scholarly journals Impact of Fluoxetine on Behavioral Invigoration of Appetitive and Aversively Motivated Responses: Interaction With Dopamine Depletion

2021 ◽  
Vol 15 ◽  
Author(s):  
Carla Carratalá-Ros ◽  
Laura López-Cruz ◽  
Andrea Martínez-Verdú ◽  
Régulo Olivares-García ◽  
John D. Salamone ◽  
...  
Keyword(s):  
Behavioral Activation ◽  
Food Reinforcement ◽  
Forced Swim Test ◽  
Choice Task ◽  
Sucrose Intake ◽  
Dopamine Depletion ◽  
Symptoms Of Depression ◽  
Relative Preference ◽  
Cd1 Mice ◽  
Exercise Preference

Impaired behavioral activation and effort-related motivational dysfunctions like fatigue and anergia are debilitating treatment-resistant symptoms of depression. Depressed people show a bias towards the selection of low effort activities. To determine if the broadly used antidepressant fluoxetine can improve behavioral activation and reverse dopamine (DA) depletion-induced anergia, male CD1 mice were evaluated for vigorous escape behaviors in an aversive context (forced swim test, FST), and also with an exercise preference choice task [running wheel (RW)-T-maze choice task]. In the FST, fluoxetine increased active behaviors (swimming, climbing) while reducing passive ones (immobility). However, fluoxetine was not effective at reducing anergia induced by the DA-depleting agent tetrabenazine, further decreasing vigorous climbing and increasing immobility. In the T-maze, fluoxetine alone produced the same pattern of effects as tetrabenazine. Moreover, fluoxetine did not reverse tetrabenazine-induced suppression of RW time but it reduced sucrose intake duration. This pattern of effects produced by fluoxetine in DA-depleted mice was dissimilar from devaluing food reinforcement by pre-feeding or making the food bitter since in both cases sucrose intake time was reduced but animals compensated by increasing time in the RW. Thus, fluoxetine improved escape in an aversive context but decreased relative preference for active reinforcement. Moreover, fluoxetine did not reverse the anergic effects of DA depletion. These results have implications for the use of fluoxetine for treating motivational symptoms such as anergia in depressed patients.

INFLUENCE OF INDIVIDUAL OR GROUP HOUSING ON SUCROSE INTAKE RESPONDINGTO CHRONIC MILD STRESS (CMS) IMPOSITION IN MALE CD1 MICE

1998 ◽  
Vol 9 (1) ◽  
pp. S71
Author(s):  
J. L. Paya-Cano ◽  
A. Calvo Torrenta ◽  
M. A. Pico-Alfonsoa ◽  
RF. Brain ◽  
M. Martinez
Keyword(s):  
Chronic Mild Stress ◽  
Mild Stress ◽  
Group Housing ◽  
Sucrose Intake ◽  
Cd1 Mice

INFLUENCE OF INDIVIDUAL OR GROUP HOUSING ON SUCROSE INTAKE RESPONDINGTO CHRONIC MILD STRESS (CMS) IMPOSITION IN MALE CD1 MICE

1998 ◽  
Vol 9 (Supplement) ◽  
pp. S71
Author(s):  
J. L. Paya-Cano ◽  
A. Calvo Torrenta ◽  
M. A. Pico-Alfonsoa ◽  
RF. Brain ◽  
M. Martinez
Keyword(s):  
Chronic Mild Stress ◽  
Mild Stress ◽  
Group Housing ◽  
Sucrose Intake ◽  
Cd1 Mice

scholarly journals Habitual Behavior as a Mediator Between Food-Related Behavioral Activation and Change in Symptoms of Depression in the MooDFOOD Trial

2021 ◽  
pp. 216770262097978
Author(s):  
Matthew Owens ◽  
Ed Watkins ◽  
Mariska Bot ◽  
Ingeborg A. Brouwer ◽  
Miquel Roca ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Emotional Eating ◽  
Behavioral Activation ◽  
Community Sample ◽  
Adaptive Responses ◽  
Food Cues ◽  
Symptoms Of Depression ◽  
Uncontrolled Eating ◽  
Overweight Adults

