Impaired Antioxidant Defence Status Is Associated With Metabolic-Inflammatory Risk Factors in Preterm Children With Extrauterine Growth Restriction: The BIORICA Cohort Study

Introduction: An impaired antioxidant status has been described during foetal growth restriction (FGR). Similarly, the antioxidant defence system can be compromised in preterm children with extrauterine growth restriction (EUGR). The aim of this prospective study was to evaluate the antioxidant status in prepubertal children with a history of prematurity without FGR, with and without EUGR, compared to a healthy group.Methods: In total, 211 children were recruited and classified into three groups: 38 with a history of prematurity and EUGR; 50 with a history of prematurity and adequate extrauterine growth (AEUG); and 123 control children born at term. Catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione reductase (GR) activities were assessed in lysed erythrocytes with spectrophotometric methods. Plasma levels of the antioxidants α-tocopherol, retinol and β-carotene were determined through solvent extraction and ultra-high-pressure liquid chromatography coupled to mass spectrometry.Results: Children with the antecedent of EUGR and prematurity had lower CAT activity than the other two groups and lower GPx activity than the control children. Lower SOD, GPx and GR activities were observed in the AEUG group compared to the controls. However, higher concentrations of α-tocopherol and β-carotene were found in the EUGR group compared to the other groups; retinol levels were also higher in EUGR than in AEUG children. In EUGR and AEUG children, enzymatic antioxidant activities and plasma antioxidants were associated with metabolic syndrome components and pro-inflammatory biomarkers.Conclusions: This study reveals, for the first time, that the EUGR condition and prematurity appear to be linked to an impairment of the antioxidant defence status, which might condition an increased risk of adverse metabolic outcomes later in life.

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Changes in plasma adipokines in prepubertal children with a history of extrauterine growth restriction

Nutrition ◽

10.1016/j.nut.2013.04.015 ◽

2013 ◽

Vol 29 (11-12) ◽

pp. 1321-1325 ◽

Cited By ~ 8

Author(s):

María Ortiz-Espejo ◽

Juan Luís Pérez-Navero ◽

Josune Olza ◽

María Carmen Muñoz-Villanueva ◽

Concepción María Aguilera ◽

...

Keyword(s):

Growth Restriction ◽

Prepubertal Children ◽

History Of ◽

Extrauterine Growth Restriction

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Plasma Adipokines Profile in Prepubertal Children with a History of Prematurity or Extrauterine Growth Restriction

Nutrients ◽

10.3390/nu12041201 ◽

2020 ◽

Vol 12 (4) ◽

pp. 1201

Author(s):

María Dolores Ordóñez-Díaz ◽

Mercedes Gil-Campos ◽

Katherine Flores-Rojas ◽

María Carmen Muñoz-Villanueva ◽

Concepción María Aguilera-García ◽

...

Keyword(s):

Adipose Tissue ◽

Growth Restriction ◽

Healthy Children ◽

Anthropometric Parameters ◽

Metabolic Markers ◽

Prepubertal Children ◽

Very Preterm Infants ◽

History Of ◽

The Difference ◽

Extrauterine Growth Restriction

Adipose tissue programming could be developed in very preterm infants with extrauterine growth restriction (EUGR), with an adverse impact on long-term metabolic status, as was studied in intrauterine growth restriction patterns. The aim of this cohort study was to evaluate the difference in levels of plasma adipokines in children with a history of EUGR. A total of 211 school age prepubertal children were examined: 38 with a history of prematurity and EUGR (EUGR), 50 with a history of prematurity with adequate growth (PREM), and 123 healthy children born at term. Anthropometric parameters, blood pressure, metabolic markers and adipokines (adiponectin, resistin, leptin) were measured. Children with a history of EUGR showed lower values of adiponectin (μg/mL) compared with the other two groups: (EUGR: 10.6 vs. PREM: 17.7, p < 0.001; vs. CONTROL: 25.7, p = 0.004) and higher levels of resistin (ng/mL) (EUGR: 19.2 vs. PREM: 16.3, p =0.007; vs. CONTROL: 7.1, p < 0.001. The PREM group showed the highest values of leptin (ng/mL), compared with the others: PREM: 4.9 vs. EUGR: 2.1, p = 0.048; vs. CONTROL: 3.2, p = 0.029). In conclusion, EUGR in premature children could lead to a distinctive adipokines profile, likely associated with an early programming of the adipose tissue, and likely to increase the risk of adverse health outcomes later in life.

