scholarly journals Influence of histologic chorioamnionitis and funisitis on the level of peripheral blood C-reactive protein at birth in preterm infants

2010 ◽  
Vol 53 (1) ◽  
pp. 33 ◽  
Author(s):  
Do-Hyun Kim ◽  
Heun Ji Lee ◽  
Hee Sup Kim ◽  
Byoung Hoon Yoo
Keyword(s):  
Preterm Infants ◽  
Peripheral Blood ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Histologic Chorioamnionitis

scholarly journals Expression of CD62P and CD154 in peripheral blood of patients with rheumatoid arthritis and their correlation with clinical indexes

2019 ◽  
Vol 17 ◽  
pp. 205873921882268
Author(s):  
Shiping Qu ◽  
Chunyi Yu ◽  
Qian Xing ◽  
Haisheng Hu ◽  
Haiyan Jin
Keyword(s):  
Rheumatoid Arthritis ◽  
Peripheral Blood ◽  
Healthy Subjects ◽  
Disease Activity Score ◽  
Control Group ◽  
Disease Course ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Erythrocyte Sedimentation ◽  
Pearson Test

The aim of this study is to investigate the expression of CD62P and CD154 in peripheral blood of patients with rheumatoid arthritis (RA) and their correlation with the clinical indexes of RA. A total of 60 RA patients diagnosed and treated in the Department of Rheumatism in our hospital from January to December 2016 were selected as the RA group, and 60 cases of healthy subjects were selected as the control group. CD62P and CD154 levels in peripheral blood were determined by flow cytometry using the FACS Vantage flow cytometer, and the correlation analysis with the clinical indexes of RA patients were conducted. The levels of CD62P and CD154 in the peripheral blood of RA group were 28.75% ± 1.48% and 26.84% ± 1.03%, respectively, which were significantly higher than those of the control group ( P < 0.05). The levels of white blood cell (WBC), platelet (PLT), erythrocyte sedimentation rate (ESR), rheumatoid factor (RF), C-reactive protein (CRP), and interleukin (IL)-37 in the RA group were significantly higher than those in the control group ( P < 0.05). Pearson test showed that CD62P and CD154 levels in the peripheral blood in the RA group were positively correlated with serum WBC, PLT, ESR, RF, CRP, IL-37, and disease activity score 28 (DAS28) ( P < 0.05), but not correlated with disease course ( P > 0.05). The expression of CD62P and CD154 in peripheral blood of patients with RA was upregulated, and their expression levels were correlated with the activity of RA and the degree of joint lesion.

Leukocytes in peripheral blood in patients with bipolar disorder – Trait and state alterations and association with levels of cytokines and C-reactive protein

2018 ◽  
Vol 261 ◽  
pp. 383-390 ◽  
Author(s):  
Klaus Munkholm ◽  
Anne Sophie Jacoby ◽  
Toke Lenskjold ◽  
Helle Bruunsgaard ◽  
Maj Vinberg ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Peripheral Blood ◽  
C Reactive Protein ◽  
Reactive Protein

Postnatal Paraclinical Parameters Associated to Occurrence of Intracerebral Hemorrhage in Preterm Infants

2019 ◽  
Vol 50 (02) ◽  
pp. 103-110 ◽  
Author(s):  
Varvara Turova ◽  
Nikolai Botkin ◽  
Laura Eckardt ◽  
Ursula Felderhoff-Müser ◽  
Esther Rieger-Fackeldey ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Preterm Infants ◽  
Gestational Age ◽  
Clinical Observation ◽  
Statistical Evaluation ◽  
C Reactive Protein ◽  
Mean Values ◽  
Reactive Protein ◽  
Before And After ◽  
Clinical Records

