Visual hallucinations in Gentington's disease: ophthalmic validation of ‘North-East Visual Hallucinations Interview

2021 ◽  
pp. 26-31
Author(s):  
S. N. Svetozarsky ◽  
S. V. Kopishinskaya ◽  
M. A. Korotysh ◽  
I. A. Velichko ◽  
D. A. Smirnova

Huntington's disease (HD) is a steadily progressive neurodegenerative disease caused by a mutation in the huntingtin gene, with progressive motor, cognitive and mental impairments.The aim of the study is to determine the validity of the North‑East Visual Hallucinations Interview (NEVHI) in a Russian sample of patients.Materials and methods. 78 subjects were examined: 26 patients at the manifest stage of HD, 21 pre‑manifest carriers of the HD gene and 31 volunteers of the control group.Results. The low incidence of visual hallucinations according to the NEVHI does not allow us to conclude about their specificity for HD. Failure to achieve the level of statistical significance in this case suggests a high risk of type II error associated with the low occurrence of the symptom and the relatively small group size.Conclusion. The study showed that the NEVHI questionnaire can serve as an adequate method for the diagnosis of visual hallucinations in HD.

Author(s):  
Valentina Tagliapietra ◽  
Flavia Riccardo ◽  
Giovanni Rezza

Italy is considered a low incidence country for tick-borne encephalitis (TBE) in Europe. Areas at higher risk for TBE in Italy are geographically clustered in the forested and mountainous regions and provinces in the north east part of the country, as suggested by TBE case series published over the last decade.


Italy is considered a low-incidence country for tick-borne encephalitis (TBE) in Europe.1 Areas at higher risk for TBE in Italy are geographically clustered in the forested and mountainous regions and provinces in the north east part of the country, as suggested by TBE case series published over the last decade.2-5 A national enhanced surveillance system for TBE has been established since 2017.6 Before this, information on the occurrence of TBE cases at the national level in Italy was lacking. Both incidence rates and the geographical distribution of the disease were mostly inferred from endemic areas where surveillance was already in place, ad hoc studies and international literature.1


1996 ◽  
Vol 1 (1) ◽  
pp. 25-28 ◽  
Author(s):  
Martin A. Weinstock

Background: Accurate understanding of certain basic statistical terms and principles is key to critical appraisal of published literature. Objective: This review describes type I error, type II error, null hypothesis, p value, statistical significance, a, two-tailed and one-tailed tests, effect size, alternate hypothesis, statistical power, β, publication bias, confidence interval, standard error, and standard deviation, while including examples from reports of dermatologic studies. Conclusion: The application of the results of published studies to individual patients should be informed by an understanding of certain basic statistical concepts.


1997 ◽  
Vol 84 (1) ◽  
pp. 319-322 ◽  
Author(s):  
Helen C. Beh ◽  
Peter McLaughlin

The cognitive performance of groups of subjects was tested after flights lasting between 7.5–9.5 hours to the north, east and west of Sydney ( ns = 10, 12, and 12) and compared with the performance of a ground-based control group ( n = 12). Analysis showed an impairment in performance of the flight groups following the flights. The analysis suggests that part of the performance change following transzonal flights may result from stress induced during the flight rather than adjustment to new time zones.


Author(s):  
Tore Scherstén

Few would argue that the randomized clinical trial is the most definitive instrument available for measuring the safety and efficacy of a new medical technology, be it drug, device, or procedure. Randomization removes the potential for bias in the allocation of subjects to the intervention group or to the control group. In addition, randomization tends to produce comparable groups which can be further strengthened by stratification and by stratified analyses. The randomized controlled trial guarantees validity of statistical tests, as long as the sample size is large enough to avoid type-II error.


