scholarly journals Maternal vitamin D levels in patients with hypertensive disorders of pregnancy

2021 ◽  
Vol 5 (1) ◽  
pp. 435-439
Author(s):  
Dr. Saika ◽  
Dr. Saba Wani
Keyword(s):  
Vitamin D ◽  
Hypertensive Disorders Of Pregnancy ◽  
Maternal Vitamin ◽  
Hypertensive Disorders ◽  
Vitamin D Levels

LOW MATERNAL VITAMIN D LEVELS AND RISK OF DEVELOPING HYPERTENSIVE DISORDERS OF PREGNANCY

2021 ◽  
pp. 74-75
Author(s):  
Rakhi Kumari ◽  
Swati Swati ◽  
Kavita Kavita
Keyword(s):  
Vitamin D ◽  
Immunologic Tolerance ◽  
Trophoblast Invasion ◽  
Hypertensive Disorders Of Pregnancy ◽  
Maternal Vitamin ◽  
Hypertensive Disorders ◽  
Vitamin D Levels ◽  
And Function

Preeclampsia is thought to originate in abnormal angiogenesis and immunologic adaptation occurring during implantation and trophoblast invasion at the beginning of pregnancy. There is evidence that vitamin D affects transcription and function of genes responsible for trophoblast invasion, angiogenesis critical for implantation, 1 and fetal allograft immunologic “tolerance”.

scholarly journals Maternal vitamin D levels in hypertensive disorders of pregnancy

2020 ◽  
Vol 9 (12) ◽  
pp. 4870
Author(s):  
Vatika Tyagi ◽  
Mamta Tyagi ◽  
Smriti Gupta ◽  
Esha Khanuja ◽  
Yamini Varma
Keyword(s):  
Vitamin D ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Maternal Complications ◽  
Maternal Vitamin ◽  
Medical College ◽  
Serum Vitamin D ◽  
Hypertensive Disorders ◽  
Vitamin D Levels ◽  
Significant Difference

Background: Current study was conducted with the objective to evaluate maternal vitamin D levels in patients with hypertensive disorders of pregnancy.Methods: The present prospective observational study was conducted among 200 pregnant women attending gynaecological OPD of Subharti medical college, Meerut, over a period of two years and satisfying the inclusion criteria were enrolled. On admission, patient demographic profile, complete history was recorded, and comprehensive clinical examination was done. In all the patients, blood samples for routine examination along with LFT, RFT, random blood sugar, serum electrolytes, serum uric acid and serum vitamin D were drawn, and serum levels of these biochemical parameters were determined according to standard laboratory procedures. Subjects were classified into three categories according to serum vitamin D level i.e. >20 ng/ml (mild), 10-20 ng/ml (moderate deficiency), <10 ng/ml (severe deficiency).Results: Insignificant difference was found between case (hypertensive) and control (normotensive) group when compared in relation to age, education, parity and socioeconomic status. The mean vitamin D level of women with HDP was 5.7+2.99 ng/ml as compared to 17.34+5.79 ng/ml in normotensive women with statistically significant difference as p<0.001. No correlation was found between severity of vitamin D deficiency and maternal complications (p=0.318).Conclusions: The results of the present study concluded that women with hypertension had significantly lower vitamin D level as compared to normotensive women.

scholarly journals Prevalence of vitamin D deficiency in patients of hypertensive disorders of pregnancy and normal pregnant women

2020 ◽  
Vol 8 (12) ◽  
pp. 4383
Author(s):  
Asha Sharma ◽  
Jaya Choudhary ◽  
Piyush Joshi ◽  
Neha Bardhar
Keyword(s):  
Vitamin D ◽  
Pregnant Women ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Hypertensive Disorders Of Pregnancy ◽  
Serum Vitamin D ◽  
Hypertensive Disorders ◽  
Vitamin D Levels ◽  
Study Population ◽  
Labour Room

Background: The aim of this study was to compare vitamin D level in normal pregnant women and patients of hypertensive disorders of pregnancy and to study the prevalence of vitamin D deficiency in patients of hypertensive disorders of pregnancy and normal pregnant women.Methods: 50 women affected by hypertensive disorders of pregnancy and 50 normal pregnant women more than 20 weeks of gestation, admitted to the ward or to labour room in the Obstetrics and Gynaecology Department, of Mahatma Gandhi Medical College and Hospital were enrolled in the study. Assessment of serum 25 hydroxy vitamin D was done by chemiluminescent immunoassay method.Results: Serum vitamin D levels were low in women with hypertensive disorders of pregnancy with mean serum vitamin D level 13.66±7.358 ng/ml as compared to normal normotensive pregnant women 21.14±8.241ng/ml, which is statistically significant (p=0.001). Mean vitamin D level in study population was 17.40±8.634 ng/ml. The prevalence of vitamin D deficiency in hypertensive disorders of pregnancy group was very high 88% compared to 50% in normal normotensive pregnant women group. The difference was statistically significant (p=0.001). vitamin D deficiency was found among 69% in study population.  Conclusions: Vitamin D levels are deficient in patients of hypertensive disorders of pregnancy as compared to normal pregnant women. There is increased prevalence of vitamin D deficiency with hypertensive disorders of pregnancy suggesting that vitamin D deficiency can be a risk factor for the development of hypertensive disorders of pregnancy.

