2. Introduction to Part 1; Internalizing and diffusing the PRA approach: the case of Ethiopia; Scaling-up PRA: lessons from Vietnam; The rush to scale: lessons being learnt in Indonesia; Scaling-down as the key to scaling-up? The role of participatory municipal planning in Bolivia’s Law of Popular Participation

Who Changes ◽  
1998 ◽  
pp. 9-39
Author(s):  
Dereje Wordofa ◽  
Bardolf Paul ◽  
Nilanjana Mukherjee ◽  
James Blackburn ◽  
Costanza de Toma
2021 ◽  
Author(s):  
Gina G Turrigiano ◽  
Chi-Hong Wu ◽  
Vedakumar Tatavarty ◽  
Pierre M Jean-Beltran ◽  
Andrea Guerrero ◽  
...  

Homeostatic synaptic plasticity requires widespread remodeling of synaptic signaling and scaffolding networks, but the role of posttranslational modifications in this process has not been systematically studied. Using deepscale, quantitative analysis of the phosphoproteome in mouse neocortical neurons, we found wide-spread and temporally complex changes during synaptic scaling up and down. We observed 424 bidirectionally modulated phosphosites that were strongly enriched for synapse-associated proteins, including S1539 in the ASD-associated synaptic scaffold protein Shank3. Using a parallel proteomic analysis performed on Shank3 isolated from rat neocortical neurons by immunoaffinity, we identified two sites that were hypo-phosphorylated during scaling up and hyper-phosphorylated during scaling down: one (rat S1615) that corresponded to S1539 in mouse, and a second highly conserved site, rat S1586. The phosphorylation status of these sites modified the synaptic localization of Shank3 during scaling protocols, and dephosphorylation of these sites via PP2A activity was essential for the maintenance of synaptic scaling up. Finally, phosphomimetic mutations at these sites prevented scaling up but not down, while phosphodeficient mutations prevented scaling down but not up. Thus, an activity-dependent switch between hypo- and hyperphosphorylation at S1586/ S1615 of Shank3 enables scaling up or down, respectively. Collectively our data show that activity-dependent phosphoproteome dynamics are important for the functional reconfiguration of synaptic scaffolds, and can bias synapses toward upward or downward homeostatic plasticity.


2015 ◽  
Vol 9 (2) ◽  
pp. 147-165 ◽  
Author(s):  
Adam Possamai ◽  
Arathi Sriprakash ◽  
Ellen Brackenreg ◽  
John McGuire

As universities in Australia are faced with a growth in diversity and intensity of religion and spirituality on campus, this article explores the work of chaplains and its reception by students on a multi-campus suburban university. It finds that the religious work of these professionals is not the primary emphasis in the university context; what is of greater significance to students and the university institution is the broader pastoral and welfare-support role of chaplains. We discuss these findings in relation to post-secularism theory and the scaling down of state-provided welfare in public institutions such as universities.


2021 ◽  
Vol 19 (S1) ◽  
Author(s):  
Qudsia Uzma ◽  
Nausheen Hamid ◽  
Rizwana Chaudhri ◽  
Nadeem Mehmood ◽  
Atiya Aabroo ◽  
...  

Abstract Background Pakistan is among a number of countries facing protracted challenges in addressing maternal mortality with a concomitant weak healthcare system complexed with inequities. Sexual and reproductive health and rights (SRHR) self-care interventions offer the best solution for improving access to quality healthcare services with efficiency and economy. This manuscript documents country experience in introducing and scaling up two selected SRHR self-care interventions. A prospective qualitative study design was used and a semi-structured questionnaire was shared with identified SRHR private sector partners selected through convenience and purposive sampling. The two interventions include the use of misoprostol for postpartum hemorrhage and the use of subcutaneous depomedroxyprogesterone acetate (DMPA) as injectable contraceptive method. Data collection was done through emails and telephone follow-up calls. Results Nine of the 13 partners consulted for the study responded. The two selected self-care interventions are mainly supported by private sector partners (national and international nongovernmental organizations) having national or subnational existence. Their mandates include all relevant areas, such as policy advocacy, field implementation, trainings, supervision and monitoring. A majority of partners reported experience related to the use of misoprostol; it was introduced more than a decade ago, is registered and is procured by both public and private sectors. Subcutaneous DMPA is a new intervention, having been introduced only recently, and commodity availability remains a challenge. It is being delivered through health workers/providers and is not promoted as a self-administered contraceptive. Community engagement and awareness raising is reported as an essential element of successful field implementation; however, no beneficiary data was collected for the study. Training approaches differ considerably, are standalone or integrated with SRHR topics and their duration varies between 1 and 5 days, covering a range of cadres. Conclusion Pubic sector ownership and patronage is essential for introducing and scaling up self-care interventions as a measure to support the healthcare system in delivering quality sexual and reproductive health services. Supervision, monitoring and reporting are areas requiring further support, as well as the leadership and governance role of the public sector. Standardization of trainings, community awareness, supervision, monitoring and reporting are required together with integration of self-care in routine capacity building activities (pre- and in-service) on sexual and reproductive health in the country.


