HUBUNGAN TEKANAN DARAH  DENGAN KADAR KOLESTEROL LDL(Low Density Lipoprotein) PADA PENDERITA PENYAKIT  JANTUNG KORONERDI RSUP.Dr.M.DJAMIL PADANG

Coronary heart disease is a disease caused by narrowing of the coronary arteries of the heart. This happens because of its high cholesterol levels can cause atherosclerosis in blood vessels Hypercholesterolemia mainly occurs when increased production of LDL (Low Density Lipoprotein). As a result of the narrowing of blood vessels blood flow to the heart will be disrupted, causing symptoms of chest pain that is a typical symptom of coronary heart disease. Chronic atherosclerosis can cause blood flow to the heart to be disturbed, so that the left ventricle must pump stronger to produce enough force to push blood through the atherosclerotic vascular system that can lead to increased systolic and diastolic blood pressure resulting in hypertension. This study included descriptive analytic research using cross sectional approach, is dependent variable (incidence of coronary heart disease) and indenpendent variable (blood pressure and LDL cholesterol level) collected at the same time. The study was conducted on September 10, 2016 - April 4, 2017 at the Central Laboratory and Heart Ward RSUP.Dr. M. Djamil Padang. The sampling technique used is purposive sampling, that is the technique of determining the sample with certain consideration. Of 36 samples of patients with coronary heart disease (CHD) showed a correlation between systolic blood pressure with LDL cholesterol level has a value of 0.585> 0.05 which states there is a moderate relationship between the two variables, and has significant significance of 0.00 <0, 05 and Ha are received. The correlation between diastolic blood pressure and LDL levels has a value of 0,507> 0,05 which states there is a moderate relationship between the two variables, and has significant value of 0.02 significance <0.05 and Ha is accepted. Based on these results then there is a significant relationship between blood pressure with LDL cholesterol levels in the blood.

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The Description of Low Density Lipoprotein (LDL) Levels on Smoker and Non Smoker Adolescent in Buyan Hamlet, Pancasari Village, Sukasada District, Buleleng, Bali

Bali Medika Jurnal ◽

10.36376/bmj.v4i1.57 ◽

2017 ◽

Vol 4 (1) ◽

pp. 39-44

Author(s):

Ni Made Restina Juliani ◽

I Putu Oka Dharmawan ◽

Putu Ayu Parwati

Keyword(s):

Physical Activity ◽

Coronary Heart Disease ◽

Heart Disease ◽

Ldl Cholesterol ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

The Body ◽

Low Density ◽

Blood Samples ◽

Cholesterol Levels

Introduction: Low Density Lipoprotein (LDL) is a type of low-density lipoprotein and the most widely transported cholesterol in the body. Increased levels of LDL in the body can be affected by genetics, age, gender, obesity, physical activity, lifestyle, drug consumption and smoking. Substances in a cigarette can cause an increase of LDL levels. Increased of LDL cholesterol levels can cause Coronary Heart Disease (CHD). The purpose of this research is to know the description of Low Density Lipoprotein (LDL) levels on smoker and non-smoker adolescent in Buyan Hamlet, Pancasari Village, Sukasada District, Buleleng Bali. Method: The type of this research is descriptive. This research was conducted in April-May 2017, which used fasting blood samples of 42 respondents. Result: From the average result of LDL level in smoker adolescent that is 134,91 mg/dL higher than the average of LDL level in non-smoker adolescent that is 74,90 mg/dL. The result of LDL cholesterol levels was determined by 21 smoker adolescent respondents with the close to optimal category (100-129 mg/dL) as many as 9 people (42,8%), and 12 people (57,3%) with worry category (130-159 mg/dL). Whereas in 21 non-smoker adolescent respondents obtained result of LDL cholesterol level test with optimal category (<100 mg/dL) counted 18 people (87,71%) and 3 person (14,30%) with close to optimal category (100-129 mg/dL). Discussion: Based on the results of this research can be concluded that in smoker adolescent obtained LDL levels with close to optimal category and worrying whereas in non-smoker adolescents obtained LDL levels in the optimal category and close to optimal.

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Association of apolipoprotein E polymorphism, low-density lipoprotein cholesterol, and coronary artery disease.

Clinical Chemistry ◽

10.1093/clinchem/32.5.778 ◽

1986 ◽

Vol 32 (5) ◽

pp. 778-781 ◽

Cited By ~ 115

Author(s):

H J Lenzen ◽

G Assmann ◽

R Buchwalsky ◽

H Schulte

Keyword(s):

Myocardial Infarction ◽

Coronary Heart Disease ◽

Heart Disease ◽

Apolipoprotein E ◽

Ldl Cholesterol ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Low Density ◽

Apolipoprotein E Polymorphism ◽

Artery Disease

Abstract We determined the frequencies of genetic apolipoprotein E isoforms in 570 survivors of myocardial infarction, all with demonstrable coronary heart disease, as compared with 624 healthy persons. In controls, E-4/E-3 heterozygosity was associated with total cholesterol concentrations of 1985 (SD 364) mg/L and low-density lipoprotein (LDL)-cholesterol concentrations of 1306 (SD 332) mg/L. Significantly lower values, 1811 (SD 312) mg/L and 1121 (SD 274) mg/L, respectively, were observed for E-3/E-2 heterozygous persons. In survivors of myocardial infarction, the respective values were significantly higher than in controls, differing between E-4/E-3 and E-3/E-2 heterozygous patients by 233 and 220 mg/L, respectively. Moreover, E-4/E-3 heterozygosity was accompanied by earlier age of myocardial infarction (48.8 +/- 7.4 years) as compared with E-3/E-2 heterozygosity (53.4 +/- 6.9 years) and E-3/E-3 homozygosity (51.2 +/- 7.7 years). Evidently, apolipoprotein E polymorphism can contribute to total and LDL-cholesterol concentrations in serum, thereby affecting risk of coronary heart disease and myocardial infarction.

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