scholarly journals Reporting on the Role of miRNAs and Affected Pathways on the Molecular Backbone of Ovarian Insufficiency: A Systematic Review and Critical Analysis Mapping of Future Research

2021 ◽  
Vol 8 ◽  
Author(s):  
Anna Rapani ◽  
Dimitra Nikiforaki ◽  
Dimitra Karagkouni ◽  
Konstantinos Sfakianoudis ◽  
Petroula Tsioulou ◽  
...  
Keyword(s):  
Critical Analysis ◽  
Common Ground ◽  
Gene Expression Regulation ◽  
Individualized Medicine ◽  
Gene Set Enrichment Analysis ◽  
Future Research ◽  
Common Denominator ◽  
Ovarian Insufficiency ◽  
The Common

Ovarian insufficiency is identified as a perplexing entity in the long list of pathologies impairing fertility dynamics. The three distinct classifications of ovarian insufficiency are poor ovarian response, premature ovarian insufficiency/failure, and advanced maternal age, sharing the common denominator of deteriorated ovarian reserve. Despite efforts to define clear lines among the three, the vast heterogeneity and overlap of clinical characteristics renders their diagnosis and management challenging. Lack of a consensus has prompted an empirically based management coupled by uncertainty from the clinicians’ perspective. Profiling of patients in the era of precision medicine seems to be the way forward, while the necessity for a novel approach is underlined. Implicating miRNAs in the quest for patient profiling is promising in light of their fundamental role in cellular and gene expression regulation. To this end, the current study sets out to explore and compare the three pathophysiologies—from a molecular point of view—in order to enable profiling of patients in the context of in vitro fertilization treatment and enrich the data required to practice individualized medicine. Following a systematic investigation of literature, data referring to miRNAs were collected for each patient category based on five included studies. miRNA–target pairs were retrieved from the DIANA-TarBase repository and microT-CDS. Gene and miRNA annotations were derived from Ensembl and miRbase. A subsequent gene-set enrichment analysis of miRNA targets was performed for each category separately. A literature review on the most crucial of the detected pathways was performed to reveal their relevance to fertility deterioration. Results supported that all three pathophysiologies share a common ground regarding the affected pathways, naturally attributed to the common denominator of ovarian insufficiency. As evidenced, miRNAs could be employed to explore the fine lines and diverse nature of pathophysiology since they constitute invaluable biomarkers. Interestingly, it is the differentiation through miRNAs and not through the molecular affected pathways that corresponds to the three distinctive categories. Alarming discrepancies among publications were revealed, pertaining to employment of empirical and arbitrary criteria in categorizing the patients. Following bioinformatic analysis, the final step of the current study consisted of a critical analysis of the molecular data sourced, providing a clear and unique insight into the physiological mechanisms involved. It is our intention to contribute to mapping future research dedicated to ovarian insufficiency and to help researchers navigate the overwhelming information published in molecular studies.

Positive Psychology Competences of Pre-School Teachers as a Tool for Understanding and Nurturing Children's Play

2017 ◽  
pp. 134-152 ◽  
Author(s):  
Sanja Tatalović Vorkapić ◽  
Petra Prović
Keyword(s):  
Positive Psychology ◽  
Natural Environment ◽  
Common Ground ◽  
Preschool Teachers ◽  
Future Research ◽  
Basic Principles ◽  
Children's Play ◽  
Research And Practice ◽  
Children’S Play ◽  
The Common

The Positive Psychology frame and definition present a natural environment for understanding and researching children's play in the context of nurturing overall positive characteristics in children's development. Therefore, this article presents a structured review of the common ground between the basic principles of positive psychology and children's play in the context of early and preschool institutions. Also, it demonstrates the implementation of positive psychology principles in children's play and the methods by which positive psychology could be promoted through children's play in kindergartens. Within that frame, the importance is given to the needed preschool teachers' competences in this area. In this context, various activities are presented that reflect a common ground of positive psychology and children's play. Finally, some significant guidelines for future research and practice enhancement are presented.

scholarly journals Epigenetic Regulations of AhR in the Aspect of Immunomodulation

