scholarly journals Employment of Artificial Intelligence Based on Routine Laboratory Results for the Early Diagnosis of Multiple Myeloma

2021 ◽  
Vol 11 ◽  
Author(s):  
Wei Yan ◽  
Hua Shi ◽  
Tao He ◽  
Jian Chen ◽  
Chen Wang ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Multiple Myeloma ◽  
Early Diagnosis ◽  
Machine Learning Algorithms ◽  
Support Vector ◽  
Diagnostic Model ◽  
Routine Laboratory ◽  
Data Set ◽  
Hepatic Diseases ◽  
Laboratory Results

ObjectiveIn order to enhance the detection rate of multiple myeloma and execute an early and more precise disease management, an artificial intelligence assistant diagnosis system is developed.Methods4,187 routine blood and biochemical examination records were collected from Shengjing Hospital affiliated to China Medical University from January 2010 to January 2020, which include 1,741 records of multiple myeloma (MM) and 2,446 records of non-myeloma (infectious diseases, rheumatic immune system diseases, hepatic diseases and renal diseases). The data set was split into training and test subsets with the ratio of 4:1 while connecting hemoglobin, serum creatinine, serum calcium, immunoglobulin (A, G and M), albumin, total protein, and the ratio of albumin to globulin data. An early assistant diagnostic model of MM was established by Gradient Boosting Decision Tree (GBDT), Support Vector Machine (SVM), Deep Neural Networks (DNN), and Random Forest (RF). Out team calculated the precision and recall of the system. The performance of the diagnostic model was evaluated by using the receiver operating characteristic (ROC) curve.ResultsBy designing the features properly, the typical machine learning algorithms SVM, DNN, RF and GBDT all performed well. GBDT had the highest precision (92.9%), recall (90.0%) and F1 score (0.915) for the myeloma group. The maximized area under the ROC (AUROC) was calculated, and the results of GBDT (AUC: 0.975; 95% confidence interval (CI): 0.963–0.986) outperformed that of SVM, DNN and RF.ConclusionThe model established by artificial intelligence derived from routine laboratory results can accurately diagnose MM, which can boost the rate of early diagnosis.

scholarly journals Screening of key biomarkers of tendinopathy based on bioinformatics and machine learning algorithms

2021 ◽  
Author(s):  
Yaxi Zhu ◽  
Jia Qiang Huang ◽  
Yun Dong Zhou ◽  
Yu Yang Ming ◽  
Zhao Zhuang ◽  
...  
Keyword(s):  
Early Diagnosis ◽  
Expression Profiles ◽  
Enrichment Analysis ◽  
Gaussian Mixture ◽  
Machine Learning Algorithms ◽  
Support Vector ◽  
Data Set ◽  
Regulatory Pathways ◽  
Immune Infiltration ◽  
Key Genes

Abstract Tendinopathy is a complex, multifaceted tendon disease that is often associated with overuse and causes significant health care costs with its high prevalence. At present, the pathogenesis and effective treatment of tendinopathy cannot be fully elucidated. This study aims to deeply explore and analyze the key genes, functional pathways, and immune infiltration characteristics of the occurrence and development of tendinopathy.MethodsThe gene expression profiles of GSE106292, GSE26051 and GSE167226 were downloaded from GEO database. The WGCNA analysis was performed on GSE106292 data set by the R package in R software, and differential gene analysis was performed on GSE26051 and GSE167226 data sets by combining and screening. The gene enrichment analysis of GO and KEGG and immune cell infiltration analysis were performed. Lasso logistic regression, support vector machine (SVM-REF) and Gaussian mixture model (GMMS) algorithm were used to screen and identify early diagnostic genes.ResultsWe have obtained a total of 171 DEGs through WGCNA analysis and screening of different expressed genes. By GO and KEGG enrichment analysis, it was found that these malregulated genes were related to mTOR, HIF-1, MAPK, NF-κB and VEGF signaling pathways. Immunoinfiltration analysis showed that M1 macrophages, activated mast cells and activated NK cells had infiltration significance. MacroD1 may be an early diagnosis gene, and it was found based on Lasso, SVM-REF and GMMS algorithm.ConclusionsBased on comprehensive bioinformatics analysis, we identified the potential early diagnosis genes MACROD1, key regulatory pathways and immune infiltration characteristics of tendinopathy. These key genes and pathways may be used as biomarkers and molecular therapeutic targets for early tendon injury to guide drugs and basic research.

scholarly journals Screening of key biomarkers of tendinopathy based on bioinformatics and machine learning algorithms

