scholarly journals Analysis of Serum Vitamin D Level and Related Factors in Patients With Restless Legs Syndrome

2021 ◽  
Vol 12 ◽  
Author(s):  
Hui Miao Liu ◽  
Miao Chu ◽  
Chen Fei Liu ◽  
Ting Zhang ◽  
Ping Gu
Keyword(s):  
Vitamin D ◽  
Correlation Analysis ◽  
Scale Score ◽  
Restless Legs Syndrome ◽  
Rating Scale ◽  
Serum Vitamin ◽  
Healthy People ◽  
Related Factors ◽  
Restless Legs ◽  
Serum Vitamin D

Objective: This study aimed to detect serum vitamin D (VitD) levels in patients with primary restless legs syndrome (RLS). The further objective was to analyze the relationship of VitD levels with the severity of RLS symptoms, sleep, anxiety, and depression.Methods: The serum 25-hydroxyvitamin D [25(OH)D] levels of 57 patients with primary RLS and the healthy physical examinees in our hospital during the same period were detected. The International Restless Legs Syndrome Study Group (IRLSSG) rating scale for measuring RLS severity and Pittsburgh Sleep Quality Index (PSQI) Scale, 24-item Hamilton Depression Rating Scale (HAMD24), and 14-item Hamilton Anxiety Scale (HAMA14) were used to assess the severity of symptoms, sleep, and emotional state of patients with RLS. Based on VitD level and IRLSSG score, they were grouped for analysis.Results: The serum 25(OH)D level was significantly lower in patients with RLS than in healthy controls, and the incidence of insufficient serum VitD levels was significantly higher in patients with RLS than in healthy people (both P < 0.05). The serum VitD level was significantly lower in (extremely) severe patients with RLS than in mild to moderate patients with RLS (P < 0.05). The IRLSSG scale score and HAMD24 score were significantly higher in patients with RLS with insufficient serum VitD levels than those with normal serum VitD levels (both P < 0.05). Correlation analysis of IRLSSG scale score with serum VitD level and each scale score in patients with RLS showed that IRLSSG scale score was negatively correlated with VitD level, but positively correlated with PSQI, HAMA14, and HAMD24 scores. The results of correlation analysis between serum VitD levels and each scale score in patients with RLS indicated that serum VitD levels were negatively correlated with IRLSSG scale scores, PSQI scores, and HAMD24 scores.Conclusion: The serum VitD level is generally lower in patients with RLS than in healthy people, and lower serum VitD level is associated with more severe symptoms of RLS, worse quality of sleep, and worse depression.

scholarly journals Correction to: Serum vitamin D, vitamin D receptor and binding protein genes polymorphisms in restless legs syndrome

2021 ◽  
Vol 268 (4) ◽  
pp. 1473-1473
Author(s):  
Félix Javier Jiménez-Jiménez ◽  
Gemma Amo ◽  
Hortensia Alonso-Navarro ◽  
Marisol Calleja ◽  
Mónica Díez-Fairén ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Restless Legs Syndrome ◽  
Binding Protein ◽  
Serum Vitamin ◽  
Restless Legs ◽  
Serum Vitamin D

Serum vitamin D, vitamin D receptor and binding protein genes polymorphisms in restless legs syndrome

2020 ◽  
Author(s):  
Félix Javier Jiménez-Jiménez ◽  
Gemma Amo ◽  
Hortensia Alonso-Navarro ◽  
Marisol Calleja ◽  
Mónica Díez-Fairén ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Restless Legs Syndrome ◽  
Binding Protein ◽  
Serum Vitamin ◽  
Restless Legs ◽  
Serum Vitamin D

scholarly journals Effect of hypovitaminosis D and its related factors in pregnant women and their newborns

2019 ◽  
Vol 8 (3) ◽  
pp. 1115
Author(s):  
Amrita Sandhu ◽  
Ruchira Nautiyal ◽  
Vinit Mehrotra ◽  
Sanober Wasim
Keyword(s):  
Vitamin D ◽  
Cord Blood ◽  
Pregnant Women ◽  
Vitamin D Deficiency ◽  
Negative Correlation ◽  
Serum Vitamin ◽  
Related Factors ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
The Impact

Background: Maternal and fetal vitamin D deficiency has nowadays emerged as a frequent morbidity. Adequate vitamin D concentrations during pregnancy are necessary to maintain neonatal calcium homeostasis, bone maturation and mineralization. Objectives of this study were to evaluate serum vitamin D concentration in mothers and its correlation with neonatal cord blood vitamin D at the time of delivery and to study the impact of hypovitaminosis on neonatal anthropometry. Effect of related factors like calcium (Ca), alkaline phosphatase (ALP) and parathyroid hormone (PTH) on maternal vitamin D levels were to be evaluated.Methods: Cross sectional study was done on a total of 220 healthy uncomplicated antenatal females with singleton pregnancy attending labor room at the time of delivery. Maternal and neonatal cord blood samples were drawn in the delivery room and analyzed. Neonatal anthropometry was recorded. Correlations among various maternal and neonatal factors were studied.Results: Widespread vitamin D deficiency was observed in expectant subjects and neonates with 70.91% having deficient levels which were also reflected in newborns (71.82%). Maternal ALP (r= -0.5503, p=0.000) bears a weak negative correlation (p<0.05), maternal serum Ca positive correlation (r = 0.7486, p=0.000) and plasma PTH levels a negative correlation (r = -2.084, p=0.000) with hypovitaminosis. No significant correlation was observed between neonatal anthropometry and vitamin D levels.Conclusions: High prevalence of hypovitaminosis was observed among pregnant women and their neonates in this study. A positive linear relationship was seen between maternal and cord blood vitamin D (r 0.974, p 0.0001).

