scholarly journals Prognostic markers in Chronic Lymphocytic Leukaemia - A flow cytometric analysis

2020 ◽  
Vol 36 (3) ◽  
Author(s):  
Hala Haq ◽  
Nasir Uddin ◽  
Saleem Ahmed Khan ◽  
Sunia Ghaffar
Keyword(s):  
Chronic Lymphocytic Leukaemia ◽  
Prognostic Markers ◽  
Lymphocytic Leukaemia ◽  
Flow Cytometric Analysis ◽  
Sampling Technique ◽  
Armed Forces ◽  
Cross Sectional Study ◽  
Military Hospital ◽  
Cross Sectional ◽  
Flow Cytometric

Objective: To find out the frequency of ZAP-70, CD38 and CD49d in patients diagnosed with CLL in our population. Methods: This is a cross sectional study conducted in Army Medical College in collaboration with Armed Forces Institute of Pathology and Military Hospital Rawalpindi from 1st January 2018 to 30th November 2018. Permission from Institutional Ethical Committee was obtained. Blood samples were collected by non-probability consecutive sampling technique and analyzed for blood counts and flow cytometry was done for ZAP-70, CD38 and CD49d. Manufacturer’s instructions for the kits were strictly followed. Results: Fifty-one newly diagnosed patients with CLL were studied for the prognostic markers in CLL. CD 38 was expressed in 25(49%) and CD49d in 21(41.2%). ZAP-70 expression was not detected in our series of patients. Conclusion: We conclude that CD38 and CD49d expression was detected in almost half of the patients of CLL in our series. CD49d showed statistically positive correlation with CD38, showing that it is a more pragmatic choice for reliable prognostication of CLL along with CD38. doi: https://doi.org/10.12669/pjms.36.3.541 How to cite this:Haq H, Uddin N, Khan SA, Sunia Ghaffar4. Prognostic markers in Chronic Lymphocytic Leukaemia - A flow cytometric analysis. Pak J Med Sci. 2020;36(3):---------. doi: https://doi.org/10.12669/pjms.36.3.541 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Health Problems of Elderly Patients attending Combined Military Hospital, Dhaka

2017 ◽  
Vol 13 (1) ◽  
pp. 8-12
Author(s):  
SM Humayun Kabir ◽  
Md Ziaul Islam ◽  
Masuda Begum ◽  
Masud Ahmed ◽  
Mohammad Mohsin ◽  
...  
Keyword(s):  
Elderly Patients ◽  
Health Care Providers ◽  
Family Income ◽  
Sampling Technique ◽  
Armed Forces ◽  
The Elderly ◽  
Health Problems ◽  
Military Hospital ◽  
Care Providers ◽  
Cross Sectional

Introduction: Health problems of elderly are an emerging health burden throughout the world. Bangladesh is currently undergoing a demographic transition and the proportion of the population of 60 years and older is increasing rapidly. Health care providers and policymakers are highly concerned with this burning issue. Objective: To know the disease pattern among the elderly patients in Combined Military Hospital, Dhaka. Materials and Methods: This cross-sectional study was carried out from July 2015 to June 2016 among 152 elderly patients above 60 years of age admitted in Combined Military Hospital (CMH), Dhaka Cantonment. Data were collected by face-to-face interview with semi-structured questionnaire and checklist following purposive sampling technique. Analysis of data was done by Statistical Package for Social Science (SPSS, version 20.0). Results: Mean age of the elderly was 72.06±4.56 years with the range of 60-80 years and majority (90.8%) of the elderly was male. Out of total 152 elderly patients, by occupation majority (31.6%) were in the business group followed by 30.3% in the retired group and 9.2 % in the housewife group. Average monthly family income was BDT 17927.63±7360.75 with the range of BDT 6000-35000. With initial complaints elderly patients reported to doctors in private chamber (38.2%), private hospital (25.6%) and Govt hospital (5.9%). Among all of the elderly patients, majority (21.1%) had Diabetes Mellitus followed by Rheumatoid Arthritis (17.6%), Asthma (12.5%), Cataract (11.2%), ENT problem (6.6%), Malignancy (5.9%) and Benign Enlargement of Prostate 8(5.3%). Conclusion: The number of elderly people is expanding rapidly; it also presents multifaceted health problems and thus creates unique challenges for the national healthcareservices. Early identification of problem and ensuring the availability of health with economic and social support can have a control over the elderly health problems. Journal of Armed Forces Medical College Bangladesh Vol.13(1) 2017: 8-12