In this study, we tested potential mediators that may explain change in depressive symptoms following exposure to a food-related behavioral activation intervention (F-BA). These included behavioral activation, avoidance and rumination, eating styles, body mass index, and dietary behavior at baseline and 3-month and 12-month follow-up. The trial used a community sample of 1,025 overweight adults with elevated depressive symptoms without current major depression. Participants were randomly assigned to one of four trial arms: either daily nutritional supplements (vs. placebo) alone or in combination with F-BA (vs. no F-BA) over 12 months. Although F-BA did not significantly reduce depressive symptoms (standardized regression coefficient [ b] = −0.223, SE = 0.129; p = .084), significant mediators included emotional eating ( b = −0.028, SE = 0.014; p = .042) and uncontrolled eating ( b = −0.039, SE = 0.016; p = .013), suggesting that learning adaptive responses to emotional and food cues may underlie effects of F-BA on depressive symptoms.

scholarly journals Comparative Effects of Alkaloid and Saponin Fractions of Rauwolfia vomitoria on Social Behaviour and Depression in a CD1 Mouse Model of Memory Impairment

2019 ◽  
pp. 1-11
Author(s):  
Sunday A. Bisong ◽  
Favour E. Abuo ◽  
Augustine L. Udefa ◽  
Veronica E. Ironbar ◽  
Gloria B. Bassey
Keyword(s):  
Social Behaviour ◽  
Memory Impairment ◽  
Forced Swim Test ◽  
Tail Suspension Test ◽  
Treated Group ◽  
Root Bark ◽  
Cd1 Mice ◽  
Alkaloid Fraction ◽  
Saponin Fraction ◽  
Rauwolfia Vomitoria

Aqueous root bark extracts of Rauwolfia vomitoria (RV) has been reported to reduce anxiety among other uses. The study compared the effect of alkaloid and saponin fractions of RV on social behaviour and depression in scopolamine-induced memory-impaired CD1 mice. The alkaloid and saponin fractions were extracted from the root bark of the plant using standard methods. Forty-two (42) CD1 mice were grouped into six (n=7): Control mice were given placebo; three groups were given scopolamine (1.0 mg/kg, i.p.(explain) for 5 days to induce memory impairment), with 2 of them treated with the alkaloid (0.15 mg/kg, p.o.) and saponin (0.10 mg/kg, p.o.) fractions of R. vomitoria respectively. The other 2 groups were given either of the alkaloid fraction or saponin fraction of RV. Treatment lasted 21 days, after which mice were given the forced swim test and tail suspension test to assess depression and nesting test to assess social behaviour. Results showed that latency to immobility for the alkaloid fraction-treated group decreased significantly while the duration of immobility increased significantly (P<0.05) compared to control. This shows a strong positive depressive symptom. The saponin fraction-treated group however showed a significant increased in the latency to immobility while the duration of immobility decreased significantly compared to control (P<0.05). Thus, the saponin fraction of R. vomitoria decreased depression. In the test to assess social behaviour, the alkaloid group showed a significant decrease in nesting score which indicates social loss whereas the saponin group showed a significant increase (P<0.05) in nesting score compared to control. Therefore, the saponin constituent of Rauwolfia vomitoria has a high antidepressant advantage over the alkaloids fraction.

INFLUENCE OF INDIVIDUAL OR GROUP HOUSING ON SUCROSE INTAKE RESPONDINGTO CHRONIC MILD STRESS (CMS) IMPOSITION IN MALE CD1 MICE

1998 ◽  
Vol 9 (1) ◽  
pp. S71
Author(s):  
J. L. Paya-Cano ◽  
A. Calvo Torrenta ◽  
M. A. Pico-Alfonsoa ◽  
RF. Brain ◽  
M. Martinez
Keyword(s):  
Chronic Mild Stress ◽  
Mild Stress ◽  
Group Housing ◽  
Sucrose Intake ◽  
Cd1 Mice

scholarly journals The Steroidogenesis Inhibitor Finasteride Reduces the Response to Both Stressful and Rewarding Stimuli

Biomolecules ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. 749 ◽  
Author(s):  
Sean C. Godar ◽  
Roberto Cadeddu ◽  
Gabriele Floris ◽  
Laura J. Mosher ◽  
Zhen Mi ◽  
...  
Keyword(s):  
Risk Taking ◽  
Behavioral Activation ◽  
Stress Reactivity ◽  
Forced Swim Test ◽  
Male Rats ◽  
Corticotropin Release Hormone ◽  
Impulsive Behavior ◽  
Rate Limiting Step ◽  
Vulnerable Subjects ◽  
Rate Limiting

