scholarly journals Clinico-demographic, Investigation and Outcomes Profiles of Subacute Sclerosing Panencephalitis (SSPE) Patients at A Referral Neurology Hospital in Bangladesh

2019 ◽  
Vol 5 (2) ◽  
pp. 97-100
Author(s):  
Mohammad Enayet Hussain ◽  
AFM Al Masum Khan ◽  
Md Abdullah Yusuf ◽  
Md Ferdous Mian ◽  
Md Nahidul Islam ◽  
...  
Keyword(s):  
Age Of Onset ◽  
Subacute Sclerosing Panencephalitis ◽  
Late Complication ◽  
Socioeconomic Condition ◽  
Male Predominance ◽  
Initial Symptoms ◽  
First Onset ◽  
Study Population ◽  
The Mean ◽  
Lost To Follow Up

Background: SSPE is a late complication of measles and is fatal in most cases. Objectives: The purpose of the study was to observe the clinico-demographic, investigation and outcome profiles of SSPE patients. Methodology: This prospective cohort study was conducted in the Department of Neurophysiology at National Institute of Neurosciences and Hospital, Dhaka, Bangladesh from September 2014 to August 2017. Patients of SSPE who were diagnosed by Dyken's Criteria were selected as study population. Details socio-demographic, clinical profiles, investigations and outcome were recorded. The outcome was assessed from the time of first onset of the symptoms till closing of the study. Results: The mean age of the study population was 14.3±4.209 years with the male predominance (73.5%). Majority were from rural area (70.6%) and were of low socio-economic condition (52.9%). The mean age of onset of disease was 13.6±4.30 years. History of previous measles infection was reported in 13(38.2%) cases among which 12(92.3%) cases were vaccinated. The mean age of measles infection was 17.0±15.44 months. The time of first symptom of SSPE from primary measles infection was 11.50±4.80 years. Recurrent fall (47.1%) and myoclonic jerks (17.6%) were the most frequent initial symptoms of the patient. Cognitive decline was observed in 28(82.4%) cases. EEG background was slow in 23(67.6%) patients and periodic burst was observed in all (100.0%) cases. Anti-measles antibody in CSF was positive in all cases. MRI was abnormal in 7(25.9%) cases out of 27 cases. Twelve (35.3%) patients died, 18(52.9%) were alive and 4(11.8%) were lost to follow up when the study was closed. Conclusion: Early aged male from lower socioeconomic condition are found to be suffering from SSPE. Recurrent fall is the commonest initial presentation. Spontaneous recovery can occur in very few patients. Journal of National Institute of Neurosciences Bangladesh, 2019;5(2): 97-100

scholarly journals POS1018 IMPORTANCE OF LATERAL SPINE VIEW IN DXA BONE DENSITOMETRY IN PATIENTS WITH SPONDYLOARTHRITIS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 776.3-777
Author(s):  
S. Miri ◽  
H. Ferjani ◽  
K. Maatallah ◽  
A. Kasraoui ◽  
D. Kaffel ◽  
...  
Keyword(s):  
Femoral Neck ◽  
Structural Changes ◽  
Age Of Onset ◽  
Posterior Part ◽  
Lateral View ◽  
Mineral Density ◽  
Lateral Spine ◽  
Male Predominance ◽  
T Score ◽  
The Mean

