scholarly journals Amaranthus spinosus Attenuated Obesity-Induced Metabolic Disorders in High-Carbohydrate-High-Fat Diet-Fed Obese Rats

2021 ◽  
Vol 8 ◽  
Author(s):  
Md. Raihan Uzzaman Prince ◽  
S. M. Neamul Kabir Zihad ◽  
Puja Ghosh ◽  
Nazifa Sifat ◽  
Razina Rouf ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Metabolic Disorders ◽  
Methanol Extract ◽  
Food Supplement ◽  
Fat Deposition ◽  
Organ Weight ◽  
High Fat ◽  
High Carbohydrate ◽  
Amaranthus Spinosus ◽  
Obese Rats

Amaranthus spinosus is a common vegetable of Bangladesh and well-known for its ethnomedicinal uses. In this study, we have evaluated the ability of powdered supplementation, methanol extract, and aqueous extract of A. spinosus in attenuating in high-carbohydrate-high-fat (HCHF) diet-induced obesity and associated metabolic disorders in female obese rates. Several parameters have been analyzed in this study including body weight, organ weight, fat deposition, glycemic status, lipid levels, hepatic and renal biomarkers, hepatic antioxidant status, and hepatosteatosis. All three samples of A. spinosus significantly reduced weight gain, organ weight, and abdominal fat deposition. Improved glucose tolerance and lipid parameters were seen in obese rats administered with A. spinosus powder, methanol extract, and aqueous extract. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and creatine kinase levels were normalized by the test samples. A. spinosus boosted hepatic antioxidant levels including reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx). Histopathology of liver tissue revealed increased fat infiltration and higher steatosis score in HCHF diet-fed obese rats which was brought down by A. spinosus. Analyzing all the results it can be concluded that this medicinal herb is beneficial in the management of obesity and obesity-induced metabolic disorders, making it a prospective food supplement.

Supplementation of Heliotropium indicum Linn attenuates obesity and associated metabolic disorders in high‐carbohydrate‐high‐fat diet‐induced obese rats

2020 ◽  
Vol 44 (11) ◽  
Author(s):  
Nazifa Sifat ◽  
S. M. Neamul Kabir Zihad ◽  
Farhana Lovely ◽  
Razina Rouf ◽  
Gazi Mohammad Al Shajib ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Metabolic Disorders ◽  
High Fat ◽  
High Carbohydrate ◽  
Obese Rats ◽  
Heliotropium Indicum

Hepatoprotective effect of coffee pulp aqueous extract combined with simvastatin against hepatic steatosis in high-fat diet-induced obese rats

2019 ◽  
Vol 54 ◽  
pp. 568-577 ◽  
Author(s):  
Atcharaporn Ontawong ◽  
Oranit Boonphang ◽  
Tipthida Pasachan ◽  
Acharaporn Duangjai ◽  
Anchalee Pongchaidecha ◽  
...  
Keyword(s):  
Hepatic Steatosis ◽  
Aqueous Extract ◽  
High Fat Diet ◽  
Hepatoprotective Effect ◽  
High Fat ◽  
Coffee Pulp ◽  
Obese Rats

scholarly journals Antidyslipidemic, Anti-Inflammatory, and Antioxidant Activities of Aqueous Leaf Extract of Dioscoreophyllum cumminsii (Stapf) Diels in High-Fat Diet-Fed Rats

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
O. B. Ibitoye ◽  
U. M. Ghali ◽  
J. B. Adekunle ◽  
J. N. Uwazie ◽  
T. O. Ajiboye
Keyword(s):  
Aqueous Extract ◽  
High Fat Diet ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Protein Carbonyl ◽  
Lipoprotein Cholesterol ◽  
Low Density Lipoprotein Cholesterol ◽  
High Fat ◽  
Obese Rats ◽  
Anti Inflammatory

Dioscoreophyllum cumminsii (Stapf) Diels leaves are widely used in the treatment of diabetes, obesity, and cardiovascular related complications in Nigeria. This study investigates the anti-inflammatory and antiobesity effect of aqueous extract of Dioscoreophyllum cumminsii leaves in high-fat diet- (HFD-) induced obese rats. HFD-fed rats were given 100, 200, and 400 mgkg−1 body weight of aqueous extract of Dioscoreophyllum cumminsii leaves for 4 weeks starting from 9th week of HFD treatment. D. cumminsii leaves aqueous extract reversed HFD-mediated decrease in the activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and glucose 6-phosphate dehydrogenase. Moreover, HFD-mediated elevation in the levels of conjugated dienes, lipid hydroperoxides, malondialdehyde, protein carbonyl, and DNA fragmentation in rats liver was lowered. HFD-mediated alterations in serum total cholesterol, triacylglycerol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and very low-density lipoprotein cholesterol were significantly reversed by the extract. The treatment of HFD-fed rats reduced the levels of insulin, leptin, protein carbonyl, fragmented DNA, and tumour necrosis factor-α and interleukin- (IL-) 6 and IL- 8 and increased the adiponectin level. This study showed that aqueous extract of Dioscoreophyllum cumminsii leaves has potential antiobesity and anti-inflammatory effects through modulation of obesity-induced inflammation, oxidative stress, and obesity-related disorder in HFD-induced obese rats.

