Indicators of mineral bone density in male patients with osteoarthritis of knee joint of elderly and old age depending on condition of muscular system

2021 ◽  
pp. 42-48
Author(s):  
M. V. Koroleva ◽  
M. V. Letaeva ◽  
T. A. Raskina ◽  
O. S. Malyshenko ◽  
Y. V. Averkieva
Keyword(s):  
Old Age ◽  
Proximal Femur ◽  
Study Cohort ◽  
Muscular System ◽  
Mineral Density ◽  
Muscle Area ◽  
Knee Oa ◽  
Male Patients ◽  
Skeletal Muscle Area ◽  
Mineral Bone Density

Objective. To evaluate bone mineral density (BMD) indices in elderly and old age male patients with knee osteoarthritis (OA) depending on the state of the muscular system.Subjects and methods. The trial enrolled 32 patients with knee OA. The mean age of the patients was 68.7 (66.1; 70.3) years. The diagnosis of knee OA was established according to the diagnostic criteria of the American College of Rheumatologists (ACR, 1991). For comparative analysis, all patients with knee OA were divided into 3 groups according to muscle condition (EWGSOP, 2010: muscle mass was assessed by multispiral computed tomography, muscle strength was measured using a wrist dynamometer, muscle function was examined using a battery of short tests): the 1st – 9 patients without sarcopenia, the 2nd – 11 patients with presarcopenia, and the 3rd – 12 patients with sarcopenia. BMD was assessed by dual-energy X-ray absorptiometry in the neck and proximal femur as a whole and in the lumbar spine.Results. Osteopenic syndrome in the study cohort was diagnosed in 23 (71,9%) patients: osteopenia – in 19 (59,4%) patients, osteoporosis – in 4 (12,5%). Normal BMD values were observed in 9 (28.1%) patients. Osteopenic syndrome was detected in patients with sarcopenia signifcantly more often compared to patients without sarcopenia (p > 0.05) and with presarcopenia (p = 0.05). BMD indices in patients with sarcopenia in the neck and proximal femur in general were statistically signifcantly lower than in patients without sarcopenia and with presarcopenia (p < 0.05). There was a direct correlation between total skeletal muscle area at the LIII level and densitometric indices of the femoral neck.Conclusions. Sarcopenia is associated with low BMD indices in the neck and proximal femur in general in elderly and senile male patients with knee OA

scholarly journals Bone mineral density in patients with coronary artery disease and sarcopenia

2020 ◽  
Vol 14 (3) ◽  
pp. 84-90
Author(s):  
I. I. Grigorieva ◽  
T. A. Raskina ◽  
M. V. Letaeva ◽  
V. I. Ivanov ◽  
V. L. Masenko
Keyword(s):  
Bone Mineral Density ◽  
Muscle Strength ◽  
Bone Mineral ◽  
Proximal Femur ◽  
Mineral Density ◽  
Muscle Area ◽  
Male Patients ◽  
Group 2 ◽  
Skeletal Muscle Area ◽  
The Relationship

Objective: to assess the relationship between bone mineral density (BMD) and the muscular apparatus in male patients with coronary heart disease (CHD).Patients and methods. The investigation enrolled 79 male patients (median age, 63 [57; 66] years) with an established diagnosis of CHD verified by coronary angiography.Muscle mass was assessed by multispiral computed tomography, by determining the axial muscle tissue area (cm2 ) at the level of LIII. Muscle strength was measured with a wrist dynamometer. Muscle function was examined using the tests of the Short Physical Performance Battery (SPPB). BMD at the neck and proximal femur as a whole and at the lumbar spine was measured by dual energy X-ray absorptiometry.For comparative analysis, the patients were divided into three groups (EWGSOP, 2010). Group 1 included 31 patients without sarcopenia; Group 2 consisted of 21 patients with presarcopenia; and Group 3 comprised 27 patients with sarcopenia.Results and discussion. Osteopenic syndrome was diagnosed in 34 (43%) patients: osteopenia and osteoporosis in 31 (39%) and 3 (4%) patients, respectively. Normal BMD values were observed in 45 (57%) men. The prevalence of osteopenic syndrome was significantly higher in the patients with sarcopenia than in those with presarcopenia (p=0.050) and was comparable to that in men without sarcopenia (p>0.050). BMD at the neck and proximal femur as a whole was significantly lower in the patients with sarcopenia than in those without sarcopenia or with presarcopenia (p<0.050). There was a direct correlation between BMD and the characteristics of muscle mass and muscle strength. Regression analysis showed that the total skeletal muscle area at the level of LIII had a significant direct impact on BMD at the neck and proximal femur as a whole, and the reverse – walking speed.Conclusion. The relationship between the characteristics of the muscular apparatus and BMD requires further investigation.

