scholarly journals Impact of High Intensity Exercise on Muscle Morphology in EAE Rats

2015 ◽  
pp. 907-923 ◽  
Author(s):  
I. WENS ◽  
U. DALGAS ◽  
K. VERBOVEN ◽  
L. KOSTEN ◽  
A. STEVENS ◽  
...  
Keyword(s):  
Muscle Fiber ◽  
High Intensity ◽  
High Intensity Exercise ◽  
Muscle Performance ◽  
Autoimmune Encephalomyelitis ◽  
Cross Sectional ◽  
Muscle Work ◽  
General Exercise ◽  
The Impact ◽  
Experimental Autoimmune

The impact of high-intensity exercise on disease progression and muscle contractile properties in experimental autoimmune encephalomyelitis (EAE) remains unclear. Control (CON) and EAE rats were divided into sedentary and exercise groups. Before onset (experiment 1, n=40) and after hindquarter paralysis (experiment 2, n=40), isokinetic foot extensor strength, cross sectional area (CSA) of tibialis anterior (TA), extensor digitorum longus (EDL) and soleus (SOL) and brain-derived neurotrophic factor (BDNF) levels were assessed. EAE reduced muscle fiber CSA of TA, EDL and SOL. In general, exercise was not able to affect CSA, whereas it delayed hindquarter paralysis peak. CON muscle work peaked and declined, while it remained stable in EAE. BDNF-responses were not affected by EAE or exercise. In conclusion, EAE affected CSA-properties of TA, EDL and SOL, which could, partly, explain the absence of peak work during isokinetic muscle performance in EAE-animals. However, exercise was not able to prevent muscle fiber atrophy.

scholarly journals The impact of 2 years of high‐intensity exercise training on a model of integrated cardiovascular regulation

2018 ◽  
Vol 597 (2) ◽  
pp. 419-429 ◽  
Author(s):  
Michinari Hieda ◽  
Erin J. Howden ◽  
Satyam Sarma ◽  
William Cornwell ◽  
Justin S. Lawley ◽  
...  
Keyword(s):  
Exercise Training ◽  
High Intensity ◽  
Cardiovascular Regulation ◽  
High Intensity Exercise ◽  
The Impact

scholarly journals Deletion of arginase 2 attenuates neuroinflammation in an experimental model of optic neuritis

PLoS ONE ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. e0247901
Author(s):  
Amritha A. Candadai ◽  
Fang Liu ◽  
Abdelrahman Y. Fouda ◽  
Moaddey Alfarhan ◽  
Chithra D. Palani ◽  
...  
Keyword(s):  
Optic Neuritis ◽  
Experimental Model ◽  
Axonal Degeneration ◽  
Wild Type ◽  
Autoimmune Encephalomyelitis ◽  
Optic Nerves ◽  
Clinical Presentations ◽  
Retinal Neurodegeneration ◽  
The Impact ◽  
Experimental Autoimmune

Vision impairment due to optic neuritis (ON) is one of the major clinical presentations in Multiple Sclerosis (MS) and is characterized by inflammation and degeneration of the optic nerve and retina. Currently available treatments are only partially effective and have a limited impact on the neuroinflammatory pathology of the disease. A recent study from our laboratory highlighted the beneficial effect of arginase 2 (A2) deletion in suppressing retinal neurodegeneration and inflammation in an experimental model of MS. Utilizing the same model, the present study investigated the impact of A2 deficiency on MS-induced optic neuritis. Experimental autoimmune encephalomyelitis (EAE) was induced in wild-type (WT) and A2 knockout (A2-/-) mice. EAE-induced cellular infiltration, as well as activation of microglia and macrophages, were reduced in A2-/- optic nerves. Axonal degeneration and demyelination seen in EAE optic nerves were observed to be reduced with A2 deletion. Further, the lack of A2 significantly ameliorated astrogliosis induced by EAE. In conclusion, our findings demonstrate a critical involvement of arginase 2 in mediating neuroinflammation in optic neuritis and suggest the potential of A2 blockade as a targeted therapy for MS-induced optic neuritis.

scholarly journals The impact of short duration, high intensity exercise on cardiac troponin release

2014 ◽  
Vol 36 (4) ◽  
pp. 281-285 ◽  
Author(s):  
Keith P George ◽  
Marie Clare Grant ◽  
Bruce Davies ◽  
Julien S. Baker
Keyword(s):  
Short Duration ◽  
High Intensity ◽  
Cardiac Troponin ◽  
High Intensity Exercise ◽  
Troponin Release ◽  
The Impact

scholarly journals Lowering blood cholesterol does not affect neuroinflammation in experimental autoimmune encephalomyelitis