Background:Osteoporosis is an increasingly important health problem among patients with spondyloarthritis (SPA). The Measure of Bone Mineral Density BMD is routinely carried out in an anteroposterior (AP) view of the spine. However, the syndesmophytes, ligaments calcifications, and the posterior part of vertebrae affect AP scanning. A lateral spine view is a more sensitive tool in assessing bone loss in trabecular bone.Objectives:We aimed to evaluate the association between lateral lumbar DXA and syndesmophyte grading in patients with SPA.Methods:We conducted a retrospective study including 75 patients with SPA. Bone density of the hip and lumbar spine was measured with a GE Lunar Prodigy Advance Bone Densitometer equipment. All patients had lumbar lateral, AP, and proximal femur DXA scans. The T-score, which measures the difference between a patient’s BMD and young-normal subjects, was computed and age-matched.Results:The mean age of the patients was 36±11 years. Male predominance was noted with a sex ratio of 4.76. The mean BMI was 25±5 kg/m2. Eight percent were obese. Fifty-two percent had Vitamin D deficiency.Forty-eight percent of the patients had axial SPA, while 52% had axial and peripheral symptoms.The mean age of onset was 27±7 years. Fifty-two percent of the patients had high inflammatory biomarkers. The BASDAI, ASDAS-VS, and ASDAS-CRP mean levels were respectively: 3.5±2.4, 3.1±0.9, and 3±0.8. The mean BASRI and mass were respectively 8 + 4.8 and 16.4 + 19.4. Analyses of T-score values obtained over the femoral neck revealed osteoporosis in 18.7% of the cases and osteopenia in 32% of the cases. On the other hand, analyses of AP, spine views revealed osteoporosis in 25.3% and osteopenia in 45.3% of patients (p=0.028, r=0.254). We detected the highest percentage of osteoporosis in lateral lumbar view and T-scores matched more closely with femoral neck values; osteoporosis in 29.3%, and osteopenia in 22.7% of the patients (p<10-3, r=0.562). BMD measured in AP, and lateral views were in good agreement (p<10-3, p=0.592). Age was inversely but not significantly associated with BMD in lateral (p=0.442, r=-0.09), AP (p=0.319, r=-0.117) and femoral neck projections (p=0.179, r=-0.157). Femoral neck BMD was associated with the activity of SPA (ASDAS vs (p=0.027, r= -0.295), and the mobility limitation BASMI (p=0.032, r= -0.247). Coxitis, BASRI, or mSASS were independent of BMD.Conclusion:We conclude that spine lateral view in DXA accurately measures BMD exceeding the AP spine views and femoral neck values. Therefore, structural changes do not affect this measurementDisclosure of Interests:None declared.

scholarly journals PHARMACORESISTENT TEMPORAL LOBE & EXTRA TEMPORAL EPILEPSY: OUTCOMES AFTER SURGERY.

2021 ◽  
Vol 5 (6) ◽  
Author(s):  
Govind Mangal ◽  
Uday Bhaumik ◽  
Giriraj Prajapati ◽  
Poojan Thakor
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Age Of Onset ◽  
Hippocampal Sclerosis ◽  
Temporal Lobectomy ◽  
Temporal Epilepsy ◽  
Post Surgery ◽  
Study Population ◽  
The Mean

Background: Our aim was to follow up patients postoperatively to identify seizure remission and relapse after surgery, to enable individuals considering surgery to make informed choices. Methods: Ninteen consecutive patients operated for drug resistant Temporal lobe & extra temporal lobe epilepsy between 2019 and 2020, at our centre. All the patients had at least one year post surgery follow-up. Results: The mean age of study population was 20.87 ± 10.08 years. The mean age of onset of epilepsy in study population was 14.9 ± 8 years. There were no acute post operative seizures. The most common histpathological finding was hippocampal sclerosis in 15 patients. The patients were followed up and 15 were in the class 1 of engel classification. 2 in class 2, rest had one each Conclusion: Following surgery approx half of patients were seizure free and Engel's favourable outcome was noted. The predictors of unfavourable outcome were younger age of onset and pronged duration and of epilepsy Keywords: Temporal lobe epilepsy, temporal lobectomy, amygdalohippocampectomy, outcome, extra temporal lobe epilepsy, extra temporal lobectomy

scholarly journals A Comparative Evaluation on the effect of Zinc-Probiotic combination versus Zinc alone therapy in children (3month-5year) with acute watery diarrhea attending the outpatient clinic of Sub-District hospital, Uttarakhand

2021 ◽  
Vol 9 (4) ◽  
pp. 263-268
Author(s):  
Dr. Mamta Nikhurpa ◽  
◽  
Dr. Renu Agnihotri ◽  
Keyword(s):  
Watery Diarrhea ◽  
Male Predominance ◽  
Watery Stool ◽  
Acute Watery Diarrhea ◽  
Group A ◽  
Study Population ◽  
The Mean ◽  
Group B ◽  
Time Required