Finasteride (FIN) is the prototypical inhibitor of steroid 5α-reductase (5αR), the enzyme that catalyzes the rate-limiting step of the conversion of progesterone and testosterone into their main neuroactive metabolites. FIN is clinically approved for the treatment of benign prostatic hyperplasia and male baldness; while often well-tolerated, FIN has also been shown to cause or exacerbate psychological problems in vulnerable subjects. Evidence on the psychological effects of FIN, however, remains controversial, in view of inconsistent clinical reports. Here, we tested the effects of FIN in a battery of tests aimed at capturing complementary aspects of mood regulation and stress reactivity in rats. FIN reduced exploratory, incentive, prosocial, and risk-taking behavior; furthermore, it decreased stress coping, as revealed by increased immobility in the forced-swim test (FST). This last effect was also observed in female and orchiectomized male rats, suggesting that the mechanism of action of FIN does not primarily reflect changes in gonadal steroids. The effects of FIN on FST responses were associated with a dramatic decrease in corticotropin release hormone (CRH) mRNA and adrenocorticotropic hormone (ACTH) levels. These results suggest that FIN impairs stress reactivity and reduces behavioral activation and impulsive behavior by altering the function of the hypothalamus–pituitary–adrenal (HPA) axis.

Does Amount and Type of Activity Matter in Behavioral Activation? A Preliminary Investigation of the Relationship between Pleasant, Functional, and Social Activities and Outcome

2014 ◽  
Vol 43 (4) ◽  
pp. 396-411 ◽  
Author(s):  
Rachel Hershenberg ◽  
Daniel Paulson ◽  
Daniel F. Gros ◽  
Ron Acierno
Keyword(s):  
Behavioral Activation ◽  
Research Question ◽  
Preliminary Investigation ◽  
Relative Proportion ◽  
Dissemination And Implementation ◽  
Social Activities ◽  
Symptoms Of Depression ◽  
Preliminary Study ◽  
Complicated Bereavement ◽  
The Relationship

Background: Accumulating evidence supports behavioral activation (BA) as an effective stand-alone treatment for improving depression and related conditions, though little is known about the factors that influence positive outcomes. Such research is ripe for future dissemination and implementation efforts, particularly among vulnerable older adult populations in need of such efficacious and transportable treatments.Aims: Given the central but largely unexamined role that increasing activities plays in BA, we investigated the association between participation in weekly activities and treatment outcome.Method: As a preliminary study of this research question, we report on a sample of 20 older adults with symptoms of depression and complicated bereavement who completed 5 weeks of BA, pre- and posttreatment measures, and weekly planners of BA activities. All activities were coded as either functional or pleasurable (by participants) and if they were social in nature (by trained coders).Results: Overall, BA was associated with reductions in symptomatology. However, participants’ total number of reported activities, and their relative proportion of functional, pleasurable, and social activities, did not significantly relate to their improvement in symptoms.Conclusion: One interpretation of the findings suggests that countering avoidance more generally, potentially independent of the specific type or total amount of activation activities, may be associated with amelioration of symptomatology.

Longitudinal Predictions of Depression Symptoms Using the Activation and Avoidance Subscales of the Japanese Behavioral Activation for Depression Scale-Short Form

2016 ◽  
Vol 120 (1) ◽  
pp. 130-140 ◽  
Author(s):  
Yusuke Shudo ◽  
Tatsuya Yamamoto ◽  
Makoto Sakai
Keyword(s):  
Behavioral Activation ◽  
Short Form ◽  
Depression Scale ◽  
Epidemiologic Studies ◽  
Depression Symptoms ◽  
Symptoms Of Depression ◽  
Client Behavior ◽  
Behavioral Activation Therapy ◽  
Activation Therapy ◽  
Relationship Of

The Behavioral Activation for Depression Scale-Short Form (BADS-SF) is a questionnaire containing two subscales: Activation and Avoidance and was developed to measure changes in client behavior over the course of behavioral activation therapy. This study examines whether the subscales of the Japanese BADS-SF predict the future development of depression. Japanese university students ( N = 129) completed the BADS-SF and the Center for Epidemiologic Studies Depression Scale (CES-D) at the baseline and second test conducted eight weeks later, with no intervention in between. Multiple regression analyses revealed that baseline avoidance scores predicted the scores of CES-D during the second test, after controlling for baseline CES-D and the other BADS-SF subscale scores, but the relationship of the Activation subscale with the CES-D scores was not significant. Therefore, the results indicate that the avoidance scale predicts the occurrence of symptoms of depression.

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