Comparison of Dual Energy X-Ray Absorptiometry of the Proximal Femur with Morphologic Data

1992 ◽  
Vol 33 (5) ◽  
pp. 477-481 ◽  
Author(s):  
P. Hübsch ◽  
H. Kocanda ◽  
S. Youssefzadeh ◽  
B. Schneider ◽  
F. Kainberger ◽  
...  
Keyword(s):  
Proximal Femur ◽  
Normal Subjects ◽  
Poor Correlation ◽  
Mineral Density ◽  
X Ray ◽  
Singh Index ◽  
Trochanteric Region ◽  
Male Patients ◽  
Morphologic Data ◽  
Normal Controls

Measurements of bone mineral density (BMD) of the proximal femur (including femoral neck, Ward's triangle and trochanteric region) were compared with the Singh index grading in 40 normal subjects (20 male, 20 female) and in 116 patients (18 male, 98 female) referred for assessment of possible osteoporosis. Additionally, the BMD and the Singh index of 12 cadaver specimens (6 male, 6 female) of the proximal femur were compared with each other and with the histomorphology of the femoral necks of the specimens. Although there was a good correlation of Singh index with BMD in the group of male patients with suspected osteoporosis and in the series of bone specimens, there was a poor correlation in the group of female patients as well as in the normal controls and in the patient population as a whole. There was also poor correlation of Singh index values with histomorphologic data, whereas the BMD measurements correlated well with the amount of calcified bone found histologically in the femoral necks of the bone specimens. We conclude that the Singh index cannot be used to predict BMD of the proximal femur accurately.

scholarly journals Assessment of Bone Mineral Density in old age patients ( >60yrs) having proximal femur fracture

2016 ◽  
Vol 4 (3) ◽  
pp. 275
Author(s):  
Viral Prajapati ◽  
Pratik Prajapati ◽  
Prashant Patel ◽  
Ketan Kakani ◽  
Sandeep Patil
Keyword(s):  
Bone Mineral Density ◽  
Old Age ◽  
Bone Mineral ◽  
Proximal Femur ◽  
Femur Fracture ◽  
Proximal Femur Fracture ◽  
Mineral Density

scholarly journals Associations of LRP5 and MTHFR Gene Variants With Osteoarthritis Prevalence in General Elderly Women: A Japanese Cohort Survey Randomly Sampled From a Basic Resident Registry

2021 ◽  
Author(s):  
Masaki Nakano ◽  
Haruka Yui ◽  
Shingo Kikugawa ◽  
Ryosuke Tokida ◽  
Noriko Sakai ◽  
...  
Keyword(s):  
Methylenetetrahydrofolate Reductase ◽  
Elderly Women ◽  
Population Aging ◽  
Ldl Receptor ◽  
The Elderly ◽  
Study Cohort ◽  
Mineral Density ◽  
Knee Oa ◽  
Number Of Patients ◽  
Japanese Elderly