scholarly journals Haematological Changes in Peripheral Blood of HIV – Infected Persons with Correlation to CD4 Cell Count

2015 ◽  
Vol 32 (3) ◽  
pp. 130-136 ◽  
Author(s):  
Md Mizanur Rahman ◽  
Susane Giti ◽  
Md Saiful Islam ◽  
Md Mostafizur Rahman
Keyword(s):  
Cell Count ◽  
Peripheral Blood ◽  
Flow Cytometric Analysis ◽  
Armed Forces ◽  
Cross Sectional ◽  
Cd4 Cell Count ◽  
Flow Cytometric ◽  
Erythrocyte Sedimentation ◽  
Haematological Changes ◽  
Cd4 Cell

Objective: Aims at recognizing the haematological abnormalities in peripheral blood associated with HIV infection and to correlate the haematological abnormalities with CD4 cell count to highlight these manifestations with disease progression.Methodology: Observational cross sectional study.Setting: Department of Haematology, Armed Forces Institute of Pathology (AFIP), Dhaka cantonment.Patients: Two hundred four (204) HIV – infected patients receiving antiretroviral therapy aged from three years to 65 years. There were 132 male and 72 female patients.Results: Anaemia was found in 103 (50.5%) cases. Leucopenia and thrombocytopenia were observed in ten (4.9%) and seven (3.4%) cases respectively. Lymphopenia was found in 12 (5.9%) cases. In 50 (24.5%) cases Erythrocyte Sedimentation Rate (ESR) was > 20 mm at the end of 1st hour. Flow cytometric analysis for CD4 cell count showed < 200 cells/cmm in 65 (31.8%) cases, in between 200 cells/cmm and 499 cells/cmm in 117 (57.4%) cases and > 500 cells/cmm in 22 (10.8%) cases.Conclusion: Haematological abnormalities are common in HIV – infected patients and responsible for significant morbidity and mortality in these patients. These abnormalities are more frequent with disease progression. The present study revealed a significant increase in the number of anaemia, leucopenia, lymphopenia and thrombocytopenia with decreasing CD4 cell count.J Bangladesh Coll Phys Surg 2014; 32: 130-136

scholarly journals Psychological State of Selected Infertile Couples of Bangladesh

2019 ◽  
Vol 14 (1) ◽  
pp. 41-45
Author(s):  
SM Nurul Irfan ◽  
Md Mahbubur Rahman ◽  
Sangita Mithun ◽  
SM Yasir Arafat ◽  
Farzana Zafreen
Keyword(s):  
Computer Software ◽  
Armed Forces ◽  
Cross Sectional Study ◽  
Psychological State ◽  
Military Hospital ◽  
Infertile Couple ◽  
Depression Anxiety Stress Scale ◽  
Cross Sectional ◽  
Medical College ◽  
Infertile Couples

Introduction: Infertility is an increasingly prevalent condition which causes considerable psychological problems among infertile couples. Objective: To assess the psychological state of infertility in terms of depression, anxiety and stress among the infertile couples of Bangladesh. Materials and Methods: This cross-sectional study was conducted in the fertility centre of Combined Military Hospital, Dhaka from January to July 2018 among purposively selected 112 infertile couple. Data were collected by face to face interview through a pretested semi-structured Bangla questionnaire of Depression-Anxiety-Stress Scale and analyzed by computer software SPSS 19.0. Results: Among the 112 infertile couples, depression was found among 54.5%, anxiety among 53.6% and stress in 30.4% of females. Whereas among males depression was found in 38.4%, anxiety 26.8% and stress 21.4%. This study also revealed that couples with primary infertility had more depression, anxiety and stress than others. Conclusion: Females have been psychologically more affected than their husbands due to infertility. More than half of the females had depression and anxiety and about one third was affected by stress which was higher than their husbands. Journal of Armed Forces Medical College Bangladesh Vol.14(1) 2018: 41-45

scholarly journals COMPARISON OF MANIFESTATIONS OF GIARDIA AND ASCARIS INFESTATIONS BETWEEN BOTH GENDERS PRESENTING WITH DIARRHEA