2021 ◽  
Author(s):  
solenne vigne ◽  
Donovan Duc ◽  
Yannick Yersin ◽  
Jessica Rebeaud ◽  
Florian Ruiz ◽  
...  
Keyword(s):  
Experimental Autoimmune Encephalomyelitis ◽  
Cholesterol Level ◽  
Blood Cholesterol ◽  
Lipid Lowering ◽  
Blood Levels ◽  
Disease Course ◽  
Blood Cholesterol Level ◽  
Autoimmune Encephalomyelitis ◽  
The Impact ◽  
Experimental Autoimmune

Abstract Background: Multiple sclerosis (MS) is a chronic disabling disease of the central nervous system (CNS) commonly affecting young adults. There is increasing evidence that environmental factors are important in the development and course of MS. Metabolic syndrome (MetS) including dyslipidemia has been associated with a worse outcome in MS disease. Furthermore, the lipid lowering drugs statins have been proposed to improve MS disease course. However, cholesterol is also rate-limiting for myelin biogenesis and promotes remyelination in MS animal models. Thus, the impact of circulating blood cholesterol level during the disease remains debated and controversial. Methods: We assessed the role of circulating cholesterol on the murine model of MS, the experimental autoimmune encephalomyelitis (EAE) disease using two different approaches: 1) the mouse model of familial hypercholesterolemia induced by low density lipoprotein receptor (LDLr) deficiency, and 2) the use of the monoclonal anti-PCSK9 neutralizing antibody alirocumab which reduces LDLr degradation and consequently lowers blood levels of cholesterol. Results: Elevated blood cholesterol levels induced by LDLr deficiency did not worsen clinical symptoms of mice during EAE. In addition, we observed that the anti-PCSK9 antibody alirocumab did not influence EAE disease course, nor modulate the immune response in EAE. Conclusions: These findings suggest that blood cholesterol level has no direct role in neuro-inflammatory diseases and that the previously shown protective effects of statins in MS are not related to circulating cholesterol.

scholarly journals Impact of Single Bout of Physical Exercise on Adolescents’ Strength and Balance Abilities

2018 ◽  
Vol 1 (96) ◽  
Author(s):  
Lina Kreivėnaitė ◽  
Vytautas Streckis ◽  
Sandra Raizgytė ◽  
Asta Lileikienė
Keyword(s):  
Physical Exercise ◽  
High Intensity ◽  
Postural Sway ◽  
High Intensity Exercise ◽  
Body Balance ◽  
Low Intensity ◽  
Eyes Closed ◽  
Single Bout ◽  
Eyes Open ◽  
The Impact

Background. There is evidence of physical exercise effect on the adolescents’ balance and strength; however it is not known how aforementioned variables respond to physical exercise with different loads and intensities. Therefore, the aim of the study was to assess the impact of single bout of physical exercise of different intensity on adolescents’ body balance and muscular strength.Methods. Thirty healthy, physically active 11–13-year-old adolescents were randomly allocated to one of the two groups. Both groups performed single bout of physical exercise of high- or low-intensity climbing up and down-stairs. Postural sway and maximum voluntary contractions (MVC) were assessed before and after physical exercise. Results. No statistically significant impact of low or high intensity exercise was found at adolescents’ MVC. High intensity exercise influenced bigger postural sway with eyes closed compared to eyes open ( p < .05). After high-intensity exercise there was a significantly greater postural sway with eyes closed than with eyes open (p < .05). Conclusions. High and low intensity physical exercise had no impact on the adolescents’ maximum voluntary contraction, whereas high intensity exercise deteriorated body balance with eyes closed.Keywords:  adolescence, physical exercise, MVC, balance

Secondary malposition of a PICC-port due to heavy physical exercise: A case report

2021 ◽  
pp. 112972982110394
Author(s):  
Sonia D’Arrigo ◽  
Maria Giuseppina Annetta ◽  
Andrea Musarò ◽  
Mariagrazia Distefano ◽  
Mauro Pittiruti
Keyword(s):  
Physical Exercise ◽  
High Intensity ◽  
Central Venous Access ◽  
Venous Access ◽  
High Intensity Exercise ◽  
Mechanical Complication ◽  
Secondary Migration ◽  
Chest X Ray ◽  
Venous Access Device ◽  
The Impact