Background: Diarrhea is the major cause of morbidity and mortality among children worldwide.Various studies were done on the role of zinc therapy and probiotic therapy in reducing the durationand severity of acute watery diarrhea. This study aimed to compare the effect of Zinc –probioticcombination versus Zinc only therapy in acute watery diarrhea in pediatric patients. Material andMethods: This was an open, randomized control trial in the pediatric outpatient department of Sub-District Female Hospital, Haldwani (Uttarakhand), from June 2020 till August 2020 for three months.Total 104 children aged six months to 5 years with acute diarrhea who met the inclusion criteriawere enrolled and divided into 52 patients each. 1stGroup A (n=52) received Zinc-Probioticscombination therapy, and 2ndGroup B (n=52) received Zinc only. Measurement of disease severitywas based on the frequency of diarrhea (times/day) and duration of diarrhea (hours) after initialdrug consumption. The resolution was assessed in mean remission time (time required to form solidstool from watery stool).Result: Among the study population in group A, 62% were male, 38%were female, and in group B, 65% were male & 35% were female. Male predominance was observedin both groups. The mean frequency of diarrhea before treatment in Group A was 7.46 ± 4.1times/day as compared to 6.69 ± 3.6 times/day in Group B. Mean duration of diarrhea in Group Awas 53.5 ± 30.5 hours as compared to 57.6 ± 34.3 hours in Group B. Conclusion: Combinationtherapy was more effective than Zinc only therapy in early remission and resolution of acute waterydiarrhea in children.

scholarly journals Clinical and laboratory features of childhood systemic lupus erythematosus and its course in Department of Child Health, Cipto Mangunkusumo Hospital, Jakarta

2006 ◽  
Vol 41 (4) ◽  
pp. 214
Author(s):  
Zakiudin Munasir ◽  
Tuty Mariana ◽  
Rulina Suradi
Keyword(s):  
Child Health ◽  
Lupus Erythematosus ◽  
Age Of Onset ◽  
Time Interval ◽  
Frequent Interval ◽  
Renal Complication ◽  
Initial Symptoms ◽  
Age Of Diagnosis ◽  
The Mean ◽  
Diffuse Proliferative Glomerulonephritis

A descriptive, retrospective study has been performed among 33 children with SLE during the period of January 1986 to December 1999 in Department of Child Health, Cipto Mangunkusumo Hospital. The results of the present study show that SLE in childhood was more commonly found in girls than in boys, with a ratio of 4.5: 1. The mean age of onset was 10.5 years and the mean age of diagnosis was 10.9 years, most frequently observed in the age of > 10 years and rarely found in the age of < 5 years. The time interval between the time of onset and time of diagnosis ranged from 1 to 24 months and the most frequent interval was 1-3 months. The most common initial symptoms were prolonged fever, rash on the skin and face, and athralgia. In its natural history of the disease, kidneys, skin/mucous membrane and joints are the most frequent organs involved. Most of the SLE patients develop anemia. Positive anti ds-DNA, ANA and decreased levels of C3 and C4 respectively in 28 (28/31), in 29 (29/30), in 25 (25/33), and in 19 (19/27) cases. LE cells were encountered only in four (4/17) cases.  Out of 11 cases upon which renal biopsies were done, the most common histological features were mesangeal glomerulonephritis (class II) and diffuse proliferative glomerulonephritis (class IV). The mean time interval between the onset and renal complication manifestations was 6.96 months, cardiac complication was 16.77 months, central nerve system was 22.71 months and lungs were 25.0 months. Duration of illness of patients with SLE ranged from 2 to 175 with the mean of 31.3 months. The causes of death were mostly due to gastrointestinal bleeding and renal failure.

