scholarly journals OPTIMASI KONDISI UNTUK RENDEMEN HASIL EKSTRAKSI KULIT MANGGIS (Garcinia mangostana L.) Optimization of Conditions for Yield Extraction of Mangosteen Pericarp (Garcinia mangostana L.)

2012 ◽  
Vol 2 (2) ◽  
pp. 153-159
Author(s):  
Akhmad Endang Zainal Hasan ◽  
Husain Nashrianto ◽  
Rani Novia Juhaeni
Keyword(s):  
Response Surface Methodology ◽  
Ethanol Concentration ◽  
Heating Time ◽  
Microwave Assisted Extraction ◽  
Garcinia Mangostana ◽  
Microwave Assisted ◽  
Assisted Extraction ◽  
Water As Solvent ◽  
Optimum Extraction ◽  
Central Composite

The aim of this study is to determine the levels of yield extract of mangosteen pericarp extracted using Response Surface Methodology (RSM) Central Composite Design (CCD) with various concentrations of ethanol (in the range of 45 to 96 %) and duration of microwave heating (in the range 5.8 to 34.1 o C) or Microwave Assisted Extraction (MAE). The yield extract was calculated as percentage to the weight of origin. The results showed that optimum extraction conditions for yield extract were at ethanol concentration of 70% and heating time of 31.5 minutes which resulted in yield extract of 19.45%. More over, under these conditions resulted yield of 19.83%. The yield extract equation of mangosteen pericarp is Y = -73,7883 + 0,5293 X heating time and X 2 1 + 2,4230 X 2 is ethanol concentration in water as solvent. 0,0084X12 0,00173 X2 2 , where X1 is heating time and X2 is ethanol concentration in water as solvent.Key words : Optimization, Mangosteen, RSM CCD, MAE, yield

scholarly journals Optimisation of microwave-assisted extraction of flavonoids and phenolics from celery (Apium graveolens L.) leaves by response surface methodology

2016 ◽  
Vol 34 (No. 4) ◽  
pp. 341-349 ◽  
Author(s):  
Q. He ◽  
Y. Li ◽  
P. Zhang ◽  
A. Zhang ◽  
H. Wu
Keyword(s):  
Antioxidant Activity ◽  
Response Surface Methodology ◽  
Response Surface ◽  
Ethanol Concentration ◽  
Apium Graveolens ◽  
Solvent Ratio ◽  
Microwave Assisted Extraction ◽  
Inhibition Rate ◽  
Microwave Assisted ◽  
Assisted Extraction

The conditions for microwave-assisted extraction (MAE) of total flavonoids (TF) and total phenols (TP), and antioxidant activity from celery (Apium graveolens L.) leaves by response surface methodology (RSM) were optimised. The 3-level, 3-factorial Box-Behnken design (BBD) was employed to study three main extraction conditions: microwave power (300–500 W), solid-solvent ratio (15–30 ml/g), and ethanol concentration (50–80%). It was found that microwave power of 500 W at 30 ml/g solid-solvent ratio with 75.6% (v/v) ethanol concentration was the most optimum conditions for the extraction of TF and TP from celery leaves with the consequent high antioxidant activity measured by the DPPH inhibition rate. Using the optimum extraction conditions, the extraction yields of TF and TP were 0.62 g RUE/100 g DW, 3.01 g GAE/100 g DW, respectively, and the DPPH inhibition rate was 88%. The results indicated that the nutritional quality of celery (Apium graveolens L.) leaves could be improved significantly by optimising the extraction process of MAE using response surface methodology.

scholarly journals Optimasi Metode Microwave-Assisted Extraction (MAE) untuk Menentukan Kadar Flavonoid Total Alga Coklat Padina australis

2020 ◽  
Vol 16 (1) ◽  
pp. 38
Author(s):  
Bina Lohita Sari ◽  
Triastinurmiatiningsih Triastinurmiatiningsih ◽  
Tri Saptari Haryani
Keyword(s):  
Microwave Power ◽  
Ethanol Concentration ◽  
Total Flavonoid ◽  
Total Flavonoid Content ◽  
Microwave Assisted Extraction ◽  
Flavonoid Content ◽  
Extraction Condition ◽  
Microwave Assisted ◽  
Assisted Extraction ◽  
Optimum Extraction

