Possibilities of intestinal dysfunction treatment in period of convalescence of COVID-19

2021 ◽  
pp. 55-58
Author(s):  
D. A. Khavkina ◽  
P. V. Chukhliaev ◽  
T. A. Ruzhentsova
Keyword(s):  
Gastrointestinal Tract ◽  
Total Duration ◽  
Gastrointestinal Disorder ◽  
Laboratory Diagnosis ◽  
Normal Function ◽  
Duration Of Treatment ◽  
Immunocompetent Organs ◽  
The Moment

The article presents a clinical example of the treatment of persistent intestinal dysfunction in a patient with a relapse and in the period of COVID-19 convalescence. Differential approaches to the clinical and laboratory diagnosis of gastrointestinal disorders in patients with COVID-19 or SARS-CoV-2 infection and with a high risk of pseudomembranous colitis are considered. The role of bacteriophages in restoring the normal function of the gastrointestinal tract is considered. The total duration of treatment of a patient with a gastrointestinal disorder on the background of relapse and subsequent convalescence of COVID-19 from the moment of treatment was 8 weeks with the active use of anti-inflammatory, sorbing, anticoagulant, antiviral and antibacterial therapy. A significant contribution to the process of clinical improvement was made by the use of intestinal bacteriophage, reducing the risk of pseudomembranous colitis.Conclusions. COVID-19 is a disease characterized by a multisystem lesion and long-term consequences for immunocompetent organs, including the gastrointestinal tract. This fact forces us to reconsider some aspects of traditional therapy for intestinal dysfunction and provides opportunities for new, less aggressive treatments.

scholarly journals Case Report: Clostridium neonatale Bacteremia in a Preterm Neonate With Necrotizing Enterocolitis

2021 ◽  
Vol 9 ◽  
Author(s):  
Nadim Cassir ◽  
Isabelle Grandvuillemin ◽  
Manon Boxberger ◽  
Priscilla Jardot ◽  
Farid Boubred ◽  
...  
Keyword(s):  
Necrotizing Enterocolitis ◽  
Potential Role ◽  
Preterm Neonate ◽  
Gastrointestinal Disorder ◽  
Etiologic Agent ◽  
Preterm Neonates ◽  
Environmental Cleaning ◽  
Life Threatening

Necrotizing enterocolitis is a life-threatening acquired gastrointestinal disorder among preterm neonates and is associated with a high mortality rate and long-term neurodevelopmental morbidity. No etiologic agent has been definitively established; nonetheless, the most implicated bacteria include members of the Clostridium genus. We reported here on a case of Clostridium neonatale bacteremia in a preterm neonate with necrotizing enterocolitis, providing more information regarding the potential role of this bacterium in pathogenesis of necrotizing enterocolitis. We emphasized the sporulating form of C. neonatale that confers resistance to disinfectants usually applied for the hospital environmental cleaning. Further works are needed to establish the causal relationship between the occurrence of NEC and the isolation of C. neonatale, with promising perspectives in terms of diagnostic and therapeutic management.

scholarly journals Patterns of spatial methane distribution in the upper layers of permafrost in Central Yakutia

2017 ◽  
pp. 105-112
Author(s):  
M. Yu. Cherbunina ◽  
D. G. Shmelev ◽  
A. V. Brouchkov ◽  
V. S. Kazantsev ◽  
R. N. Argunov
Keyword(s):  
Field Studies ◽  
Methane Content ◽  
Central Yakutia ◽  
The Difference ◽  
The Moment ◽  
Methane Distribution ◽  
The Right ◽  
Ice Complex

The article presents the results of long-term field studies of methane in the upper part of permafrost for the different geomorphological levels of Central Yakutia. Patterns of spatial distribution of methane content across different landscapes were found. The highest concentrations of methane are found in alas deposits, the major role of methane in the conservation there goes to the moment of freezing the thermokarst lake draining. The difference in methane content in the sediments of the Late Pleistocene Ice Complex on the left and the right bank of the river Lena was identified. That is likely caused by the conditions of ice complex formation.