Ocular dermoids in 13 cats: a multicentre retrospective study

2021 ◽  
pp. 1098612X2110438
Author(s):  
Anaïs Cathelin ◽  
Anne-Sandrine Augsburger ◽  
Jennifer Anne ◽  
Sylvain Medan ◽  
Julien Michel ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Ocular Surface ◽  
Rare Condition ◽  
Surgical Excision ◽  
Genetic Transmission ◽  
Study Population ◽  
The Mean ◽  
Lost To Follow Up ◽  
Multicentre Retrospective Study

Objectives The aim of this multicentre retrospective study was to review the clinical data, outcomes and histopathological features of cats that had been treated for ocular surface dermoids. Methods Thirteen cats from various private practices in France with a clinical diagnosis of ocular surface dermoid were included in the study. Results The mean age of the study population at the time of diagnosis was 5 months. There were nine males and four females. Three different breeds were, including: domestic shorthair (n = 7), Birman (n = 4) and Havana Brown (n = 2). Two of the four Birmans were related (same sire). The two Havana Browns were also related (same sire). All of the dermoids were unilateral. Five of the dermoids were strictly conjunctival. Four affected both the conjunctiva and the cornea. Three affected both the conjunctiva and the eyelid, and one was strictly corneal. They were located in various positions: temporal (n = 9), inferonasal (n = 1), dorsonasal (n = 1) and dorsotemporal (n = 1). The last dermoid was heterogeneous and involved the nasal, dorsal and temporal quadrants. Concurrent eye diseases were observed in five patients: four cats exhibited associated eyelid agenesis and one cat exhibited persistent iris-to-iris pupillary membranes. Ten dermoids were surgically excised with no recurrences. Surgery was not performed for three cats: one cat died a few days after diagnosis and two cats were lost to follow-up after initial presentation. Conclusions and relevance Ocular surface dermoids are a rare condition in cats that can be treated successfully by surgical excision. Although our study reports only a small number of cases, the observation of ocular surface dermoids in two related cats in two different breeds indicates that genetic transmission is likely.

scholarly journals Clinico-mycological study of otomycosis in Raichur, Karnataka: a hospital based study

2017 ◽  
Vol 4 (1) ◽  
pp. 233
Author(s):  
Arvind Kumar B. Sangavi ◽  
Basavaraj Peerapur ◽  
Nirmita Gummadi
Keyword(s):  
Climatic Conditions ◽  
Common Symptom ◽  
Detailed History ◽  
Male Predominance ◽  
Bacterial Cultures ◽  
Chief Complaints ◽  
Study Population ◽  
The Mean ◽  
Age Range ◽  
Severe Type

<p class="abstract"><strong>Background:</strong> <span lang="EN-IN">Otomycosis is a fungal infection of the ear canal. It is mostly seen in hot and humid climatic conditions of the tropical and subtropical countries. It can also occur as a result of decreased immunity (and has been seen as a common occurrence as an opportunistic infection in the immunocompromised). </span></p><p class="abstract"><strong>Methods:</strong> <span lang="EN-IN">Patients clinically diagnosed with otomycosis and coming to the ENT department RIMS teaching hospital were first subjected to detailed history taking. The samples from ear will then be collected by three sterile cotton swabs and sent to Microbiology Department, RIMS. Fungal, bacterial cultures were performed and microscopic examination was done.  </span></p><p class="abstract"><strong>Results:</strong> <span lang="EN-IN">Patients presented with a wide age range, the youngest patient being 6 months old and eldest being 28.31 years old. The mean age of the study population was 28.31 years. The ratio between male and female patients was 1.13:1 with male predominance. There were 26 patients (81.2%) who had a habit of using pins or sticks. The chief complaints of majority of the patients were pain and itching. Pain ranged from mild to severe type. Least common symptom was tinnitus. </span></p><p class="abstract"><strong>Conclusions:</strong> <span lang="EN-IN">In our study male predominance was seen and majority of cases were unilateral. There were only 5 patients who were immunocompromised. The most common presenting symptom was pain and itching. There were 81.2% patients who had a habit of using pins/ sticks.</span></p>

scholarly journals Metabolic Changes and Serum Ghrelin Level in Patients with Psoriasis

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Haydar Ucak ◽  
Betul Demir ◽  
Demet Cicek ◽  
Ilker Erden ◽  
Suleyman Aydin ◽  
...  
Keyword(s):  
Age Of Onset ◽  
Experimental Studies ◽  
Ghrelin Level ◽  
Control Group ◽  
Pasi Score ◽  
Healthy Control ◽  
Study Population ◽  
The Mean ◽  
Clinical Changes ◽  
Serum Ghrelin

