Clinical value of echocardiography in patients with COVID-19: a systematic review

2021 ◽  
pp. 8-13
Author(s):  
M. N. Alekhin ◽  
S. I. Ivanov ◽  
A. I. Stepanova
Keyword(s):  
Infectious Disease ◽  
Systematic Review ◽  
Clinical Studies ◽  
Cardiovascular Complications ◽  
Emerging Infectious Disease ◽  
Clinical Value ◽  
Medical Databases ◽  
Contagious Disease ◽  
The Given

This systematic review is dedicated to the role of echocardiography in diagnostics of possible cardiovascular complications in patients with COVID-19, the emerging infectious disease that has recently challenged global healthcare. The results of the largest current available clinical studies on the given topic from the leading medical databases were analyzed. Up-to-date data about the beneficial advantages and possible limitations of the use of echocardiography in the highly contagious disease pandemic is provided.

scholarly journals Role of Kynurenine pathway and its metabolites in mood disorders: A systematic review and meta-analysis of clinical studies

2018 ◽  
Vol 92 ◽  
pp. 477-485 ◽  
Author(s):  
Danilo Arnone ◽  
Smita Saraykar ◽  
Haitham Salem ◽  
Antonio L. Teixeira ◽  
Robert Dantzer ◽  
...  
Keyword(s):  
Systematic Review ◽  
Mood Disorders ◽  
Clinical Studies ◽  
Meta Analysis ◽  
Kynurenine Pathway

scholarly journals The use of surface electromyography in assessing the effectiveness of manual therapy: a systematic review

2020 ◽  
Vol 4 (1) ◽  
pp. 89-107
Author(s):  
Rui Santiago ◽  
J. Santos Baptista ◽  
André Magalhães ◽  
J. Torres Costa
Keyword(s):  
Systematic Review ◽  
Health Care ◽  
Data Collection ◽  
Manual Therapy ◽  
Clinical Studies ◽  
Surface Electromyography ◽  
Treatment Modality ◽  
Reporting Standards ◽  
Methodologic Quality

Research on the use of surface electromyography (sEMG) for analyzing the effects of Manual Therapy (MT) seems to have very dispersed intentions. The development of data collection protocols using sEMG might not be stable for conducting clinical studies. This study aimed to evaluate the current literature using surface sEMG in the context of MT and verify if it is a useful tool to verify its effectiveness. Also, to assess the methodologic quality and reporting standards and make a reflective analysis of how this technique has been used for this treatment modality. A computerized search was performed in May 2017 and repeated in June 2018, the search was performed in 8 electronic databases following PRISMA protocol. Thirty-one papers were included. More and better-designed studies are needed to create improved protocols. Further exploration and validation of these protocols may help to conduct more reliable clinically driven trials and it may inform policymakers of the role of MT in health care. The detection of clinically meaningful electrical alterations in muscles seems to be the main objective of most authors. Several sEMG items were not reported, and overall methodology quality was low.

The protective role of melatonin in chemotherapy‐induced nephrotoxicity: a systematic review of non-clinical studies

2018 ◽  
Vol 14 (9) ◽  
pp. 937-950 ◽  
Author(s):  
Hamed Haghi-Aminjan ◽  
Bagher Farhood ◽  
Mahban Rahimifard ◽  
Tina Didari ◽  
Maryam Baeeri ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Studies ◽  
Protective Role

scholarly journals A higiene bucal de bebês edêntulos e sua influência na microbiota bucal: os profissionais de saúde devem preconizá-la? – revisão crítica

2021 ◽  
Vol 62 (1) ◽  
pp. 108-120
Author(s):  
Dalila Miranda de Jesus ◽  
Lilian Lopes Barbosa ◽  
Thais Manzano Parisotto ◽  
Rogério Lacerda dos Santos ◽  
Hugo Lemes Carlo ◽  
...  
Keyword(s):  
Systematic Review ◽  
Oral Cavity ◽  
Oral Hygiene ◽  
Health Professionals ◽  
Clinical Studies ◽  
Scientific Evidence ◽  
Pediatric Dentistry ◽  
Google Scholar ◽  
Oral Microbiota