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Work-Related Asthma in Automobile Spray Painters: Two Case Reports

Archives of Industrial Hygiene and Toxicology ◽

10.2478/10004-1254-59-2008-1858 ◽

2008 ◽

Vol 59 (2) ◽

pp. 117-125 ◽

Cited By ~ 1

Author(s):

Jordan Minov ◽

Jovanka Karadžinska-Bislimovska ◽

Kristin Vasilevska ◽

Snežana Risteska-Kuc ◽

Sašo Stoleski

Keyword(s):

Occupational Asthma ◽

Diagnostic Procedure ◽

Case Reports ◽

Bronchial Hyperresponsiveness ◽

Diurnal Variations ◽

The Other ◽

Respiratory Impairment ◽

Work Related ◽

Increased Risk ◽

History Of

Work-Related Asthma in Automobile Spray Painters: Two Case ReportsThis report describes two patients who had developed asthma after working as automobile painters with isocyanate-based aerosol paint for two years or over. In both patients asthma was confirmed using the standard diagnostic procedure. One of the subjects was atopic. One was ex-smoker and the other had never smoked. Neither had a family history of asthma. The symptoms occurred after workplace exposure lasting two years in one patient and three in the other. As both reported work-relatedness of the symptoms, they underwent serial peak expiratory flow rate (PEFR) measurement and bronchoprovocation testing. Significant work-related changes in PEFR diurnal variations and in non-specific bronchial hyperresponsiveness (NSBH) were observed in one patient, suggesting allergic occupational asthma (OA), while the other patient was diagnosed work-exacerbated asthma (WEA). Our data confirm that spray painting is an occupation with increased risk of respiratory impairment and asthma.

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Hepatitis E, Schistosomiasis and Echinococcosis–Prevalence in a Cohort of Pregnant Migrants in Germany and Their Influence on Fetal Growth Restriction

Pathogens ◽

10.3390/pathogens11010058 ◽

2022 ◽

Vol 11 (1) ◽

pp. 58

Author(s):

Janine Zöllkau ◽

Juliane Ankert ◽

Mathias W. Pletz ◽

Sasmita Mishra ◽

Gregor Seliger ◽

...

Keyword(s):

Fetal Growth ◽

Fetal Growth Restriction ◽

Hepatitis E ◽

Growth Restriction ◽

Premature Delivery ◽

Delivery Methods ◽

Increased Risk ◽

History Of ◽

Adverse Pregnancy ◽

History Of Migration

Background: Infections, as well as adverse birth outcomes, may be more frequent in migrant women. Schistosomiasis, echinococcosis, and hepatitis E virus (HEV) seropositivity are associated with the adverse pregnancy outcomes of fetal growth restriction and premature delivery. Methods: A cohort study of 82 pregnant women with a history of migration and corresponding delivery of newborns in Germany was conducted. Results: Overall, 9% of sera tested positive for anti-HEV IgG. None of the patients tested positive for anti-HEV IgM, schistosomiasis, or echinococcus serology. Birth weights were below the 10th percentile for gestational age in 8.5% of the neonates. No association between HEV serology and fetal growth restriction (FGR) frequency was found. Conclusions: In comparison to German baseline data, no increased risk for HEV exposure or serological signs of exposure against schistosomiasis or echinococcosis could be observed in pregnant migrants. An influence of the anti-HEV serology status on fetal growth restriction could not be found.

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Incidence and associated factors of extrauterine growth restriction (EUGR) in preterm infants, a cross-sectional study in selected NICUs in Ethiopia

BMJ Paediatrics Open ◽

10.1136/bmjpo-2020-000765 ◽

2020 ◽

Vol 4 (1) ◽

pp. e000765

Author(s):

Netsanet Workneh Gidi ◽

Robert L Goldenberg ◽

Assaye K Nigussie ◽

Elizabeth McClure ◽

Amha Mekasha ◽

...