Background. Serum ghrelin levels may be related to metabolic and clinical changes in patients with psoriasis.Objective. This study was performed to determine the possible effects of serum ghrelin in patients with psoriasis.Methods. The study population consisted of 25 patients with plaque psoriasis. The patients were questioned with regard to age, gender, age of onset, duration of disease, height, weight, and body mass index (BMI). In addition, fasting blood sugar, triglyceride, cholesterol levels, insulin, and ghrelin levels were measured.Results. The mean serum ghrelin level was 45.41 ± 22.41 in the psoriasis group and 29.92 ± 14.65 in the healthy control group. Serum ghrelin level was significantly higher in the psoriasis group compared with the controls (P=0.01). The mean ghrelin level in patients with a lower PASI score was significantly higher than in those with a higher PASI score (P=0.02).Conclusion. The present study was performed to determine the effects of ghrelin in psoriasis patients. We found a negative correlation between severity of psoriasis and ghrelin level. Larger and especially experimental studies focusing on correlation of immune system-ghrelin levels and severity of psoriasis may be valuable to clarify the etiopathogenesis of the disease.

scholarly journals Ala97Ser transthyretin amyloidosis-associated polyneuropathy, clinical and neurophysiological profiles in a Thai cohort

BMC Neurology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Nath Pasutharnchat ◽  
Chamaiporn Taychargumpoo ◽  
Yongkasem Vorasettakarnkij ◽  
Jakkrit Amornvit
Keyword(s):  
Early Onset ◽  
Age Of Onset ◽  
Late Onset ◽  
Detection Threshold ◽  
Han Chinese ◽  
Motor Neuropathy ◽  
Transthyretin Amyloidosis ◽  
Initial Symptoms ◽  
Chinese Descent ◽  
The Mean

Abstract Background Ala97Ser transthyretin amyloidosis-associated polyneuropathy (ATTRA97S-PN) is a rare form of inherited polyneuropathy, usually manifesting with late-onset (> 50) progressive polyneuropathy. This mutation is mostly prevalent in Taiwanese and Han-Chinese individuals. The aim of this study was to describe the clinical and comprehensive neurophysiological profiles of ATTRA97S-PN in Thai patients. Methods The clinical profiles and serial neurophysiologic studies (nerve conduction study (NCS), quantitative sensory test (QST), and comprehensive autonomic function test (AFT)) of symptomatic ATTRA97S-PN patients who had been followed-up at King Chulalongkorn Memorial Hospital during 2010–2020 were retrospectively reviewed. Results Nine symptomatic patients (55.6 % were male) from four unrelated families were included. All were Thais of mixed Thai Chinese descent. The mean age of onset was 48.3 (32–60) years. The mean age at diagnosis was 54.8 (33–66) years. Three patients developed early-onset (< 40y) polyneuropathy. The mean Neuropathy Impairment Score was 41.33 (10–92) at diagnosis. Sensory (9/9) and autonomic (9/9) neuropathies were more frequent than motor neuropathy (5/9), which appeared in the late stage of disease. Hypoesthesia in the feet, and gastrointestinal autonomic symptoms were frequently reported as the initial symptoms. The course of neuropathy progressed over years to decades. The worsening of neuropathy tended to progress faster once motor nerves were affected in both clinical and neurophysiological aspects. Concurrent cardiac amyloidosis was found in 6/9 patients. NCS showed length-dependent sensorimotor axonal polyneuropathy in 5/9 patients, and median neuropathy at the wrist (mostly bilateral) in 7/9 patients. QST showed abnormalities in the vibratory detection threshold, the cold detection threshold and the heat pain sensation in 8/9, 8/9 and 7/7 tested patients, respectively. AFT results were abnormal in all. The mean composite autonomic severity score was 5 (3–9). Conclusions This clinical study is the first of ATTRA97S-PN in Thai patients. The mixed polyneuropathy-cardiopathy phenotype was the most common manifestation. In this cohort, the age of onset was lower, and the course of neuropathy was relatively longer, than that in previous studies. Some patients may develop early-onset polyneuropathy. This mutation has not yet been documented in any population other than Han Chinese-related populations, probably suggesting a founder effect. Further studies are warranted.

