scholarly journals Cellular and Molecular Mechanism of Traditional Chinese Medicine on Ventricular Remodeling

2021 ◽  
Vol 8 ◽  
Author(s):  
Yong-Chun Zhu ◽  
Bo Liang ◽  
Ning Gu
Keyword(s):  
Immune System ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Molecular Mechanism ◽  
Clinical Application ◽  
Ventricular Remodeling ◽  
Herbal Medicines ◽  
Basic Research ◽  
Chinese Herbal ◽  
Signal Regulation

Ventricular remodeling is related to the renin-angiotensin-aldosterone system, immune system, and various cytokines involved in inflammation, apoptosis, and cell signal regulation. Accumulated studies have shown that traditional Chinese medicine can significantly inhibit the process of ventricular remodeling, which may be related to the mechanism mentioned above. Here, we conducted a system overview to critically review the cellular and molecular mechanism of traditional Chinese medicine on ventricular remodeling. We mainly searched PubMed for basic research about the anti-ventricular remodeling of traditional Chinese medicine in 5 recent years, and then objectively summarized these researches. We included more than 25 kinds of Chinese herbal medicines including Qi-Li-Qian-Xin, Qi-Shen-Yi-Qi Pill, Xin-Ji-Er-Kang Formula, and Yi-Qi-Wen-Yang Decoction, and found that they can inhibit ventricular remodeling effectively through multi-components and multi-action targets, which are promoting the clinical application of traditional Chinese medicine.

Treatment of Diabetes Using Traditional Chinese Medicine: Past, Present and Future

2012 ◽  
Vol 40 (05) ◽  
pp. 877-886 ◽  
Author(s):  
Xiao-Lin Tong ◽  
Liu Dong ◽  
Liang Chen ◽  
Zhong Zhen
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Herbal Medicines ◽  
Basic Research ◽  
Holistic Approach ◽  
Medical Problem ◽  
The Past ◽  
Chinese Herbal ◽  
Treatment Of Diabetes ◽  
Tcm Theory

Diabetes is a major medical problem that imperils public health. Over two thousand years ago, Traditional Chinese Medicine (TCM) called diabetes-related symptoms "Xiaoke" disease. In ancient China, TCM and Chinese herbal medicines were used widely in treating Xiaoke and abundant experience has been accumulated. This article discusses the TCM theory on diabetes and its achievements in the prevention and treatment of diabetes in the past. Using Chinese herbal medicine, recent progress in diabetes therapeutics, including data from clinical trials, are presented. Mechanistic studies from basic research are discussed. Yin-yang balance and a holistic approach of TCM may complement diabetes treatment in Western medicine. With continuous efforts, TCM could play a more important role in fighting this disease.

scholarly journals Therapeutic Effects and Molecular Mechanisms of Bioactive Compounds Against Respiratory Diseases: Traditional Chinese Medicine Theory and High-Frequency Use

2021 ◽  
Vol 12 ◽  
Author(s):  
Jing Wang ◽  
Qibiao Wu ◽  
Lu Ding ◽  
Siyu Song ◽  
Yaxin Li ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Clinical Application ◽  
Bioactive Compounds ◽  
High Frequency ◽  
Lung Diseases ◽  
Respiratory Diseases ◽  
Molecular Mechanisms ◽  
Therapeutic Effects ◽  
Chinese Herbal

Respiratory diseases, especially the pandemic of respiratory infectious diseases and refractory chronic lung diseases, remain a key clinical issue and research hot spot due to their high prevalence rates and poor prognosis. In this review, we aimed to summarize the recent advances in the therapeutic effects and molecular mechanisms of key common bioactive compounds from Chinese herbal medicine. Based on the theories of traditional Chinese medicine related to lung diseases, we searched several electronic databases to determine the high-frequency Chinese medicines in clinical application. The active compounds and metabolites from the selected medicines were identified using the Traditional Chinese Medicine Systems Pharmacology Database (TCMSP) by analyzing oral bioavailability and drug similarity index. Then, the pharmacological effects and molecular mechanisms of the selected bioactive compounds in the viral and bacterial infections, inflammation, acute lung injury (ALI), chronic obstructive pulmonary disease (COPD), pulmonary fibrosis, asthma, and lung cancer were summarized. We found that 31 bioactive compounds from the selected 10 common Chinese herbs, such as epigallocatechin-3-gallate (EGCG), kaempferol, isorhamnetin, quercetin, and β-sitosterol, can mainly regulate NF-κB, Nrf2/HO-1, NLRP3, TGF-β/Smad, MAPK, and PI3K/Akt/mTOR pathways to inhibit infection, inflammation, extracellular matrix deposition, and tumor growth in a series of lung-related diseases. This review provides novel perspectives on the preclinical study and clinical application of Chinese herbal medicines and their bioactive compounds against respiratory diseases.