Physical exercise is often encouraged in cancer patients, mainly for the purpose of rehabilitation and for its psychological benefit. Some authors also suggest that exercise—specially in patient with peripherally inserted central venous access devices—may contribute to reduce the risk of catheter-related thrombosis. Still, the impact of physical exercise on the risk of device-related complications is not yet defined. We report a case of secondary migration of the tip of an arm port, caused by high-intensity exercise in a woman undergoing chemotherapy because of ovarian cancer. Tip migration was suspected because of malfunction (persistent withdrawal occlusion) and diagnosis established after ultrasound examination and chest x-ray. Even if exercise may yield benefit in the cancer patient on chemotherapy, the risk of mechanical complication of the venous access device—such as tip migration—should be considered in the case of high-intensity exercise.

scholarly journals CD169 is a marker for highly pathogenic phagocytes in multiple sclerosis

2017 ◽  
Vol 24 (3) ◽  
pp. 290-300 ◽  
Author(s):  
Jeroen FJ Bogie ◽  
Ellen Boelen ◽  
Els Louagie ◽  
Peter Delputte ◽  
Dirk Elewaut ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Autoimmune Encephalomyelitis ◽  
Highly Pathogenic ◽  
Disease Symptoms ◽  
Effector Cells ◽  
Diphtheria Toxin Receptor ◽  
Therapeutic Value ◽  
Toxin Receptor ◽  
The Impact ◽  
Experimental Autoimmune

Background: Phagocytes, such as macrophages and microglia, are key effector cells in the pathophysiology of multiple sclerosis (MS). It is widely accepted that they instigate and promote neuroinflammatory and neurodegenerative events in MS. An increasing amount of studies indicate that Siglec-1, also known CD169, is a marker for activated phagocytes in inflammatory disorders. Objective: In this study, we set out to define how CD169+ phagocytes contribute to neuroinflammation in MS. Methods: CD169-diphtheria toxin receptor (DTR) mice, which express human DTR under control of the CD169 promoter, were used to define the impact of CD169+ cells on neuroinflammation. Flow cytometry and immunohistochemistry were utilized to determine the expression and distribution of CD169. Results: We show that CD169 is highly expressed by lesional and circulating phagocytes in MS and experimental autoimmune encephalomyelitis (EAE). Our data further indicate that CD169 represents a selective marker for early activated microglia in MS and EAE lesions. Depletion of CD169+ cells markedly reduced neuroinflammation and ameliorated disease symptoms in EAE-affected mice. Conclusion: Our findings indicate that CD169+ cells promote neuroinflammation. Furthermore, they suggest that CD169+ phagocytes play a key role in the pathophysiology of MS. Hence, targeting CD169+ phagocytes may hold therapeutic value for MS.

scholarly journals Mental health and stress among ICU healthcare professionals in France according to intensity of the COVID-19 epidemic

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Alexandra Laurent ◽  
Alicia Fournier ◽  
Florent Lheureux ◽  
Guillaume Louis ◽  
Saad Nseir ◽  
...  
Keyword(s):  
Mental Health ◽  
Intensive Care ◽  
Perceived Stress ◽  
High Intensity ◽  
General Health Questionnaire ◽  
Positive Thinking ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Mediation Analyses ◽  
The Impact

Abstract Background We investigated the impact of the COVID-19 crisis on mental health of professionals working in the intensive care unit (ICU) according to the intensity of the epidemic in France. Methods This cross-sectional survey was conducted in 77 French hospitals from April 22 to May 13 2020. All ICU frontline healthcare workers were eligible. The primary endpoint was the mental health, assessed using the 12-item General Health Questionnaire. Sources of stress during the crisis were assessed using the Perceived Stressors in Intensive Care Units (PS-ICU) scale. Epidemic intensity was defined as high or low for each region based on publicly available data from Santé Publique France. Effects were assessed using linear mixed models, moderation and mediation analyses. Results In total, 2643 health professionals participated; 64.36% in high-intensity zones. Professionals in areas with greater epidemic intensity were at higher risk of mental health issues (p < 0.001), and higher levels of overall perceived stress (p < 0.001), compared to low-intensity zones. Factors associated with higher overall perceived stress were female sex (B = 0.13; 95% confidence interval [CI] = 0.08–0.17), having a relative at risk of COVID-19 (B = 0.14; 95%-CI = 0.09–0.18) and working in high-intensity zones (B = 0.11; 95%-CI = 0.02–0.20). Perceived stress mediated the impact of the crisis context on mental health (B = 0.23, 95%-CI = 0.05, 0.41) and the impact of stress on mental health was moderated by positive thinking, b = − 0.32, 95% CI = − 0.54, − 0.11. Conclusion COVID-19 negatively impacted the mental health of ICU professionals. Professionals working in zones where the epidemic was of high intensity were significantly more affected, with higher levels of perceived stress. This study is supported by a grant from the French Ministry of Health (PHRC-COVID 2020).

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