2020 ◽  
Vol 21 (17) ◽  
pp. 6404
Author(s):  
Anna Wajda ◽  
Joanna Łapczuk-Romańska ◽  
Agnieszka Paradowska-Gorycka
Keyword(s):  
Autoimmune Disease ◽  
Environmental Factors ◽  
Common Ground ◽  
Future Research ◽  
Disease Manifestation ◽  
Genetic Changes ◽  
Immunological Responses ◽  
Autoimmune Antibodies ◽  
Physiological Processes ◽  
The Common

Environmental factors contribute to autoimmune disease manifestation, and as regarded today, AhR has become an important factor in studies of immunomodulation. Besides immunological aspects, AhR also plays a role in pharmacological, toxicological and many other physiological processes such as adaptive metabolism. In recent years, epigenetic mechanisms have provided new insight into gene regulation and reveal a new contribution to autoimmune disease pathogenesis. DNA methylation, histone modifications, chromatin alterations, microRNA and consequently non-genetic changes in phenotypes connect with environmental factors. Increasing data reveals AhR cross-roads with the most significant in immunology pathways. Although study on epigenetic modulations in autoimmune diseases is still not well understood, therefore future research will help us understand their pathophysiology and help to find new therapeutic strategies. Present literature review sheds the light on the common ground between remodeling chromatin compounds and autoimmune antibodies used in diagnostics. In the proposed review we summarize recent findings that describe epigenetic factors which regulate AhR activity and impact diverse immunological responses and pathological changes.

scholarly journals Eye pupil signals information gain

2019 ◽  
Author(s):  
Alexandre Zénon
Keyword(s):  
Information Gain ◽  
Stimulus Presentation ◽  
Mental Effort ◽  
Pupillary Response ◽  
Future Research ◽  
Common Denominator ◽  
Large Set ◽  
Pupillary Dilation ◽  
Information Theoretic ◽  
The Common

In conditions of constant illumination, the eye pupil diameter indexes the modulation of arousal state and responds to a large breadth of cognitive processes, including mental effort, attention, surprise, decision processes, decision biases, value beliefs, uncertainty, volatility, exploitation/exploration trade-off or learning rate. Here, I propose an information theoretic framework that has the potential to explain the ensemble of these findings as reflecting pupillary response to information processing. In short, updates of brain internal model, quantified formally as the Kullback-Leibler (KL) divergence between prior and posterior beliefs, are the common denominator to all these instances of pupillary dilation to cognition. I show that stimulus presentation leads to pupillary response that is proportional to the amount of information the stimulus carries about itself and to the quantity of information it provides about other task variables. In the context of decision making, pupil dilation in relation to uncertainty is explained by the wandering of the evidence accumulation process, leading to large summed KL divergences. Finally, pupillary response to mental effort and variations in tonic pupil size are also formalized in terms of information theory. On the basis of this framework, I compare pupillary data from past studies to simple information theoretic simulations of task designs and show good correspondance with data across studies. The present framework has the potential to unify the large set of results reported on pupillary dilation to cognition and to provide a theory to guide future research.

Positive Psychology Competences of Pre-School Teachers as a Tool for Understanding and Nurturing Children's Play

2021 ◽  
pp. 498-516
Author(s):  
Sanja Tatalović Vorkapić ◽  
Petra Prović
Keyword(s):  
Positive Psychology ◽  
Natural Environment ◽  
Common Ground ◽  
Preschool Teachers ◽  
Future Research ◽  
Basic Principles ◽  
Children's Play ◽  
Research And Practice ◽  
Children’S Play ◽  
The Common

The Positive Psychology frame and definition present a natural environment for understanding and researching children's play in the context of nurturing overall positive characteristics in children's development. Therefore, this article presents a structured review of the common ground between the basic principles of positive psychology and children's play in the context of early and preschool institutions. Also, it demonstrates the implementation of positive psychology principles in children's play and the methods by which positive psychology could be promoted through children's play in kindergartens. Within that frame, the importance is given to the needed preschool teachers' competences in this area. In this context, various activities are presented that reflect a common ground of positive psychology and children's play. Finally, some significant guidelines for future research and practice enhancement are presented.