scholarly journals Vitamin D Supplementation does not Effect Adiposity in Healthy Adults

2017 ◽  
Vol 1 (2) ◽  
pp. 101
Author(s):  
Zujaja-Tul-Noor Hamid Mehmood ◽  
Dimitrios Papandreou
Keyword(s):  
Vitamin D ◽  
Serum Vitamin ◽  
Epidemiological Data ◽  
Serum Levels ◽  
Vitamin D Supplementation ◽  
Hip Circumference ◽  
Related Factors ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
24 Hour Recall

Introduction: Vitamin D is crucial for skeletal and extraskeletal health outcomes as Vitamin D binding receptors are located through out body, and epidemiological data supports its link with many conditions. Data on vitamin D levels and especially Vitamin D supplementation in U.A.E. is essentially inadequate.Design: Subjects (n=20) in this 1 month prospective study were given 2000 IU of daily Vitamin D without any special dietary or physical activity changes. Anthropometrics (weight, waist circumference, hip circumference), Vitamin D/ Calcium food frequency questionnaire and 24 –Hour recall were collected.Results: Mean age of subjects was 28.7 years, and baseline mean serum Vitamin D level of 17.5 ng/mL ±6.47. It increased Vitamin D serum levels by a mean of 6.76 ng/mL. Hip Circumference also reduced statistically significantly by moderate 2% (p 0.03 ±0.59),Conclusion: Vitamin D supplementation moderate dose daily can be pivotal in acquiring health benefits and reducing adiposity related factors. However, this surely calls for further investigation for longer period.

Family‐related factors may affect serum vitamin D levels

2019 ◽  
Vol 108 (12) ◽  
pp. 2301-2302
Author(s):  
Maria Grazia Clemente ◽  
Dario Argiolas ◽  
Mary E. Blue ◽  
Lino Argiolas ◽  
Angela Bitti ◽  
...  
Keyword(s):  
Vitamin D ◽  
Serum Vitamin ◽  
Related Factors ◽  
Serum Vitamin D ◽  
Vitamin D Levels

scholarly journals The Use of 25-hydroxyvitamin D Saliva Test to Replace Vitamin D Serum Blood Test in Healthy People

2021 ◽  
Vol 9 (T3) ◽  
pp. 40-43
Author(s):  
Dina Keumala Sari ◽  
Liza Meutia Sari ◽  
Lidya Imelda Laksmi ◽  
Farhat Farhat
Keyword(s):  
Vitamin D ◽  
Active Form ◽  
Serum Vitamin ◽  
Cross Sectional Study ◽  
Healthy People ◽  
Cross Sectional ◽  
Hydroxyvitamin D ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
25 Hydroxyvitamin D

BACKGROUND: Routine examination of Vitamin D levels is carried out by checking serum 25-hydroxyvitamin D (25[OH]D) levels which indicate circulating Vitamin D levels. While serum 1.25(OH)D levels are less frequently performed, although serum 1.25(OH)D levels represent the active form of Vitamin D be a substitute for checking Vitamin D levels. AIMS: This study aims to see the correlation between Vitamin D levels, namely, 25(OH)D and 1.25(OH)D saliva, which correlate with serum 25(OH)D and 1.25(OH)D levels so that the examination of salivary Vitamin D levels can be a substitute for checking serum Vitamin D levels. MATERIAL AND METHODS: This study is a cross-sectional study involving healthy men and women, aged 20–50 years, sampling in Lima Puluh Village, Batubara District, North Sumatra Province, Indonesia. The parameters studied were 25(OH)D and 1.25(OH)D levels of saliva and serum. RESULTS: This study involved 56 study subjects, male and female, with a percentage of deficiencies of 78.6% by examining 25(OH)D saliva and 76.8% by examining 25(OH)D serum. As for the 1.25(OH)D examination of saliva and serum, all were within normal limits. The analysis showed that a moderate correlation was obtained for levels of 25(OH)D saliva with serum 25(OH)D (p = 0.424) and a weak correlation for levels of 1.25(OH)D saliva with serum 25(OH)D (p = 0.339). CONCLUSIONS: Salivary 25(OH)D assay can be used to replace serum 25(OH)D assay in healthy people as a non-invasive alternative.