Keyword(s):

Preterm Infants ◽

Gestational Age ◽

Low Income ◽

Associated Factors ◽

Cross Sectional Study ◽

Growth Restriction ◽

Sectional Study ◽

Cross Sectional ◽

Increased Risk ◽

Extrauterine Growth Restriction

BackgroundPreterm infants have high risk of developing growth restriction and long-term complications. Enteral feeding is often delayed in neonatal intensive care units (NICUs) for the fear of feeding intolerance and the associated necrotising enterocolitis, and recent advances in nutritional support are unavailable in low-income countries.ObjectiveThe aim of this study was to assess the incidence and associated factors of extrauterine growth restriction (EUGR) among preterm infants in selected NICUs in Ethiopia.MethodThis was a cross-sectional study involving a subgroup analysis of preterm infants admitted to hospitals, from a multicentre descriptive study of cause of illness and death in preterm infants in Ethiopia, conducted from 2016 to 2018. EUGR was defined as weight at discharge Z-scores <−1.29 for corrected age. Clinical profiles of the infants were analysed for associated factors. SPSS V.23 software was used for analysis with a significance level of 5% and 95% CI.ResultFrom 436 preterm infants included in the analysis, 223 (51%) were male, 224 (51.4%) very low birth weight (VLBW) and 185 (42.4%) small for gestational age (SGA). The mean (SD) of weight for corrected age Z-score at the time of discharge was −2.5 (1.1). The incidence of EUGR was 86.2%. Infants who were SGA, VLBW and longer hospital stay over 21 days had increased risk of growth restriction (p-value<0.01). SGA infants had a 15-fold higher risk of developing EUGR at the time of discharge from hospital than those who were appropriate or large for gestational age (OR (95% CI)=15.2 (4.6 to 50.1).ConclusionThe majority of the infants had EUGR at the time of discharge from the hospital, which indicates suboptimal nutrition. Revision of national guidelines for preterm infants feeding and improvement in clinical practice is highly required.

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Nutritional assessment in neonatal and prepubertal children with a history of extrauterine growth restriction

Early Human Development ◽

10.1016/j.earlhumdev.2013.06.003 ◽

2013 ◽

Vol 89 (9) ◽

pp. 763-768 ◽

Cited By ~ 7

Author(s):

María Ortiz-Espejo ◽

Juan Luís Pérez-Navero ◽

María Carmen Muñoz-Villanueva ◽

Gil-Campos Mercedes

Keyword(s):

Nutritional Assessment ◽

Growth Restriction ◽

Prepubertal Children ◽

History Of ◽

Extrauterine Growth Restriction

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Vertically transmitted infections and extrauterine growth restriction in preterm neonates: a new risk factor

Revista Brasileira de Saúde Materno Infantil ◽

10.1590/1806-93042021000100006 ◽

2021 ◽

Vol 21 (1) ◽

pp. 107-115

Author(s):

Verônica Cheles Vieira ◽

Raquel Cristina Gomes Lima ◽

Daiane Borges Queiroz ◽

Danielle Souto de Medeiros

Keyword(s):

Premature Infants ◽

Gestational Age ◽

Neonatal Intensive Care ◽

Positive Association ◽

Final Analysis ◽

Growth Restriction ◽

Preterm Neonates ◽

Clinical Practices ◽

Increased Risk ◽

Extrauterine Growth Restriction

Abstract Objectives: to investigate the association between Vertically Transmitted Infections (VTI) and Extrauterine Growth Restriction (EUGR) among premature infants in Neonatal Intensive Care Units (NICU). Methods: part of a large non-concurrent cohort study with medical records analysis. We evaluated EUGR in premature infants at a gestational age at birth of > 32 weeks and <36 weeks and presented a corrected gestational age of 36 completed weeks during a 27-day birth follow-up. Premature infants with major congenital anomalies were excluded. We analyzed associations among EUGR, VTI and covariables related to maternal disease, birth characteristics, perinatal morbidities and clinical practices. Results: out of the 91 premature infants, 59.3% (CI95%=48.9-69.0%) developed EUGR. VTI were observed in 4.4%o of the population; all premature infants affected by VTI had EUGR. The VTI found were syphilis, cytomegalovirus disease and toxoplasmosis. The final analysis has showed a positive association between VTI and EUGR (RR=1.57; CI95%o=1.07-2.30); the female covariables (RR=1.50; CI95%=1.11-2.02), moderate premature classification (RR=1.41; CI95%=1.06-1.87) and small for gestational age (RR=2.69; CI95% 1.853.90) have also influenced this outcome. Conclusion: this study revealed VTI as an important morbidity factor, with impact on the increased risk of EUGR between premature infants affected by these diseases.

