scholarly journals Cholesterol and Its Metabolites in Tumor Growth: Therapeutic Potential of Statins in Cancer Treatment

2019 ◽  
Vol 9 ◽  
Author(s):  
Adele Chimento ◽  
Ivan Casaburi ◽  
Paola Avena ◽  
Francesca Trotta ◽  
Arianna De Luca ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Cancer Treatment ◽  
Therapeutic Potential

PROFESSOR VOLODYMYR OLEKSIIOVYCH SHLYAKHOVENKO (on the 80th birth anniversary)

2018 ◽  
Vol 40 (4) ◽  
pp. 345
Author(s):  
Editorial Board
Keyword(s):  
Tumor Growth ◽  
Cancer Treatment ◽  
Front Edge

The studies by Prof. V. Shlyakhovenko are always on the front edge of the science. And nowadays he focuses on the search for the markers of tumor growth and monitoring of cancer treatment.

scholarly journals The regio-selective synthesis of 10-hydroxy camptothecin norcantharidin conjugates and their biological activity evaluation in vitro

2018 ◽  
Vol 5 (6) ◽  
pp. 172317 ◽  
Author(s):  
Chang K. Zhao ◽  
Chan Li ◽  
Xian H. Wang ◽  
Yu J. Bao ◽  
Fu H. Yang ◽  
...  
Keyword(s):  
Biological Activity ◽  
Cell Growth ◽  
Cancer Treatment ◽  
Cancer Cell ◽  
Therapeutic Potential ◽  
Selective Synthesis ◽  
Cancer Cell Growth ◽  
Activity Evaluation ◽  
Moderate Yield

A series of conjugates of 10-hydroxy camptothecin (HCPT) with functionalized norcantharidin derivatives were regio-selectively synthesized in the condition of (3-dimethylaminopropyl) ethyl-carbodiimide monohydrochloride in a moderate yield. The synthesized conjugate HCPT pro-drugs can also suppress cancer cell growth in vitro . These conjugated pro-drug constructs possess therapeutic potential as novel bi-functional conjugate platforms for cancer treatment.

scholarly journals Natural products with therapeutic potential in melanoma metastasis

2015 ◽  
Vol 32 (8) ◽  
pp. 1170-1182 ◽  
Author(s):  
A. AlQathama ◽  
J. M. Prieto
Keyword(s):  
Natural Products ◽  
Cancer Treatment ◽  
Therapeutic Potential ◽  
Melanoma Cells ◽  
Mechanisms Of Action ◽  
Melanoma Metastasis ◽  
Pharmacological Effects ◽  
Cytotoxic Compounds

Natural products continue to provide lead cytotoxic compounds for cancer treatment but less attention has been given to antimigratory compounds. We here systematically and critically survey more than 30 natural products with direct in vitro and in vivo pharmacological effects on migration and/or metastasis of melanoma cells and chart the mechanisms of action for this underexploited property.

scholarly journals Optimizing multi-modal cancer treatment under 3D spatio-temporal tumor growth

2019 ◽  
Vol 307 ◽  
pp. 53-69 ◽  
Author(s):  
Eyyüb Y. Kıbış ◽  
İ. Esra Büyüktahtakın
Keyword(s):  
Tumor Growth ◽  
Cancer Treatment ◽  
Spatio Temporal

Curcumin-based nanoformulations to target breast cancer: current trends and challenges

2021 ◽  
Vol 06 ◽  
Author(s):  
Adnan Badran ◽  
Joelle Mesmar ◽  
Nadine Wehbe ◽  
Riham El Kurdi ◽  
Digambara Patra ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Treatment ◽  
Therapeutic Potential ◽  
Low Cost ◽  
Folk Medicine ◽  
Research Area ◽  
Delivery Systems ◽  
Treatment Modalities ◽  
Anticancer Efficacy ◽  
Future Direction

: Breast cancer remains one of the most common cancers in women worldwide, and despite significant improvements in treatment modalities, the prognosis of this cancer is still poor. Herbs and plant extracts have been associated with various health benefits, and traditional folk medicine is still receiving great interest among patients as proven by accumulated records, tolerable side effects of herbal compounds compared to their synthetic counterparts, and low cost. Curcumin is a polyphenol identified as the main active ingredient in turmeric and has been used in the treatment of various diseases and ailments. Additionally, the pharmacological activities of curcumin on many cancers have been investigated substantially due to its ability to regulate many signaling pathways involved in cancer tumorigenesis and metastasis. However, the low solubility and bioavailability of curcumin limit its benefits, urging the need for new curcumin formulations and delivery systems. Nanotechnology has been widely publicized in cancer treatment not only to overcome the limitations of poorly soluble and physiologically unstable compounds but also to improve the delivery of the drug to the diseased site and cellular uptake. In this review, we summarized the main anti-tumor effect of curcumin and its mode of action on breast cancer and focused on the anticancer efficacy of various and recent curcumin nanoformulations and delivery systems. Such nanotechnological systems could pave the way to address a new future direction in this research area, enhancing the therapeutic potential of curcumin in the treatment of breast cancer. In the next few years, there will be more focus on developing curcumin-based materials for breast cancer treatment.

