Response of CHOP therapy in the treatment of Non-Hodgkin’s Lymphoma - one year study in CMH, Dhaka

2015 ◽  
Vol 10 (1) ◽  
pp. 93-98
Author(s):  
Md Mostafil Karim ◽  
Shahina Akhter ◽  
Mushtaq Ahmad
Keyword(s):  
Bone Marrow ◽  
Partial Remission ◽  
Armed Forces ◽  
Military Hospital ◽  
Single Node ◽  
Chop Regimen ◽  
Medical College ◽  
Number Of Patients ◽  
One Year ◽  
Physical Findings

Introduction: The lymphoma’s are a group of malignant disease that originate from uninhibited growth of cellular elements normally found in lymphatic tissue. All forms of lymphoma have the potential to spread from their origin in a single node or chain of nodes to other nodes and eventually to disseminate to spleen, liver and bone marrow. Objective: To assess the response rate and to evaluate the toxicity and safety of CHOP regimen. Methods: In this study 50 cases were selected of all age irrespectively and both sexes diagnosed at Combined Military Hospital, Dhaka. A prescribed proforma was used for each patient. It included particulars of the patient, history, physical findings, laboratory investigations (biopsy, cytology, and bone marrow study), ultrasonography and CT-scan in appropriate cases. Results: In this study, starting from July 2009 to June 2010, 50 patients were included. Out of them, 30 patients (60.00%) achieved complete remission, 12 patients (24.00%) had partial remission. Overall responses were 84 percent and 8 patients (16.00%) were non-responder. Two patients (4%) of non-responder died during chemotherapy. Conclusion: In this study a significant number of patients achieved complete and partial remission. The response was rapid and most of the patients achieved complete or partial remission after receiving only 2-3 cycles of therapy. Considering the toxicities, the patients were well-tolerated to CHOP regimen. DOI: http://dx.doi.org/10.3329/jafmc.v10i1.22932 Journal of Armed Forces Medical College Bangladesh Vol.10(1) 2014

scholarly journals Response of systemic PUVA in vitiligo - experience with 25 cases in Combined Military Hospital, Dhaka

2015 ◽  
Vol 10 (1) ◽  
pp. 29-33
Author(s):  
ATM Rezaul Karim ◽  
Md Abdul Latif Khan ◽  
Md Sayeed Hasan ◽  
Moyassaque Ahmed ◽  
Shirajul Islam Khan ◽  
...  
Keyword(s):  
Therapeutic Response ◽  
Previous Treatment ◽  
Armed Forces ◽  
The Body ◽  
Military Hospital ◽  
Study Group ◽  
Inclusion Criteria ◽  
Medical College ◽  
Number Of Patients ◽  
Prospective Longitudinal

Introduction: It is a pigmentation disorder in which melanocytes (the cells that make pigment) in the skin are destroyed. As a result, white patches appear in the skin in different parts of the body. Objective: The objective of this study is to see the efficacy of systemic PUVA in the treatment of vitiligo patient. Methods: This is an prospective longitudinal interventional study, carried out in the depigmented area was assessed according to the department of Dermatology and Venereology, Combined Military Hospital, Dhaka in between the duration of April 2010 to March 2011. Total 25 vitiligo patients based on inclusion criteria like patient with vitiligo affecting more than 5% body surface area, patient having ivory- white fluorescence on Wood’s lamp, patient who was above 15 years of age, patient who had given written consent, patient was not taken any previous treatment etc. Results: This study showed the therapeutic response of study group after 04 weeks of therapy, 05 (20%) patients responsed Fair, 15 (60%) patients responsed Poor and no responsed by 05 (20%) patients. Therapeutic response of study group after 08 weeks of therapy showed that 15 (60%) patients responsed Fair and 10 (40%) patients responsed Poor. It was observed after 12 weeks of therapy that 13 (52%) patients responsed Poor followed by 10 (40%) patients responsed Fair and 02 (08%) patients responsed well. 29 JAFMC Bangladesh. Vol 10, No 1 (June) 2014 Therapeutic response of study group after 16 weeks of therapy was 15 (60%) patients responsed Fair, followed by 06 (24%) patients responsed Poor and 04 (16%) patients responsed Good. It was showed that after 20 weeks of therapy 13 (52%) patients responsed Fair, followed by 08 (32%) patients responsed Good, 03 (12%) patients responsed Poor and 01 (04%) patients responsed Excellent. It was observed that after 24 weeks of therapy 12 (48%) patients responsed Good, followed by 08 (32%) patients responsed Fair, 03 (12%) patients responsed Poor and 02 (08%) patients responsed Excellent. Conclusion: Systemic PUVA for the repigmentation of vitiligo seems to be effective. Study needs large number of patients for longer period of duration for confirmation of results. DOI: http://dx.doi.org/10.3329/jafmc.v10i1.22900 Journal of Armed Forces Medical College Bangladesh Vol.10(1) 2014