2011 ◽  
Vol 18 (1) ◽  
Author(s):  
David T. Doran

<p class="MsoBodyText3" style="text-align: justify; margin: 0in 0.5in 0pt;"><span style="font-size: 10pt;"><span style="font-family: Times New Roman;">Divergent earnings are those that differ from expected.<span style="mso-spacerun: yes;">&nbsp; </span>Doran (2000) provides evidence that nonparametric tests based upon rank values are superior to parametric alternatives in detecting divergent earnings.<span style="mso-spacerun: yes;">&nbsp; </span>He also finds that deflator choice (i.e., forecasted earnings or market price of the stock) is of little importance when superior nonparametric methods are used.<span style="mso-spacerun: yes;">&nbsp; </span>This study extends the efforts of Doran (2000) by testing for benefit derived from the common research method of deflating earnings data.<span style="mso-spacerun: yes;">&nbsp; </span>The data used here is the same as used by Doran (2000), where Value Line is the source of all earnings data.<span style="mso-spacerun: yes;">&nbsp; </span>One hundred independent two sample tests are performed between a positive earnings group and a matched control group.<span style="mso-spacerun: yes;">&nbsp; </span>The tests are performed with various levels (1%, 3%, 5%, 7%, and 10 %) of positive actual earnings introduced.<span style="mso-spacerun: yes;">&nbsp; </span>Failure to reject the null hypothesis of no positive earnings divergence indicates the existence of Type II error (determined using the nonparametric Mann Whitney test).<span style="mso-spacerun: yes;">&nbsp; </span>The Mann Whitney test was performed on the undeflated data, and the same data deflated by: 1) forecasted earnings, and 2) market price of the stock.<span style="mso-spacerun: yes;">&nbsp; </span>Difference in frequency of type II error is determined using the Chi-square test.<span style="mso-spacerun: yes;">&nbsp; </span>The results generally indicate no significant difference in the ability to identify abnormal divergent earnings when utilizing deflated data.<span style="mso-spacerun: yes;">&nbsp; </span>Statistical tests are found here to be at least as powerful when undeflated earnings data are used.<span style="mso-spacerun: yes;">&nbsp; </span>There is weak evidence supporting the notion that deflating earnings data inhibits the ability to detect abnormal earnings.<span style="mso-spacerun: yes;">&nbsp; </span>These findings indicate that the common practice of deflating earnings data is unnecessary, and may actually weaken the power of statistical tests.<span style="mso-spacerun: yes;">&nbsp;&nbsp;&nbsp; </span></span></span></p>


2020 ◽  
Vol 45 (1) ◽  
pp. 52-61 ◽  
Author(s):  
TD Grubbs ◽  
M Vargas ◽  
J Kolker ◽  
EC Teixeira

SUMMARY Purpose: The purpose of this study was to investigate the effect of four direct restorative materials that can be used in the proximal box elevation (PBE) technique. Methods and Materials: Seventy-five molar teeth were randomly assigned to one of five groups (n=15): type II glass ionomer (GI), type II resin-modified glass ionomer (RMGI), resin-based composite (RBC), bulk-fill (BF) resin-based composite, and a control with no box elevation procedure. Specimens were prepared for a standard mesio-occlusal-distal, computer-aided design/computer-aided manufactured (CAD-CAM) resin, nanoceramic onlay with mesial cervical margins located 1 mm above the cementoenamel junction (CEJ) and distal cervical margins located 2 mm below the CEJ. PBE was used to elevate the distal margins to 1 mm above the CEJ in all groups except the control group. For the control group the onlay margin was placed directly on the prepared distal tooth structure without PBE. A Lava Ultimate CAD/CAM resin, nanoceramic onlay restorative was manufactured and bonded on all specimens with RelyX Ultimate adhesive resin cement. The quality of the tooth-PBE material and PBE material-onlay interface was evaluated with scanning electron microscopy using epoxy resin replicas before and after cyclic loading (100,000 cycles, 1.2 Hz at 65N and 37°C). In addition to margin quality, the fracture resistance of each group was measured using a universal testing machine. Fracture pattern was recorded by visual examination. The Levene test for homogeneity and the Welch analysis of variance were completed for fracture resistance and margin quality. A χ2 test was completed for break mode. Results: For dentin margins, a statistically significant difference was detected between the RMGI and control groups at baseline (p=0.0442). All other groups—GI, RBC, and BF—showed no difference from the control at baseline (p&gt;0.05). No statistical significance was observed among groups for post-cyclic fatigue (p=0.8735). For onlay margins, no statistical significance was observed among groups for pre-cyclic fatigue, post-cyclic fatigue, or change (p=0.9713, p=0.528, p=0.4385, respectively). No significant difference was observed for the fracture resistance among groups or for the type of break by material used (p=0.1593, p=0.77, respectively). Conclusion: Within the parameters of this study, after mechanical fatigue, the materials used for PBE: RMGI, RBC, and BF, did not influence results in terms of margin quality and fracture resistance. Therefore, collective findings suggest that these materials might be suitable for PBE procedures. Nevertheless, clinical caution is recommended with any PBE procedure and further testing of GI materials is needed.


