genera in the family by the presence of an ossified crucifix-shaped second basibranchial; ectopterygoid bone shaped as an inverted comma, with its distal end narrow and directed medially towards the mesopterygoid; anterior fontanel elongated, reaching a transverse line at sensory canal opening of the sphenotic bone; caudal fin emarginated with rounded edges and ventral lobe more developed than the dorsal lobe; caudal fin with a dark spot from its base and fused with the peduncular spot, covering the anterior three quarters of its length, distal rim totally hyaline. Coloration of the species is described in vivo, and the shared diagnostic characters with the other genera within the Pseudopimelodidae are discussed. The phylogenetic position of the new genus is proposed and new insights in the family interrelationships are presented.

Cytotoxic, Hypoglycemic Activity And Phytochemical Analysis Of Rubus Imperialis (Rosaceae)

2002 ◽  
Vol 57 (3-4) ◽  
pp. 272-276 ◽  
Author(s):  
Márcia Kanegusuku ◽  
Jean Carlo Benassi ◽  
Rozangela Curi Pedrosa ◽  
Rosendo Augusto Yunes ◽  
Valdir Cechinel Filho ◽  
...  
Keyword(s):  
Ethyl Acetate ◽  
Brine Shrimp ◽  
Methanolic Extract ◽  
Ethyl Acetate Fraction ◽  
Hypoglycemic Activity ◽  
The Other ◽  
Phytochemical Analysis ◽  
Antidiabetic Agent ◽  
In Vivo Assays

Screening of different extracts, fractions and compounds from Rubus imperialis Chum. Schl. (Rosaceae) has been conduced using the brine shrimp microwell cytotoxicity assay. Three parts of the plant (methanolic extract from leaves, roots and stems), three fractions from roots (hexane, ethyl acetate and butanol) and three isolated compounds (niga-ichigoside F1, 23-hydroxytormentic acid, ellagic acid derivative) were tested. The most promising material (LC50 <1000 μg/ml) were the methanolic extract and ethyl acetate fraction from roots. However, there was little correlation observed in the degree of toxicities observed between the isolated compounds. On the other hand, the cytotoxicity and in vivo assays confirmed the hypoglycemic activity of methanolic extract and validated the Brazilian popular use of R. imperialis as an antidiabetic agent

scholarly journals Phytochemical screening and evaluation of antidepressant activity of methanolic extract of the spadix of Colocasia affinis Schott

2018 ◽  
Vol 18 (4) ◽  
pp. 104-110
Author(s):  
C. Lalremruati ◽  
C. Malsawmtluangi ◽  
H. Lalhlenmawia
Keyword(s):  
Methanolic Extract ◽  
Petroleum Ether Extract ◽  
Antidepressant Activity ◽  
Tail Suspension Test ◽  
Chloroform Extract ◽  
Control Group ◽  
Force Swim Test ◽  
Standard Drug ◽  
In Vivo Test

The objective of this study was to determine the phytoconstituents present in successive extracts and the antidepressant activity of methanolic extract of the spadix of Colocasia affinis. The preliminary phytochemical investigation indicated the presence of fats and fixed oils, steroids and triterpenoids in petroleum ether extract, steroids and triterpenoids in chloroform extract, flavonoids and tannins in methanol extract and carbohydrates in the aqueous extract. An in vivo test for antidepressant activity was performed on the methanolic extract of the plant at two different doses using force swim test and tail suspension test on an experimental animal model (rat). Imipramine was used as a standard drug for the study. The methanolic extract at 200 and 400 mg/kg, produced significant reduction (p<0.001) in the immobility period when compared with that of control group animals in both the tests. Thus, the result indicates that the methanolic extract exhibited significantly good antidepressant activity. Further investigation may be needed to understand the actual mechanism of action.

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