LOW MATERNAL VITAMIN D LEVELS AND RISK OF DEVELOPING HYPERTENSIVE DISORDERS OF PREGNANCY

2021 ◽  
pp. 74-75
Author(s):  
Rakhi Kumari ◽  
Swati Swati ◽  
Kavita Kavita
Keyword(s):  
Vitamin D ◽  
Immunologic Tolerance ◽  
Trophoblast Invasion ◽  
Hypertensive Disorders Of Pregnancy ◽  
Maternal Vitamin ◽  
Hypertensive Disorders ◽  
Vitamin D Levels ◽  
And Function

Preeclampsia is thought to originate in abnormal angiogenesis and immunologic adaptation occurring during implantation and trophoblast invasion at the beginning of pregnancy. There is evidence that vitamin D affects transcription and function of genes responsible for trophoblast invasion, angiogenesis critical for implantation, 1 and fetal allograft immunologic “tolerance”.

scholarly journals Maternal vitamin D levels in hypertensive disorders of pregnancy

2020 ◽  
Vol 9 (12) ◽  
pp. 4870
Author(s):  
Vatika Tyagi ◽  
Mamta Tyagi ◽  
Smriti Gupta ◽  
Esha Khanuja ◽  
Yamini Varma
Keyword(s):  
Vitamin D ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Maternal Complications ◽  
Maternal Vitamin ◽  
Medical College ◽  
Serum Vitamin D ◽  
Hypertensive Disorders ◽  
Vitamin D Levels ◽  
Significant Difference

Background: Current study was conducted with the objective to evaluate maternal vitamin D levels in patients with hypertensive disorders of pregnancy.Methods: The present prospective observational study was conducted among 200 pregnant women attending gynaecological OPD of Subharti medical college, Meerut, over a period of two years and satisfying the inclusion criteria were enrolled. On admission, patient demographic profile, complete history was recorded, and comprehensive clinical examination was done. In all the patients, blood samples for routine examination along with LFT, RFT, random blood sugar, serum electrolytes, serum uric acid and serum vitamin D were drawn, and serum levels of these biochemical parameters were determined according to standard laboratory procedures. Subjects were classified into three categories according to serum vitamin D level i.e. >20 ng/ml (mild), 10-20 ng/ml (moderate deficiency), <10 ng/ml (severe deficiency).Results: Insignificant difference was found between case (hypertensive) and control (normotensive) group when compared in relation to age, education, parity and socioeconomic status. The mean vitamin D level of women with HDP was 5.7+2.99 ng/ml as compared to 17.34+5.79 ng/ml in normotensive women with statistically significant difference as p<0.001. No correlation was found between severity of vitamin D deficiency and maternal complications (p=0.318).Conclusions: The results of the present study concluded that women with hypertension had significantly lower vitamin D level as compared to normotensive women.

scholarly journals Prevalence of vitamin D deficiency in patients of hypertensive disorders of pregnancy and normal pregnant women

2020 ◽  
Vol 8 (12) ◽  
pp. 4383
Author(s):  
Asha Sharma ◽  
Jaya Choudhary ◽  
Piyush Joshi ◽  
Neha Bardhar
Keyword(s):  
Vitamin D ◽  
Pregnant Women ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Hypertensive Disorders Of Pregnancy ◽  
Serum Vitamin D ◽  
Hypertensive Disorders ◽  
Vitamin D Levels ◽  
Study Population ◽  
Labour Room

Background: The aim of this study was to compare vitamin D level in normal pregnant women and patients of hypertensive disorders of pregnancy and to study the prevalence of vitamin D deficiency in patients of hypertensive disorders of pregnancy and normal pregnant women.Methods: 50 women affected by hypertensive disorders of pregnancy and 50 normal pregnant women more than 20 weeks of gestation, admitted to the ward or to labour room in the Obstetrics and Gynaecology Department, of Mahatma Gandhi Medical College and Hospital were enrolled in the study. Assessment of serum 25 hydroxy vitamin D was done by chemiluminescent immunoassay method.Results: Serum vitamin D levels were low in women with hypertensive disorders of pregnancy with mean serum vitamin D level 13.66±7.358 ng/ml as compared to normal normotensive pregnant women 21.14±8.241ng/ml, which is statistically significant (p=0.001). Mean vitamin D level in study population was 17.40±8.634 ng/ml. The prevalence of vitamin D deficiency in hypertensive disorders of pregnancy group was very high 88% compared to 50% in normal normotensive pregnant women group. The difference was statistically significant (p=0.001). vitamin D deficiency was found among 69% in study population.  Conclusions: Vitamin D levels are deficient in patients of hypertensive disorders of pregnancy as compared to normal pregnant women. There is increased prevalence of vitamin D deficiency with hypertensive disorders of pregnancy suggesting that vitamin D deficiency can be a risk factor for the development of hypertensive disorders of pregnancy.

scholarly journals Prevention of Hypertensive Disorders of Pregnancy—Is There a Place for Metformin?