1959 ◽  
Vol 1 (2) ◽  
pp. 135-138 ◽  
Author(s):  
T. R. Preston ◽  
Isoline Greenhalgh ◽  
N. A. MacLeod

1. 768 lambs on fourteen farms in the north-east of Scotland were divided into a control group and groups receiving two 5 mg., three 5 mg., two 7·5 mg., and one 15 mg. pellet of hexoestrol.2. On every farm the mean rate of live-weight gain of the treated lambs was greater than that of the controls.3. There appeared to be very little difference between implantations of two 5 mg., three 5 mg. and two 7·5 mg. pellets of hexoestrol but on four farms where a direct comparison was made one 15 mg. pellet was slightly inferior to three 5 mg. pellets.


2021 ◽  
Vol 94 (2) ◽  
pp. 183-200
Author(s):  
Magdalena Kuchcik ◽  
Krzysztof Błażejczyk ◽  
Agnieszka Halaś

The assessment of thermal stress stimuli in Poland was based on the Universal Thermal Climate Index (UTCI). Daily values of UTCI at 24 stations selected to represent the whole area of Poland at 12:00 UTC were calculated over the period 1951-2018. Various UTCI characteristics, i.e., spatial averages of daily, monthly and annual values, daily spatial contrasts (i.e., the difference between daily highest and lowest UTCI values) were defined in each of 8 bioclimatic regions of Poland. Ten-year trends for UTCI and spatial contrast values were counted and their statistical significance was analysed. A statistically significant increase in UTCI values was found in all the regions of Poland. However, contrasts in thermal stress both for Poland as a whole and in most of the regions decreased significantly, especially in the north-east of Poland, the country’s coldest region. This indicates a reduction in the stimuli of thermal environment in Poland and in most of the individual regions.


2015 ◽  
Vol 20 (40) ◽  
Author(s):  
Giovanni Rezza ◽  
Francesca Farchi ◽  
Patrizio Pezzotti ◽  
Maurizio Ruscio ◽  
Alessandra Lo Presti ◽  
...  

Italy is considered at low incidence of tick-borne encephalitis (TBE), and the occurrence of human cases of TBE appears to be geographically restricted to the north east of the country. However, most information to date derives from case series, with no systematic data collection. To estimate incidence rates (IR) and spatial distribution of TBE cases, we conducted a retrospective study in north-eastern Italy. Data were collected through the infectious disease units and public health districts of three regions (Friuli Venezia Giulia, Trentino Alto Adige and Veneto) between 2000 and 2013. Overall, 367 cases were identified (IR: 0.38/100,000). The cases’ median age was 56 years and 257 (70%) were male. Central nervous system involvement was reported in 307 cases (84%). Annual fluctuations in case numbers occurred, with peaks in 2006 and in 2013, when 44 and 42 cases were respectively observed. A strong seasonality effect was noted, with the highest number of cases in July. In terms of geographical location, three main endemic foci with high TBE IR (> 10/100,000) were identified in three provinces, namely Belluno (Veneto region), Udine (Friuli Venezia Giulia) and Trento (Trentino Alto-Adige). When investigating the whole study area in terms of altitude, the IR between 400 and 600 m was greater (2.41/100,000) than at other altitudes (p< 0.01). In conclusion, the incidence of TBE in Italy is relatively low, even considering only the three known affected regions. However, three endemic foci at high risk were identified. In these areas, where the risk of TBEV infection is likely high, more active offer of TBE vaccination could be considered.


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