scholarly journals Children’s Creativity: A Theoretical Framework and Systematic Review

2018 ◽  
Vol 89 (1) ◽  
pp. 93-124 ◽  
Author(s):  
Elisa Kupers ◽  
Andreas Lehmann-Wermser ◽  
Gary McPherson ◽  
Paul van Geert
Keyword(s):  
Systematic Review ◽  
Three Dimensional ◽  
Future Research ◽  
Dynamic Systems Theory ◽  
School Students ◽  
Creative Development ◽  
Complex Dynamic Systems ◽  
The Moment

Within education, the importance of creativity is recognized as an essential 21st-century skill. Based on this premise, the first aim of this article is to provide a theoretical integration through the development of a framework based on the principles of complex dynamic systems theory, which describes and explains children’s creativity. This model is used to explain differing views on the role of education in developing children’s creativity. Our second aim is empirical integration. On the basis of a three-dimensional taxonomy, we performed a systematic review of the recent literature (2006–2017, 184 studies) on primary school students’ creativity. Our results show that creativity is most often measured as a static, aggregated construct. In line with our theoretical model, we suggest ways that future research can elaborate on the moment-to-moment interactions that form the basis of long-term creative development, as well as on the mechanisms that connect different levels of creativity.

scholarly journals Treatment of Lower Limb Fractures in Children with Multiple and Concomitant Injuries

2015 ◽  
pp. 5-12
Author(s):  
V. V. Timofeev ◽  
A. V. Bondarenko ◽  
A. A. Podsonnyi
Keyword(s):  
Lower Limb ◽  
Total Duration ◽  
Long Term Results ◽  
Duration Of Treatment ◽  
Concomitant Injuries ◽  
Lower Limb Fractures ◽  
Fractures In Children ◽  
Fixation Devices ◽  
Limb Fractures

Treatment results for 306 children (1-17 years) with lower limb fractures accompanied by multiple and concomitant injuries were studied during 2005 - 2014. Comparative assessment of conservative treatment, transcutaneous osteosynthesis with external fixation devices and internal fixation was performed. The number of complications, duration and number of hospitalizations, total duration of treatment, long-term results and quality of life at terms from 1 to 3 years after injury were evaluated. Indications to the application of every osteosynthesis technique were determined.

Children as creative thinkers in music

2012 ◽  
Author(s):  
Peter R. Webster
Keyword(s):  
Creative Thinking ◽  
Teaching And Learning ◽  
Music Listening ◽  
Formal Learning ◽  
Affective Variables ◽  
Human Thinking ◽  
The Moment ◽  
The Many

The study of creative thinking in music involves a complex combination of cognitive and affective variables, often executed at the highest levels of human thinking and feeling. This is such a complicated set of long-term engagements (composition, repeated music listening, or decisions about previously composed music in performance) or ‘in the moment’ engagements (improvisation and one-time listening), that it becomes quickly apparent why this field has not attracted more music researchers and why many feel the topic is hopelessly impregnable. However, the changes in education and the role of music in formal learning demands that we address creative thinking as best we can. This article takes a decidedly ‘teaching and learning’ approach in summarizing the many studies on creative thinking in music. While it is generally acknowledged that children's creative thinking in music occurs as part of many music experiences such as listening, performance, conducting, and improvising, the focus here is on composition.

scholarly journals First Insights into the Diverse Human Archaeome: Specific Detection of Archaea in the Gastrointestinal Tract, Lung, and Nose and on Skin

mBio ◽  
2017 ◽  
Vol 8 (6) ◽  
Author(s):  
Kaisa Koskinen ◽  
Manuela R. Pausan ◽  
Alexandra K. Perras ◽  
Michael Beck ◽  
Corinna Bang ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Human Health ◽  
Potential Role ◽  
Tissue Samples ◽  
Biogeographic Patterns ◽  
Processing Pipeline ◽  
Health And Disease ◽  
First Time