AbstractIntracerebral hemorrhage (ICH) is the most frequent complication in postnatal development of preterm infants. The purpose of the present work is the statistical evaluation of seven standard paraclinical parameters and their association to the development of ICH. Clinical records of 265 preterm infants with gestational age (GA) 23 to 30 weeks were analyzed. According to ICH status, patients were divided into control (without ICH) and affected (with ICH) groups. Mean values of paraclinical parameters at each week of gestation were compared. Different ICH grades, periods before and after ICH were considered separately. Lower hematocrit, SaO2, and pH were statistically significant for preterm infants with 23 to 30 weeks GA and diagnosis of ICH relative to infants without ICH. Additionally, for preterm infants with 27 to 30 weeks GA, higher C-reactive protein, as well as lower values of thrombocytes were associated with the occurrence of ICH. Preterm infants with 23 to 26 weeks GA showed C-reactive protein values similar to those in the group without ICH and lower levels of thrombocytes after bleeding. Significant differences in paraclinical parameters between preterm infants with and without ICH may constitute useful indicators for closer clinical observation of preterm infants at risk of ICH.

Rapid, semi-quantitative assay of C-reactive protein evaluated

1991 ◽  
Vol 37 (11) ◽  
pp. 1981-1982 ◽  
Author(s):  
H Vallance ◽  
G Lockitch
Keyword(s):  
Preterm Infants ◽  
Screening Test ◽  
Quantitative Method ◽  
Comparison Method ◽  
Quantitative Assay ◽  
Plasma Samples ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Nephelometric Method ◽  
Semiquantitative Method

Abstract We evaluated a new rapid semi-quantitative immunometric assay of C-reactive protein (CRP) as a screening test for sepsis by comparison with an automated nephelometric method. Plasma samples (n = 101) from preterm infants during the first week of life were saved for CRP analyses. We measured CRP by the Nycocard semiquantitative method and compared the results with those obtained with a Behring Nephelometer. A CRP value less than 10 mg/L was considered to be negative for infection. All CRP results read as less than 10 mg/L (negative) by the Nycocard method were also less than 10 mg/L by the comparison method, and all CRP values found to be greater than 20 mg/L (positive) by the Nycocard method were also positive by the comparison method. Results in the 10-20 mg/L range were considered equivocal. We conclude that the Nycocard CRP semi-quantitative method is a rapid and useful screening test for sepsis in preterm infants.

scholarly journals C-reactive protein induces human peripheral blood monocytes to synthesize tissue factor

Blood ◽  
1993 ◽  
Vol 82 (2) ◽  
pp. 513-520 ◽  
Author(s):  
J Cermak ◽  
NS Key ◽  
RR Bach ◽  
J Balla ◽  
HS Jacob ◽  
...  
Keyword(s):  
Tissue Factor ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
De Novo ◽  
Human Peripheral Blood ◽  
Umbilical Vein ◽  
Blood Monocytes ◽  
C Reactive Protein ◽  
Dot Blot ◽  
Reactive Protein

The acute inflammatory response is frequently accompanied by serious thrombotic events. We show that C-reactive protein (CRP), an acute- phase reactant that markedly increases its serum concentration in response to inflammatory stimuli, induced monocytes to express tissue factor (TF), a potent procoagulant. Purified human CRP in concentrations commonly achieved in vivo during inflammation (10 to 100 micrograms/mL) induced a 75-fold increase in TF procoagulant activity (PCA) of human peripheral blood mononuclear cells (PBM), with a parallel increase in TF antigen levels. CRP-induced PCA was completely blocked by a monoclonal antibody against human TF but not by irrelevant murine IgG. Dot blot analysis showed a significant increase of TF mRNA after 4 hours of incubation with CRP, followed by a peak of PCA within 6 and 8 hours. Actinomycin D and cycloheximide blocked CRP-stimulated PCA, suggesting that de novo TF protein synthesis was required. Endotoxin (LPS) contamination of CRP was excluded as the mediator of TF synthesis because: (1) CRP was Limulus assay negative; (2) induction of TF PCA by CRP was not blocked by Polymyxin B, in contrast to LPS- induced PCA; (3) antihuman CRP IgG inhibited CRP-induced PCA, but not LPS-induced PCA; (4) CRP was able to stimulate TF production in LPS- pretreated PBM refractory to additional LPS stimulation; and, (5) unlike LPS, CRP was incapable of inducing TF in human umbilical vein endothelial cells. We suggest that CRP-mediated TF production in monocytes may contribute to the development of disseminated intravascular coagulation and thrombosis in inflammatory states.

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