scholarly journals TCMIP v2.0 Powers the Identification of Chemical Constituents Available in Xinglou Chengqi Decoction and the Exploration of Pharmacological Mechanisms Acting on Stroke Complicated With Tanre Fushi Syndrome

2021 ◽  
Vol 12 ◽  
Author(s):  
Ping Wang ◽  
Shuang Wang ◽  
Hong Chen ◽  
Xiaofang Deng ◽  
Luoqi Zhang ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Acute Stroke ◽  
Molecular Mechanism ◽  
Chemical Constituents ◽  
Basic Research ◽  
Chemical Components ◽  
Pathological State ◽  
Mrna Levels ◽  
Network Prediction

Xinglou Chengqi (XLCQ) decoction, composed of three botanical drugs and one inorganic drug, is used in clinics during the treatment of acute stroke complicated with Tanre Fushi (TRFS) syndrome in China. However, its active ingredients and the molecular mechanism have not been clarified. So, we aimed to preliminarily characterize its chemical constituents and investigate its pharmacological mechanisms using an integrative pharmacology strategy, including component analysis, network prediction, and experimental verification. We employed UPLC-QTOF-MS/MS to describe the chemical profile of XLCQ, Integrative Pharmacology-based Network Computational Research Platform of Traditional Chinese Medicine (TCMIP v2.0, http://www.tcmip.cn/), to assist in identifying the chemical components and predict the putative molecular mechanism against acute stroke complicated with TRFS, and LPS-stimulated BV-2 cells to verify the anti-neuroinflammatory effects of luteolin, apigenin, and chrysoeriol. Altogether, 197 chemical compounds were identified or tentatively characterized in the water extraction of XLCQ, 22 of them were selected as the key active constituents that may improve the pathological state by regulating 27 corresponding targets that are mainly involved in inflammation/immune-related pathways, and furthermore, luteolin, apigenin, and chrysoeriol exhibited good anti-neuroinflammatory effects from both protein and mRNA levels. In summary, it is the first time to employ an integrative pharmacology strategy to delineate 22 constituents that may improve the pathological state of stroke with TRFS by regulating 27 corresponding targets, which may offer a highly efficient way to mine the scientific connotation of traditional Chinese medicine prescriptions. This study might be a supplement for the deficiency of the basic research of XLCQ.

Phytochemistry and Pharmacology of the Genus Pedicularis Used in Traditional Chinese Medicine

2014 ◽  
Vol 42 (05) ◽  
pp. 1071-1098 ◽  
Author(s):  
Mao-Xing Li ◽  
Xi-Rui He ◽  
Rui Tao ◽  
Xinyuan Cao
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Chemical Constituents ◽  
Iridoid Glycosides ◽  
In Vivo Studies ◽  
Chemical Components ◽  
Wide Range ◽  
Phenylpropanoid Glycosides

In the present review, the literature data on the chemical constituents and biological investigations of the genus Pedicularis are summarized. Some species of Pedicularis have been widely applied in traditional Chinese medicine. A wide range of chemical components including iridoid glycosides, phenylpropanoid glycosides (PhGs), lignans glycosides, flavonoids, alkaloids and other compounds have been isolated and identified from the genus Pedicularis. In vitro and in vivo studies indicated some monomer compounds and extracts from the genus Pedicularis have been found to possess antitumor, hepatoprotective, anti-oxidative, antihaemolysis, antibacterial activity, fatigue relief of skeletal muscle, nootropic effect and other activities.

Pharmacological Effects and Chemical Constituents of Bupleurum

2018 ◽  
Vol 19 (1) ◽  
pp. 34-55 ◽  
Author(s):  
Peng Sun ◽  
Yijie Li ◽  
Sheng Wei ◽  
Tingting Zhao ◽  
Yang Wang ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Chemical Constituents ◽  
Healthy Food ◽  
Chemical Components ◽  
Pharmacological Effects ◽  
Volatile Oils ◽  
Triterpenoid Saponins ◽  
Recent Increase ◽  
Radix Bupleuri

