scholarly journals A Modified Surgical Ventricular Reconstruction in Post-infarction Mice Persistently Alleviates Heart Failure and Improves Cardiac Regeneration

2021 ◽  
Vol 8 ◽  
Author(s):  
Siyuan Ma ◽  
Junyu Yan ◽  
Dexuan Yang ◽  
Wangjun Liao ◽  
Jianping Bin ◽  
...  
Keyword(s):  
Heart Failure ◽  
Heart Function ◽  
Myocardial Strain ◽  
Cardiac Regeneration ◽  
Heart Weight ◽  
Control Group ◽  
Long Term Outcome ◽  
Surgical Ventricular Reconstruction ◽  
Ventricular Reconstruction ◽  
Lv Volume

Objectives: Large ventricular aneurysm secondary to myocardial infarction (MI) results in severe heart failure (HF) and limits the effectiveness of regeneration therapy, which can be improved by surgical ventricular reconstruction (SVR). However, the conventional SVR procedures do not yield optimal long-term outcome in post-MI rodents. We hypothesized that a modified SVR procedure without aggressive purse string suture would persistently alleviate HF and improve cardiac regeneration in post-MI mice.Methods: Adult male C57 mice were subjected to MI or sham surgery. Four weeks later, mice with MI underwent SVR or 2nd open-chest operation alone. SVR was performed by plicating the aneurysm with a single diagonal linear suture from the upper left ventricle (LV) to the right side of the apex. Cardiac remodeling, heart function and myocardial regeneration were evaluated.Results: Three weeks after SVR, the scar area, LV volume, and heart weight/body weight ratio were significantly smaller, while LV ejection fraction, the maximum rising and descending rates of LV pressure, LV contractility and global myocardial strain were significantly higher in SVR group than in SVR-control group. The inhibitory effects of SVR on LV remodeling and HF persisted for at least eight-week. SVR group exhibited improved cardiac regeneration, as reflected by more Ki67-, Aurora B- and PH3-positive cardiomyocytes and a higher vessel density around the plication area of the infarcted LV.Conclusions: SVR with a single linear suture results in a significant and sustained reduction in LV volume and improvement in both LV systolic and diastolic function as well as cardiac regeneration.

scholarly journals 106 * RIGHT VENTRICULAR FUNCTION AFTER SURGICAL VENTRICULAR RECONSTRUCTION IN HEART FAILURE

2013 ◽  
Vol 17 (suppl 2) ◽  
pp. S95-S95
Author(s):  
S. Castelvecchio ◽  
M. Guazzi ◽  
F. Bandera ◽  
M. Pellegrino ◽  
A. Garatti ◽  
...  
Keyword(s):  
Heart Failure ◽  
Right Ventricular ◽  
Ventricular Function ◽  
Right Ventricular Function ◽  
Surgical Ventricular Reconstruction ◽  
Ventricular Reconstruction

scholarly journals Surgical ventricular reconstruction and subendocardial resection for the treatment of refractory ventricular tachycardia

2014 ◽  
Vol 96 (8) ◽  
pp. e26-e27
Author(s):  
NA Ismail ◽  
J Bence ◽  
TJ Spyt
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Ventricular Tachycardia ◽  
Medical Treatment ◽  
Female Patient ◽  
Acute Heart Failure ◽  
Surgical Intervention ◽  
Clinical Scenario ◽  
Surgical Ventricular Reconstruction ◽  
Ventricular Reconstruction

We describe a case of 64-year-old female patient with ventricular tachycardia intractable to medical treatment and acute heart failure following myocardial infarction. Emergency surgical ventricular reconstruction and subendocardial resection was undertaken. We discuss the option of surgical intervention in this difficult and unusual clinical scenario.

scholarly journals Comparable outcomes between genders in patients undergoing surgical ventricular reconstruction for ischaemic heart failure

2020 ◽  
Author(s):  
Serenella Castelvecchio ◽  
Valentina Milani ◽  
Marianna Volpe ◽  
Michele Citarella ◽  
Federico Ambrogi ◽  
...  
Keyword(s):  
Heart Failure ◽  
Surgical Ventricular Reconstruction ◽  
Ventricular Reconstruction

scholarly journals Surgical ventricular reconstruction for ischaemic heart failure: state of the art

2016 ◽  
Vol 18 (suppl E) ◽  
pp. E8-E14 ◽  
Author(s):  
Serenella Castelvecchio ◽  
Andrea Garatti ◽  
Pier Vincenzo Gagliardotto ◽  
Lorenzo Menicanti
Keyword(s):  
Heart Failure ◽  
State Of The Art ◽  
Surgical Ventricular Reconstruction ◽  
Failure State ◽  
Ventricular Reconstruction

scholarly journals Effects of enteral nutrition on heart function, inflammatory markers and immune function in elderly patients with chronic heart failure