2020 ◽  
Vol 70 (6) ◽  
pp. 1681-85
Author(s):  
Kanwal Jehanzeb ◽  
Zia Ul Haq ◽  
Saeed Zaman Khattak ◽  
Sajid Ali Shah ◽  
Munir Akmal Lodhi ◽  
...  
Keyword(s):  
Sampling Technique ◽  
Cross Sectional Study ◽  
Military Hospital ◽  
P Value ◽  
Common Symptom ◽  
Chi Square ◽  
Cross Sectional ◽  
Worm Infestation ◽  
Number Of Patients ◽  
Common Parasite

Objective: To assess the occurrence and intensity of Giardia and Ascaris infestations in children of both genders reporting with diarrhea. Study Design: Comparative cross sectional study. Place and Duration of Study: Paediatrics department, Combined Military Hospital, Gilgit, from Jul 2016 to Jul2018. Methodology: Patients of either gender with worm infestation were included in the study. Patients more than13 years old were excluded. The sampling technique used was non probability consecutive sampling. The stoolexamination (R/E) for the diagnosis of worm infestation was done. Stratification was done with regards to age,mother education, gender, type of water used and post stratification chi square test was applied. p-value was0.613 when calculated for the manifestation between both genders. p-value ≤0.05 was considered significant. Results: Total number of patients in our study was 100. Among them, males were 65 (65%) and females were 35(35%). Mean age of patients in our study was 4.20 ± 2.61 years (Mean ± SD). Abdominal pain being most common symptom in 43 (43%) of patients. Majority of the patients were from 2 to 10 years of age, 79 (79%). Helminthic infestation was the most common observed in 52 (52%) whereas Protozoal infestation was observed in 48 (48%) patients. The most common parasite isolated was Giardia 41 (41%) followed by Ascaris 36 (36%). p-value of 0.613 was found between both gender. Conclusion: In our study Helminthic infestation was more common. The most common parasite isolated wasGiardia followed by Ascaris.

scholarly journals PATIENTS SATISFACTION ABOUT HEALTH CARE DELIVERY IN OUT-PATIENTS DEPARTMENT OF COMBINED MILITARY HOSPITAL RAWALPINDI

2020 ◽  
Vol 70 (6) ◽  
pp. 1929-34
Author(s):  
Tahir Sardar ◽  
Iqbal Ahmad Khan ◽  
Muhammed Alamgir Khan
Keyword(s):  
Health Care ◽  
Health Care Delivery ◽  
Care Delivery ◽  
Cost Effective ◽  
Armed Forces ◽  
Cross Sectional Study ◽  
Military Hospital ◽  
Nursing Assistant ◽  
Cross Sectional ◽  
Level Of Satisfaction

Objective: To determine patient’s level of satisfaction and factors leading to dissatisfaction in selected patientsgroup with health care delivery in outpatients department of CMH Rawalpindi. Study Design: Cross sectional study. Place and Duration of Study: Out Patients Department of Combined Military Hospital Rawalpindi, from Sep2013 to Aug 2015. Methodology: Before data collection, written informed consent was taken from all the participants. The studypopulation comprised of armed forces personnel and their families. Patients, including both, males and females, coming to the outpatient department of Combined Military Hospital Rawalpindi were included in the study through consecutive sampling. Results: Results revealed that only 30% were satisfied. 67% patients were satisfied with the facilities in reception and 70% were satisfied with cleanliness in waiting area. A relatively low level of satisfaction with dealing of nursing assistant was recorded while very high percentage of satisfaction with performance of doctor i.e. 91%, examination done by doctor 91% and information provided by doctor 93% was recorded.90% patients reported high level of satisfaction with medicines provided.95.33% patients were satisfied with lab tests being done in hospital. Conclusion: Assessing satisfaction of patients is a simple and cost effective way for assessment of hospitalservices. Most of the patients were contented with services delivered in OPD and showed their trust in doctors,medicines provided and lab facilities offered. Majority were willing to revisit the hospital if required.

