scholarly journals Autologous serum skin test and skin prick test in patients with chronic urticaria: a cross sectional study

2017 ◽  
Vol 3 (1) ◽  
pp. 46
Author(s):  
Mounika K. ◽  
Shivaswamy K. N.
Keyword(s):  
Skin Prick Test ◽  
Skin Test ◽  
Cross Sectional Study ◽  
Chronic Idiopathic Urticaria ◽  
Autologous Serum ◽  
Chi Square ◽  
Cross Sectional ◽  
Autologous Serum Skin Test ◽  
Prick Test ◽  
History Of

<p class="abstract"><strong>Background:</strong> <span lang="EN-IN">Urticaria is an allergic skin disorder characterized by wheals. Though the diagnosis is easy, it is difficult to identify the cause for the episodes. Autologous serum skin test (ASST) and skin prick test (SPT) help in the identification of the cause. The objective of the study was to determine the frequency of ASST and SPT positivity in patients with chronic idiopathic urticaria (CIU).</span></p><p class="abstract"><strong>Methods:</strong> Fifty-six patients attending the dermatology OPD with chronic idiopathic urticaria were evaluated and taken up for the study. ASST and SPT were performed on all the patients and the obtained results were documented. Data was analyzed using Chi square test.<strong></strong></p><p class="abstract"><strong>Results:</strong> Among the 56 patients studied, males (53.57%) outnumbered females and the majority was in the age group 21 to 30 years (33.9%). One third of the study patients gave history of known food allergy and 10.7% gave history of dust allergy. ASST positivity was seen in 30.3% and SPT positivity was seen in 64.3%. Ten of our patients (17.8%) were positive to both ASST and SPT. Amongst the SPT positives 33.3% showed positivity to food allergens, 19.4% showed positivity to aeroallergens and 47.2% showed positivity to both<span lang="EN-IN">. </span></p><p class="abstract"><strong>Conclusions:</strong> ASST and SPT are two reliable tools in identifying the cause for urticaria and this in turn helps in avoidance of possible causes and providing proper treatment<span lang="EN-IN">.</span></p>

scholarly journals Skin prick test reactivity in atopic children and their number of siblings

2015 ◽  
Vol 55 (4) ◽  
pp. 189
Author(s):  
Beatrix Siregar ◽  
Lily Irsa ◽  
Supriatmo Supriatmo ◽  
Sjabaroeddin Loebis ◽  
Rita Evalina
Keyword(s):  
Skin Prick Test ◽  
Specific Ige ◽  
Cross Sectional Study ◽  
Chi Square ◽  
Cross Sectional ◽  
Positive Skin ◽  
Prick Test ◽  
Group I ◽  
History Of ◽  
Skin Prick Tests

Background Some studies have shown that low birth order is a risk factor for developing atopy, although these results remain inconclusive. Those studies put forth the hygiene hypothesis, which states that early childhood infections in siblings may protect against atopy. Hence, an inverse relationship between family numbers and atopy was found. Atopy may be diagnosed from a history of atopy in an individual or his family, and can be confirmed by specific IgE for allergens or positive skin prick tests.Objective To assess for an association between skin prick test reactivity in atopic children and their number of siblings.Methods A cross-sectional study was conducted in May to June 2010 in elementary school children at the Kampung Baru District, Medan Regency, North Sumatera. Subjects were divided into two groups. Group I had children with < 3 siblings and group II had children with ≥ 3 siblings. Skin prick tests were done in 7 to 10-year-old children with a history of asthma, allergic rhinitis and atopic dermatitis. Skin prick test reactivity results were analyzed by Chi-square test.Results A total of 192 subjects were enrolled in this study, with 96 subjects in each group. Positive skin prick tests were significantly higher in subjects with <3 siblings than in those with >3 siblings (75% and 53.1%, respectively; P=0.003).Conclusion Atopic children with <3 siblings had more positive skin prick tests than children with >3 siblings.

scholarly journals Soil-transmitted helminth infection and skin prick test reactivity in children