2021 ◽  
Vol 38 (1) ◽  
Author(s):  
Dan Zhang ◽  
Hongli Li ◽  
Xiang Tian ◽  
Sujuan Zhang
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Enteral Nutrition ◽  
Elderly Patients ◽  
Immune Function ◽  
Inflammatory Markers ◽  
Heart Function ◽  
Inflammatory Factors ◽  
Control Group ◽  
Experimental Group

Objectives: To evaluate the effect of enteral nutrition on heart function, inflammatory markers and immune function in elderly patients with chronic heart failure and its clinical significance. Methods: Eighty patients with moderate and severe heart failure admitted to the Cardiology Intensive Care Unit (CCU) of Baoding First Central Hospital from May 2019 to May 2020 were included in this study and randomly divided into two groups: the experimental group and the control group, with 40 patients in each group. The experimental group was given enteral nutrition support therapy on the basis of conventional therapy for one month, while the control group was given restricted salt and water intake on the basis of conventional therapy, and patients were given free diet according to their wishes. The changes in heart function before and after treatment, changes in inflammatory factors such as TNF-a, CRP, IL-6, changes in levels of immunoglobulins such as IgA, IgM, and IgG, and the improvement of the performance status of the two groups were compared and analyzed. Results: After treatment, indicators such as BNP, LVEDD, LVEF and 6min walking distance in the experimental group were significantly improved compared with the control group, with statistically significant differences (p<0.05), and the levels of inflammatory factors such as TNF-a, CRP and IL-6 in the experimental group were significantly reduced compared with those in the control group (p=0.00). The levels of IgG, IgA, IgM and other immunoglobulins in the experimental group improved more significantly after treatment than those in the control group, with statistically significant differences (IgG, IgA, p=0.00; IgM, p=0.01). Moreover, the experimental group was significantly superior to the control group in the improvement rate of performance status score (ECOG) after treatment (p=0.04); The incidence of gastrointestinal adverse reactions in the experimental group was 20%, and that in the control group was 15%. No statistically significant difference can be observed in the gastrointestinal tolerance of both groups (p=0.56). Conclusions: Reasonable enteral nutrition boasts a variety of benefits for the recovery of elderly patients with chronic heart failure. With reasonable enteral nutrition, the heart function of elderly patients with chronic heart failure can be significantly improved, inflammatory factors can be reduced, immunity and performance status can be enhanced, and gastrointestinal tolerance can be ameliorated without obvious gastrointestinal reactions. doi: https://doi.org/10.12669/pjms.38.1.4451 How to cite this:Zhang D, Li H, Tian X, Zhang S. Effects of enteral nutrition on heart function, inflammatory markers and immune function in elderly patients with chronic heart failure. Pak J Med Sci. 2022;38(1):---------.  doi: https://doi.org/10.12669/pjms.38.1.4451 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Miokardo gyvybingumas – svarbus požymis numatant chirurginį išeminio širdies nepakankamumo gydymą

2007 ◽  
Vol 5 (3) ◽  
pp. 0-0
Author(s):  
Elvyra Voluckienė ◽  
Loreta Ivaškevičienė ◽  
Virginija Grabauskienė ◽  
Jurgita Židanavičiūtė ◽  
Giedrius Uždavinys
Keyword(s):  
Heart Failure ◽  
Nyha Class ◽  
Left Ventricular ◽  
Ischemic Heart ◽  
Ischemic Heart Failure ◽  
Surgical Ventricular Reconstruction ◽  
Ventricular Reconstruction ◽  
The Mean ◽  
Vilnius University ◽  
One Year