scholarly journals Stability of Alkaloids during Drying Process and Their Effect on Anticoagulating Activity of Uncariae Ramulus Cum Uncis

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Lu Zou ◽  
Fengyu Lu ◽  
Bing Lin ◽  
Ying Zhou ◽  
Tingting Liu ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Constant Temperature ◽  
Herbal Medicines ◽  
Procoagulant Activity ◽  
Drying Process ◽  
Coagulation Time ◽  
Chinese Herbal Medicines ◽  
Chinese Herbal

The drying process of Uncariae Ramulus Cum Uncis (URCU), a kind of traditional Chinese medicine, was studied in a scale dryer in laboratory at 65°C. It was observed that the alkaloids content of URCU firstly showed a tendency of increasing and then decreasing after reaching the peak at the 570th minute in the process of constant temperature drying. Moreover, the coagulation time of rabbit determined by test tubes has been adopted to study the effect imposed by the content of alkaloids on the anticoagulating activity of URCU. In addition, the software of Minitab was also utilized to fit the correlation between the content of alkaloids and the anticoagulating activity of URCU. The results obtained demonstrated that anticoagulant activities were available in both rhynchophylline and isorhynchophylline, among which the latter was the stronger one, while procoagulant activity was shown in corynoxeine. The case study can provide a useful reference for the research on drying other Chinese herbal medicines (CHMs) and further study on URCU.

The Application of Virtual Simulation Technology in Chinese Herbal Medicine Teaching

2011 ◽  
Vol 271-273 ◽  
pp. 1688-1693
Author(s):  
Ou Tao ◽  
Yan Ling Zhang ◽  
Yun Wang ◽  
Yan Jiang Qiao
Keyword(s):  
Chinese Medicine ◽  
Herbal Medicine ◽  
Traditional Chinese Medicine ◽  
Herbal Medicines ◽  
Virtual Simulation ◽  
Simulation Technology ◽  
Chinese Herbal ◽  
Educational Engineering ◽  
Tcm Theory ◽  
Theory And Experiments

Virtual simulation technology plays an important role in educational engineering. The limitation of enough Chinese herbal medicines and instrument obscured the better understanding of Traditional Chinese Medicine (TCM). In this paper, the concept of virtual simulation technology and its application was outlined in the teaching of TCM theory and experiments. The superiority and insufficiency of this technology was also approached. The basic idea on building a virtual teaching and simulation platform for TCM was discussed, which may provide referred methods in the innovation of Chinese medicine teaching.

scholarly journals Use of Chinese medicine in the prevention and treatment of COVID-19 in China and Asia

2020 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Siukan Law ◽  
Chuanshan Xu ◽  
Albert Wingnang Leung
Keyword(s):  
Immune System ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Complementary Therapy ◽  
Syndrome Differentiation ◽  
Content Type ◽  
Patent Medicines ◽  
Chinese Herbal ◽  
Prevention And Treatment ◽  
The Usa

PurposeThe purpose of this paper is to describe and discuss the use of Chinese medicine in the prevention and treatment of coronavirus disease 2019 (COVID-19) in China and Asia.Design/methodology/approachThis paper provides a brief overview of the COVID-19. Based on the syndrome differentiation (辨證論治), the concept of clearing heat and detoxifying lung in traditional Chinese medicine is used to prevent and treat COVID-19 through restoring the vital qi (正氣) in human body and regulating the lung as well as spleen to strengthen the immune system. Traditional Chinese medicine has been used as a complementary therapy for the possible intervention of COVID-19 including traditional Chinese herbal decoctions, Chinese traditional patent medicines, acupuncture and moxibustion as well as the traditional health exercises in China and parts of Asia.FindingsTraditional Chinese medicine plays a significant role in the prevention and treatment of COVID-19 pandemic. The infection cases of China are around 80,000 and a steady decline compared with the USA which has 5,000,000 infection cases and continuous increases. It is shown that more than 90% of patients recovered after the treatment of traditional Chinese herbal decoctions and Chinese traditional patent medicines without any side-effect compared to the use of Remdesivir (GS-5734). Acupuncture (針灸) and moxibustion (艾灸) stimulate the immune and nervous systems for preventing infectious diseases. Taichi (太極) and Baduanjin (八段錦) as the auxiliary aerobic exercise under the theory of Chinese medicine can enhance the immune system and improve the lung function. Thus, an integration of traditional Chinese Medicine and Western medicine is the best strategy for the prevention, treatment and control of COVID-19 pandemic in the future.Originality/valueThis paper describes traditional Chinese medicine as an effective way for the prevention and treatment of COVID-19.

scholarly journals Interaction Between Chinese Medicine and Warfarin: Clinical and Research Update

