scholarly journals Nanoparticles for Stem Cell Therapy Bioengineering in Glioma

2020 ◽  
Vol 8 ◽  
Author(s):  
Henry Ruiz-Garcia ◽  
Keila Alvarado-Estrada ◽  
Sunil Krishnan ◽  
Alfredo Quinones-Hinojosa ◽  
Daniel M. Trifiletti
Keyword(s):  
Stem Cells ◽  
Malignant Gliomas ◽  
High Morbidity ◽  
Therapeutic Approaches ◽  
New Paradigm ◽  
Current Standard ◽  
Natural Properties ◽  
Recent Developments ◽  
Tumor Homing ◽  
Antitumor Properties

Gliomas are a dismal disease associated with poor survival and high morbidity. Current standard treatments have reached a therapeutic plateau even after combining maximal safe resection, radiation, and chemotherapy. In this setting, stem cells (SCs) have risen as a promising therapeutic armamentarium, given their intrinsic tumor homing as well as their natural or bioengineered antitumor properties. The interplay between stem cells and other therapeutic approaches such as nanoparticles holds the potential to synergize the advantages from the combined therapeutic strategies. Nanoparticles represent a broad spectrum of synthetic and natural biomaterials that have been proven effective in expanding diagnostic and therapeutic efforts, either used alone or in combination with immune, genetic, or cellular therapies. Stem cells have been bioengineered using these biomaterials to enhance their natural properties as well as to act as their vehicle when anticancer nanoparticles need to be delivered into the tumor microenvironment in a very precise manner. Here, we describe the recent developments of this new paradigm in the treatment of malignant gliomas.

scholarly journals Recommendations from the Association for European Paediatric and Congenital Cardiology for training in pulmonary hypertension

2019 ◽  
Vol 29 (11) ◽  
pp. 1323-1327 ◽  
Author(s):  
Hannes Sallmon ◽  
Shahin Moledina ◽  
Dimpna C. Albert ◽  
Maurice Beghetti ◽  
Rolf M. F. Berger ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Medical Training ◽  
Healthcare Providers ◽  
High Morbidity ◽  
Therapeutic Approaches ◽  
Non Invasive ◽  
European Paediatric ◽  
Recent Developments ◽  
Children And Young Adults ◽  
Multiple Health

AbstractPulmonary hypertension is a complex and progressive condition that is either idiopathic or heritable, or associated with one or multiple health conditions, with or without congenital or acquired cardiovascular disease. Recent developments have tremendously increased the armamentarium of diagnostic and therapeutic approaches in children and young adults with pulmonary hypertension that is still associated with a high morbidity and mortality. These modalities include non-invasive imaging, pharmacotherapy, interventional and surgical procedures, and supportive measures. The optimal, tailored diagnostic and therapeutic strategies for pulmonary hypertension in the young are rapidly evolving but still face enormous challenges: Healthcare providers need to take the patient’s age, development, disease state, and family concerns into account when initiating advanced diagnostics and treatment. Therefore, there is a need for guidance on core and advanced medical training in paediatric pulmonary hypertension. The Association for European Paediatric and Congenital Cardiology working group “pulmonary hypertension, heart failure and transplantation” has produced this document as an expert consensus statement; however, all recommendations must be considered and applied in the context of the local and national infrastructure and legal regulations.

Human Colon Cancer Stem Cells: A New Paradigm in Gastrointestinal Oncology

2008 ◽  
Vol 26 (17) ◽  
pp. 2828-2838 ◽  
Author(s):  
Bruce M. Boman ◽  
Emina Huang
Keyword(s):  
Colorectal Cancer ◽  
Stem Cells ◽  
Colon Cancer ◽  
Cancer Stem Cells ◽  
Tumor Growth ◽  
Human Colon ◽  
Tissue Level ◽  
New Paradigm ◽  
Human Colon Cancer ◽  
Recent Developments

For the past half century, oncologists have had systemic drugs available, agents that are able to induce tumor responses in patients with colorectal cancer. However, in cases of advanced colorectal cancer, these regimens are almost never curative. The recently introduced concept that cancer stem cells (SCs) drive tumor growth suggests a reason for these therapeutic failures— current chemotherapeutics target rapidly dividing cells but cancer SCs divide only slowly, and, they are relatively resistant to cytotoxic systemic therapies. It also suggests a solution—development of therapeutics that target cancer SCs. However, there is a paucity of information about the mechanisms by which SC populations are maintained and about the mechanisms by which tumor SCs are involved in colon cancer development. In this article, we discuss these mechanisms and recent developments in the identification and isolation of colon cancer SCs using new SC markers. We then discuss the role of SCs in homeostasis of normal colonic epithelium, and mechanisms by which dysregulation of crypt mechanisms can lead to initiation and progression of colon cancer. Our hypothesis, which has received recent experimental support, is that the mechanism that links abnormalities at the gene level (eg, APC mutations) and abnormalities at the tissue level (eg, proliferative shift, dysplasia, carcinoma) from cancer initiation to metastasis is SC overpopulation. Finally, we discuss the concept that symmetric cancer SC division is an essential mechanism that drives tumor growth, and that development of a new generation of therapeutics that target colon cancer SCs by inhibiting symmetric SC division holds promise for truly curative approaches for patients with advanced colorectal cancers.