Epidemics ◽  
2009 ◽  
Vol 1 (2) ◽  
pp. 77-82 ◽  
Author(s):  
T.B. Hallett ◽  
S. Dube ◽  
Í. Cremin ◽  
B. Lopman ◽  
A. Mahomva ◽  
...  

2018 ◽  
Vol 4 (4) ◽  
pp. 205630511880791 ◽  
Author(s):  
Marcia Mundt ◽  
Karen Ross ◽  
Charla M Burnett

In this article, we explore the potential role of social media in helping movements expand and/or strengthen themselves internally, processes we refer to as scaling up. Drawing on a case study of Black Lives Matter (BLM) that includes both analysis of public social media accounts and interviews with BLM groups, we highlight possibilities created by social media for building connections, mobilizing participants and tangible resources, coalition building, and amplifying alternative narratives. We also discuss challenges and risks associated with using social media as a platform for scaling up. Our analysis suggests that while benefits of social media use outweigh its risks, careful management of online media platforms is necessary to mitigate concrete, physical risks that social media can create for activists.


2019 ◽  
Vol 8 (3) ◽  
Author(s):  
Gholam Reza Mirie ◽  
Mohsen Sadeghi

The purpose of the present study was to determine the performance of responsible organizations in urban affairs administration as an important factor in the development of the city of Pars Abad. The statistical population of this research includes inhabitants of Parasabad city and managers and experts of urban affairs in 1396. The method of this study is descriptive-practical study. For data collection, library and field method is used for urban data and questionnaire. These data are analyzed using SPSS software and also used to test the hypothesis of T-test. The results of this study show that the performance of the responsible unit in the affairs of the city has a significant relationship with the management and organization of the physical-space development process, equipping the service space and organizing facilities and facilities in the city of Parsabad. While the responsibility of the responsible authority in affairs of the city is not significantly related to the development of the employment and business environment and the establishment of effective communication channels with citizens and the development of popular participation


2017 ◽  
Author(s):  
Stephen Schuster ◽  
◽  
Joven Balbosa ◽  
Christine Tang ◽  
Takuji Komatzuzaki ◽  
...  

Author(s):  
Jeannie Van Wyk

This note offers a critical reflection of the recent landmark decision in City of Johannesburg Metropolitan Municipality v Gauteng Development Tribunal which lay to rest the negative consequences of employing the DFA procedures of the Development Facilitation Act 67 of 1995 (DFA) alongside those of the provincial Ordinances to establish townships (or to use DFA parlance, “land development areas”). The welcome and timely decision in City of Johannesburg Metropolitan Municipality v Gauteng Development Tribunal has declared invalid chapters V and VI of the DFA. Moreover, it has formalised planning terminology in South Africa, delineated the boundaries of “municipal planning” and “urban planning and development” as listed in Schedules 4 and 5 of the Constitution of the Republic of South Africa, 1996 and, in the process, clarified the structure of planning law. This note examines the decision of the SCA and focus on the role it will clearly have in reforming some of the law relating to planning. It considers the facts of the case, uncertainties around terminology, the structure of planning in South Africa, the content of municipal planning, the role of the DFA and the consequences of the declaration of invalidity by the SCA.


Sign in / Sign up

Export Citation Format

Share Document