Introduction: The indication of oral hygiene in edentulous babies is still controversial among health professionals, being necessary the search of this recommendation and the standardization of information. Objective: To investigate critically the evidence related to the indication of oral hygiene for edentulous babies. Methods: The search for articles was performed in the PUBMED, LILACS and GOOGLE SCHOLAR databases, in order to assess the following question: "Can oral cavity hygiene of edentulous babies influence oral microbiota? A search in 8 books of Pediatric Dentistry was also performed. Results: 317 articles were found (167-PUBMED, 146-GOOGLE SCHOLAR and 4-LILACS). There were no primary studies that evaluated the effect of oral hygiene of edentulous infants on microbiota, which impair the conduction of a systematic review. Thus, it was included for this review six studies that investigated microorganisms in the oral cavity of edentulous infants and the role of salivary immunoglobulins. Among the textbooks evaluated, only 4 indicated the oral hygiene in edentulous infants. Conclusion: According to the data, there are no primary studies that assessed the effect of oral hygiene in the oral microbiota of edentulous babies. It is relevant to conduct clinical studies in order to obtain scientific evidence about the indication or no of the oral hygiene in edentulous babies.

scholarly journals The protean role of haptoglobin and haptoglobin genotypes on vascular complications in diabetes mellitus

2018 ◽  
Vol 25 (14) ◽  
pp. 1502-1519 ◽  
Author(s):  
Rinkoo Dalan ◽  
Goh Liuh Ling
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Vitamin E ◽  
Clinical Studies ◽  
Vascular Complications ◽  
Cardiovascular Complications ◽  
Diabetes Patients

Introduction and background Haptoglobin (Hp) is considered to be an antioxidant and protective against cardiovascular complications. Polymorphisms in the Hp gene interact with diabetes mellitus to affect the risk of vascular complications. Methods We review the updated literature about the protean role of Hp and Hp genotypes spanning genomics, molecular, translational and clinical studies. We searched Pubmed, SCOPUS and Google Scholar for all articles using the keywords: haptoglobin and/or haptoglobin polymorphism and diabetes. We review the diverse Hp genotypes, phenotypes and the impact on diabetes complications, including lessons from animal models and in vitro models. We describe the clinical studies on the associations of Hp genotypes with vascular complications in type 1 and type 2 diabetes comprehensively. We review the studies looking at vitamin E supplementation in a personalized manner in Hp2-2 diabetes individuals. Results and conclusion Hp genotypes have evolved as a result of deletions in the traditional Hp genes. The Hp genotypes have been associated with microvascular and macrovascular complications in type 1 diabetes mellitus but the association in type 2 diabetes is more consistent with cardiovascular complications. A preferential benefit of vitamin E and other antioxidants in the Hp2-2 genotype for cardiovascular complications in type 2 diabetes has been seen presumably secondary to interaction with high-density lipoprotein function. Hence, the Hp genotype can be used to personalize antioxidant therapeutics in diabetes patients. These results need to be corroborated in large, global, pragmatic, prospective, cardiovascular outcome trials in type 2 diabetes patients.

scholarly journals Endometriosis and Phytoestrogens: Friends or Foes? A Systematic Review

Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2532
Author(s):  
Ludovica Bartiromo ◽  
Matteo Schimberni ◽  
Roberta Villanacci ◽  
Jessica Ottolina ◽  
Carolina Dolci ◽  
...  
Keyword(s):  
Systematic Review ◽  
Animal Models ◽  
Cultured Cells ◽  
Regulatory Pathways ◽  
Medical Databases ◽  
Lesion Growth ◽  
Experimental Findings