2014 ◽  
Vol 54 (1) ◽  
pp. 52
Author(s):  
Schenny Regina Lubis ◽  
Lily Lrsa ◽  
Rita Evalina ◽  
Supriatmo Supriatmo ◽  
M. Sjabaroeddin
Keyword(s):  
Skin Prick Test ◽  
Urban Areas ◽  
Allergic Diseases ◽  
Developed Countries ◽  
Cross Sectional Study ◽  
Stool Examination ◽  
School Students ◽  
Chi Square ◽  
Cross Sectional ◽  
Prick Test

Background Allergic diseases cause an increasingly largeburden in developed countries and in urban areas of middleincomecountries . Paras itic infections may induce allergicresponses in humans, particularly soil-transmitted helminth(STH) infections that are prevalent in childhood in developingcountries. Although soil-transmitted helminth infec tions havebeen associated with lower prevalence of allergen skin testreactivity, study outcomes remain inconclusive.Objective To analyze for an association between STH infectionsand skin prick test reactivity in children.Methods We conducted a cross-sectional study in August 2009among primary school students aged 7- 12 years, at SecanggangSubdistrict, Langkat District, North Sumatera Province. Sixtyeight children were recruited in this study consisted of 34 childrenwith STH infections and the other 34 children without any STHinfection. Soil-transmitted helminth infections were determinedby Kato-Katz stool examination s. All subjects underwent skinprick tests for seven allergens. Results were con sidered to bepositive if wheal diameters 2: 3 mm and negative when whealdiameters < 3 mm. Data was an alysed by Chi-square test.Results Stool examinations revealed that the most commoninfec tion was T. trichiura (18/34 subjects), followed by mixedinfections (T. trichiura and A lumbricoides; 12/34 subjects), andA. lumbricoides (4134 subjects). There was a significant associationbetween STH infections and negative skin prick test (P= 0.002).In addition, there were significant associations with negative skinprick tests for each helminth type: A. lumbricoides (P=0.001) ,T. trichiura (P=0.01) and mixed infection (P = 0.006). Severeinfection intensity was also significantly associated with negativeskin prick tests (P=0.031) .Conclusion Children with STH infections tend to have negativeskin prick test results.

scholarly journals Association of body mass index with atopy and allergic diseases

2016 ◽  
Vol 56 (4) ◽  
pp. 221
Author(s):  
Afnita Lestary ◽  
Lily Irsa ◽  
Tiangsa Sembiring ◽  
Rita Evalina ◽  
Meiviliani Sinaga
Keyword(s):  
Body Mass Index ◽  
Skin Prick Test ◽  
Body Mass ◽  
Bronchial Asthma ◽  
International Study ◽  
Allergic Diseases ◽  
Chi Square ◽  
Cross Sectional ◽  
Prick Test ◽  
History Of

Background Prevalence of atopy, allergic diseases, and obesity are increasing. Atopy is an individu and/or familial tendency to sensitization in response to ordinary exposure to allergens. Obesity is defined as body mass index (BMI) greater or equal to 95 percentile. Research on association of BMI with atopy and allergic diseases in children were limited, with inconclusive results. Objective To assess association of BMI with atopy and allergic diseases in chidren.Methods A cross-sectional was conducted in school children aged 6-12 years in Lhokseumawe City, Aceh, June 2012. Children were assessed for BMI, skin prick test, and  International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. Statistical analyses included Chi-square, Fisher exact, and logistic regression.Results Children consisted of 137 (85.6%) normoweight, 12 (7.5%) overweight, and 11 (6.9%) obesity. Skin prick test results were positive in 44 (27.5%) and negative in 116 (72.5%) subjects. Allergic manifestations were allergic rhinitis (AR) 17 (10.6%), bronchial asthma 6 (3.8%), and atopic dermatitis (AD) 3 (1.9%). There was significant association of obesity with atopy, compared with normoweight (OR=3.78; 95%CI 1.08 to 13.19; P=0.037), but no significant association found when family history of atopy also assesed. There was significant association of obesity with bronchial asthma (OR=9.92; 95%CI 1.46 to 67.18; P=0.004) and AR (OR=6.49; 95%CI 1.64 to 25.66; P=0.015), compared with normoweight. Significant association of overweight with atopy and allergic disease was not found.Conclusion Obesity significantly associates with atopy, bronchial asthma, and AR, but overweight and normoweight  do not.  