The Common Ground of Wesley and Edwards

1990 ◽  
Vol 83 (3) ◽  
pp. 271-303 ◽  
Author(s):  
Richard E. Brantley
Keyword(s):  
Common Ground ◽  
Jonathan Edwards ◽  
Philosophical Theology ◽  
Great Awakening ◽  
Common Denominator ◽  
John Wesley ◽  
Direct Impact ◽  
The World ◽  
The Common ◽  
Religious Morality

Although evangelicalism is “spiritual” and empiricism is “natural,” the great principle of empiricism, that one must see for oneself and be in the presence of the thing one knows, applies as well to evangelical faith. Each of these two methodologies operates along a continuum that joins emotion to intellect; each joins externality to words through “ideas/ideals of sensation,” that is, through either perception or grace-in-perception or both. While empiricism refers to immediate contact with and direct impact from objects and subjects in time and place, evangelicalism entertains the notions that religious truth is concerned with experiential presuppositions and that experience need not be nonreligious. On the basis of the experiential common denominator between empiricism and evangelicalism, through the “both/and” logic of philosophical theology, I argue that John Wesley (1703–91), founder of British Methodism, and Jonathan Edwards (1703–58), leader of the American Great Awakening, theologize empiricism. They ground transcendentalism in the world, balance religious myths and religious morality with scientific reverence for fact and detail, and ally empirical assumptions with “disciplined” spirit. Above all, they share the simultaneously rational and sensationalist reliance on experience as the avenue to both natural and spiritual knowledge.

scholarly journals Eye pupil signals information gain

2019 ◽  
Vol 286 (1911) ◽  
pp. 20191593 ◽  
Author(s):  
Alexandre Zénon
Keyword(s):  
Information Gain ◽  
Stimulus Presentation ◽  
Mental Effort ◽  
Pupillary Response ◽  
Future Research ◽  
Common Denominator ◽  
Large Set ◽  
Pupillary Dilation ◽  
Information Theoretic ◽  
The Common

In conditions of constant illumination, the eye pupil diameter indexes the modulation of arousal state and responds to a large breadth of cognitive processes, including mental effort, attention, surprise, decision processes, decision biases, value beliefs, uncertainty, volatility, exploitation/exploration trade-off, or learning rate. Here, I propose an information theoretic framework that has the potential to explain the ensemble of these findings as reflecting pupillary response to information processing. In short, updates of the brain’s internal model, quantified formally as the Kullback–Leibler (KL) divergence between prior and posterior beliefs, would be the common denominator to all these instances of pupillary dilation to cognition. I show that stimulus presentation leads to pupillary response that is proportional to the amount of information the stimulus carries about itself and to the quantity of information it provides about other task variables. In the context of decision making, pupil dilation in relation to uncertainty is explained by the wandering of the evidence accumulation process, leading to large summed KL divergences. Finally, pupillary response to mental effort and variations in tonic pupil size are also formalized in terms of information theory. On the basis of this framework, I compare pupillary data from past studies to simple information-theoretic simulations of task designs and show good correspondance with data across studies. The present framework has the potential to unify the large set of results reported on pupillary dilation to cognition and to provide a theory to guide future research.

scholarly journals Formins in Human Disease

Cells ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 2554
Author(s):  
Leticia Labat-de-Hoz ◽  
Miguel A. Alonso
Keyword(s):  
Nervous System ◽  
Hearing Loss ◽  
Primary Ovarian Insufficiency ◽  
Future Research ◽  
Ovarian Insufficiency ◽  
Developmental Defects ◽  
Monogenic Disorders ◽  
Pathological Conditions ◽  
Human Disorders

Almost 25 years have passed since a mutation of a formin gene, DIAPH1, was identified as being responsible for a human inherited disorder: a form of sensorineural hearing loss. Since then, our knowledge of the links between formins and disease has deepened considerably. Mutations of DIAPH1 and six other formin genes (DAAM2, DIAPH2, DIAPH3, FMN2, INF2 and FHOD3) have been identified as the genetic cause of a variety of inherited human disorders, including intellectual disability, renal disease, peripheral neuropathy, thrombocytopenia, primary ovarian insufficiency, hearing loss and cardiomyopathy. In addition, alterations in formin genes have been associated with a variety of pathological conditions, including developmental defects affecting the heart, nervous system and kidney, aging-related diseases, and cancer. This review summarizes the most recent discoveries about the involvement of formin alterations in monogenic disorders and other human pathological conditions, especially cancer, with which they have been associated. In vitro results and experiments in modified animal models are discussed. Finally, we outline the directions for future research in this field.