scholarly journals Patients Satisfaction about Magnetic Resonance Imaging Services at Combined Military Hospital, Dhaka

2020 ◽  
Vol 15 (1) ◽  
pp. 61-63
Author(s):  
Md Rezaur Rahman ◽  
Umar Rashed Munir ◽  
Farzana Zafreen ◽  
Md Abdul Wahab
Keyword(s):  
Waiting Time ◽  
Study Finding ◽  
Armed Forces ◽  
Cross Sectional Study ◽  
Military Hospital ◽  
Positive Finding ◽  
Cross Sectional ◽  
Face To Face ◽  
Medical College ◽  
The Past

Introduction: MRI investigation indicates sensitivity as well as specificity. The increasing clinical utility, coupled with the greater availability and capacity to per¬form, has resulted in a dramatic increase in their use over the past de¬cades. The expectation of the care seekers has also increased and it is a major concern whether this increase in MRI result has improved patient outcomes or not. Objective: The study was carried out with the aim to evaluate various aspects of satisfaction among the MRI performing patients at Combined Military Hospital, Dhaka. Materials and Methods: This descriptive cross sectional study was carried out on patient satisfaction of MRI services at CMH, Dhaka. A total of 186 patients performing investigation at MRI Department of CMH Dhaka since 01st May 2011 to 15th May 2011 were interviewed. Data were collected and analysed by face-to-face interview and reviewing medical record with the help of a questionnaire and checklist. Results: The waiting time of 8-12 weeks for MRI was maximum among 24.7% patients; followed by 17.7% for 2-4 weeks and 16.1% for 1-2 weeks. It also revealed that waiting time was higher (8-12 weeks) in Neurosurgery referred cases (33.3%), Orthopaedic (28.2%) followed by Neurology (14.3%) (p<0.05). The outdoor patients experienced more waiting time in comparison to indoor patients. Orthopaedic referred cases had the highest (53.8%) positive finding followed by Neurosurgery (15.1%) and Medicine (7.5%). A significant majority of the patients are satisfied (68.81%) or very satisfied (25.80%) with the MRI service. Conclusion: This study finding will help the hospital administrator not only in monitoring the investigation but also to take measures to improve the facilities of MRI department. Journal of Armed Forces Medical College Bangladesh Vol.15 (1) 2019: 61-63

scholarly journals LEVETIRACETAM USE, AVAILABILITY AND KNOWLEDGE OF TOXICITY AMONG EPILEPTIC PATIENTS AND THEIR CARE GIVERS: A CROSS-SECTIONAL STUDY IN KING SALMAN ARMED FORCES HOSPITAL TABUK SAUDI ARABIA

2021 ◽  
pp. 1-4
Author(s):  
Olayan Alatawi ◽  
Faisal Alzahrani ◽  
Nasrin S Saiyed
Keyword(s):  
Saudi Arabia ◽  
Side Effect ◽  
Sampling Technique ◽  
Armed Forces ◽  
Cross Sectional Study ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Care Givers ◽  
Epileptic Patients ◽  
Study Participants