Abstract Osteoarthritis (OA) is a common and degenerative joint disorder in the elderly. A greater importance of understanding the relationship between genetic factors and OA prevalence has emerged with population aging. We therefore investigated the associations of several bone disease-related genetic variants with the prevalence of OA and osteoporosis in Japanese elderly women from the Obuse study cohort, which was randomly sampled from a basic town resident registry. In total, 206 female participants (mean ± standard deviation age: 69.7 ± 11.0 years) who completed OA, bone mineral density, and genotype assessments were included. The number of patients diagnosed as having knee/hip OA and osteoporosis was 59 (28.6%) and 30 (14.6%), respectively. Fisher's exact testing revealed significant relationships between the minor T allele of LDL receptor related protein 5 (LRP5) rs3736228 and the prevalences of knee/hip OA and osteoporosis. The respective odds ratios (ORs) of the TT genotype for knee/hip OA and osteoporosis were 7.28 (95% confidence interval [CI] 2.22–28.08) and 5.24 (95% CI 0.95–26.98). An additional subgroup analysis for knee OA revealed that the frequency of the common C allele of methylenetetrahydrofolate reductase (MTHFR) rs1801133 had a statistically significant protective association with the prevalence of knee OA (OR 0.58, 95% CI 0.35–0.97). In sum, the present study demonstrated significant associations of LRP5 rs3736228 and MTHFR rs1801133 with knee/hip OA and osteoporosis prevalences and knee OA prevalence, respectively, in Japanese elderly women. These results will help further the understanding of OA pathogenesis and related genetic risk factors.

Bone mineral density in male patients with type 2 diabetes mellitus, with and without hypogonadism

2017 ◽  
Author(s):  
Agathi Vasileiou ◽  
Ioanna Karathanassi ◽  
Parthena Navrozidou ◽  
Marianna Vlychou ◽  
Georgios Koukoulis ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Bone Mineral Density ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Bone Mineral ◽  
Mineral Density ◽  
Male Patients

scholarly journals Association of coagulation dysfunction with cardiac injury among hospitalized patients with COVID-19

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Liang Chen ◽  
Wei Hu ◽  
Xiaoxiao Guo ◽  
Ping Zhao ◽  
Jia Tang ◽  
...  
Keyword(s):  
Hospital Mortality ◽  
Clinical Outcomes ◽  
Old Age ◽  
Serum Ferritin ◽  
Leukocyte Count ◽  
Cardiac Injury ◽  
Study Cohort ◽  
Common Complication ◽  
Coagulation Dysfunction ◽  
D Dimer

AbstractCardiac injury is a common complication of the coronavirus disease 2019 (COVID-19), and is associated with adverse clinical outcomes. In this study, we aimed to reveal the association of cardiac injury with coagulation dysfunction. We enrolled 181 consecutive patients who were hospitalized with COVID-19, and studied the clinical characteristics and outcome of these patients. Cardiac biomarkers high-sensitivity troponin I (hs-cTnI), myohemoglobin and creatine kinase-myocardial band (CK-MB) were assessed in all patients. The clinical outcomes were defined as hospital discharge or death. The median age of the study cohort was 55 (IQR, 46–65) years, and 102 (56.4%) were males. Forty-two of the 181 patients (23.2%) had cardiac injury. Old age, high leukocyte count, and high levels of aspartate transaminase (AST), D-dimer and serum ferritin were significantly associated with cardiac injury. Multivariate regression analysis revealed old age and elevated D-dimer levels as being strong risk predictors of in-hospital mortality. Interleukin 6 (IL6) levels were comparable in patients with or without cardiac injury. Serial observations of coagulation parameters demonstrated highly synchronous alterations of D-dimer along with progression to cardiac injury. Cardiac injury is a common complication of COVID-19 and is an independent risk factor for in-hospital mortality. Old age, high leukocyte count, and high levels of AST, D-dimer and serum ferritin are significantly associated with cardiac injury, whereas IL6 are not. Therefore, the pathogenesis of cardiac injury in COVID-19 may be primarily due to coagulation dysfunction along with microvascular injury.

Clinical impact of skeletal muscle area in patients with non-small cell lung cancer treated with anti-PD-1 inhibitors

2020 ◽  
Vol 146 (5) ◽  
pp. 1217-1225 ◽  
Author(s):  
Kazuki Takada ◽  
Yasuto Yoneshima ◽  
Kentaro Tanaka ◽  
Isamu Okamoto ◽  
Mototsugu Shimokawa ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Skeletal Muscle ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Clinical Impact ◽  
Small Cell Lung ◽  
Muscle Area ◽  
Skeletal Muscle Area
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