Elvyra Voluckienė1, Loreta Ivaškevičienė2, Virginija Grabauskienė3, Jurgita Židanavičiūtė4, Giedrius Uždavinys21 Vilniaus universiteto ligoninės Santariškių klinikų Širdies chirurgijos centras,Santariškių g. 2, LT-08661 Vilnius2 Vilniaus universiteto Širdies chirurgijos centras, Santariškių g. 2, LT-08661 Vilnius3 Vilniaus universiteto Kardiologijos ir angiologijos centras4 Vilniaus Gedimino technikos universitetasEl paštas: [email protected] Tikslas Nustatyti priešoperacinės kairiojo skilvelio (KS) funkcijos prognostinę reikšmę pacientams, sergantiems sunkiu išeminiu širdies nepakankamumu (IŠN), po chirurginės kairiojo skilvelio rekonstrukcijos (KSR) ir aortos bei vainikinių jungčių (AVJ) suformavimo operacijos. Ligoniai ir metodai Retrospektyvinei analizei tikslingai atrinkti 37 pacientai (32 vyrai, vidutinis amžius 59 ± 10,5 m.), sergantys IŠN ir KS išvarymo frakcija (IF) < 30%, kuriems buvo atlikta KSR ir AVJ suformavimo operacija. Po persirgto Q bangos priekinio miokardo infarkto buvo praėję vidutiniškai 5,8 ± 3,3 mėnesio. Vidutinė NYHA klasė buvo 3,4 ± 1,3. KS funkcijos rodikliai buvo apskaičiuoti dobutamino echokardiografijos tyrimo ramybės (r) ir mažos dobutamino dozės (mdd) metu: diastolinio skersmens indeksas – DDI cm/m² (r), IF (%) (r), sienos judėjimo indeksas – SJIr ir SJImdd, asinergijos plotas (Aproc.) (mdd). Hospitalinis mirštamumas buvo 13,5%; mirštamumas per vienus metus buvo 6,25%. Vidutinė NYHA klasė po vienų metų buvo 2,2 ± 1,1. Rezultatai Logistinės regresijos analizė ir „Proportional Odds“ modelis parodė, kad priešoperacinis KS Aproc. (mdd) buvo statistiškai reikšmingas prognostinis pooperacinės vienų metų NYHA klasės požymis (OR 0,86, p = 0,0086). Išvada Priešoperacinis kairiojo skilvelio asinergijos dydis, nustatytas dobutamino echokardiografijos tyrimo metu, yra svarbus požymis, numatant pooperacinę vienų metų NYHA klasę pacientams, sergantiems sunkiu išeminiu širdies nepakankamumu po chirurginės kairiojo skilvelio rekonstrukcijos ir aortos bei vainikinių jungčių suformavimo operacijos. Pagrindiniai žodžiai: išeminis širdies nepakankamumas, kairiojo skilvelio rekonstrukcija Myocardial viability predicts improvement in patients after surgical treatment of ischemic heart failure Elvyra Voluckienė1, Loreta Ivaškevičienė2, Virginija Grabauskienė3, Jurgita Židanavičiūtė4, Giedrius Uždavinys21 Vilnius University Hospital Santariškių Clinics, Cardial Surgery Centre,Santariškių str. 2, LT-08661 Vilnius, Lithuania2 Vilnius University, Cardiac Surgery Centre, Santariškių str. 2, LT-08661 Vilnius, Lithuania3 Vilnius University, Centre of Cardiology and Angiology4 Vilnius Gediminas Technical UniversityE-mail: [email protected] Objective This study sought to define the prognostic value of myocardial viability in patients with severe ischemic heart failure, who underwent surgical ventricular reconstruction with associated coronary grafting. Patients and methods This retrospective study selected 37 consecutive patients (32 men, mean age 59 ± 10.5 years) who underwent surgical ventricular reconstruction with associated coronary grafting, and preoperative left ventricular (LV) ejection fraction < 30% (mean, 25 ± 4.6%). The mean New York Heart Association (NYHA) class before operation was 3.4 ± 1.3. The time-frame of the large anterior myocardial infarction was 5.8 ± 3.3 months. LV systolic function was assessed by echo-dobutamine: the wall motion score index at rest (WMSIr), WMSI and the extent of LV asynergy (A%) during low-dose dobutamine (ldd). In-hospital mortality was 13.5%. After one-year, the mean functional NYHA class was 2.2 ± 1.1, and at one-year the mortality was 6.25%. Results Logistic regression analysis and the Proportional Odds model showed that LV A% during ldd (OR 0.86, p = 0.0086) was an independent predictor for the one-year postoperative functional NYHA class. Conclusions The preoperative extent of left ventricular asynergy during echo-dobutamine can predict the expectation of functional NYHA class improvement in patients with a severe ischemic heart failure one-year following surgical ventricular reconstruction with associated coronary grafting. Key words: ischemic heart failure, surgical ventricular reconstruction

P1616L-2-hydroxyglutarate dehydrogenase (L2HGDH) is a novel target for heart failure due to pressure overload

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
A Remes ◽  
L Ding ◽  
B Kamlage ◽  
U E E Rennefahrt ◽  
P Ternes ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ribosomal Protein ◽  
Mitochondrial Membrane ◽  
Heart Function ◽  
Mtor Signaling ◽  
Heart Weight ◽  
Macrophage Migration ◽  
Mrna Levels ◽  
Ribosomal Protein S6