2021 ◽  
Vol 10 (13) ◽  
pp. 2805
Author(s):  
Elżbieta Poniedziałek-Czajkowska ◽  
Radzisław Mierzyński ◽  
Dominik Dłuski ◽  
Bożena Leszczyńska-Gorzelak
Keyword(s):  
Risk Factors ◽  
Risk Groups ◽  
Trophoblast Invasion ◽  
Pregnancy Induced Hypertension ◽  
Hypertensive Disorders Of Pregnancy ◽  
Hypertensive Disorders ◽  
Induced Hypertension ◽  
Endothelium Function ◽  
Hypoglycemic Drug ◽  
The Ideal

The possibility of prophylaxis of hypertensive disorders of pregnancy (HDPs) such as preeclampsia (PE) and pregnancy-induced hypertension is of interest due to the unpredictable course of these diseases and the risks they carry for both mother and fetus. It has been proven that their development is associated with the presence of the placenta, and the processes that initiate it begin at the time of the abnormal invasion of the trophoblast in early pregnancy. The ideal HDP prophylaxis should alleviate the influence of risk factors and, at the same time, promote physiological trophoblast invasion and maintain the physiologic endothelium function without any harm to both mother and fetus. So far, aspirin is the only effective and recommended pharmacological agent for the prevention of HDPs in high-risk groups. Metformin is a hypoglycemic drug with a proven protective effect on the cardiovascular system. Respecting the anti-inflammatory properties of metformin and its favorable impact on the endothelium, it seems to be an interesting option for HDP prophylaxis. The results of previous studies on such use of metformin are ambiguous, although they indicate that in a certain group of pregnant women, it might be effective in preventing hypertensive complications. The aim of this study is to present the possibility of metformin in the prevention of hypertensive disorders of pregnancy with respect to its impact on the pathogenic elements of development

Lower Vitamin D Level as a Risk Factor for Late Onset Neonatal Sepsis: An Observational Case–Control Study

2021 ◽  
Author(s):  
Shaimaa Reda Abdelmaksoud ◽  
Mostafa Abdel-Azim Mostafa ◽  
Rana Atef khashaba ◽  
Effat Assar
Keyword(s):  
Vitamin D ◽  
Case Control Study ◽  
Late Onset ◽  
Case Control ◽  
Sepsis Group ◽  
Term Neonates ◽  
Maternal Vitamin ◽  
Vitamin D Levels ◽  
25 Oh Vitamin D ◽  
Control Study

Objective The aim of the study is to investigate the relation of neonatal and maternal vitamin D and late-onset sepsis (LOS) Study Design One-hundred twenty term neonates along with their mothers were enrolled in this case–control study. Sixty neonates who were admitted in the neonatal intensive care unit by LOS and had not been previously admitted for last 48 hours and did not receive antibiotics or vitamin D were enrolled as cases (sepsis) group. On the other hand, 60 healthy term neonates were referred as control group. Maternal and neonatal serum 25-OH vitamin D levels were assessed in both the cohorts. Results Maternal and neonatal 25-OH vitamin D levels in cases (17.2 and 16.1 ng/mL, respectively) were significantly lower than in controls (22.7 and 21 ng/mL, respectively) p = 0.001. In the study group, the neonatal 25-OH vitamin D was negatively correlated with C-reactive protein and length of hospital stay (r = −0.616 and −0.596, respectively) p <0.001 for both. With a cut-off value of 12.9 ng/mL, the specificity and positive predictive value of neonatal vitamin D were 83.3 and 74.4%, respectively. The odds ratio was 1.088 (95% CI = 1.034–1.144)) for LOS in vitamin D-deficient neonates. Conclusion Neonates with higher vitamin D level are at lower risk of LOS than those with vitamin D deficiency. Maternal vitamin D correlates with neonatal vitamin D. These data suggest that maternal vitamin supplementation during pregnancy may lower the risk of LOS. Key Points

scholarly journals Left ventricular mass and myocardial scarring in women with hypertensive disorders of pregnancy

Open Heart ◽  
2020 ◽  
Vol 7 (2) ◽  
pp. e001273
Author(s):  
Odayme Quesada ◽  
Ki Park ◽  
Janet Wei ◽  
Eileen Handberg ◽  
Chrisandra Shufelt ◽  
...  
Keyword(s):  
Vascular Dysfunction ◽  
Obstructive Coronary Artery Disease ◽  
Left Ventricular ◽  
Hypertensive Disorders Of Pregnancy ◽  
Similar Frequency ◽  
Hypertensive Disorders ◽  
Lv Mass ◽  
Scar Size ◽  
History Of ◽  
And Function

AimsHypertensive disorders of pregnancy (HDP) predict future cardiovascular events. We aim to investigate relations between HDP history and subsequent hypertension (HTN), myocardial structure and function, and late gadolinium enhancement (LGE) scar.Methods and resultsWe evaluated a prospective cohort of women with suspected ischaemia with no obstructive coronary artery disease (INOCA) who underwent stress/rest cardiac magnetic resonance imaging (cMRI) with LGE in the Women’s Ischemia Syndrome Evaluation-Coronary Vascular Dysfunction study. Self-reported history of pregnancy and HDP (gestational HTN, pre-eclampsia, toxaemia and eclampsia) were collected at enrollment. In our cohort of 346, 20% of women report a history of HDP. HDP history was associated with 3.2-fold increased odds of HTN. Women with a history of both HDP and HTN had higher cMRI measured left ventricular (LV) mass compared with women with HDP only (99.4±2.6 g vs 87.7±3.2 g, p=0.02). While we found a similar frequency of LGE scar, we observed a trend towards increased LGE scar size (5.1±3.4 g vs 8.0±3.4 g, p=0.09) among the women with HDP history compared to women without.ConclusionIn a high-risk cohort of women with suspected INOCA, 20% had a history of HDP. Women with HDP history were more likely to develop HTN. Our study demonstrates higher LV mass in women with HDP and concomitant HTN. Although the presence of LGE scar was not different in women with and without HDP history, we observed a trend towards larger scar size in women with HDP. Future studies are needed to better assess the relationship of HDP and cardiac morphology and LGE scarring in a larger cohort of women.

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