2021 ◽  
Vol 12 ◽  
Author(s):  
Wei Zhuang ◽  
Shaoli Liu ◽  
Xusheng Zhao ◽  
Nan Sun ◽  
Tao He ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Literature Search ◽  
Herbal Medicines ◽  
Anticoagulant Effect ◽  
Therapeutic Window ◽  
Cochrane Library ◽  
Clinical Use ◽  
Chinese Herbal Medicines ◽  
Chinese Herbal

Background: Warfarin is a commonly used oral anticoagulant. It has a narrow therapeutic window and wide variation in individualized dosing, and is used clinically for the treatment of thromboembolic diseases. Due to the widespread use of traditional Chinese medicine (TCM) in China and the complex composition and diverse mechanisms of action of TCM, the combination of TCM and warfarin in patients has led to fluctuations in the international normalized ratio of warfarin or bleeding. To ensure rational clinical use, we summarize the TCMs with which warfarin interacts and the possible mechanisms, with a view to providing a clinical reference.Aim of the study: To summarize the mechanisms by which Chinese herbal medicines affect the enhancement or weakening of the anticoagulant effect of warfarin, to provide theoretical references for clinicians and pharmacists to use warfarin safely and rationally, and to avoid the adverse effects associated with the combination of Chinese herbal medicines and warfarin.Methods: A computerized literature search of electronic databases, including PubMed, MEDLINE, Cochrane Library, Web of Science (WOS), China National Knowledge Infrastructure (CNKI) and WANFANG Data was performed. Key words used in the literature search were “warfarin”, “Chinese medicine”, “traditional Chinese medicine”, “Chinese patent medicine” etc. and their combinations in a time limit from January 1, 1990 to May 1, 2021. A total of 64 articles were obtained following the selection process, including clinical reports, pharmacological experiments and in vitro experiments which were reviewed to determine the mechanism of the anticoagulant effect of herbal medicine on warfarin.Results: The mechanisms affecting the anticoagulant effect of warfarin are complex, and herbal medicines may enhance and diminish the anticoagulant effect of warfarin through a variety of mechanisms; thus, clinical use needs to be cautious. Some herbal medicines have shown inconsistent results in both in vivo and ex vivo experiments, pharmacology and clinical studies, and should be the focus of future research.Conclusion: With the widespread use of TCM, the combination of warfarin and TCM is more common. This article will promote clinicians’ knowledge and understanding of the TCMs which interact with warfarin, in order to avoid the occurrence of adverse clinical treatment processes, and improve the efficacy and safety.

scholarly journals TCMIP v2.0 Powers the Identification of Chemical Constituents Available in Xinglou Chengqi Decoction and the Exploration of Pharmacological Mechanisms Acting on Stroke Complicated With Tanre Fushi Syndrome

2021 ◽  
Vol 12 ◽  
Author(s):  
Ping Wang ◽  
Shuang Wang ◽  
Hong Chen ◽  
Xiaofang Deng ◽  
Luoqi Zhang ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Acute Stroke ◽  
Molecular Mechanism ◽  
Chemical Constituents ◽  
Basic Research ◽  
Chemical Components ◽  
Pathological State ◽  
Mrna Levels ◽  
Network Prediction

Xinglou Chengqi (XLCQ) decoction, composed of three botanical drugs and one inorganic drug, is used in clinics during the treatment of acute stroke complicated with Tanre Fushi (TRFS) syndrome in China. However, its active ingredients and the molecular mechanism have not been clarified. So, we aimed to preliminarily characterize its chemical constituents and investigate its pharmacological mechanisms using an integrative pharmacology strategy, including component analysis, network prediction, and experimental verification. We employed UPLC-QTOF-MS/MS to describe the chemical profile of XLCQ, Integrative Pharmacology-based Network Computational Research Platform of Traditional Chinese Medicine (TCMIP v2.0, http://www.tcmip.cn/), to assist in identifying the chemical components and predict the putative molecular mechanism against acute stroke complicated with TRFS, and LPS-stimulated BV-2 cells to verify the anti-neuroinflammatory effects of luteolin, apigenin, and chrysoeriol. Altogether, 197 chemical compounds were identified or tentatively characterized in the water extraction of XLCQ, 22 of them were selected as the key active constituents that may improve the pathological state by regulating 27 corresponding targets that are mainly involved in inflammation/immune-related pathways, and furthermore, luteolin, apigenin, and chrysoeriol exhibited good anti-neuroinflammatory effects from both protein and mRNA levels. In summary, it is the first time to employ an integrative pharmacology strategy to delineate 22 constituents that may improve the pathological state of stroke with TRFS by regulating 27 corresponding targets, which may offer a highly efficient way to mine the scientific connotation of traditional Chinese medicine prescriptions. This study might be a supplement for the deficiency of the basic research of XLCQ.

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