Abstract Background We have found L-2-hydroxyglutarate dehydrogenase (L2HGDH) to be downregulated in the myocardium of mice subjected to transverse aortic constriction (TAC). L2HGDH is an important regulator of mitochondrial bioenergetics by catalyzing the conversion of L-2-hydroxyglutarate (L2-HG) to α-ketoglutarate. However, the connection between L2-HG accumulation and heart failure is not yet understood. Purpose Purpose of our study was to investigate the role of increased L2-HG levels in heart failure and the potential role of L2HGDH overexpression as therapeutic strategy. Methods For in vitro studies, primary rat neonatal cardiomyocytes (NRVCMs) were incubated with L2-HG. L2HGDH was overexpressed using adeno-associated virus (AAV) 6 vectors. Mitochondrial membrane potential was measured using TMRE (tetramethylrhodamine ethyl ester) dye. Mitochondrial reactive oxygen species production was monitored using MitoSOX. We further determined activation of fetal gene program by real time qPCR and macrophage migration using RAW 264.7 cells and transwell inserts. mTOR activation was analyzed by Western blot with antibodies against phosphorylated mTOR and ribosomal protein S6. AAV9 expressing L2HGDH or luciferase was injected in C57BL/6N mice two weeks prior to TAC and heart function was monitored by echocardiography for 6 weeks. Results L2-HG acts as a pro-hypertrophic stimulus in NRVCMs as shown by upregulation of a fetal gene expression pattern and an increase in cardiomyocyte cross-sectional area upon L2-HG treatment. Furthermore, mRNA levels of macrophage chemoattractant protein 1 were increased in L2-HG treated cells, which correlated with enhanced macrophage migration towards supernatant of L2-HG treated NRVCMs. Furthermore, we could confirm that L2-HG augmented mTOR signaling by affecting the phosphorylation status of ribosomal protein S6. AAV-mediated L2HGDH overexpression in NRVCMs led to a significant 2.1-fold decrease in the accumulation of ROS production. Moreover, we found an inhibition of endothelin-1 induced mitochondrial membrane depolarization in AAV6-L2HGDH transduced cells. Pretreatment of mice with AAV9-L2HGDH prior to TAC resulted in significantly reduced heart weight to tibia length ratios (HW/TL) and cardiomyocyte area. Importantly, heart function was notably improved in mice receiving gene therapy (ejection fraction, EF: 36.18±6.63%, fractional shortening, FS: 16.72±4.01%) whereas control animals showed marked decline in myocardial contractility (EF: 20.14±8.24%, FS: 12.66±6.66%). Conclusion L2-HG causes cardiomyocyte dysfunction by activating mTOR signaling pathway, a well-characterized critical inducer of myocyte hypertrophy, and enhancing macrophage migration, leading to establishment of a pro-inflammatory environment in the myocardium. Moreover, our results point out towards a novel preventive approach for cardiac hypertrophy and heart failure by cardiomyocyte-specific L2HGDH overexpression. Acknowledgement/Funding DZHK (Deutsches Zentrum für Herz-Kreislaufforschung)

The Effect of Acute Allergic Reactions on Diastolic Heart Function

2014 ◽  
Vol 37 (2) ◽  
pp. 70
Author(s):  
Oguz Kaan Kaya ◽  
Necati Dagli ◽  
Mustafa Yildiz ◽  
Ilgin Karaca ◽  
Bilal Ustundag ◽  
...  
Keyword(s):  
Heart Failure ◽  
Heart Function ◽  
Systolic Function ◽  
Diastolic Heart Failure ◽  
Coronary Artery Spasm ◽  
Laboratory Data ◽  
Control Group ◽  
Allergic Reactions ◽  
Laboratory Findings ◽  
Significant Difference

Purpose: Diastolic heart failure is characterized by the presence of heart failure symptoms despite preserved systolic function. Cytokines released during allergic reactions may impair diastolic heart function, either through their direct toxic effects or by inducing coronary artery spasm. The purpose of this study was to examine the effects of acute allergic reactions on diastolic heart function. Methods: Fifty patients, randomly selected from those who were admitted to the emergency room between May 2010 and December 2010 with the complaints of rash and itching, and who were subsequently diagnosed with allergic reactions based on the clinical and laboratory findings, were included in the study as the allergy group. Thirty healthy volunteers, in whom the diagnosis of allergy was ruled out based on the clinical and laboratory data, were use as the control group. Diastolic heart functions were evaluated in patients presenting with allergic reaction as well as in control subjects. Results: There was no significant difference between the two groups in terms of basal systolic functions, diameters of the cavities and wall thicknesses, and biochemical parameters. Color M mode flow progression velocities, E ratios, E/A ratios and mitral lateral annulus tissue Doppler velocities measured by echocardiography at Day 0 and Day 5 were significantly altered in the allergy group (p < 0.05). Conclusion: Impairment in diastolic functions was observed following acute allergic reactions. Acute allergic reactions could be a cause of mortality and morbidity if they lead to the development of diastolic heart failure.

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