ABSTRACT Human-associated archaea remain understudied in the field of microbiome research, although in particular methanogenic archaea were found to be regular commensals of the human gut, where they represent keystone species in metabolic processes. Knowledge on the abundance and diversity of human-associated archaea is extremely limited, and little is known about their function(s), their overall role in human health, or their association with parts of the human body other than the gastrointestinal tract and oral cavity. Currently, methodological issues impede the full assessment of the human archaeome, as bacteria-targeting protocols are unsuitable for characterization of the full spectrum of Archaea. The goal of this study was to establish conservative protocols based on specifically archaea-targeting, PCR-based methods to retrieve first insights into the archaeomes of the human gastrointestinal tract, lung, nose, and skin. Detection of Archaea was highly dependent on primer selection and the sequence processing pipeline used. Our results enabled us to retrieve a novel picture of the human archaeome, as we found for the first time Methanobacterium and Woesearchaeota (DPANN superphylum) to be associated with the human gastrointestinal tract and the human lung, respectively. Similar to bacteria, human-associated archaeal communities were found to group biogeographically, forming (i) the thaumarchaeal skin landscape, (ii) the (methano)euryarchaeal gastrointestinal tract, (iii) a mixed skin-gastrointestinal tract landscape for the nose, and (iv) a woesearchaeal lung landscape. On the basis of the protocols we used, we were able to detect unexpectedly high diversity of archaea associated with different body parts. IMPORTANCE In summary, our study highlights the importance of the primers and data processing pipeline used to study the human archaeome. We were able to establish protocols that revealed the presence of previously undetected Archaea in all of the tissue samples investigated and to detect biogeographic patterns of the human archaeome in the gastrointestinal tract and on the skin and for the first time in the respiratory tract, i.e., the nose and lungs. Our results are a solid basis for further investigation of the human archaeome and, in the long term, discovery of the potential role of archaea in human health and disease. IMPORTANCE In summary, our study highlights the importance of the primers and NGS data processing pipeline used to study the human archaeome. We were able to establish protocols that revealed the presence of previously undetected Archaea in all of the tissue samples investigated and to detect biogeographic patterns of the human archaeome in the gastrointestinal tract, on the skin, and for the first time in the respiratory tract, i.e., the nose and lungs. Our results are a solid basis for further investigation of the human archaeome and, in the long term, discovery of the potential role of archaea in human health and disease.

scholarly journals Synuclein Deficiency Results in Age-Related Respiratory and Cardiovascular Dysfunctions in Mice

2020 ◽  
Vol 10 (9) ◽  
pp. 583
Author(s):  
Patrick S. Hosford ◽  
Natalia Ninkina ◽  
Vladimir L. Buchman ◽  
Jeffrey C. Smith ◽  
Nephtali Marina ◽  
...  
Keyword(s):  
Therapeutic Potential ◽  
Physiological Role ◽  
Normal Function ◽  
Whole Body ◽  
Cardiovascular Reflexes ◽  
Long Term Effects ◽  
Gene Encoding ◽  
Age Related

Synuclein (α, β, and γ) proteins are highly expressed in presynaptic terminals, and significant data exist supporting their role in regulating neurotransmitter release. Targeting the gene encoding α-synuclein is the basis of many animal models of Parkinson’s disease (PD). However, the physiological role of this family of proteins in not well understood and could be especially relevant as interfering with accumulation of α-synuclein level has therapeutic potential in limiting PD progression. The long-term effects of their removal are unknown and given the complex pathophysiology of PD, could exacerbate other clinical features of the disease, for example dysautonomia. In the present study, we sought to characterize the autonomic phenotypes of mice lacking all synucleins (α, β, and γ; αβγ−/−) in order to better understand the role of synuclein-family proteins in autonomic function. We probed respiratory and cardiovascular reflexes in conscious and anesthetized, young (4 months) and aged (18–20 months) αβγ−/− male mice. Aged mice displayed impaired respiratory responses to both hypoxia and hypercapnia when breathing activities were recorded in conscious animals using whole-body plethysmography. These animals were also found to be hypertensive from conscious blood pressure recordings, to have reduced pressor baroreflex gain under anesthesia, and showed reduced termination of both pressor and depressor reflexes. The present data demonstrate the importance of synuclein in the normal function of respiratory and cardiovascular reflexes during aging.