PLoS ONE ◽  
2021 ◽  
Vol 16 (10) ◽  
pp. e0259475
Author(s):  
Ya xi Zhu ◽  
Jia qiang Huang ◽  
Yu yang Ming ◽  
Zhao Zhuang ◽  
Hong Xia
Keyword(s):  
Gene Expression ◽  
Early Diagnosis ◽  
Enrichment Analysis ◽  
Machine Learning Algorithms ◽  
Molecular Therapy ◽  
Support Vector ◽  
Immune Gene ◽  
Data Set ◽  
Immune Infiltration ◽  
Functional Pathways

Tendinopathy is a complex multifaceted tendinopathy often associated with overuse and with its high prevalence resulting in significant health care costs. At present, the pathogenesis and effective treatment of tendinopathy are still not sufficiently elucidated. The purpose of this research is to intensely explore the genes, functional pathways, and immune infiltration characteristics of the occurrence and development of tendinopathy. The gene expression profile of GSE106292, GSE26051 and GSE167226 are downloaded from GEO (NCBI comprehensive gene expression database) and analyzed by WGCNA software bag using R software, GSE26051, GSE167226 data set is combined to screen the differential gene analysis. We subsequently performed gene enrichment analysis of Gene Ontology (GO) and "Kyoto Encyclopedia of Genes and Genomes" (KEGG), and immune cell infiltration analysis. By constructing the LASSO regression model, Support vector machine (SVM-REF) and Gaussian mixture model (GMMs) algorithms are used to screen, to identify early diagnostic genes. We have obtained a total of 171 DEGs through WGCNA analysis and differentially expressed genes (DEGs) screening. By GO and KEGG enrichment analysis, it is found that these dysregulated genes were related to mTOR, HIF-1, MAPK, NF-κB and VEGF signaling pathways. Immune infiltration analysis showed that M1 macrophages, activated mast cells and activated NK cells had infiltration significance. After analysis of THE LASSO SVM-REF and GMMs algorithms, we found that the gene MACROD1 may be a gene for early diagnosis. We identified the potential of tendon disease early diagnosis way and immune gene regulation MACROD1 key infiltration characteristics based on comprehensive bioinformatics analysis. These hub genes and functional pathways may as early biomarkers of tendon injuries and molecular therapy level target is used to guide drug and basic research.

scholarly journals Artificial intelligence assisted electrocardiography for early diagnosis of thyrotoxic periodic paralysis

2021 ◽  
Author(s):  
Chin Lin ◽  
Chin-Sheng Lin ◽  
Ding-Jie Lee ◽  
Chia-Cheng Lee ◽  
Sy-Jou Chen ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Early Diagnosis ◽  
Validation Cohort ◽  
Laboratory Data ◽  
Diagnostic System ◽  
Periodic Paralysis ◽  
Medical Emergency ◽  
Diagnostic Process ◽  
Routine Laboratory ◽  
Thyrotoxic Periodic Paralysis

Abstract CONTEXT Thyrotoxic periodic paralysis (TPP) characterized by acute weakness, hypokalemia and hyperthyroidism is a medical emergency with a great challenge in early diagnosis since most TPP patients do not have overt symptoms. OBJECTIVE To assess artificial intelligence (AI)-assisted electrocardiography (ECG) combined with routine laboratory data in the early diagnosis of TPP. METHODS A deep learning model (DLM) based on ECG12Net, an 82-layer convolutional neural network, was constructed to detect hypokalemia and hyperthyroidism. The development cohort consisted of 39 ECGs from patients with TPP and 502 ECGs of hypokalemic control; the validation cohort consisted of 11 ECGs of TPP and 36 ECGs of non-TPP with weakness. The AI-ECG based TPP diagnostic process was then consecutively evaluated in 22 male patients with TTP-like features. RESULTS In the validation cohort, the DLM-based ECG system detected all cases of hypokalemia in TPP patients with a mean absolute error of 0.26 mEq/L and diagnosed TPP with an area under curve (AUC) of ~80%, surpassing the best standard ECG parameter (AUC=0.7285 for the QR interval). Combining the AI predictions with the estimated glomerular filtration rate (eGFR) and serum chloride (Cl -) boosted the diagnostic accuracy of the algorithm to AUC 0.986. In the prospective study, the integrated AI and routine laboratory diagnostic system had a PPV of 100% and F-measure 87.5%. CONCLUSIONS An AI-ECG system reliably identifies hypokalemia in patients with paralysis and integration with routine blood chemistries provides valuable decision support for the early diagnosis of TPP.

