Clinical Coping with Prescribing Opioids within the Context of Obesity and Diabetes Mellitus

Journal of Heterocyclics ◽

10.33805/2638-812x.117 ◽

2019 ◽

pp. 39-44

Author(s):

Robert G Smith

Keyword(s):

Diabetes Mellitus ◽

Drug Interactions ◽

Age Differences ◽

Coping Mechanism ◽

Pharmacokinetics And Pharmacodynamics ◽

Patient Demographics ◽

Disease States ◽

Obesity And Diabetes ◽

Sex And Age Differences

The purpose of this article is to provide podiatric physicians with the strategies for identifying, assessing and responding to patients who may have changes in opioid pharmacokinetics and pharmacodynamics due to sex and age differences and disease states. First of all, possible opioid drug interactions that exist within the context of patient demographics and disease states are presented and described. Secondly, both pharmacokinetic and pharmacodynamics changes of opioid agents within certain patient demographics are presented. Lastly, the art of clinical coping mechanism to prescribe opioids to patients that may be elderly or presenting with disease states that may alter opioid pharmacokinetics.

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Gestational microbiome: metabolic perturbations and developmental programming

Reproduction ◽

10.1530/rep-21-0241 ◽

2021 ◽

Vol 162 (6) ◽

pp. R85-R98

Author(s):

Sophia Han ◽

Charlotte C Ellberg ◽

Isoken N Olomu ◽

Arpita K Vyas

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Gestational Diabetes ◽

Human Microbiome ◽

Disease States ◽

Microbial Dysbiosis ◽

Obesity And Diabetes ◽

Growing Body

A growing body of research suggests that alterations to the human microbiome are associated with disease states, including obesity and diabetes. During pregnancy, these disease states are associated with maternal microbial dysbiosis. This review discusses the current literature regarding the typical maternal and offspring microbiome as well as alterations to the microbiome in the context of obesity, type 2 diabetes mellitus, and gestational diabetes mellitus. Furthermore, this review outlines the proposed mechanisms linking associations between the maternal microbiome in the aforementioned disease states and offspring microbiome. Additionally, this review highlights associations between alterations in offspring microbiome and postnatal health outcomes.

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The Insulin Receptor in Circulating Cells, with Special Reference to the Red Blood Cells. Its Characteristics in Some Disease States (Obesity and Diabetes Mellitus)

Hormone and Metabolic Research ◽

10.1055/s-2007-1010776 ◽

1988 ◽

Vol 20 (03) ◽

pp. 133-137

Author(s):

B. Wajchenberg ◽

A. Lerario

Keyword(s):

Diabetes Mellitus ◽

Red Blood Cells ◽

Special Reference ◽

Insulin Receptor ◽

Blood Cells ◽

Disease States ◽

Circulating Cells ◽

Obesity And Diabetes

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Risk of cause-specific death, its sex and age differences, and life expectancy in post-pancreatitis diabetes mellitus

Acta Diabetologica ◽

10.1007/s00592-021-01683-0 ◽

2021 ◽

Author(s):

Jaelim Cho ◽

Stephen J. Pandol ◽

Maxim S. Petrov

Keyword(s):

Diabetes Mellitus ◽

Life Expectancy ◽

Age Differences ◽

Sex And Age Differences

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Child and Adolescent Suicides in Bosnia and Herzegovina Before and After the War (1992–1995)

Crisis ◽

10.1027/0227-5910/a000021 ◽

2010 ◽

Vol 31 (3) ◽

pp. 160-164 ◽

Cited By ~ 3

Author(s):

Almir Fajkic ◽

Orhan Lepara ◽

Martin Voracek ◽

Nestor D. Kapusta ◽

Thomas Niederkrotenthaler ◽

...

Keyword(s):

Bosnia And Herzegovina ◽

Age Differences ◽

Suicide Risk ◽

Child And Adolescent ◽

Youth Suicide ◽

Southeastern Europe ◽

Suicide Rates ◽

Before And After ◽

Sex And Age Differences

Background: Evidence on youth suicides from Southeastern Europe is scarce. We are not aware of previous reports from Bosnia and Herzegovina, which experienced war from 1992 to 1995. Durkheim’s theory of suicide predicts decreased suicide rates in wartime and increased rates afterward. Aims: To compare child and adolescent suicides in Bosnia and Herzegovina before and after the war. Methods: Data on youth suicide for prewar (1986–90) and postwar (2002–06) periods were analyzed with respect to prevalence, sex and age differences, and suicide methods. Suicide data from 1991 through 2001 were not available. Results: Overall youth suicide rates were one-third lower in the postwar than in the prewar period. This effect was most pronounced for girls, whose postwar suicide rates almost halved, and for 15–19-year-old boys, whose rates decreased by about a one-fourth. Suicides increased among boys aged 14 or younger. Firearm suicides almost doubled proportionally and were the predominant postwar method, while the most common prewar method had been hanging. Conclusions: The findings from this study indicate the need for public education in Bosnia and Herzegovina on the role of firearm accessibility in youth suicide and for instructions on safe storage in households. Moreover, raising societal awareness about suicide risk factors and suicide prevention is needed.

