scholarly journals Open Characterization of Vaping Liquids in Canada: Chemical Profiles and Trends

2021 ◽  
Vol 9 ◽  
Author(s):  
Ivana Kosarac ◽  
Cariton Kubwabo ◽  
Xinghua Fan ◽  
Shabana Siddique ◽  
Dora Petraccone ◽  
...  

Currently, there is a lack of comprehensive data on the diversity of chemicals present in vaping liquids. To address this gap, a non-targeted analysis of 825 vaping liquids collected between 2017 and 2019 from Canadian retailers was conducted. Prior to mass spectrometry analysis, samples were diluted 1:500 v/v with methanol or acetonitrile. Chemical compound separation and analysis was carried out using gas chromatography and triple quadrupole mass spectrometry (GC-MS/MS) systems operated in the full scan mode and mass range of 35–450 m/z. Mass spectrum for each sample was obtained in electron ionization at 70 eV and processed. Non-targeted identification workflow included use of automated mass spectral deconvolution and identification system (AMDIS), where required, as well as a number of commercially available spectral libraries. In order to validate identities, an in-house database of expected compounds previously detected in vaping liquids was used along with genuine analytical standards for compounds of interest. This resulted in a dataset of over 1,500 unique detected chemicals. Approximately half of these chemical compounds were detected only once in a single product and not in multiple products analyzed. For any sample analyzed, on average, 40% of the chemical constituents appeared to have flavouring properties. The remainder were nicotine and related alkaloids, processing, degradation or indirect additives, natural extractives and compounds with unknown roles. Data published here from the project on the Open Characterization of vaping liquids is unique as it offers a detailed understanding of products’ flavour chemical profiles, the presence and frequency of chemicals of potential health concern, as well as trends and changes in products’ chemical complexity over a three-year period. Non-targeted chemical surveillance such as this present valuable tools to public health officials and researchers in responding to emergent issues such as vaping associated lung injury or informing chemical based strategies which may be aimed at addressing product safety or appeal.

Nanoscale ◽  
2017 ◽  
Vol 9 (46) ◽  
pp. 18359-18367 ◽  
Author(s):  
Han-Wei Chu ◽  
Ju-Yi Mao ◽  
Chia-Wen Lien ◽  
Pang-Hung Hsu ◽  
Yu-Jia Li ◽  
...  

Mass spectrometry analysis of pulse laser-induced fragmentation of carbon quantum dots allows characterization of the surface functional groups and carbon core with various heteroatom doping.


2015 ◽  
Vol 26 (8) ◽  
pp. 1299-1310 ◽  
Author(s):  
Roger Théberge ◽  
Sergei Dikler ◽  
Christian Heckendorf ◽  
David H. K. Chui ◽  
Catherine E. Costello ◽  
...  

2015 ◽  
Author(s):  
Kok-Gan Chan ◽  
Wen-Si Tan

Enterobacter cancerogenus strain M004 genome size is 5.67 Mb. Here, its luxI homologue, designated as ecnI which is ecnI gene (633 bp) was cloned and overexpressed. Its AHL synthesis activity was verified using the high-resolution liquid chromatography-mass spectrometry analysis revealed the production of N-(3-oxo-hexanoyl)-L-homoserine lactone (3-oxo-C6-HSL) and N-(3-oxo-hexanoyl)-L-homoserine lactone (3-oxo-C8-HSL). The cloning and characterization of luxI homologue of E. cancerogenus strain M004 was firstly reported here.


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