Application of Nanomaterials in Regulating the Fate of Adipose-derived Stem Cells

2021 ◽  
Vol 16 (1) ◽  
pp. 3-13
Author(s):  
Lang Wang ◽  
Yong Li ◽  
Maorui Zhang ◽  
Kui Huang ◽  
Shuanglin Peng ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Stem Cell Research ◽  
Adult Stem Cells ◽  
Adipose Derived Stem Cells ◽  
Proliferation And Differentiation ◽  
Recent Developments ◽  
Good Biocompatibility ◽  
Regulatory Effects ◽  
New Treatment

Adipose-derived stem cells are adult stem cells which are easy to obtain and multi-potent. Stem-cell therapy has become a promising new treatment for many diseases, and plays an increasingly important role in the field of tissue repair, regeneration and reconstruction. The physicochemical properties of the extracellular microenvironment contribute to the regulation of the fate of stem cells. Nanomaterials have stable particle size, large specific surface area and good biocompatibility, which has led them being recognized as having broad application prospects in the field of biomedicine. In this paper, we review recent developments of nanomaterials in adipose-derived stem cell research. Taken together, the current literature indicates that nanomaterials can regulate the proliferation and differentiation of adipose-derived stem cells. However, the properties and regulatory effects of nanomaterials can vary widely depending on their composition. This review aims to provide a comprehensive guide for future stem-cell research on the use of nanomaterials.

scholarly journals The Importance of Tumor Stem Cells in Glioblastoma Resistance to Therapy

2021 ◽  
Vol 22 (8) ◽  
pp. 3863
Author(s):  
Vincenzo Mattei ◽  
Francesca Santilli ◽  
Stefano Martellucci ◽  
Simona Delle Monache ◽  
Jessica Fabrizi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Radical Surgery ◽  
Cellular Heterogeneity ◽  
Molecular Characteristics ◽  
Tumor Stem Cells ◽  
Current Standard ◽  
New Approach ◽  
Experimental Therapies ◽  
Technical Advances ◽  
New Anticancer Drugs

Glioblastoma (GBM) is known to be the most common and lethal primary malignant brain tumor. Therapies against this neoplasia have a high percentage of failure, associated with the survival of self-renewing glioblastoma stem cells (GSCs), which repopulate treated tumors. In addition, despite new radical surgery protocols and the introduction of new anticancer drugs, protocols for treatment, and technical advances in radiotherapy, no significant improvement in the survival rate for GBMs has been realized. Thus, novel antitarget therapies could be used in conjunction with standard radiochemotherapy approaches. Targeted therapy, indeed, may address specific targets that play an essential role in the proliferation, survival, and invasiveness of GBM cells, including numerous molecules involved in signal transduction pathways. Significant cellular heterogeneity and the hierarchy with GSCs showing a therapy-resistant phenotype could explain tumor recurrence and local invasiveness and, therefore, may be a target for new therapies. Therefore, the forced differentiation of GSCs may be a promising new approach in GBM treatment. This article provides an updated review of the current standard and experimental therapies for GBM, as well as an overview of the molecular characteristics of GSCs, the mechanisms that activate resistance to current treatments, and a new antitumor strategy for treating GSCs for use as therapy.

scholarly journals EXTH-07. TUMOR-HOMING INDUCED NEURAL STEM CELLS SECRETING A CYTOTOXIC PAYLOAD AS AN ADJUVANT TREATMENT FOR NON-SMALL CELL LUNG CANCER BRAIN METASTASES

2020 ◽  
Vol 22 (Supplement_2) ◽  
pp. ii88-ii88
Author(s):  
Alison Mercer-Smith ◽  
Wulin Jiang ◽  
Alain Valdivia ◽  
Juli Bago ◽  
Scott Floyd ◽  
...  
Keyword(s):  
Stem Cells ◽  
Brain Metastases ◽  
Neural Stem Cells ◽  
Adjuvant Treatment ◽  
Small Cell ◽  
Small Cell Lung ◽  
Tumor Homing ◽  
Induced Neural Stem Cells