<p>Metode <em>Microwave-Assisted Extraction</em> (MAE) digunakan untuk mengekstraksi senyawa flavonoid dari simplisia alga coklat <em>Padina australis</em>. Sampel diperoleh dari Pantai Bayah, Banten Indonesia. Kondisi optimal ekstraksi ditentukan dengan <em>Response Surface Methodology </em>(RSM). Desain Box-Behnken (BBD) digunakan untuk mengevaluasi pengaruh 3 faktor dengan 3 <em>level</em> yaitu daya <em>microwave</em> (300, 450, 600 watt), konsentrasi etanol  (30, 50, 70%), dan waktu ekstraksi (7, 8 dan 9 menit) dengan 15 perlakuan yang berbeda. Hasil disain eksperimen dengan BBD menunjukkan kondisi ekstraksi optimum yaitu pada daya <em>microwave</em> 414 watt, konsentrasi etanol 50,33% dan waktu ekstraksi 7,89 menit menghasilkan kadar prediksi flavonoid sebesar nilai 0,2963%. Nilai ini mendekati nilai kadar flavonoid yang diperoleh secara eksperimental sebesar 0,2961%, pada kondisi menggunakan daya microwave sebesar 450 watt, konsentrasi etanol 50% dengan lama ekstraksi 8 menit. Berdasarkan hasil penelitian, kadar flavonoid total dapat meningkat secara signifikan dengan melakukan optimasi proses MAE menggunakan RSM.</p><p><strong>Optimization of Microwave-Assisted Extraction for Total Flavonoid Content of <em>Padina australis</em> Brown Algae. </strong><strong> </strong>Microwave-Assisted Extraction (MAE) was done to extraction flavonoid from<em> Padina australis</em> brown algae simplicial. The sample collected from Bayah coastal waters, Banten Indonesia. Optimum extraction condition was determined by the response surface methodology (RSM). The Box-Behnken design (BBD) was used to evaluate the influence of 3 factors with 3 levels extraction that is microwave power (300, 450, 600 watts), ethanol concentration (30, 50, 70%), and extraction time (7, 8 and 9 minutes) with 15 different runs. The research showed that optimum extraction condition was at 414 watts of microwave power, 50.33% ethanol concentration, and time extraction of 7.89 minutes yielded a predicted value of total flavonoid content of 0.2963%. This value approaches to the flavonoid content obtained experimentally at 0.2961% under condition of 450 watts microwave power, 50% ethanol concentration, and time extraction of 8 minutes. Based on the result, total flavonoid content can be significantly increased by optimizing the MAE process use RSM.</p>

Microwave-Assisted Extraction of Andrographolide, 14-Deoxy-11,12- didehydroandrographolide and Neoandrographolide from Andrographis paniculata: An Optimisation Study

2020 ◽  
Vol 16 (9) ◽  
pp. 1318-1325 ◽  
Author(s):  
Vi V. Chia ◽  
Sook F. Pang ◽  
Sureena Abdullah ◽  
Mashitah M. Yusoff ◽  
Jolius Gimbun
Keyword(s):  
Regression Analysis ◽  
Microwave Power ◽  
Ethanol Concentration ◽  
Mesh Size ◽  
Andrographis Paniculata ◽  
Solvent Ratio ◽  
Microwave Assisted Extraction ◽  
Microwave Assisted ◽  
Assisted Extraction ◽  
Central Composite

Background: Andrographis paniculata is often used as functional foods owing to its broad range of pharmaceutical activities due to the presence of main terpene compounds such as andrographolide, 14-deoxy-11,12-didehydroandrographolide and neoandrographolide. The aforementioned compounds must be extracted from the plant material before it can be routinely used as a functional food ingredient. Objective: This work presents an optimisation study of microwave-assisted extraction (MAE) of terpene from Andrographis paniculata. In this study, two factors at three-level central composite face centred design was employed to optimise the process variables, including the effect of microwave power (75-175 W) and ethanol concentration (20-85%) on extraction of terpene from Andrographis paniculata. Methods: The experimental design was set based on initial screening on the effect of mesh size and solid solvent ratio. The present work was performed at fixed mesh size and solid solvent ratio, which corresponds to the highest yield established experimentally. Two most significant factors, i.e. microwave power and ethanol concentration was chosen and further studied for optimisation using a response surface methodology. The three-level, two-factor central composite design (CCD) has been employed to determine the effect of microwave power (15, 25 and 35 W/mL) and ethanol concentration (20, 52.5 and 85%) on the yield of terpene extraction. Identification and quantification of the terpene were performed via Ultra-Performance Liquid Chromatography- Photodiode Array (UPLCPDA). Results: The regression analysis showed good fit of the experimental data to the quadratic equation with coefficient of determination (R2) value of 0.997. The optimum condition was found at microwave power of 140 W with 85% ethanol concentration, produced the highest yield of andrographolide (10.926 ± 0.053 mg/g DW), 14-deoxy-11,12-didehydroandrographolide (4.336 ± 0.215 mg/g DW) and neoandrographolide (5.698 ± 0.252 mg/g DW). The model developed through response surface modelling has a desirability of 97.5% and the error between the experiment and the model predictions ranged from 2.4 to 5.2%. Conclusion: A successful optimisation of terpene extraction from A. paniculata via MAE was achieved at microwave power of 140 W and 85% ethanol. The model developed from the regression analysis is sufficiently accurate and can be used to predict the yield of terpene extraction from A. paniculata.