Artificial Intelligence Based Approach for Predicting Fatigue Strength Using Composition and Process Parameters

2020 ◽  
Author(s):  
Arvind Keprate ◽  
R. M. Chandima Ratnayake
Keyword(s):  
Artificial Intelligence ◽  
Fatigue Strength ◽  
Process Parameters ◽  
Fatigue Testing ◽  
Simulated Data ◽  
Machine Learning Algorithms ◽  
Coefficient Of Determination ◽  
Gradient Boosting ◽  
Data Set ◽  
Strength Based

Abstract Accurate prediction of the fatigue strength of steels is vital, due to the extremely high cost (and time) of fatigue testing and the often fatal consequences of fatigue failures. The work presented in this paper is an extension of the previous paper submitted to OMAE 2019. The main objective of this manuscript is to utilize Artificial Intelligence (AI) to predict fatigue strength, based on composition and process parameters, using the fatigue dataset for carbon and low alloy steel available from the National Institute of Material Science (NIMS) database, MatNavi. A deep learning framework Keras is used to build a Neural Network (NN), which is trained and tested on the data set obtained from MatNavi. The fatigue strength values estimated using NN are compared to the values predicted by the gradient boosting algorithm, which was the most accurate model in the OMAE 2019 paper. The comparison is done using metrics such as root mean square error (RMSE), Mean Absolute Error (MAE), Coefficient of Determination (R2) and Explained Variance Score (EVS). Thereafter, the trained NN model is used to make predictions of fatigue strength for the simulated data (1 million samples) of input parameters, which is then used to generate conditional probability tables for the Bayesian Network (BN). The main advantage of using BN over previously used machine learning algorithms is that BN can be used to make both forward and backward propagation during the Bayesian inference. A case study illustrating the applicability of the proposed approach is also presented. Furthermore, a dashboard is developed using PowerBI, which can be used by practicing engineers to estimate fatigue strength based on composition and process parameters.

scholarly journals SCENE AND OBJECT CLASSIFICATION USING BRAIN WAVES SIGNAL

2017 ◽  
Vol 10 (13) ◽  
pp. 137
Author(s):  
Darshan A Khade ◽  
Ilakiyaselvan N
Keyword(s):  
Artificial Intelligence ◽  
Event Related Potentials ◽  
Machine Learning Algorithms ◽  
Support Vector ◽  
Eeg Signals ◽  
Future Technology ◽  
Brain Waves ◽  
Brain Signals ◽  
Related Potentials ◽  
Signal Machine

This study aims to classify the scene and object using brain waves signal. The dataset captured by the electroencephalograph (EEG) device by placing the electrodes on scalp to measure brain signals are used. Using captured EEG dataset, classifying the scene and object by decoding the changes in the EEG signals. In this study, independent component analysis, event-related potentials, and grand mean are used to analyze the signal. Machine learning algorithms such as decision tree, random forest, and support vector machine are used to classify the data. This technique is useful in forensic as well as in artificial intelligence for developing future technology. 

scholarly journals Evaluation of Prognosis in Nasopharyngeal Cancer Using Machine Learning

2020 ◽  
Vol 19 ◽  
pp. 153303382090982
Author(s):  
Melek Akcay ◽  
Durmus Etiz ◽  
Ozer Celik ◽  
Alaattin Ozen
Keyword(s):  
Machine Learning ◽  
Logistic Regression ◽  
Naive Bayes ◽  
Nasopharyngeal Cancer ◽  
Naïve Bayes ◽  
Machine Learning Algorithms ◽  
Support Vector ◽  
Tumor Diameter ◽  
Survival Prognosis ◽  
Data Set

Background and Aim: Although the prognosis of nasopharyngeal cancer largely depends on a classification based on the tumor-lymph node metastasis staging system, patients at the same stage may have different clinical outcomes. This study aimed to evaluate the survival prognosis of nasopharyngeal cancer using machine learning. Settings and Design: Original, retrospective. Materials and Methods: A total of 72 patients with a diagnosis of nasopharyngeal cancer who received radiotherapy ± chemotherapy were included in the study. The contribution of patient, tumor, and treatment characteristics to the survival prognosis was evaluated by machine learning using the following techniques: logistic regression, artificial neural network, XGBoost, support-vector clustering, random forest, and Gaussian Naive Bayes. Results: In the analysis of the data set, correlation analysis, and binary logistic regression analyses were applied. Of the 18 independent variables, 10 were found to be effective in predicting nasopharyngeal cancer-related mortality: age, weight loss, initial neutrophil/lymphocyte ratio, initial lactate dehydrogenase, initial hemoglobin, radiotherapy duration, tumor diameter, number of concurrent chemotherapy cycles, and T and N stages. Gaussian Naive Bayes was determined as the best algorithm to evaluate the prognosis of machine learning techniques (accuracy rate: 88%, area under the curve score: 0.91, confidence interval: 0.68-1, sensitivity: 75%, specificity: 100%). Conclusion: Many factors affect prognosis in cancer, and machine learning algorithms can be used to determine which factors have a greater effect on survival prognosis, which then allows further research into these factors. In the current study, Gaussian Naive Bayes was identified as the best algorithm for the evaluation of prognosis of nasopharyngeal cancer.