scholarly journals Clinical aspects of pediatric Brugada syndrome

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
T Imamura ◽  
T Makiyama ◽  
H Huang ◽  
T Aizawa ◽  
J Gao ◽  
...  
Keyword(s):  
Risk Factors ◽  
Gender Difference ◽  
Brugada Syndrome ◽  
Clinical Information ◽  
Asian Population ◽  
Clinical Aspects ◽  
Cardiac Events ◽  
Male Predominance ◽  
Initial Symptoms ◽  
The Mean

Abstract Introduction Brugada syndrome (BrS) is an inherited arrhythmia characterized by a coved-type ST elevation and sudden death, especially in middle-aged males and more common in Asia. Mutations in SCN5A are detected in 15–20% and reported to be associated with poor prognosis. Among children, BrS is rare and the risk factors in pediatric BrS are unknown, especially in Asian population. Purpose The purpose of this study is to elucidate the risk factors for fatal arrhythmic events in Japanese pediatric patients with BrS. Methods We enrolled 52 Japanese children with BrS younger than 20 years, and performed genetic analysis and collected the clinical information. Results The mean age of initial symptoms was 10.7±5.5 years, and the mean follow-up period was 3.9±5.5 years. Ninety percent of patients were probands. No subjective symptom was confirmed in 28 of the patients, but aborted cardiac arrest (ACA) in 4, ventricular tachycardia in 4, ventricular fibrillation in 1, and syncope in 11. We identified mutations in SCN5A in 63%. There was no significant gender difference in ≤10 years, but a significant male predominance appeared in &gt;10 years. And no gender difference was confirmed in the incidence of severe cardiac events in ≤10 years. Conclusion No gender difference was confirmed in ≤10 years in this study about Asian children. And being girls did not reduce the risk in ≤10 years. The frequency of SCN5A mutations was higher than adults, but decreased from childhood (68%) to adolescence (59%). In BrS, genetical and environmental factors may be more effective in childhood and adulthood, respectively. Funding Acknowledgement Type of funding source: None

scholarly journals Clival canal Angle and Basal Angle in Nepalese Population- A Computed Tomography Based Study

2020 ◽  
Vol 2 (3) ◽  
pp. 25-28
Author(s):  
Jagat Narayan Rajbanshi ◽  
Archana Chaudhary ◽  
Pankaj Raj Nepal ◽  
Dinesh Kumar Thapa ◽  
Navin Kumar Yadav
Keyword(s):  
Reference Range ◽  
Sampling Technique ◽  
Posterior Longitudinal Ligament ◽  
Midsagittal Plane ◽  
Cross Sectional ◽  
Male Predominance ◽  
Basal Angle ◽  
Study Population ◽  
Tuberculum Sellae ◽  
The Mean

Background: Clival canal angle is an angle formed by the clivus and the posterior longitudinal ligament of the cervical spine and Welcher basal angle formed between the line joining the nasion to tuberculumSella and the line joining the tuberculum sellae to basion along the plane of clivus. With the aim to review the normal distribution of clival canal angle and basal angle in the Nepalese population this study was performed. Methods and materials: This is a cross-sectional analytical study with non- probability consecutive sampling technique done over the duration of 3 months. A reconstructed image of a bone window in the midsagittal plane was selected and measurement of the angles was done in CT console. Results: There was a total of 60 patients in this study with male predominance (figure 3). The mean age of the population was 49.8 (SD 18.8) years. The clival canal angle reference range was 130.8 to 168.8 degrees with a mean 149.8(SD 9.5) degree. Similarly, the reference range of Welcher basal angle in the study population was 115.49 to 140.29 degree with a mean of 127.89(SD: 6.4) degrees. Conclusion: The mean clival canal angle in the Nepalese population is 149.8 (SD: 9.5) degrees and the mean basal angle is 127.89(SD: 6.4) degree.

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