scholarly journals TR Locus Annotation and Characteristics of Rhinolophus ferrumequinum

2021 ◽  
Vol 12 ◽  
Author(s):  
Hao Zhou ◽  
Long Ma ◽  
Longyu Liu ◽  
Xinsheng Yao
Keyword(s):  
Whole Genome Sequence ◽  
Health Concern ◽  
Antigen Receptors ◽  
Public Health Concern ◽  
Rhinolophus Ferrumequinum ◽  
Zoonotic Viruses ◽  
Germline Genes ◽  
Main Host ◽  
C Segments ◽  
Horseshoe Bat

T-cell antigen receptors (TRs) in vertebrates can be divided into αβ or γδ, encoded by TRA/D, TRG, or TRB loci. TRs play a central role in mammal cellular immunity, which occurs by rearrangement of V, D, J, and C genes in the loci. The bat is the only mammal with flying ability and is considered the main host of zoonotic viruses, an important public health concern. However, at present, little is known about the composition of bat TR genes. Based on the whole genome sequence of the greater horseshoe bat (Rhinolophus ferrumequinum) and referring to the TR/IG annotation rules formulated by the international ImMunoGeneTics information system (IMGT), we present a complete annotation of TRA/D, TRG, and TRB loci of R. ferrumequinum. A total of 128 V segments, three D segments, 85 J segments, and 6 C segments were annotated and compared with other known mammalian data. The characteristics of the TR locus and germline genes of R. ferrumequinum are analyzed.

scholarly journals The TR locus annotation and characteristics of Rhinolophus ferrumequinum

2021 ◽  
Author(s):  
Hao Zhou ◽  
Xin Sheng Yao ◽  
Long Ma ◽  
Long Yu Liu
Keyword(s):  
Public Health ◽  
Whole Genome ◽  
Antigen Receptors ◽  
Zoonotic Virus ◽  
Rhinolophus Ferrumequinum ◽  
Germline Genes ◽  
Main Host ◽  
C Segments ◽  
V Gene ◽  
Important Position

T cell antigen receptors (TCRs) in vertebrate could be divided into αβ or γδ, which are encoded by TRA/D, TRG and TRB loci respectively. TCRs play a central role in mammal cellular immunity, which are functionally produced by rearrangement of V gene, D gene, J gene and C gene in the loci. Bat is the only mammal with flying ability, and is considered as the main host of zoonotic virus, which occupies an important position in the field of public health. At present, little is known about the composition of bat TRs gene. According to the whole genome sequencing results of the Rhinolophus ferrumequinum, and referring to the TR/IG annotation rules formulated by IMGT. We make a complete annotation on the TRA/D, TRG and TRB loci of the Rhinolophus ferrumequinum. A total of 128 V segments, 3 D segments, 85 J segments and 6 C segments were annotated, in addition to compared with the known mammalian, the characteristics of the TRs locus and germline genes of the Rhinolophus ferrumequinum were analyzed.

scholarly journals The TR locus annotation and characteristics of Rhinolophus ferrumequinum

2021 ◽  
Author(s):  
Xinsheng Yao ◽  
Hao Zhou ◽  
Li Zhou ◽  
Long Liu
Keyword(s):  
Public Health ◽  
Genome Sequencing ◽  
Whole Genome ◽  
Zoonotic Virus ◽  
Rhinolophus Ferrumequinum ◽  
Germline Genes ◽  
Main Host ◽  
C Segments ◽  
V Gene ◽  
Important Position

Abstract Rhinolophus ferrumequinumin vertebrate could be divided into αβ or γδ, which are encoded by TRA/D, TRG and TRB loci respectively. TCRs play a central role in mammal cellular immunity, which are functionally produced by rearrangement of V gene, D gene, J gene and C gene in the loci. Bat is the only mammal with flying ability, and is considered as the main host of zoonotic virus, which occupies an important position in the field of public health. At present, little is known about the composition of bat TRs gene. According to the whole genome sequencing results of the Rhinolophus ferrumequinum, and referring to the TR/IG annotation rules formulated by IMGT. We make a complete annotation on the TRA/D, TRG and TRB loci of the Rhinolophus ferrumequinum. A total of 128 V segments, 3 D segments, 85 J segments and 6 C segments were annotated, in addition to compared with the known mammalian, the characteristics of the TRs locus and germline genes of the Rhinolophus ferrumequinum were analyzed.