scholarly journals USE OF RHETORIC IN MULTI-LEVEL MARKETING

2021 ◽  
pp. 170-173
Author(s):  
Abel T. Gumaran ◽  
Danna Karyl Jane C. Talde
Keyword(s):  
Critical Analysis ◽  
Common Ground ◽  
Qualitative Design ◽  
Shared Interest ◽  
Frequency Identification ◽  
The Common ◽  
Frequency Source ◽  
Multi Level ◽  
Identification Strategy ◽  
Descriptive Qualitative

This study aimed to analyze how identification worked as a key to persuasion among agents in Frontrow Enterprise, an MLM company. Specifically, it sought to find the prevalent source of identification, identification strategy used by the Frontrow agents in their speeches, and their level of persuasion. This study employed descriptive-qualitative design which utilized critical analysis using the Theory of Identification and Consubstantiality. Results show that the highest frequency source of identification found in the speeches is the idealistic identification and the highest frequency identification strategy is the common ground. Based on the findings of the study, it can be concluded that persuasion is manifested using shared interest, attitude, perceptions, values, beliefs, and ideas through establishing common grounds with the audience. KEYWORDS: Multi-level Marketing, Identification and Consubstantiality, Level of Persuasion, Agents’ Speeches, Sources of Identification, Identification Strategies

Lexical Typology in Morphology

2020 ◽  
Author(s):  
Maria Koptjevskaja-Tamm ◽  
Ljuba N. Veselinova
Keyword(s):  
Common Ground ◽  
Word Formation ◽  
Future Research ◽  
Critical Examination ◽  
Systematic Exploration ◽  
The Common ◽  
Research Questions ◽  
Lexical Items ◽  
Linguistic Units ◽  
Working Out

The goal of this chapter is to explicate the common ground and shared pursuits of lexical typology and morphology. Bringing those to the fore is beneficial to the scholarship of both disciplines and will allow their methodologies to be combined in more fruitful ways. In fact, such explication also opens up a whole new domain of study. This overview article focuses on a set of important research questions common to both lexical typology and morphology. Specifically, it considers vocabulary structure in human languages, cross-linguistic research on morphological analysis and word formation, and finally inventories of very complex lexical items. After a critical examination of the pertinent literature, some directions for future research are suggested. Some of them include working out methodologies for more systematic exploration of vocabulary structure and further scrutiny of how languages package and distribute semantic material among linguistic units. Finally, more effort is to be devoted to the study of vocabularies where basic concepts are encoded by complex lexical items.

scholarly journals A speaker-oriented multidimensional approach to risks and causes of miscommunication

2012 ◽  
Vol 2 (2) ◽  
pp. 216-243 ◽  
Author(s):  
Arto Mustajoki
Keyword(s):  
Common Ground ◽  
Physiological State ◽  
Cognitive Effort ◽  
Common Denominator ◽  
Multidimensional Approach ◽  
Multidimensional Model ◽  
Research Directions ◽  
The Common ◽  
Physical Defects ◽  
Mental Worlds

Combining ideas from different research directions and fields, the paper presents a multidimensional model of communication which enables to explain the risks of communication more comprehensively than before. The process of producing and interpreting speech is described through a message transfer circle. The model also includes the mental worlds of the speaker and the recipient, which substantially influence interaction. In addition, special attention is paid to recipient design, which plays a crucial role in interaction. One may even argue that such frequently mentioned factors as misreference or ambiguity are not causes of miscommunication but only risks for it; the real cause of miscommunication is incomplete recipient design. The common denominator is the egocentrism of the speaker: avoidance of cognitive effort, common ground fallacy, emotional overdrive, obstacles caused by physiological state or physical defects, and attaching greater importance to other things at the expense of recipient design.

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