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Management of Hypertension in Elderly Pregnant Women with IVF Conception: A Case Report

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2021/v33i38a32065 ◽

2021 ◽

pp. 113-118

Author(s):

Aparna M. Kawale ◽

Manoj Patil

Keyword(s):

Antihypertensive Drugs ◽

Gestational Hypertension ◽

Previous History ◽

Growth Restriction ◽

Fluid Replacement ◽

Obstetric History ◽

Increased Risk ◽

Uterine Growth ◽

History Of ◽

Intra Uterine Growth Restriction

Introduction: Hypertensive complications associated with pregnancy are the primary cause of maternal and fetal morbidity. Early development of cardiovascular disease is also anticipated relatively early after pregnancy is terminated. Over the past 20 years, infertility treatments have steadily increased and proven effective in achieving significant successful conception rates and live birth rates, even among women younger than 35 years of age. Symptoms and important clinical findings: A 45 year sold female was admitted in AVBRH on date 22/01/2021 with chief complaint of breathing difficulty (elderly G5P1D1A3 with 28 weeks of gestational age)having history of previous LSCS with IVF conception with gestational hypertension. Obstetric history: Patient had bad obstetric history of three abortionsand one still-birth. In 2017 she had got the menopause. After menopause she took the treatment in AVBRH Sawangi (M) Wardha and got the regular menses.After regular menses, shereceived IVF cycle and she was conceived in 2nd IVF cycle. The main diagnoses, therapeutic interventions, and outcomes: After physical examination and investigations, this case was diagnosed having 28 weeks of gestation with hypertension. Patient had previous history of LSCS.Patient was treated with antihypertensive drugs to reduce the symptoms of eclampsia. Alsoshe was provided calcium supplement and iron supplement. Present case was stable but ultrasonography revealedsign of stage I- intra uterine growth restriction. Nursing perspectives: Fluid replacement i.e. DNS and RL, monitoring offetal heart rate and vital signs per hourly. Conclusion: Conception with in vitro fertilization have increased risk of gestational hypertension as well as fetal complications like intra uterine growth restriction. But timely treatment and management improves the outcome of pregnancy.

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Antioxidant status and its association with elevated depressive symptoms among US adults: National Health and Nutrition Examination Surveys 2005–6

British Journal Of Nutrition ◽

10.1017/s0007114512003467 ◽

2012 ◽

Vol 109 (9) ◽

pp. 1714-1729 ◽

Cited By ~ 25

Author(s):

May A. Beydoun ◽

Hind A. Beydoun ◽

Adel Boueiz ◽

Monal R. Shroff ◽

Alan B. Zonderman

Keyword(s):

Depressive Symptoms ◽

National Health ◽

Antioxidant Status ◽

Community Dwelling ◽

The Other ◽

Total Serum ◽

Inverse Association ◽

Total Carotenoids ◽

Health And Nutrition ◽

Β Carotene

We examined the relationship of elevated depressive symptoms with antioxidant status. Cross-sectional data from the National Health and Nutrition Examination Surveys 2005–6 on US adults aged 20–85 years were analysed. Depressive symptoms were measured using the Patient Health Questionnaire with a score cut-off point of 10 to define ‘elevated depressive symptoms’. Serum antioxidant status was measured by serum levels of carotenoids, retinol (free and retinyl esters), vitamin C and vitamin E. The main analyses consisted of multiple logistic and zero-inflated Poisson regression models, taking into account sampling design complexity. The final sample consisted of 1798 US adults with complete data. A higher total serum carotenoid level was associated with a lower likelihood of elevated depressive symptoms with a reduction in the odds by 37 % overall with eachsdincrease in exposure, and by 34 % among women (P< 0·05). A dose–response relationship was observed when total serum carotenoids were expressed as quartiles (Q4 (1·62–10·1 μmol/l)v.Q1(0·06–0·86 μmol/l): OR 0·41; 95 % CI 0·23, 0·76,P< 0·001;Pfor trend = 0·035), though no significant associations were found with the other antioxidant levels. Among carotenoids, β-carotene (men and women combined) and lutein+zeaxanthins (women only, after control for dietary lutein+zeaxanthin intake and supplement use) had an independent inverse association with elevated depressive symptoms among US adults. None of the other serum antioxidants had a significant association with depressive symptoms, independently of total carotenoids and other covariates. In conclusion, total carotenoids (mainly β-carotene and lutein+zeaxanthins) in serum were associated with reduced levels of depressive symptoms among community-dwelling US adults.

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