Lower Vitamin D Level as a Risk Factor for Late Onset Neonatal Sepsis: An Observational Case–Control Study

2021 ◽  
Author(s):  
Shaimaa Reda Abdelmaksoud ◽  
Mostafa Abdel-Azim Mostafa ◽  
Rana Atef khashaba ◽  
Effat Assar
Keyword(s):  
Vitamin D ◽  
Case Control Study ◽  
Late Onset ◽  
Case Control ◽  
Sepsis Group ◽  
Term Neonates ◽  
Maternal Vitamin ◽  
Vitamin D Levels ◽  
25 Oh Vitamin D ◽  
Control Study

Objective The aim of the study is to investigate the relation of neonatal and maternal vitamin D and late-onset sepsis (LOS) Study Design One-hundred twenty term neonates along with their mothers were enrolled in this case–control study. Sixty neonates who were admitted in the neonatal intensive care unit by LOS and had not been previously admitted for last 48 hours and did not receive antibiotics or vitamin D were enrolled as cases (sepsis) group. On the other hand, 60 healthy term neonates were referred as control group. Maternal and neonatal serum 25-OH vitamin D levels were assessed in both the cohorts. Results Maternal and neonatal 25-OH vitamin D levels in cases (17.2 and 16.1 ng/mL, respectively) were significantly lower than in controls (22.7 and 21 ng/mL, respectively) p = 0.001. In the study group, the neonatal 25-OH vitamin D was negatively correlated with C-reactive protein and length of hospital stay (r = −0.616 and −0.596, respectively) p <0.001 for both. With a cut-off value of 12.9 ng/mL, the specificity and positive predictive value of neonatal vitamin D were 83.3 and 74.4%, respectively. The odds ratio was 1.088 (95% CI = 1.034–1.144)) for LOS in vitamin D-deficient neonates. Conclusion Neonates with higher vitamin D level are at lower risk of LOS than those with vitamin D deficiency. Maternal vitamin D correlates with neonatal vitamin D. These data suggest that maternal vitamin supplementation during pregnancy may lower the risk of LOS. Key Points

High maternal vitamin D levels in early pregnancy may protect against behavioral difficulties at preschool age: the Rhea mother–child cohort, Crete, Greece

2017 ◽  
Vol 27 (1) ◽  
pp. 79-88 ◽  
Author(s):  
Vasiliki Daraki ◽  
Theano Roumeliotaki ◽  
Katerina Koutra ◽  
Georgia Chalkiadaki ◽  
Marianna Katrinaki ◽  
...  
Keyword(s):  
Vitamin D ◽  
Early Pregnancy ◽  
Preschool Age ◽  
Behavioral Difficulties ◽  
Maternal Vitamin ◽  
Vitamin D Levels

scholarly journals Do Maternal Vitamin D Levels Influence Vitamin D Levels in Preterm Neonates?

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
M. Panda ◽  
J. McIntosh ◽  
T. Chaudhari ◽  
A. L. Kent
Keyword(s):  
Vitamin D ◽  
Neonatal Intensive Care ◽  
Demographic Data ◽  
Current Level ◽  
Vitamin Supplementation ◽  
Preterm Neonates ◽  
Maternal Vitamin ◽  
Vitamin D Levels ◽  
Reduce Risk ◽  
Median Birth Weight

Objective. To determine the prevalence of Vitamin D (VitD) deficiency/insufficiency in mothers of preterm neonates less than or equal to 32 weeks of gestation and determine if the current level of VitD supplementation used for preterm neonates is appropriate.Design. Prospective study from10thMay 2015 to1stNovember 2016.Setting. Neonatal Intensive Care Unit at the Canberra Hospital.Patients. Mothers and their preterm neonates born less than or equal to 32 weeks gestation.Interventions. Maternal VitD levels were obtained within 3-4 days following delivery. Neonatal VitD levels were obtained in the first 3-4 days of life, at 3-4 weeks of age, and at 6-8 weeks of age. Demographic data and data on VitD intake from parenteral nutrition, enteral feeds, and vitamin supplementation agents were collected.Results. 70 neonates were enrolled into the study. Median gestation was 29 (27-30) weeks and median birth weight 1197 (971.2-1512.5) grams. Median maternal VitD level was 54.5 (36-70.7) nmol/L, median neonatal Vit D level at birth was 57 (42-70) nmol/L. Median Vit D level at 3 weeks and 6 weeks were 63.5 nmol/L (53-80.2) nmol/L and 103 (71.5-144) nmol/L respectively. 22/55 (40%) mothers were VitD deficient/insufficient. 25/70 (36%) neonates were VitD deficient/insufficient at birth. Of those neonates who were VitD deficient/insufficient at birth 5/25(10%) were deficient/insufficient at 6 weeks. The median intake of VitD at 6 weeks was 826.5 (577.5-939.5) IU/day.Conclusions. VitD deficiency/insufficiency in mothers of preterm neonates and in preterm neonates at birth is common. Routine screening of maternal VitD and their preterm neonates along with individualized supplementation regimens in mothers and preterm infants may optimize VitD status and reduce risk of ongoing VitD deficiency/insufficiency.

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