An Overview of Dementias

2012 ◽  
Vol 21 (3) ◽  
pp. 75-84
Author(s):  
Venkata Vijaya K. Dalai ◽  
Jason E. Childress ◽  
Paul E Schulz
Keyword(s):  
Clinical Presentation ◽  
Treatment Options ◽  
Current Treatment ◽  
Great Variability ◽  
Health Concern ◽  
Public Health Concern ◽  
Life Threatening ◽  
The Common ◽  
Neurodegenerative Dementias ◽  
Made In

Dementia is a major public health concern that afflicts an estimated 24.3 million people worldwide. Great strides are being made in order to better diagnose, prevent, and treat these disorders. Dementia is associated with multiple complications, some of which can be life-threatening, such as dysphagia. There is great variability between dementias in terms of when dysphagia and other swallowing disorders occur. In order to prepare the reader for the other articles in this publication discussing swallowing issues in depth, the authors of this article will provide a brief overview of the prevalence, risk factors, pathogenesis, clinical presentation, diagnosis, current treatment options, and implications for eating for the common forms of neurodegenerative dementias.

Reframing Fatness: Critiquing ‘Obesity’

2018 ◽  
Author(s):  
Bethan Evans ◽  
Charlotte Cooper
Keyword(s):  
Public Health ◽  
Weight Loss ◽  
Michel Foucault ◽  
Overweight And Obesity ◽  
Health Concern ◽  
Public Health Concern ◽  
Policy Language ◽  
Religious Imagery ◽  
Fat Bodies

Over the last twenty years or so, fatness, pathologised as overweight and obesity, has been a core public health concern around which has grown a lucrative international weight loss industry. Referred to as a ‘time bomb’ and ‘the terror within’, analogies of ‘war’ circulate around obesity, framing fatness as enemy.2 Religious imagery and cultural and moral ideologies inform medical, popular and policy language with the ‘sins’ of ‘gluttony’ and ‘sloth’, evoked to frame fat people as immoral at worst and unknowledgeable victims at best, and understandings of fatness intersect with gender, class, age, sexuality, disability and race to make some fat bodies more problematically fat than others. As Evans and Colls argue, drawing on Michel Foucault, a combination of medical and moral knowledges produces the powerful ‘obesity truths’ through which fatness is framed as universally abject and pathological. Dominant and medicalised discourses of fatness (as obesity) leave little room for alternative understandings.

European Surveillance of Antimicrobial Consumption: the ESAC programme

2004 ◽  
Vol 8 (32) ◽  
Author(s):  
Keyword(s):  
Public Health ◽  
Antimicrobial Resistance ◽  
Health Concern ◽  
Antimicrobial Consumption ◽  
Public Health Concern ◽  
Major Public Health Concern

Resistance to antimicrobials has become a major public health concern, and it has been shown that there is a relationship, albeit complex, between antimicrobial resistance and consumption

Challenges in prevention & control of COVID - 19 pandemic in dentistry: A review. (Preprint)

2020 ◽  
Author(s):  
Sameera Begum ◽  
Riaz Abdulla ◽  
Akhter Hussain
Keyword(s):  
Healthcare Professionals ◽  
Preventive Measures ◽  
Health Concern ◽  
Front Line ◽  
Public Health Concern ◽  
College Hospital ◽  
Dental Clinics ◽  
Dental Procedures ◽  
Spread Of Infection ◽  
High Chance

UNSTRUCTURED The menace of COVID 19 pandemic has become a major public health concern all over the world. It is a pandemic outbreak that originated from Wuhan, Hubei province of China in December 2019. All healthcare professionals including dental surgeons are in the front line and a high chance of constantly getting infected. Droplet and aerosol transmissions are the utmost concern in dental clinics and dental college hospitals. Hence, COVID 19 has a high risk of spread through droplets and aerosols generated during dental procedures from infected patients. This review article highlights the dental perspective and discusses the various preventive measures undertaken to control the spread of infection in dental clinics and dental college hospital setups.

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