Fubrick tea attenuates high-fat diet induced fat deposition and metabolic disorder by regulating gut microbiota and caffeine metabolism

2020 ◽  
Vol 11 (8) ◽  
pp. 6971-6986 ◽  
Author(s):  
Nana Jing ◽  
Xiaoxia Liu ◽  
Mingliang Jin ◽  
Xingbin Yang ◽  
Xin Hu ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Gut Microbiota ◽  
Aqueous Extract ◽  
High Fat Diet ◽  
Metabolic Disorder ◽  
Fat Deposition ◽  
Obese Mice ◽  
High Fat ◽  
Caffeine Metabolism

Fubrick tea aqueous extract (FTEs) improved lipid metabolism by regulating gut microbiota and caffeine metabolism in high-fat diet induced obese mice.

Antiobesity effect of Tamarindus indica L. pulp aqueous extract in high-fat diet-induced obese rats

2011 ◽  
Vol 66 (2) ◽  
pp. 333-342 ◽  
Author(s):  
Khairunnuur Fairuz Azman ◽  
Zulkhairi Amom ◽  
Azrina Azlan ◽  
Norhaizan Mohd Esa ◽  
Rasadah Mat Ali ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
High Fat Diet ◽  
Tamarindus Indica ◽  
High Fat ◽  
Obese Rats

scholarly journals Evaluation of anti-obesity potential of aqueous extract of Achyranthes aspera Linn. in high fat diet induced obese rats

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Kumaraswamy Athesh ◽  
Rangaraju Sivasubramanian ◽  
Gnanasekaran Jothi ◽  
Pemiah Brindha
Keyword(s):  
Aqueous Extract ◽  
Pancreatic Lipase ◽  
High Fat Diet ◽  
In Vivo Studies ◽  
Control Group ◽  
High Fat ◽  
Achyranthes Aspera ◽  
Obese Rats

Abstract Background Obesity, reached epidemic proportions globally is often associated with life threatening comorbidities. The unavailability of safe and effective long term medications for obesity in modern pharmacotherapy forces the scientific community to explore the potential of Ayurvedic traditional healers as they are considered safe and effective. Objective To explore the anti-obesity potential of aqueous extract of aerial parts of Achyranthes aspera L. (AEAA), a traditional healer in high fat diet (HFD) induced obese rats. Methods AEAA was prepared and subjected to in-vitro pancreatic lipase inhibition assay and in-vivo anti-obesity studies. For in-vivo studies, HFD fed obese prone Wistar albino rats were divided into five experimental groups (Group II to VI): animals fed with standard pellet chow served as normal control (Group I) while, animals continued with HFD alone served as obese control (Group II); Group III, IV and V were administered AEAA at a dose of 100, 200 and 300 mg/kg b.w. respectively along with HFD; and animals administered orlistat (30 mg/kg bw) along with HFD served as standard control (Group VI). All the drugs were administered orally once a day for a period of 60 days. At the end of the experimental period various physical, biochemical and histopathological observations were made. Results In-vitro studies showed AEAA partially but not significantly inhibited the activity of pancreatic lipase. Data of in-vivo studies revealed, significant reduction in body weights, fat pad weights and organ weights upon AEAA treatment. Elevated levels of glucose, insulin, leptin, lipid profiles and antioxidant status were also brought back to normal. Conclusion The obtained results clearly suggested that AEAA possess pronounced anti-obesity potential.

scholarly journals Lycium Barbarum Polysaccharides Regulate the Gut Microbiota To Modulate Metabolites in High Fat Diet-Induced Obese Rats

2021 ◽  
Author(s):  
Yanna Fan ◽  
Lu Yan ◽  
Mengyao Li ◽  
Zhiyu Pu ◽  
Yannan Zhang ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
High Fat Diet ◽  
Metabolic Disorders ◽  
Unsaturated Fatty Acids ◽  
Intestinal Flora ◽  
Density Lipoprotein ◽  
High Fat ◽  
Lycium Barbarum ◽  
Obese Rats ◽  
Serum Metabolomics

Abstract Previous studies had indicated that the gut microbiota was a main internal factor leading to obesity through energy storage and metabolic disorders. Lycium Barbarum Polysaccharides (LBP) have been discovered with a more protective effect on intestinal flora. But it is unclear whether LBP could regulate the gut microbiota to modulate metabolites, finally relieving obesity. A related study of high-throughput 16S rRNA sequencing and serum metabolomics profiling in LBP intervention on high fat diet-induced obese rats then explored the beneficial effects of LBP and the underlying mechanism. LBP affected lipid parameters such as total cholesterol, Triglyceride, and High-density lipoprotein. The gut microbiota result detected 16 types of the phylum of bacteria in total, while four of them (Bacteroidetes, Firmicutes, Proteobacteria, Deferribacteres) were significantly different. LBP upregulated the level of Firmicutes of obese rats. LBP might associate with the gut microbiota that participates in the membrane transport and metabolism of amino acid, carbohydrate, energy, and lipid. The serum metabolomics profiling of high-fat diet-induced obesity rats found over 30 differential metabolites between model and intervention groups. Primary metabolites include cortisol, glycohyocholic acid, homo-L-arginine, ursodeoxycholic acid, isoursodeoxycholic acid, glycoursocholic acid, 4-ethylphenylsulfate, deoxycholic acid, 7-hydroxy-3-oxocholanoic acid isomers, gly-phe, pipecolic acid, proline betaine, and pyrocatechol sulfate. Pathway analysis in serum found four disorder pathways: glycerophospholipid metabolism, glycine-serine-threonine metabolism, biosynthesis of unsaturated fatty acids, and linoleic acid metabolism. The studies revealed that LBP treatment increased the diversity of fecal microorganisms and reduced metabolic disorders in obese rats. LBP ameliorated metabolic disorders and rebalanced the gut microbiome.

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