Background: Levetiracetam (Keppra®) is a well-known second-generation anti-epileptic drug (AED). The study was aimed to addresses Levetiracetam use, availability and knowledge of toxicity among epileptic patients and their care givers in King Salman Armed Forces Hospital Tabuk Saudi Arabia. Methods: This cross-sectional survey was conducted in King Salman Armed Forces Hospital (KSAFH) in Tabuk city in Saudi Arabia. The study participants were epileptic patients and their care givers, selected from different outpatient departments using a convenient sampling technique. Data was collected using an Arabic self-reported questionnaire consisted of open-ended and closed-ended questions to facilitate study participants. Altogether, 381 persons answered the full questionnaire. The data were entered into SPSS version 26.0 for Windows, cleaned and managed before analysis. Results: Participants age ranged from 18 to 63 years, with a mean 29.6 years and standard deviation 5.8 years. 47.0% (n= 179) were male and 53.0% (n= 202) female. Six out of ten participants lived in the urban area (67.7%). Majority of the participants had knowledge about seizures (96.9%). About 31.0% of the participants and/or patients had seizures (epilepsy) since more than 20 years. Nearly 28.0% participants and/or patients had family history of seizures (epilepsy). Majority of the participants had Levetiracetam at home and aware of the correct usage of it. However, about 11% of the participants felt that Levetiracetam is used to help sleep. Eight out of ten of the participants reported “Sleepiness” as the side effect of Levetiracetam (79.3%). Half of the participants reported “Headache” as the side effect of Levetiracetam. About 94.0% of the participants knew that someone could take enough Levetiracetam to harm themselves. Conclusion: The study population used Levetiracetam, they demonstrated basic awareness of Levetiracetam use including the potential consequences of overdosing. Participants' knowledge regarding the toxicity of Levetiracetam is adequate. Special awareness programs for parents of children with epilepsy may be needed to reduce the knowledge gaps in the management of epilepsy and to ensure compliance and optimal therapeutic outcomes.

scholarly journals PENGUKURAN JUMLAH LIMFOSIT CD4 METODE PANLEUCOGATING PADA PASIEN TERINFEKSI HUMAN IMMUNODEFICIENCY VIRUS (HIV)

2016 ◽  
Vol 19 (3) ◽  
pp. 190
Author(s):  
Umi S. Intansari ◽  
Budi Mulyono ◽  
Usi Sukorini
Keyword(s):  
Flow Cytometric Analysis ◽  
Clinical Pathology ◽  
Cross Sectional Study ◽  
Altman Analysis ◽  
Cross Sectional ◽  
Bland Altman Analysis ◽  
Flow Cytometric ◽  
Percentage Difference ◽  
Immunodeficiency Virus ◽  
Good Agreement

The standard method for absolute lymphocyte CD4 count is by the use of flow cytometric analysis, but due to the high costly matter,a simpler method and less costly fee of PanLeucogating dual platform is needed. The aim of this study is to know how to replace the single platform by PanLeucogating dual platform by determining the agreement between both methods and to test the proportion of patient who have CD4 <200 cell/ul measured by PanLeucogating and single platform method. A cross sectional study was carried out in the Departement of Clinical Pathology Faculty of Medicine Gadjah Mada University Yogyakarta. The inclusion criteria of the study are HIV/AIDS patients who their CD4 were measured. Absolute count of CD4 was using FACS Calibur measured with both PanLeucogating and single platform method. The bias, correlation, regression and limit of agreement between both methods were analyzed using Bland Altman analysis to decide whether the two methods are interchangeable. The result of the study revealed an excellent correlation between the two methods (r=0.996; y=- 0.906 + 0.0.987). Bland Altman analysis revealed bias=5 cells/uL; standard deviation=18.7 and Limit of agreement (LOA)=-31.6 – 40.75. The Mean Percentage Difference (MPD)=2%; dan%LOA=-7.96 – 12.5%. PanLeucogating method has a good agreement with the single platform method and can be used interchangeable. There was no difference of the proportion of patient who has CD4 <200 cell/ul measured by Panleucogating method and single platform.

scholarly journals CORRELATION OF TRISOMY 12 WITH CLINICAL FEATURES AND OTHER LABORTARY PARAMETERS IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKAEMIA

2021 ◽  
Vol 71 (2) ◽  
pp. 473-77
Author(s):  
Ali Ahmed ◽  
Ch Altaf Hussain ◽  
Hamid Saeed Malik ◽  
M Abdul Naeem ◽  
Rafia Mehmood ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Chronic Lymphocytic Leukaemia ◽  
Lymphocytic Leukaemia ◽  
Bone Marrow Aspiration ◽  
Armed Forces ◽  
Cross Sectional ◽  
Course Of Illness ◽  
Pathologic Features ◽  
Trisomy 12 ◽  
Binet Stage

Objective: To determine the frequency of trisomy 12 in B-Cell chronic lymphocytic leukaemia (CLL), to correlate its association with clinico-pathologic features and to determine the role of this cytogenetic defect to the prognosis. Study Design: Cross sectional study. Place and Duration of Study: Haematology department, Armed Forces Institute of Pathology, Rawalpindi, from May 2017 to Aug 2018. Methodology: A total of 56 newly diagnosed patients of Chronic Lymphocytic Leukaemia were included in the study. Patients were diagnosed on the basis of National Cancer Institute Working Group guidelines. A detailed history and thorough clinical examination were performed and complete blood counts, biochemical profile, bone marrow examination, immunophenotyping on bone marrow/peripheral blood samples were done for the diagnosis of Chronic lymphocytic leukaemia. Interphase FISH studies were performed on blood/bone marrow aspiration for detection of Trisomy 12 were performed. Results: Out of 56 patients, trisomy was detected in 12 (10.7%) patients. Out of 7 patients with trisomy 12, five patients presented in late stages (Binet stage B and C), however this association of Trisomy 12 with Binet stage was also statistically insignificant (p=0.474). About six with trisomy 12 were positive for CD 38, however this association was also not statistically significant (p=0.124). Results revealed that patients having trisomy 12 underwent chemotherapy at diagnosis and during follow ups as compared to patients having other cytogenic abnormalities. Moreover, patient with trisomy 12 develop progression in disease during course of illness, however association was statistically insignificant (p>0.05)............

scholarly journals Burnout among surgeons; depression, anxiety and stress between consultant versus post-graduate trainee

2020 ◽  
Vol 36 (7) ◽  
Author(s):  
Saleh Khurshied ◽  
Aliya Hisam ◽  
Nawal Khurshid ◽  
Madiha Khurshid
Keyword(s):  
Marital Status ◽  
Sampling Technique ◽  
Cross Sectional Study ◽  
Military Hospital ◽  
P Value ◽  
Cross Sectional ◽  
Post Graduate ◽  
Creative Commons ◽  
Significant Difference ◽  
The Difference

Objective: To compare depression, anxiety and stress between consultant and post-graduate trainee (PG-trainee) surgeons and to find the difference of different factors i.e. gender, marital status, physical activity, BMI, comorbidity and Income per month between the two. Methods: A descriptive cross-sectional study of eight months duration from March 2018 to August 2018 was conducted in Military Hospital and Combined Military Hospital, Rawalpindi, Pakistan. Convenient sampling technique was used. DASS 21 questionnaire was used for data collection. Data were entered and analysed by SPSS 22. A p-value of < 0.05 was considered statistically significant. Results: The mean age of participants was 37.44±10.512 years. Out of 68 participants, 54 (79.4%) were males and 14 (20.6%) were females. There was a significant difference between the consultants and PG trainees in terms of gender, marital status and income per month (p= <0.005) PG-trainees were more depressed and anxious but not stressed as compared to consultants (p= 0.014, 0.012 and 0.280 respectively). Conclusions: There was a significant association in terms of gender, marital status and income per month between consultants and PG trainees. A statistically significant association was found between consultants and PG trainees concerning depression and anxiety showing PG trainees were more depressed and anxious. doi: https://doi.org/10.12669/pjms.36.7.1415 How to cite this:Khurshied S, Hisam A, Khurshid N, Khurshid M. Burnout among surgeons; depression, anxiety and stress between consultant versus post-graduate trainee. Pak J Med Sci. 2020;36(7):1745-1748. doi: https://doi.org/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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