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Kajian Interaksi Obat Metformin pada Pasien Diabetes Mellitus

Jurnal Farmasetis ◽

10.32583/farmasetis.v8i2.592 ◽

2019 ◽

Vol 8 (2) ◽

pp. 55-58

Author(s):

Havizur Rahman ◽

Teresia Anggi Octavia

Keyword(s):

Diabetes Mellitus ◽

Drug Interaction ◽

Data Collection ◽

Drug Interactions ◽

Degenerative Disease ◽

Moderate Severity ◽

Purposive Sampling ◽

Chronic Degenerative Disease ◽

Over Time ◽

Diabetes Melitus

Diabetes melitus merupakan penyakit degeneratif kronis yang apabila tidak ditangani dengan tepat, lama kelamaan bisa timbul berbagai komplikasi, ini cenderung menyebabkan pasien mendapatkan banyak obat dalam satu resep yang dapat menimbulkan interaksi antar obat. Tujuan dari penelitian ini adalah mengetahui persentase terjadinya interaksi obat metformin secara teori serta mengkaji efek yang mungkin timbul dan solusinya. Teknik pengambilan data dengan purpossive sampling, yaitu resep pasien rujuk balik yang menderita diabetes mellitus yang menggunakan metformin. Data yang diperoleh ditemukan bahwa obat yang berinteraksi dengan metformin dengan tingkat keparahan minor ialah sebesar 60%. Kemudian untuk tingkat keparahan moderat ialah sebesar 20%. Sedangkan untuk tingkat keparahan mayor tidak ditemukan. Dari tabel diatas juga dapat diketahui bahwa terdapat 4 obat yang saling berinteraksi dengan metformin, sedangkan untuk obat yang tidak saling berinteraksi dengan metformin terdapat 9 obat. Jumlah obat yang berinteraksi secara teori sebesar 6,85% dan yang tidak berinteraksi 93,15%. Terdapat interaksi obat metformin dengan beberapa obat yaitu furosemid, lisinopril, acarbose dan ramipril. Kata kunci: interaksi obat, metformin, diabetes mellitus STUDY OF METFORMIN INTERACTION IN MELLITUS DIABETES PATIENTS ABSTRACT Mellitus is a chronic degenerative disease which if not handled properly, over time can arise various complications, this tends to cause patients to get many drugs in one recipe that can cause interactions between drugs. The purpose of this study is to determine percentage of metformin drug interactions in theory and examine the effects that may arise and solutions. Data collection techniques using purposive sampling, which is a recipe for reconciliation patients who suffer from diabetes mellitus using metformin. The data obtained it was found that drugs that interact with metformin with minor severity were 60%. Then for moderate severity is 20%. Whereas the major severity was not found. From the table above it can also be seen that there are 4 drugs that interact with metformin, while for drugs that do not interact with metformin there are 9 drugs. The number of drugs that interacted theoretically was 6.85% and 93.15% did not interact. An interaction of the drug metformin with several drugs namely furosemide, lisinopril, acarbose and ramipril. Keywords: drug interaction, metformin, diabetes mellitus

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The Effect of Probiotics Supplementation in Maternal-Fetal Care

Current Women s Health Reviews ◽

10.2174/1573404816999200917155108 ◽

2020 ◽

Vol 16 ◽

Author(s):

Mahnaz Mardani ◽

Sadegh Rezapour

Keyword(s):

Diabetes Mellitus ◽

Protective Role ◽

Optimum Dose ◽

Active Living ◽

Maternal Weight Gain ◽

Long Term Effects ◽

Maternal Weight ◽

Human Gut ◽

Obesity And Diabetes

: Pregnancy-related complications can have long-term effects on mother and fetus/child. Microbiome within the human gut is an important factor to maintain optimum health during pregnancy and could possibly reduce the incidence of these complications. Probiotics are active living microorganisms that can provide the host with health benefits such as; immune and hormonal regulatory and metabolic benefits when administered in adequate and optimum dose. Probiotic supplementations also regulate abnormal and unbalanced microflora population that can control the pathogenesis of several diseases like obesity and diabetes. Probiotics also play a protective role in complications like preeclampsia, gestational diabetes mellitus and maternal weight gain and enhance successful outcomes of reproduction. This mini review will thereby summarize the maternal and fetal effects of probiotics during pregnancy.

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