scholarly journals Simultaneous Optimization of Microwave-Assisted Extraction of Phenolic Compounds and Antioxidant Activity of Avocado (Persea americana Mill.) Seeds Using Response Surface Methodology

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Alexander Weremfo ◽  
Felix Adulley ◽  
Martin Adarkwah-Yiadom
Keyword(s):  
Antioxidant Activity ◽  
Response Surface Methodology ◽  
Phenolic Compounds ◽  
Response Surface ◽  
Microwave Power ◽  
Ethanol Concentration ◽  
Extraction Time ◽  
Microwave Assisted Extraction ◽  
Microwave Assisted ◽  
Assisted Extraction

This study was designed to optimize three microwave-assisted extraction (MAE) parameters (ethanol concentration, microwave power, and extraction time) of total phenolics, total flavonoids, and antioxidant activity of avocado seeds using response surface methodology (RSM). The predicted quadratic models were highly significant (p<0.001) for the responses studied. The extraction of total phenolic content (TPC), total flavonoid content (TFC), and antioxidant activity was significantly (p<0.05) influenced by both microwave power and extraction time. The optimal conditions for simultaneous extraction of phenolic compounds and antioxidant activity were ethanol concentration of 58.3% (v/v), microwave power of 400 W, and extraction time of 4.8 min. Under these conditions, the experimental results agreed with the predicted values. MAE revealed clear advantages over the conventional solvent extraction (CSE) in terms of high extraction efficiency and antioxidant activity within the shortest extraction time. Furthermore, high-performance liquid chromatography (HPLC) analysis of optimized extract revealed the presence of 10 phenolic compounds, with rutin, catechin, and syringic acid being the dominant compounds. Consequently, this optimized MAE method has demonstrated a potential application for efficient extraction of polyphenolic antioxidants from avocado seeds in the nutraceutical industries.

scholarly journals Optimization of Microwave-Assisted Extraction of Total Phenolic and Total Flavonoid Contents from Fruits of Docynia indica (Wall.) Decne. Using Response Surface Methodology

Processes ◽  
2019 ◽  
Vol 7 (8) ◽  
pp. 485 ◽  
Author(s):  
Xuan Le ◽  
Manh Nguyen ◽  
Dinh Vu ◽  
Minh Pham ◽  
Quoc Pham ◽  
...  
Keyword(s):  
Response Surface Methodology ◽  
Microwave Power ◽  
Ethanol Concentration ◽  
Biological Activities ◽  
Total Flavonoid ◽  
Total Phenolic ◽  
Microwave Assisted Extraction ◽  
Microwave Assisted ◽  
Assisted Extraction ◽  
Phenolic And Flavonoid

Docynia indica (D. indica) shows various useful biological activities, such as antioxidant, anti-inflammatory, antibacterial effects, and positive benefits for human health. Such biological activities relate to the main phytochemicals of D. indica including phenolic and flavonoid. However, isolation for phenolic and flavonoid by popular methods such as hot extraction, soxhlet extraction, and ultrasonic extraction have been relatively ineffective. Therefore, in this study, microwave-assisted extraction (MAE) was used for the extraction of total phenolic and total flavonoid from D. indica. The optimization experiments were conducted based on response surface methodology (RMS) according to a central composite design with four independent variables: extraction time (min), ethanol concentration (%, v/v), microwave power (W), and pH of the solvent. Three dependent variables were total phenolic content (TPC), total flavonoid content (TFC), and yield. The optimal conditions for the extraction of phenolic and flavonoid from D. indica were: extraction time of 50 min, ethanol concentration of 65%, microwave power of 440 W, and solvent pH of 5.4. These conditions corresponded to TPC, TFC, and yield values of 33.57 ± 0.12 (mg GAE/g), 25.01 ± 0.11 (mg QE/g) and 33.44 ± 0.14 (%), respectively.

Optimization of Microwave-Assisted Extraction Conditions of Anthocyanins from Black Corn Hull Using Response Surface Methodology

2013 ◽  
Vol 864-867 ◽  
pp. 536-540 ◽  
Author(s):  
Yi Hua Jiang ◽  
Xin Long Jiang ◽  
Qing Hua Ma
Keyword(s):  
Response Surface Methodology ◽  
Ethanol Concentration ◽  
Microwave Assisted Extraction ◽  
Liquid Ratio ◽  
Power Extraction ◽  
Microwave Assisted ◽  
Assisted Extraction ◽  
Irradiation Power ◽  
Response Optimization ◽  
Solid Liquid

Abstract: Surface response optimization of microwave-assisted extraction (MAE) conditions of anthocyanins from black corn hull with the factors of ethanol concentration, microwave power, extraction time, solid/liquid ratio (g:mL) on the yield of anthocyanin were studied.The results showed that optimum extracting conditions of anthocyanin from black corn hull were as follows: adding 1:40.00 (m:v) of 79.67% alcohol (pH1.0) and extracting for 79.25 s,microwave irradiation power 560.00W.

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