Abstract INTRODUCTION Non-small cell lung cancer (NSCLC) is the most common cancer to form brain metastases. Radiation treatment is standard-of-care, but recurrence is still observed in 40% of patients. An adjuvant treatment is desperately needed to track down and kill tumor remnants after radiation. Tumoritropic neural stem cells (NSCs) that can home to and deliver a cytotoxic payload offer potential as such an adjuvant treatment. Here we show the transdifferentiation of human fibroblasts into tumor-homing induced neural stem cells (hiNSCs) that secrete the cytotoxic protein TRAIL (hiNSC-TRAIL) and explore the use of hiNSC-TRAIL to treat NSCLC brain metastases. METHODS To determine the migratory capacity of hiNSCs, hiNSCs were infused intracerebroventricularly (ICV) into mice bearing established bilateral NSCLC H460 brain tumors. hiNSC accumulation at tumor foci was monitored using bioluminescent imaging and post-mortem fluorescent analysis. To determine synergistic effects of radiation with TRAIL on NSCLC, we performed in vitro co-culture assays and isobologram analysis. In vivo, efficacy was determined by tracking the progression and survival of mice bearing intracranial H460 treated with hiNSC-TRAIL alone or in combination with 2 Gy radiation. RESULTS/CONCLUSION Following ICV infusion, hiNSCs persisted in the brain for > 1 week and migrated from the ventricles to colocalize with bilateral tumor foci. In vitro, viability assays and isobologram analysis revealed the combination treatment of hiNSC-TRAIL and 2 Gy radiation induced synergistic killing (combination index=0.64). In vivo, hiNSC-TRAIL/radiation combination therapy reduced tumor volumes > 90% compared to control-treated animals while radiation-only and hiNSC-TRAIL-only treated mice showed 21% and 52% reduced volumes, respectively. Dual-treatment extended survival 40%, increasing survival from a median of 20 days in controls to 28 days in the treatment group. These results suggest hiNSC-TRAIL can improve radiation therapy for NSCLC brain metastases and could potentially improve outcomes for patients suffering from this aggressive form of cancer.

Transforming Historical Objectivism into Historical Hermeneutics: From “Historical Illness” to Properly Lived Historicality

2019 ◽  
Vol 61 (4) ◽  
pp. 490-515
Author(s):  
Thomas Tops
Keyword(s):  
Reception History ◽  
Biblical Studies ◽  
Historical Study ◽  
Necessary Condition ◽  
New Paradigm ◽  
History Of Interpretation ◽  
Critical Methodology ◽  
Recent Developments ◽  
History Of ◽  
Biblical Texts

Summary The present study analyses recent criticisms against the use of modern-historical methodologies in Biblical Studies. These methodologies abstract from the historical horizon of the researcher. In order to relate properly to the historicality of the researcher, historical objectivism needs to be transformed into historical hermeneutics. Recent developments in the historical methodology of biblical scholars are unable to reckon with the historicality of the researcher due to the partial or incorrect implementation of Gadamer’s views on reception history. I analyse the views of Nietzsche, Kierkegaard, and Gadamer on historicality and contend that the study of reception history is a necessary condition for conducting historical study from within the limits of our historicality. Reception history should not be a distinct methodological step to study the “Nachleben” of biblical texts, but needs to clarify how the understanding of these texts is already effected by their history of interpretation. The awareness of the presuppositions that have guided previous interpretations of biblical texts enables us to be confronted by their alterity. This confrontation calls for a synthesis between reception-historical and historical-critical methodology that introduces a new paradigm for conducting historical study in Biblical Studies in dialogue with other theological disciplines.

scholarly journals A Review of the Pathogenesis of Osteoarthritis and the Use of Intra-articular Platelet Therapy for Joint Disease in Animals and Humans

2014 ◽  
Vol 5 ◽  
pp. BTRI.S14578 ◽  
Author(s):  
Girolamo A. Ortolano ◽  
Barry Wenz
Keyword(s):  
Health Care ◽  
Stem Cells ◽  
Surgical Intervention ◽  
Domestic Animals ◽  
Medical Intervention ◽  
Joint Disease ◽  
Therapeutic Approaches ◽  
Disease Modifying ◽  
Care Costs ◽  
Clinical Problems

Osteoarthritis (OA) is the most prevalent musculoskeletal disease in humans and domestic animals. It causes significant clinical problems and substantial health care costs. In the absence of disease-modifying medical intervention, therapy is currently restricted to palliative measures prior to surgical intervention. We review the pathogenesis, as well as conservative and emerging restorative therapeutic approaches, including cytokines, stem cells, and platelets. The various methods of platelet concentrate preparations and their reported outcomes are discussed. Data collected from the use of intra-articular platelet therapy (IAPT) in dogs are reviewed, which suggest that this approach may delay or in some cases even obviate the need for surgical intervention.

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