scholarly journals Chronic urticaria: a clinico-etiological study and autologous serum skin test role in chronic idiopathic urticaria

2021 ◽  
Vol 7 (4) ◽  
pp. 552
Author(s):  
Purnachandra Badabagni ◽  
Sruthi Thammineedi ◽  
Ramadevi Birudala
Keyword(s):  
Skin Test ◽  
Chronic Urticaria ◽  
Chronic Idiopathic Urticaria ◽  
Autologous Serum ◽  
Thyroid Function Tests ◽  
Cross Sectional ◽  
Autologous Serum Skin Test ◽  
Physical Urticaria ◽  
Autoimmune Urticaria ◽  
Number Of Patients

<p class="abstract"><strong>Background:</strong> Appearance of wheals daily for more than six weeks is chronic urticarial (CU). No cause is identified in about 50-70% of chronic urticaria patients and are labelled as chronic idiopathic urticaria (CIU). The aim of the present study is to study the clinical and etiological pattern of chronic urticaria and to find out the incidence of autoimmune urticaria by performing autologous serum skin test (ASST) in patients with CIU.</p><p class="abstract"><strong>Methods:</strong> This was a cross sectional study enrolling 100 chronic urticaria patients satisfying including and excluding criteria. The study was done for a period of 1 year. ASST was done in all the CIU patients after recording detailed history, complete physical and systemic examination.</p><p class="abstract"><strong>Results:</strong> Most of the patients (33%) were in 21-30 years age group with female preponderance (66%). Students (38%) followed by house wives (27%) were majorly involved. 21% patients had history of atopy and 8% had abnormal thyroid function tests. Causative factors noticed in 46% patients and remaining were idiopathic (54%). Infections (32.6%) constituted the major etiological factor followed by physical urticaria (30.4%), food (23.9%), medication (11%) and inhalants (2.1%). In infective agents, 46.6% were bacterial followed by helminthic (33.3%). In 29.6% of CIU patients, the ASST was positive indicating auto-immune urticaria.</p><p class="abstract"><strong>Conclusions:</strong> The etiology cannot be identified in most number of patients and hence they were labelled as CIU and the common causative agents observed were infections followed by physical urticaria, food and medication. ASST is considered as the relevant screening test to detect autoimmune urticaria.</p>

scholarly journals Correlation between obesity with atopy and family history of atopy in children

2011 ◽  
Vol 51 (4) ◽  
pp. 227
Author(s):  
Putria Rayani Apandi ◽  
Budi Setiabudiawan ◽  
Abdurachman Sukadi
Keyword(s):  
Risk Factors ◽  
Family History ◽  
Atopic Disease ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
Chi Square ◽  
Cross Sectional ◽  
Prick Test ◽  
Chi Square Test ◽  
History Of

Background The prevalence of childhood obesity and atopy has increased in recent decades. Research on links between obesity and atopy has shown varied results. Few previous studies have reported on the significance of family history of atopic disease in children.Objective To determine correlation between obesity with atopy and family history of atopic disease in children.Methods This cross-sectional study was conducted from April to September 2010 in the Pediatric Allergy-Immunology subdivision, Hasan Sadikin Hospital. Children aged 6−11 years were divided into four groups of 40 each: obese subjects with and without family history of atopic disease, and normal weight subjects with and without family history of atopic disease. Skin prick test was performed to determine which subjects had atopy. Chi-square test was used to analyze mutual independence, and partial Chi-square test was used to analyze correlation of obesity to atopy and family history of atopic disease in children. Environmental factors, type of childbirth, and pregnancy history were also analyzed as risk factors for atopy.Results Of 80 obese children with and without family history of atopic disease, 40 (100%) and 38 (95%), respectively, were atopic. Of 80 normal weight children with and without family history of atopic disease, 39 (98%) and 9 (23%), respectively, were atopic. Thus atopy was observed in 126 subjects, while the remaining 34 subjects were non-atopic. Partial test showed a correlation between obesity with atopy and family history of atopic disease (P < 0.001). There were no significant differences in risk factors for atopy by group.Conclusion Obesity correlates with atopy and family history of atopic disease in children.