scholarly journals Maternal and perinatal outcome in postdated pregnancy: a study of 100 cases in Bangladesh armed forces

2015 ◽  
Vol 10 (1) ◽  
pp. 39-44
Author(s):  
Salina Akhter
Keyword(s):  
Armed Forces ◽  
Well Being ◽  
Cross Sectional Study ◽  
Military Hospital ◽  
Cross Sectional ◽  
Mortality And Morbidity ◽  
Medical College ◽  
Gynecology And Obstetrics ◽  
Prolonged Pregnancy ◽  
One Year

Introduction: Any pregnancy which has passed beyond the Expected Date of Delivery (EDD) is called postdated pregnancy or prolonged pregnancy. But when pregnancy has prolonged beyond 42 weeks are called postmaturity or post term pregnancy. Incidence of prolonged pregnancy is 3-14 % of all gestations. Aim: The aim of the study is to determine the foetal and maternal outcome and complications in patients presenting with postdated pregnancy in Combined Military Hospital of Bangladesh Armed Forces. Materials & Methods: A cross-sectional study was conducted for one year at the Department of Gynecology and Obstetrics in Combined Military Hospital, Dhaka. During this period total 100 cases were studied. Cases were selected randomly. Here postdatism was applied to any pregnancy which exceeded the EDD and it also included postmaturity which is pregnancy extending beyond 42 completed weeks. A preformed proforma was used to collect data which were analyzed later on. Results: Amongst 1853 cases of labour patients, 273 cases were postdated pregnancy and 169 cases postmaturity. The incidence of postdated pregnancy in this series was 15% and postmaturity was 9.14%. 93% patients had regular antenatal checkup. 82% patients were presented not in labour situation. 60% cases were NVD and 40% cases LUCS was done. No craniotomy or forceps was required. There was no maternal death. But there were two Intra Uterine Deaths (IUD) and one neonatal death due to umbilical sepsis. 39 JAFMC Bangladesh. Vol 10, No 1 (June) 2014 Conclusion: Any pregnancy that goes beyond 41 weeks of confirmed gestational age foetal well-being must be assessed. Proper management is a pre-requisite to reduce the rate of perinatal mortality and morbidity in this group of patient. DOI: http://dx.doi.org/10.3329/jafmc.v10i1.22903 Journal of Armed Forces Medical College Bangladesh Vol.10(1) 2014

scholarly journals Comparison of KAtex, Bone Marrow Aspiration and DAT for the Diagnosis of Visceral Leishmaniasis

2019 ◽  
Vol 6 (1) ◽  
pp. 12-15
Author(s):  
Ishrat Sharmin ◽  
AKM Quamruzzaman ◽  
Rezina Parveen ◽  
M Abdulah Yusuf ◽  
Rashida Akter Khanam
Keyword(s):  
Bone Marrow ◽  
Visceral Leishmaniasis ◽  
Leishmania Donovani ◽  
Bone Marrow Aspiration ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Medical College ◽  
Kala Azar ◽  
History Of ◽  
One Year