The aim of this systematic review was to provide comprehensive and available data on the possible role of phytoestrogens (PE) for the treatment of endometriosis. We conducted an advanced, systematic search of online medical databases PubMed and Medline. Only full-length manuscripts written in English up to September 2020 were considered. A total of 60 studies were included in the systematic review. According to in vitro findings, 19 out of 22 studies reported the ability of PE in inducing anti-proliferative, anti-inflammatory and proapoptotic effects on cultured cells. Various mechanisms have been proposed to explain this in vitro action including the alteration of cell cycle proteins, the activation/inactivation of regulatory pathways, and modification of radical oxidative species levels. Thirty-eight articles on the effects of phytoestrogens on the development of endometriotic lesions in in vivo experimental animal models of endometriosis have been included. In line with in vitro findings, results also derived from animal models of endometriosis generally supported a beneficial effect of the compounds in reducing lesion growth and development. Finally, only seven studies investigated the effects of phytoestrogens intake on endometriosis in humans. The huge amount of in vitro and in vivo animal findings did not correspond to a consistent literature in the women affected. Therefore, whether the experimental findings can be translated in women is currently unknown.

scholarly journals Improvement of semen parameters after coil embolization of varicoceles: a systematic review

2021 ◽  
Vol 20 ◽  
Author(s):  
Sergio Quilici Belczak ◽  
Vanessa Stefaniak ◽  
Leonardo Garcia Góes ◽  
Felipe Coelho Neto ◽  
Walter Jr. Boim de Araújo ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Studies ◽  
Cost Effective ◽  
Semen Parameters ◽  
Semen Parameter ◽  
Cost Effective Method ◽  
Prisma Statement ◽  
Meta Analyses ◽  
The Impact

Abstract This systematic review was conducted in accordance with the 2009 Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement, including clinical studies in which one of the outcomes was semen parameter improvement after varicocele embolization using coils only. The objective of the review was to assess the evidence on the role of embolization using coils alone for semen parameter improvement in men with varicocele, since embolization using coils is the most cost-effective method of varicocele repair. Study quality was assessed using the methodological index for non-randomized studies (MINORS). Out of six retrospective and two prospective observational or comparative clinical studies involving 701 patients, semen concentration improved significantly in all five studies that assessed this parameter. Mean semen motility improved significantly in seven studies. The impact of embolization on semen density could not be analyzed.

Mycotoxin Exposure and Autism: A Systematic Review of Molecular Mechanism

2020 ◽  
Vol 13 ◽  
Author(s):  
Yılmaz Serkan ◽  
Utku Beyazit ◽  
Aynur Bütün Ayhan
Keyword(s):  
Systematic Review ◽  
Autism Spectrum Disorder ◽  
Molecular Mechanism ◽  
Systematic Approach ◽  
Web Of Science ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Almost All ◽  
The Given

Background and objective: Exposure to mycotoxins may delay and/or negatively influence the development of neurological, gastrointestinal and inflammatory mechanisms in individuals with Autism Spectrum Disorder (ASD). Therefore, there is a need to address the possible links between mycotoxins and the risk and prevalence of ASD to increase the understanding of the molecular mechanism underlying these links. In this context, the aim of this study was to investigate the molecular mechanism underpinning mycotoxin exposure and autism. Methods: The study was based on a systematic approach which focused on the possible associations between mycotoxins and ASD in addition to the role of the mycotoxins on the risk and prevalence of ASD. The systematic review included all molecular mechanism studies examining mycotoxin exposure and autism, and was not limited to a specific period of time. A search was performed on the PubMed, Web of Science, Scopus, and Google Scholar databases. Results: The investigation of the literature revealed that a total number of 11 studies with a specific focus on the molecular mechanism of mycotoxin exposure and autism were published between 2008 and 2019. Out of these studies, 7 were research and 4 were review articles. In almost all the articles, possible links between mycotoxins and ASD were revealed. Conclusion: The examination of the given studies provided data related to the links between mycotoxins and ASD. However, evidence related to these links needs to be investigated in larger samples, while the effects of separate mycotoxins and their metabolisms should also be examined.

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