scholarly journals «POKAZATELI MINERAL'NOY PLOTNOSTI KOSTNOY TKANI I UROVEN' 25-GIDROKSIVITAMINA D SYVOROTKI KROVI U ZhENShchIN REPRODUKTIVNOGO VOZRASTA

2011 ◽  
Vol 14 (3) ◽  
pp. 11-13
Author(s):  
T. L. KARONOVA
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Correlation Analysis ◽  
Direct Relationship ◽  
Serum Vitamin ◽  
Reproductive Age ◽  
Mineral Density ◽  
Women Of Reproductive Age ◽  
Serum Vitamin D ◽  
Over 40 Years

We evaluated the effect of serum Vitamin D level on bone mineral density in 270 women of reproductive age. Insufficiency and deficiency of vitamin D were found in 86.8% of women regardless of the season when the examination was performed. The DXA results showed that every 5th woman had a decreased BMD. Correlation analysis revealed a significant direct relationship between serum vitamin D level and BMD in women up to 40 years old (r=0,48, p=0,04), whereas in those over 40 years this relationship could not be seen. Additional studies are required for further assessment of vitamin D role in bone remodeling

Clinical factors correlated with vitamin D deficiency in patients with obesity scheduled for bariatric surgery: A single center experience

2020 ◽  
Vol 90 (3-4) ◽  
pp. 346-352
Author(s):  
Vincenzo Pilone ◽  
Salvatore Tramontano ◽  
Carmen Cutolo ◽  
Federica Marchese ◽  
Antonio Maria Pagano ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Inverse Correlation ◽  
Model Assessment ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Female Sex ◽  
Vitamin D Levels

Abstract. We aim to assess the prevalence of vitamin D deficiency (VDD) in patients scheduled for bariatric surgery (BS), and to identify factors that might be associated with VDD. We conducted a cross-sectional observational study involving all consecutive patients scheduled for BS from 2017 to 2019. The exclusion criteria were missing data for vitamin D levels, intake of vitamin D supplements in the 3 months prior to serum vitamin D determination, and renal insufficiency. A total of 206 patients (mean age and body mass index [BMI] of 34.9 ± 10.7 years, and 44.3 ± 6.99 kg/m2, respectively) met the inclusion criteria and were enrolled for data analysis. VDD (<19.9 ng/mL), severe VDD (<10 ng/mL), and vitamin D insufficiency (20–29.9 ng/mL) were present in 68.8 %, 12.5 %, and 31.2 % of patients, respectively. A significant inverse correlation was found between vitamin D levels and initial BMI, parathyroid hormone, and homeostatic model assessment of insulin resistance (r = −0.280, p < 0.05; r = −0.407, p = 0.038; r = −0.445, p = 0.005), respectively. VDD was significantly more prevalent in patients with higher BMI [−0.413 ± 0.12, CI95 % (−0.659; −0.167), p = 0.006], whereas no significant association between hypertension [−1.005 ± 1.65, CI95 % (−4.338; 2.326), p = 0.001], and diabetes type 2 (T2D) [−0.44 ± 2.20, CI95 % (−4.876; 3.986), p = 0.841] was found. We observed significant association between female sex and levels of vitamin D [6.69 ± 2.31, CI95 % (2.06; 11.33), p = 0.006]. The present study shows that in patients scheduled for BS, VDD deficiency is common and was associated with higher BMI, and female sex.

Relationship Between Nutrient Intake and Vitamin D Status in Osteoporotic Women

2007 ◽  
Vol 77 (6) ◽  
pp. 376-381 ◽  
Author(s):  
de Souza Genaro ◽  
de Paiva Pereira ◽  
de Medeiros Pinheiro ◽  
Szejnfeld ◽  
Araújo Martini
Keyword(s):  
Vitamin D ◽  
Mineral Metabolism ◽  
Sodium Intake ◽  
Serum Vitamin ◽  
Cross Sectional Study ◽  
Dietary Intakes ◽  
Mineral Density ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Dietary Records

Vitamin D is essential for maintaining calcium homeostasis and optimizing bone health. Its inadequacy is related to many factors including dietary intake. The aim of the present study was to evaluate serum 25(OH)D and its relationship with nutrient intakes in postmenopausal Brazilian women with osteoporosis. This cross-sectional study comprised 45 free-living and assisted elderly at São Paulo Hospital. Three-day dietary records were used to assess dietary intakes. Bone mineral density was measured with a dual-energy X-ray absorptiometer (DXA). Blood and urine sample were collected for analysis of biochemical markers of bone and mineral metabolism. Insufficiency of vitamin D was observed in 24.4% of the women and optimal levels (≥ 50 nmol/L) were observed in 75.6%. Parathyroid hormone was above the reference range in 51% of the participants. The mean calcium (724 mg/day) and vitamin D (4.2 μ g/day) intakes were lower than the value proposed by The Food and Nutrition Board and sodium intake was more than two-fold above the recommendation. Higher levels of serum 25(OH)D were inversely associated with sodium intake. Dietary strategies to improve serum vitamin D must focus on increasing vitamin D intake and should take a reduction of sodium intake into consideration.

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