Background: Newly developed KAtex test can be used as a non invasive tool for diagnosis of Kala-azar. Objectives: The aim of the present study was to compare KAtex, Bone marrow aspiration and DAT to diagnose VL. Methodology: This cross-sectional study was carried out in the Department of Microbiology at Dhaka Medical College, Dhaka, Bangladesh in collaboration with the Department of Parasitology, Institute of Epidemiology, Disease Control and Research (IEDCR), Dhaka, Bangladesh for a period of one year. Clinically suspected Kala-azar (VL) cases of different age and sex attending IEDCR, Dhaka from different Kala-azar endemic areas of Bangladesh were selected for this study. Patients having fever for more than 2 weeks, with or without splenomegaly, having history of loss of body weight following onset of fever were clinically suspected as Kala-azar cases. Microscopy and culture was performed in bone marrow (BM). KAtex was performed with urine sample. Agglutination of sensitized latex indicated presence of Leishmania donovani antigen in urine and thereby visceral leishmaniasis. No agglutination indicates absence of antigen in urine. DAT was done with serums of all cases. Result: Among 130 clinically suspected VL cases, 70 (53.85%) cases were BM positive and 60(46.15%) cases were BM negative. All the 70 BM positive cases were positive by KAtex and DAT. Among 60 BM negative cases, 15 were positive by KAtex and 23 were positive by DAT. The sensitivity of KAtex was 100.0% and specificity was 75.0%. The sensitivity of DAT was 100.0% and specificity is 61.6%. Conclusion: In conclusion, KAtex test is a good diagnostic tool for the detection of VL in comparison with DAT. Bangladesh Journal of Infectious Diseases, June 2019;6(1):12-15

scholarly journals Psychological State of Selected Infertile Couples of Bangladesh

2019 ◽  
Vol 14 (1) ◽  
pp. 41-45
Author(s):  
SM Nurul Irfan ◽  
Md Mahbubur Rahman ◽  
Sangita Mithun ◽  
SM Yasir Arafat ◽  
Farzana Zafreen
Keyword(s):  
Computer Software ◽  
Armed Forces ◽  
Cross Sectional Study ◽  
Psychological State ◽  
Military Hospital ◽  
Infertile Couple ◽  
Depression Anxiety Stress Scale ◽  
Cross Sectional ◽  
Medical College ◽  
Infertile Couples

Introduction: Infertility is an increasingly prevalent condition which causes considerable psychological problems among infertile couples. Objective: To assess the psychological state of infertility in terms of depression, anxiety and stress among the infertile couples of Bangladesh. Materials and Methods: This cross-sectional study was conducted in the fertility centre of Combined Military Hospital, Dhaka from January to July 2018 among purposively selected 112 infertile couple. Data were collected by face to face interview through a pretested semi-structured Bangla questionnaire of Depression-Anxiety-Stress Scale and analyzed by computer software SPSS 19.0. Results: Among the 112 infertile couples, depression was found among 54.5%, anxiety among 53.6% and stress in 30.4% of females. Whereas among males depression was found in 38.4%, anxiety 26.8% and stress 21.4%. This study also revealed that couples with primary infertility had more depression, anxiety and stress than others. Conclusion: Females have been psychologically more affected than their husbands due to infertility. More than half of the females had depression and anxiety and about one third was affected by stress which was higher than their husbands. Journal of Armed Forces Medical College Bangladesh Vol.14(1) 2018: 41-45

scholarly journals A clinico pathological correlation in leprosy in a tertiary care teaching institution

2019 ◽  
Vol 5 (4) ◽  
pp. 870
Author(s):  
Ramesh A. ◽  
Sampath V. ◽  
Shvedha M.
Keyword(s):  
Clinical Diagnosis ◽  
Tertiary Care ◽  
Clinical Information ◽  
Lepromatous Leprosy ◽  
Female Ratio ◽  
Histopathological Findings ◽  
Medical College ◽  
Number Of Patients ◽  
One Year ◽  
Madras Medical College