scholarly journals Cannabinoids in cancer treatment: Therapeutic potential and legislation

2019 ◽  
Vol 19 (1) ◽  
pp. 14-23 ◽  
Author(s):  
Barbara Dariš ◽  
Mojca Tancer Verboten ◽  
Željko Knez ◽  
Polonca Ferk
Keyword(s):  
Cancer Treatment ◽  
Cancer Patients ◽  
Cannabis Sativa ◽  
Therapeutic Potential ◽  
Herbal Remedy ◽  
Synthetic Cannabinoids ◽  
Cancer Type ◽  
Antitumor Effects ◽  
The Eu

The plant Cannabis sativa L. has been used as an herbal remedy for centuries and is the most important source of phytocannabinoids. The endocannabinoid system (ECS) consists of receptors, endogenous ligands (endocannabinoids) and metabolizing enzymes, and plays an important role in different physiological and pathological processes. Phytocannabinoids and synthetic cannabinoids can interact with the components of ECS or other cellular pathways and thus affect the development/progression of diseases, including cancer. In cancer patients, cannabinoids have primarily been used as a part of palliative care to alleviate pain, relieve nausea and stimulate appetite. In addition, numerous cell culture and animal studies showed antitumor effects of cannabinoids in various cancer types. Here we reviewed the literature on anticancer effects of plant-derived and synthetic cannabinoids, to better understand their mechanisms of action and role in cancer treatment. We also reviewed the current legislative updates on the use of cannabinoids for medical and therapeutic purposes, primarily in the EU countries. In vitro and in vivo cancer models show that cannabinoids can effectively modulate tumor growth, however, the antitumor effects appear to be largely dependent on cancer type and drug dose/concentration. Understanding how cannabinoids are able to regulate essential cellular processes involved in tumorigenesis, such as progression through the cell cycle, cell proliferation and cell death, as well as the interactions between cannabinoids and the immune system, are crucial for improving existing and developing new therapeutic approaches for cancer patients. The national legislation of the EU Member States defines the legal boundaries of permissible use of cannabinoids for medical and therapeutic purposes, however, these legislative guidelines may not be aligned with the current scientific knowledge.

scholarly journals A Review on Chitosan’s Uses as Biomaterial: Tissue Engineering, Drug Delivery Systems and Cancer Treatment

Materials ◽  
2020 ◽  
Vol 13 (21) ◽  
pp. 4995 ◽  
Author(s):  
Rayssa de Sousa Victor ◽  
Adillys Marcelo da Cunha Santos ◽  
Bianca Viana de Sousa ◽  
Gelmires de Araújo Neves ◽  
Lisiane Navarro de Lima Santana ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Metal Ions ◽  
Cancer Treatment ◽  
Drug Delivery Systems ◽  
Therapeutic Potential ◽  
Delivery Systems ◽  
Amino Groups ◽  
New Information ◽  
Acidic Conditions

Chitosan, derived from chitin, is a biopolymer consisting of arbitrarily distributed β-(1-4)-linked D-glucosamine and N-acetyl-D-glucosamine that exhibits outstanding properties— biocompatibility, biodegradability, non-toxicity, antibacterial activity, the capacity to form films, and chelating of metal ions. Most of these peculiar properties are attributed to the presence of free protonable amino groups along the chitosan backbone, which also gives it solubility in acidic conditions. Moreover, this biopolymer can also be physically modified, thereby presenting a variety of forms to be developed. Consequently, this polysaccharide is used in various fields, such as tissue engineering, drug delivery systems, and cancer treatment. In this sense, this review aims to gather the state-of-the-art concerning this polysaccharide when used as a biomaterial, providing information about its characteristics, chemical modifications, and applications. We present the most relevant and new information about this polysaccharide-based biomaterial’s applications in distinct fields and also the ability of chitosan and its various derivatives to selectively permeate through the cancer cell membranes and exhibit anticancer activity, and the possibility of adding several therapeutic metal ions as a strategy to improve the therapeutic potential of this polymer.

Exploration of the Therapeutic Potential of the Antiestrogen RU 58668 in Breast Cancer Treatment

1995 ◽  
Vol 761 (1) ◽  
pp. 164-175 ◽  
Author(s):  
P. VELDE ◽  
F. NIQUE ◽  
J. BRËMAUD ◽  
M-C. HAMEAU ◽  
D. PHILIBERT ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Treatment ◽  
Therapeutic Potential ◽  
Breast Cancer Treatment
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