scholarly journals Clinical Outcome of Autologous Serum Therapy in Chronic Idiopathic Urticaria

2017 ◽  
Vol 15 (1) ◽  
pp. 71-74 ◽  
Author(s):  
Dharmendra Karn ◽  
Shekhar KC
Keyword(s):  
Skin Prick Test ◽  
Chronic Urticaria ◽  
Statistical Significance ◽  
Cost Effective ◽  
Chronic Idiopathic Urticaria ◽  
Autologous Serum ◽  
P Value ◽  
Prick Test ◽  
H1 Antihistamines ◽  
Serum Therapy

Background: Quality of life in chronic idiopathic urticaria is hampered as efficacy of H1-antihistamines is limited. Autologous serum containing tolerance-generating anti-idiotype antibodies is a novel and cost-effective therapy. This study was conducted to evaluate the efficacy of autologous serum therapy (AST) among chronic urticaria patients with autologous skin prick test positive and negative status.Methods: Untreated 102 patients of chronic urticaria were enrolled in a non-randomized interventional study. Patients were categorized into two groups based on autologous serum skin prick test as test positive (ASST +) and test negative (ASST -). Patients were then treated with intramuscular injection of 0.05ml per kg body weight of autologous serum weekly for 10 weeks. Urticaria activity scoring (UAS) tool was used for quantification of the symptoms. Weekly recording of UAS (range: 0-42) was made before the therapy (baseline) and during the therapy for 10 weeks.Results: Significant improvement with AST in the mean UAS was noted from baseline to 10 weeks in both the group of patients (14.6 ± 6.3 and 10.2 ± 5.1 for ASST+ group; 16.9 ± 7.8 and 8.6 ± 4.8 for ASST- group; at baseline and 10 weeks, respectively (p-value for both <0.05)). However no statistical significance was found while comparing the efficacy of the therapy against ASST + and ASST - Groups (p-value > 0.05).Conclusions: Irrespective of autologous skin prick test results, autologous serum therapy showed significant improvement in patients with chornic idiopathic urticaria. AST can, thus, be an effective treatment modality for it.

scholarly journals Kondisi Kebersihan Lingkungan Berhubungan dengan Risiko Penularan Kasus Leptospirosis di Area Pasar Tradisional

2020 ◽  
pp. 199-208
Author(s):  
Dyah Widiastuti ◽  
Dwi Priyanto
Keyword(s):  
Cross Sectional Study ◽  
Market Area ◽  
Chi Square ◽  
Pathogenic Leptospira ◽  
Cross Sectional ◽  
Chi Square Test ◽  
History Of ◽  
Polymerase Chain ◽  
Gathering Place ◽  
The Relationship

Leptospirosis is associated with occupations which exposed workers to contaminated environments. The risk of leptospirosis exposure in the market as a gathering place for many people needs to be assessed, to obtain the basis for decision making to anticipate leptospirosis transmission. This study aimed to determine the relationship between market environmental conditions including market sanitation conditions, the level of rat density and the presence of leptospira-positive rats  toward the history of leptospirosis exposure among market workers (traders and janitors). A cross sectional study conducted in 35 markets in Banjarnegara and 175 market workers randomly selected. Blood samples analysed using ELISA against 40 Kda pathogenic Leptospira protein. Rat trapping  conducted in each market for two days with 100 traps. The caught mice examined with Polymerase Chain Reaction (PCR) to detect the presence of Leptospira bacteria in their kidneys. Leptospirosis exposure was spread in 17 markets in Banjarnegara. The PCR examination showed that the pathogenic Leptospira infected rats were spread in four markets in Banjarnegara. Chi square test showed that the hygene condition in market area was significantly associated with the leptospirosis exposure. Markets workers (traders and janitors) were at risk for leptospirosis proved by high seroprevalence of leptospirosis in this study.