Radix Bupleuri has been used in traditional Chinese medicine for thousands of years, with confirmed curative effects. This plant is also used in healthy food and cosmetics. A recent increase in studies of Radix Bupleuri’s chemical constituents (mainly comprising flavonoids, lignins, phenyl propanol derivatives, triterpenoid saponins, and volatile oils) and pharmacological effects motivates the aim of the present study: to review the chemical components and pharmacological effects of Radix Bupleuri. Our review found that Radix Bupleuri exhibits diverse pharmacological effects. More than 281 components have been isolated from Radix Bupleuri, including 15 flavonoids, 430 lignins, 12 phenyl propanol derivatives, 66 triterpenoid saponins, and 158 volatile oils.

scholarly journals Research Progress on Chemical Constituents ofLonicerae japonicae flos

2016 ◽  
Vol 2016 ◽  
pp. 1-18 ◽  
Author(s):  
Lingna Wang ◽  
Qiu Jiang ◽  
Jinghong Hu ◽  
Yongqing Zhang ◽  
Jia Li
Keyword(s):  
Systematic Review ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Organic Acids ◽  
Chemical Constituents ◽  
Healthy Food ◽  
Research Progress ◽  
Chemical Components ◽  
Volatile Oils ◽  
Specific Activities

Lonicerae japonicae flosis commonly used in traditional Chinese medicine for thousands of years with confirmed curative effects. Except for medicine, it is also used in healthy food, cosmetics, and soft beverages for its specific activities. Therefore, the chemical constituents, mainly including organic acids, flavonoids, iridoids, triterpenoids, and volatile oils, have been well studied by many scholars in recent years and a comprehensive and systematic review on chemical constituents ofLonicerae japonicae flosis indispensable. This paper aims at reviewing the chemical components of LJF in recent years through searching for the literatures both at home and abroad. Our results show that 212 components have been isolated fromLonicerae japonicae flos, including 27 flavonoids, 40 organic acids, 83 iridoids, 17 triterpenoids, and 45 other compounds, which could lay a foundation for the further application ofLonicerae japonicae flos.

scholarly journals Cellular and Molecular Mechanism of Traditional Chinese Medicine on Ventricular Remodeling

2021 ◽  
Vol 8 ◽  
Author(s):  
Yong-Chun Zhu ◽  
Bo Liang ◽  
Ning Gu
Keyword(s):  
Immune System ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Molecular Mechanism ◽  
Clinical Application ◽  
Ventricular Remodeling ◽  
Herbal Medicines ◽  
Basic Research ◽  
Chinese Herbal ◽  
Signal Regulation

Ventricular remodeling is related to the renin-angiotensin-aldosterone system, immune system, and various cytokines involved in inflammation, apoptosis, and cell signal regulation. Accumulated studies have shown that traditional Chinese medicine can significantly inhibit the process of ventricular remodeling, which may be related to the mechanism mentioned above. Here, we conducted a system overview to critically review the cellular and molecular mechanism of traditional Chinese medicine on ventricular remodeling. We mainly searched PubMed for basic research about the anti-ventricular remodeling of traditional Chinese medicine in 5 recent years, and then objectively summarized these researches. We included more than 25 kinds of Chinese herbal medicines including Qi-Li-Qian-Xin, Qi-Shen-Yi-Qi Pill, Xin-Ji-Er-Kang Formula, and Yi-Qi-Wen-Yang Decoction, and found that they can inhibit ventricular remodeling effectively through multi-components and multi-action targets, which are promoting the clinical application of traditional Chinese medicine.

Phytochemistry, Pharmacological Activities, Toxicity and Clinical Application of Momordica cochinchinensis

2019 ◽  
Vol 25 (6) ◽  
pp. 715-728 ◽  
Author(s):  
Hai-Yue Lan ◽  
Bin Zhao ◽  
Yu-Li Shen ◽  
Xiao-Qin Li ◽  
Su-Juan Wang ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Southeast Asia ◽  
Clinical Application ◽  
Chemical Constituents ◽  
Folk Medicine ◽  
Pharmacological Activities ◽  
Pharmacological Studies ◽  
Momordica Cochinchinensis