<p class="abstract"><strong>Background:</strong> Leprosy is a chronic infectious granulomatous disease caused by <em>Mycobacterium leprae</em>. The disease primarily affects peripheral nervous system, the skin and certain other tissues. It is a spectral disease which is classified into five groups based on clinical, histopathological and bacteriological and immunological criteria as tuberculoid (TT), borderline tuberculoid (BT), mid-borderline (BB), borderline lepromatous (BL), lepromatous (LL) according to Ridley-Jopling classification. Adequate clinical information combined with histopathology and bacteriological index is helpful not only in classification of different types of leprosy, but also useful for management of cases.The objective of the study was to correlate clinical diagnosis with histopathological findings of leprosy.</p><p class="abstract"><strong>Methods:</strong> A retrospective study was conducted for one year from January to December 2018 in Leprosy clinic, Department of Dermatology, Rajiv Gandhi Government General Hospital and Madras Medical College, Chennai. The histopathological findings were compared with clinical diagnosis.<strong></strong></p><p class="abstract"><strong>Results:</strong> A total number of cases attended leprosy clinic from January 2018 to December 2018 was 167 cases, among those 49 clinically diagnosed cases were included in the study. Out of 49 cases, maximum number of patients belonged to 30-50 years age group. Male to female ratio was 3.9: 1. Hypopigmented, hypoaesthetic patches were commonly seen. Clinically as well as histopathologically BT leprosy was common.The maximum histological correlation seen in lepromatous leprosy (100%) followed by BT (80%).</p><p class="abstract"><strong>Conclusions:</strong> The study emphasises the role of skin biopsy in confirming the clinical diagnosis of leprosy and also as a therapeutic guide.</p>

scholarly journals Clinicopathological Evaluation of Seronegative Arthritis in a Tertiary Care Hospital of Bangladesh

2016 ◽  
Vol 12 (2) ◽  
pp. 66-70
Author(s):  
Md Shameem Haidar ◽  
Md Abdur Razzak
Keyword(s):  
Demographic Data ◽  
Tertiary Care ◽  
Armed Forces ◽  
Military Hospital ◽  
Inflammatory Rheumatic Diseases ◽  
Case Report Form ◽  
Care Hospital ◽  
Seronegative Arthritis ◽  
Cross Sectional ◽  
Number Of Patients

Introduction: The seronegative arthritis is a heterogeneous group of inflammatory rheumatic diseases with predominant involvement of axial, peripheral joints and enthesitis. All of these have some distinct as well as some overlapping features, characteristic peripheral asymmetrical lower limb involvement and a negative rheumatoid factor. Involvement of joints is usually oligoarticular but rarely polyarthritis may be present. Diagnosis is usually made from clinical features rather than investigations. Objective: To evaluate the seronegative arthritis clinicopathologically by collecting and analyzing the relevant informations. Materials and Methods: A descriptive cross-sectional prospective study was conducted at Combined Military Hospital, Chittagong from November 2015 to October 2016. A total 74 patients of suspected seronegative arthritis were included. Detail socio-demographic data were collected from the informant and recorded in structured case report form. Clinical examination and relevant investigations were done meticulously to confirm the aetiology of seronegative arthritis. Results: Maximum number of patients was in the 3rd to 4th decade (62.1%), mean age of the patient was 37.4±8.7 and 38.7±8.1 years in male and female respectively. Malefemale ratio was 2.65:1. Symmetrical sacroiliitis was found in 15(20.2%) patients, asymmetrical sacroiliitis in 36(48.6%) and in 23(31.2%) cases sacroiliac joint was not involved. Common aetiology for seronegative arthritis showed that, reactive arthritis recognized in majority of patients 29 (39.1%) and second most common cause was seronegative rheumatoid arthritis in 23(31%) patients. Conclusion: The Seronegative arthritis is a social, economical and health-care burden. Patients who develop 66 JAFMC Bangladesh. Vol 12, No 2 (December) 2016 arthritis have high disability, discomfort and loss of quality of life. Seronegative arthritis is an interesting group of related conditions with overlapping features and genetic and familial association. That may alert the primary care physician to attain possible diagnosis of spondyloarthritis and to consider a rheumatological opinion. Journal of Armed Forces Medical College Bangladesh Vol.12(2) 2016: 66-70

scholarly journals Severe Cutaneous Adverse Drug Reactions in Bangladesh: A Review in a Tertiary Level Hospital

2016 ◽  
Vol 12 (2) ◽  
pp. 71-75
Author(s):  
Md Niamul Gani Chowdhury ◽  
Mohammad Enamul Hoque ◽  
Md Abdul Latif Khan ◽  
Md Shirajul Islam Khan
Keyword(s):  
Adverse Drug Reactions ◽  
Armed Forces ◽  
Stevens Johnson Syndrome ◽  
Military Hospital ◽  
Case Report Form ◽  
Drug Reactions ◽  
Female Ratio ◽  
Medical College ◽  
Johnson Syndrome ◽  
Systemic Symptoms