scholarly journals Diagnostic, therapeutic and prognostic aspects of uterine synechiae managed by hysteroscopy in the gyanecological endoscopic surgery and human reproductive teaching hospital

2017 ◽  
Vol 7 (1) ◽  
pp. 56
Author(s):  
Etienne Belinga ◽  
Isidore Tompeen ◽  
Claude Cyrille Noa Ndoua ◽  
Junie Metogo Ntsama ◽  
Sandrine Mendibi ◽  
...  
Keyword(s):  
Past History ◽  
Cross Sectional Study ◽  
P Value ◽  
Chi Square ◽  
Cross Sectional ◽  
Qualitative Variables ◽  
Preoperative Diagnostic ◽  
Chi Square Test ◽  
Human Reproductive ◽  
History Of

Background: Uterine synechiae refers to a total or partial union of the inner walls of the uterus resulting from endometrial trauma. It is a cause of reproductive failure. Until now, synechia was not optimally treated and has remained understudied in Cameroon. Objective of present study was to Evaluate the diagnostic, therapeutic and prognostic aspects of uterine synechiae treated by hysteroscopy.Methods: We conducted a descriptive cross-sectional study with an analytical component from January 1st 2015 to July 31st 2017 at Yaounde. All patients diagnosed with uterine synechiae and treated with hysteroscopy were our sample. Sampling was consecutive. The chi-square test was used for the comparison of qualitative variables and Fisher's test for ANOVA variance analysis. The comparison of the averages was made by the Student's test. P-value less than 0.05 was considered as statistically significant.Results: Hysteroscopies were indicated for uterine synechiae in 14.50%. Nulliparous were 56.67%. A history of curettage/aspiration was present in 66.66%. All of the patients had a form of infertility and 83.33% had menstrual disorders. Hysterosalpingography showed a better sensitivity (88%). After hysteroscopic treatment, 63.30% had a complete anatomical restitution. There is a significant correlation between the stage of severity of synechia and anatomical restitution (p=0.008; Spearman correlation coefficient=-0.477).Conclusions: Uterine synechiae represent one-sixth of all indications for hysteroscopy and present clinically as menstrual disorder associated with infertility. A past history of uterine curettage is common. Hysterosalpingography has a better preoperative diagnostic sensitivity. Hysteroscopy allows optimal treatment.

scholarly journals Relationship between Periodontitis and Glaucoma: A Cross-Sectional Study

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Soo Hwan Byun ◽  
Dae Myoung Yoo ◽  
Minwook Chang ◽  
Hyo Geun Choi ◽  
Seok Jin Hong
Keyword(s):  
Odds Ratio ◽  
Adjusted Odds Ratio ◽  
Epidemiological Data ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Epidemiology Study ◽  
Chi Square ◽  
Cross Sectional ◽  
History Of ◽  
And Control

The objective of this cross-sectional study was to evaluate the association between periodontitis and glaucoma. This prospective cohort study used epidemiological data from the Korean Genome and Epidemiology Study performed between 2004 and 2016. Among 173,209 participants, 9572 patients with periodontitis and 115,332 controls (nonperiodontitis) were selected. We analysed the history of glaucoma in periodontitis and control participants. The participants were interviewed regarding their history of hypertension, diabetes mellitus, hyperlipidaemia, periodontitis, glaucoma, smoking, and alcohol consumption by trained interviewers. A logistic regression model was created to analyse the odds ratio of having a history of glaucoma among patients with periodontitis. Two-tailed analyses using chi-square and independent t-tests were used for statistical analysis. The adjusted odds ratio of periodontitis as a risk factor for glaucoma was 3.44 (95% confidence interval = 2.99–3.97, p < 0.001 ). This study demonstrated that glaucoma was associated with periodontitis.

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