Momordica cochinchinensis (Lour.) Spreng (M. cochinchinensis) is a deciduous vine that grows in Southeast Asia. It is known as gac in Vietnam and as Red Melon in English. Gac is reputed to be extremely benificial for health and has been widely used as food and folk medicine in Southeast Asia. In China, the seed of M. cochinchinensis (Chinese name: Mu biezi) is used as traditional Chinese medicine (TCM) for the treatment of various diseases. More than 60 chemical constituents have been isolated from M. cochinchinensis. Modern pharmacological studies and clinical practice demonstrate that some chemical constituents of M. cochinchinensis possess wide pharmacological activities, such as anti-tumor, anti-oxidation, anti-inflammatory, etc. This paper reviews the phytochemistry, pharmacological activities, toxicity, and clinical application of M. cochinchinensis, aiming to bring new insights into further research and application of this ancient herb.

scholarly journals Theoretical Study of the anti-NCP Molecular Mechanism of Traditional Chinese Medicine Lianhua-Qingwen Formula (LQF)

2020 ◽  
Author(s):  
Chenghao Ye ◽  
Meina Gao ◽  
Wangqiang Lin ◽  
Kunqian Yu ◽  
Peng Li ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Molecular Mechanism ◽  
Hydrophobic Interactions ◽  
Killer Cell ◽  
Cell Receptor ◽  
The United States ◽  
Mapk Signaling ◽  
Binding Modes ◽  
Pathway Network

<div>Due to the good clinical efficacy in treating Novel Coronavirus Pneumonia (NCP) resulted from </div><div> </div><div>SARS-CoV-2, as the traditional Chinese medicine(TCM) prescription, Lianhua Qingwen Formula </div><div>(LQF) was composed into the Diagnosis and Treatment Programs of 2019 New Coronavirus<br></div><div> </div><div>Pneumonia (from fourth to seventh editions) formulated by the National Health Commission of China. </div><div> </div><div>Aiming to prevent and treat viral influenza, LQF was patented from 2003 in China, and passed the </div><div> </div><div>Phase II clinical trial by FDA in the United States in 2015. However, the molecular mechanism of LQF </div><div> </div><div>anti SARS-CoV-2 pneumonia is still not clear. It is shown that the docking scores of three components </div><div> </div><div>in LQF including Rutin, Forsythoside E, and Hyperoside to main protease of SARS-CoV-2 are very </div><div>large as -9.1, -9.0 and -8.7 kcal/mol, respectively, which are even better than those of Lopinavir at -7.3<br></div><div> </div><div>kcal/mol. Importantly, the binding modes between active compounds and protein were verified via </div><div> </div><div>molecular dynamics (MD) simulation and calculation all the binding free energies at MM-PBSA level. </div><div> </div><div>Note that these donor-acceptor systems were stabilized by non-polar interactions including hydrogen </div><div> </div><div>bonds and hydrophobic interactions. At last, from the constructed component-target-pathway network, </div><div> </div><div>it is shown that the components in LQF are related important pathways to improve the human immunity </div><div> </div><div>such as T cell, B cell receptor signaling, natural killer cell mediated cytotoxicity, as well as anti</div><div> </div><div>inflammatory pathways including Fc epsilon RI, ErbB, MAPK signaling and so on. The present </div><div> </div><div>investigation represents the first report on the molecular mechanism of LQF as NCP inhibitor</div>

scholarly journals Observations of TCRVβGene Expression in Rats with Dampness Syndrome

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Yan Chen ◽  
Bao-Guo Sun ◽  
Shi-Jun Zhang ◽  
Ze-Xiong Chen ◽  
Carlini Fan Hardi ◽  
...  
Keyword(s):  
T Cell ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Molecular Mechanism ◽  
Human Body ◽  
Humid Environment ◽  
Pathogenic Factors ◽  
Immunological Recognition ◽  
Recognition Function ◽  
Human Immune

Environmental dampness is one factor which can cause human diseases. The effects of exposure to humidity on human immune function are diverse and numerous. In the theory of traditional Chinese medicine (TCM), dampness is defined as one of the major pathogenic factors in the human body. It is divided into “external dampness” and “internal dampness.” However the molecular mechanism leading to humidity-induced immunosuppression is obscure. In the present study, we investigated the expression of the T-cell antigen receptor variableβ(TCRVβ) subfamilies in rats which were fed in different humid environment. And the expression levels of the TCRVβsubfamilies were detected using FQ-PCR. We found that the dampness might reduce the immunological recognition function of rats. And the obstruction of the immunological recognition function might be caused by internal dampness rather than external dampness.

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