Will a New Model of Economic GrowthTake Place in Russia?

2013 ◽  
pp. 4-39 ◽  
Author(s):  
Y. Yasin ◽  
N. Akindinova ◽  
L. Yakobson ◽  
A. Yakovlev
Keyword(s):  
Current Model ◽  
New Model ◽  
Government Sector ◽  
Gdp Growth Rate ◽  
New Business ◽  
The Government ◽  
The Moment ◽  
Role Of The Government

Given the present level of institutional quality and the significant role of the government sector in the economy, the Russian Federation has depleted the potential of the current model of growth which is based on commodity exports. The dramatic deceleration of the GDP growth rate down to less than 2% in the end of 2012 and the beginning of 2013 bears the evidence to this proposition. At the moment, the government considers the choice between expansionist and conservative scenarios, which both lie on the assumption of long-term conservation of existing imperfect institutions. However, according to our estimates, it is impossible to create a new model of growth ignoring the role of private initiative, healthy institutions of market economy and investment in human capital. We distinguish two groups that are increasing their influence nowadays and can potentially become the driving force of a new model of Russian economic growth: “new business”, dynamic companies that are oriented at the development in the market conditions but lack incentive to invest within existing institutional framework; “new bureaucracy”, consisting of progressive regional elites, who are interested in the development of their area, and efficient professionals of the federal level.

Early Feeding Strategies in Preterm and Critically Ill Neonates

2001 ◽  
Vol 20 (7) ◽  
pp. 7-18 ◽  
Author(s):  
Ruth Evans ◽  
Patti Thureen
Keyword(s):  
Birth Weight ◽  
Gastrointestinal Tract ◽  
Extremely Low Birth Weight ◽  
Feeding Strategies ◽  
Early Feeding ◽  
Short And Long Term ◽  
Critically Ill Neonates ◽  
Enteral Feedings

This two-part article presents feeding strategies for the NICU population over the first several weeks of life. It focuses primarily on the theory and approach to feeding extremely low birth weight (ELBW) infants, but also addresses some issues pertinent to larger, ill infants. The premise for these recommendations is that avoiding early malnutrition in ELBW and ill infants has both short- and long-term benefits. Many practitioners may consider our approach to be somewhat aggressive. In this strategy, total parenteral nutrition (TPN) is initiated in the first hours after birth and is given together with initially small, and then increasing, enteral feedings beginning on the first or second day of life. The role of the TPN is to provide rapid, maximal nutrition and that of the early enteral feedings is to “prime” the gut and stimulate normal gastrointestinal tract activity.

scholarly journals Carbohydrate Elimination or Adaptation Diet for Symptoms of Intestinal Discomfort in IBD: Rationales for “Gibsons’ Conundrum”

2012 ◽  
Vol 2012 ◽  
pp. 1-19 ◽  
Author(s):  
Q. Manyan Fung ◽  
Andrew Szilagyi
Keyword(s):  
Normal Function ◽  
Host Immunity ◽  
Genetic Interactions ◽  
Insufficient Data ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Irritable Bowel ◽  
Carbohydrate Components

Therapeutic use of carbohydrates in inflammatory bowel diseases (IBDs) is discussed from two theoretical, apparent diametrically opposite perspectives: regular ingestion of prebiotics or withdrawal of virtually all carbohydrate components. Pathogenesis of IBD is discussed connecting microbial flora, host immunity, and genetic interactions. The best studied genetic example, NOD2 in Crohn’s disease, is highlighted as a model which encompasses these interactions and has been shown to depend on butyrate for normal function. The role of these opposing concepts in management of irritable bowel syndrome (IBS) is contrasted with what is known in IBD. The conclusion reached is that, while both approaches may alleviate symptoms in both IBS and IBD, there is insufficient data yet to determine whether both approaches lead to equivalent bacterial effects in mollifying the immune system. This is particularly relevant in IBD. As such, caution is urged to use long-term carbohydrate withdrawal in IBD in remission to control IBS-like symptoms.

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