scholarly journals Identification of Leukemia Subtypes from Microscopic Images Using Convolutional Neural Network

Diagnostics ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 104 ◽  
Author(s):  
Ahmed ◽  
Yigit ◽  
Isik ◽  
Alpkocak
Keyword(s):  
Machine Learning ◽  
Data Augmentation ◽  
Nearest Neighbor ◽  
Learning Algorithms ◽  
Machine Learning Algorithms ◽  
Training Data ◽  
Support Vector ◽  
K Nearest Neighbor ◽  
Data Set ◽  
Leukemia Data

Leukemia is a fatal cancer and has two main types: Acute and chronic. Each type has two more subtypes: Lymphoid and myeloid. Hence, in total, there are four subtypes of leukemia. This study proposes a new approach for diagnosis of all subtypes of leukemia from microscopic blood cell images using convolutional neural networks (CNN), which requires a large training data set. Therefore, we also investigated the effects of data augmentation for an increasing number of training samples synthetically. We used two publicly available leukemia data sources: ALL-IDB and ASH Image Bank. Next, we applied seven different image transformation techniques as data augmentation. We designed a CNN architecture capable of recognizing all subtypes of leukemia. Besides, we also explored other well-known machine learning algorithms such as naive Bayes, support vector machine, k-nearest neighbor, and decision tree. To evaluate our approach, we set up a set of experiments and used 5-fold cross-validation. The results we obtained from experiments showed that our CNN model performance has 88.25% and 81.74% accuracy, in leukemia versus healthy and multiclass classification of all subtypes, respectively. Finally, we also showed that the CNN model has a better performance than other wellknown machine learning algorithms.

KERNEL METHODS FOR CLUSTERING: COMPETITIVE LEARNING AND c-MEANS

2006 ◽  
Vol 14 (04) ◽  
pp. 481-493 ◽  
Author(s):  
RYO INOKUCHI ◽  
SADAAKI MIYAMOTO
Keyword(s):  
Computational Complexity ◽  
Kernel Methods ◽  
Clustering Algorithms ◽  
Competitive Learning ◽  
Machine Learning Algorithms ◽  
Support Vector ◽  
Alternative Formulation ◽  
Self Organizing Map ◽  
Data Set ◽  
High Computational Complexity

Recently kernel methods in support vector machines have widely been used in machine learning algorithms to obtain nonlinear models. Clustering is an unsupervised learning method which divides whole data set into subgroups, and popular clustering algorithms such as c-means are employing kernel methods. Other kernel-based clustering algorithms have been inspired from kernel c-means. However, the formulation of kernel c-means has a high computational complexity. This paper gives an alternative formulation of kernel-based clustering algorithms derived from competitive learning clustering. This new formulation obviously uses sequential updating or on-line learning to avoid high computational complexity. We apply kernel methods to related algorithms: learning vector quantization and self-organizing map. We moreover consider kernel methods for sequential c-means and its fuzzy version by the proposed formulation.

scholarly journals Formation of a cooperation network in Mato Grosso on Machine Learning and Image Analysis: Diagnosis of COVID-19 in X-ray images

2021 ◽  
Author(s):  
Jeniffer Luz ◽  
Scenio De Araujo ◽  
Caio Abreu ◽  
Juvenal Silva Neto ◽  
Carlos Gulo
Keyword(s):  
Artificial Intelligence ◽  
Machine Learning ◽  
Early Diagnosis ◽  
Critical Mass ◽  
Disease Diagnosis ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
Mato Grosso ◽  
X Ray ◽  
Occurrence Matrix

Since the beginning of the COVID-19 outbreak, the scientific communityhas been making efforts in several areas, either by seekingvaccines or improving the early diagnosis of the disease to contributeto the fight against the SARS-CoV-2 virus. The use of X-rayimaging exams becomes an ally in early diagnosis and has been thesubject of research by the medical image processing and analysiscommunity. Although the diagnosis of diseases by image is a consolidatedresearch theme, the proposed approach aims to: a) applystate-of-the-art machine learning techniques in X-ray images forthe COVID-19 diagnosis; b) identify COVID-19 features in imagingexamination; c) to develop an Artificial Intelligence model toreduce the disease diagnosis time; in addition to demonstrating thepotential of the Artificial Intelligence area as an incentive for theformation of critical mass and encouraging research in machinelearning and processing and analysis of medical images in the Stateof Mato Grosso, in Brazil. Initial results were obtained from experimentscarried out with the SVM (Support Vector Machine) classifier,induced on a publicly available image dataset from Kaggle repository.Six attributes suggested by Haralick, calculated on the graylevel co-occurrence matrix, were used to represent the images. Theprediction model was able to achieve 82.5% accuracy in recognizingthe disease. The next stage of the studies includes the study of deeplearning models.

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