Introduction: The Severe Cutaneous Adverse Drug Reactions (SCADRs) are rare but life-threatening as these encompass drug reaction with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and acute generalized exanthematous pustulosis (AGEP). Objective: To estimate the incidence of SCADRs and to find out the cause in Bangladesh. Materials and Methods: 50 patients with SCADRs were studied over a period of 1 year from January 2015 to December 2015 in the Department of Dermatology, Combined Military Hospital, Dhaka. Data were collected from the informant and recorded in structured Case Report Form. Quantitative data were expressed as mean and standard deviation and qualitative data as frequency and percentage. Results: Clinical diagnosis of the study subjects recognized 46.0% cases as SJS, 28(19.0%) as TEN, 16.0% as DRESS and 10.0% as AGEP. The maximum incidence (46%) was seen in the age group of 31-50 years; mean age of the patient was 37.42+5.3 years. Male and female ratio was 2.84:1. Anticonvulsant group of drugs could give rise to maximum incidence of SCADRs. Carbamazepine was responsible in 22.0% cases of SCADRs, followed by Phenytoin in 16.0% patients and Phenobarbital in 14.0% cases. Conclusion: SCADRs were seen mostly with the anticonvulsant drugs belonging to Carbamazepine and Phenytoin group. SCADRs deserve continuous monitoring to plan preventive strategies. Journal of Armed Forces Medical College Bangladesh Vol.12(2) 2016: 71-75

scholarly journals Socio-demographic Profile of Abortion Cases attending at a Tertiary Level Hospital

2020 ◽  
Vol 14 (2) ◽  
pp. 200-202
Author(s):  
Feroz Ahmed Sohel ◽  
Sanzida Jahan ◽  
Saifullah Russel ◽  
Farzana Zafreen
Keyword(s):  
Unplanned Pregnancy ◽  
Economic Status ◽  
Armed Forces ◽  
Tertiary Level ◽  
College Hospital ◽  
Cross Sectional ◽  
Demographic Profile ◽  
Medical College ◽  
Number Of Patients ◽  
Level Hospital

Introduction: Abortion in Bangladesh is illegal under most situations, but menstrual regulation is often used as a substitute. Abortion can be legally performed by a physician in a hospital if it is necessary to save the life of the mother. A person, who performs an abortion under any other circumstances, including a woman who self-aborts, can be punished by a fine and imprisonment. Objective: To assess the socio-demographic profile of abortion cases attending a tertiary level hospital of Bangladesh. Materials and Methods: This cross-sectional descriptive type of study was carried out among 80 patients at the Gynae ward and out patient department of Dhaka Medical College Hospital from March 2012 to June 2012. The study population was women attending the selected hospital for an abortion or abortion-related complications. Results: Most of the respondents 35(43.8%) were below 25 years of age and all patients were housewives. The maximum number of patients 63(78.8%) had spontaneous abortion, low socio-economic status and majority were multigravidas. It was also found that patients with abortion were mostly in their second (43.8%) and third (21.3%) decade of life. Conclusion: In this study, the commonest reason for termination of pregnancy was unplanned pregnancy. Creating awareness and timely intervention might decrease the number of abortion cases. Journal of Armed Forces Medical College Bangladesh Vol.14 (2) 2018: 200-202

scholarly journals Outcome of Injection Sclerotherapy for First Degree and Second Degree Haemorrhoids– A Study of 50 Cases

2016 ◽  
Vol 12 (2) ◽  
pp. 98-101
Author(s):  
Md Ershad Ul Quadir ◽  
Md Mahbubur Rahman ◽  
Md Tanvirul Islam ◽  
SM Shakhawat Hosssain
Keyword(s):  
Symptomatic Relief ◽  
Digital Rectal Examination ◽  
Cost Effective ◽  
Armed Forces ◽  
Injection Sclerotherapy ◽  
Female Ratio ◽  
Medical College ◽  
Number Of Patients ◽  
Male Female Ratio ◽  
Second Degree

Introduction: Haemorrhoid is the frequent problem in clinical practice of general surgery. Haemorrhoids are dilatation and tortuosity of rectal veins affecting almost 4.5% of the population. Various operative and non operative therapeutic options are in practice to treat haemorrhoids, yet none has been proven cent percent effective. Sclerotherapy is a simple, safe and cost effective procedure that is widely practiced globally to treat haemorrhoids. Many sclerosants are being used with variable efficacies. Objective: To evaluate the outcome of injection Sclerotherapy in first degree and second degree haemorrhoids. Materials and Methods: Fifty patients of both gender having haemorrhoids who attended Outpatient Department (OPD) at BNS Patenga from September 2013 to August 2014 were included in this study. On the basis of history, patients were selected for Digital Rectal Examination (DRE) and proctoscopic examination to confirm the diagnosis. Sclerotherapy was repeated at interval of 6 weeks till symptomatic relief was achieved. Maximum 3 sittings of sclerotherapy were given. Patients were followed up at 3 months interval for 1 year. Results: This prospective study was conducted on 50 cases of first degree and second degree Haemorrhoids. The highest number of patients 21(42%) were in the age group of 21-30 years with majority 38(76%) being male. Male female ratio was 3.16: 1. All the patients presented with painless per-rectal bleeding. Satisfactory results were observed in 29(58%) patients of whom 20(40%) patients were having first degree haemorrhoids and 9(18%) patients were having second degree haemorrhoids. Sclerotherapy was more effective in first degree compared to second degree haemorrhoids patients. Conclusion: Injecting Sclerotherapy is a suitable office procedure for treatment of haemorrhoids. The method is easy, convenient, cheap, well accepted and comfortable for patient. More or less there are no complications and the result is also satisfactory. Journal of Armed Forces Medical College Bangladesh Vol.12(2) 2016: 98-101

scholarly journals Patients Satisfaction about Magnetic Resonance Imaging Services at Combined Military Hospital, Dhaka

2020 ◽  
Vol 15 (1) ◽  
pp. 61-63
Author(s):  
Md Rezaur Rahman ◽  
Umar Rashed Munir ◽  
Farzana Zafreen ◽  
Md Abdul Wahab
Keyword(s):  
Waiting Time ◽  
Study Finding ◽  
Armed Forces ◽  
Cross Sectional Study ◽  
Military Hospital ◽  
Positive Finding ◽  
Cross Sectional ◽  
Face To Face ◽  
Medical College ◽  
The Past

Introduction: MRI investigation indicates sensitivity as well as specificity. The increasing clinical utility, coupled with the greater availability and capacity to per¬form, has resulted in a dramatic increase in their use over the past de¬cades. The expectation of the care seekers has also increased and it is a major concern whether this increase in MRI result has improved patient outcomes or not. Objective: The study was carried out with the aim to evaluate various aspects of satisfaction among the MRI performing patients at Combined Military Hospital, Dhaka. Materials and Methods: This descriptive cross sectional study was carried out on patient satisfaction of MRI services at CMH, Dhaka. A total of 186 patients performing investigation at MRI Department of CMH Dhaka since 01st May 2011 to 15th May 2011 were interviewed. Data were collected and analysed by face-to-face interview and reviewing medical record with the help of a questionnaire and checklist. Results: The waiting time of 8-12 weeks for MRI was maximum among 24.7% patients; followed by 17.7% for 2-4 weeks and 16.1% for 1-2 weeks. It also revealed that waiting time was higher (8-12 weeks) in Neurosurgery referred cases (33.3%), Orthopaedic (28.2%) followed by Neurology (14.3%) (p<0.05). The outdoor patients experienced more waiting time in comparison to indoor patients. Orthopaedic referred cases had the highest (53.8%) positive finding followed by Neurosurgery (15.1%) and Medicine (7.5%). A significant majority of the patients are satisfied (68.81%) or very satisfied (25.80%) with the MRI service. Conclusion: This study finding will help the hospital administrator not only in monitoring the investigation but also to take measures to improve the facilities of MRI department. Journal of Armed Forces Medical College Bangladesh Vol.15 (1) 2019: 61-63

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