The Role of microRNA in Pathogenesis, Diagnosis, Different Variants, Treatment and Prognosis of Mycosis Fungoides

Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma (CTCL), accounting for approximately 50% of all CTCLs. Although various molecular changes in MF have been described in existing studies, no obvious disease-specific changes have been found thus far. microRNAs (miRs) are short, noncoding RNA molecules that play roles in the post-transcriptional regulation of oncogenes and tumor suppressor genes in various diseases. Recently, there has been rapidly expanding experimental evidence for the role of miRs in the progression, early diagnosis, prognosis prediction for MF. Efforts to improve early diagnosis and develop personalized therapy options have become more important in recent years. Here, we provide an overview and update of recent advances regarding miRs associated with MF. Furthermore, we provide insights into future opportunities for miR-based therapies.

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Erythrodermic CD4/CD8 Double-Negative Mycosis Fungoides: A Case Report

Case Reports in Oncology ◽

10.1159/000512822 ◽

2021 ◽

pp. 256-261

Author(s):

Monira Abdullah Alnasser ◽

Nour Marwan AlKhawajah ◽

Nada Ghazi AlQadri ◽

Asem Mustafa Shadid ◽

Fahad M. Alsaif

Keyword(s):

T Cell ◽

Mycosis Fungoides ◽

Cell Lymphoma ◽

Early Stage ◽

Common Type ◽

Lymphoproliferative Disorders ◽

Cell Phenotype ◽

Double Negative ◽

Cutaneous T Cell Lymphoma ◽

Cutaneous Lymphomas

Cutaneous T-cell lymphoma (CTCL) describes a group of lymphoproliferative disorders characterized by localization of neoplastic T lymphocytes to the skin. Mycosis fungoides (MF) represents the most common type of CTCL and accounts for ∼60% of all primary cutaneous lymphomas. Apart from the classic type of MF, many clinical and histopathologic variants have been described. The malignant lymphocytes in MF are usually CD3, CD4 and CD45RO positive and CD8 negative. An unusual immunohistochemical profile of a CD4-negative and CD8-positive mature T-cell phenotype has been reported in a minority of patients; up to 20% of early-stage MF demonstrates a CD8-positive phenotype. There are only a few cases of a double-negative CD4/CD8 MF phenotype reported in the literature. We present the case of a 60-year-old male presenting a double-negative CD4/CD8 MF phenotype.

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ROLE OF LYMPHOCYTIC IMMUNOHISTOCHEMICAL MARKERS IN EARLY DIAGNOSIS OF PERIPHERAL T-CELL LYMPHOMA OF THE SKIN – MYCOSIS FUNGOIDES

Journal of IMAB - Annual Proceeding (Scientific Papers) ◽

10.5272/jimab.2017233.1646 ◽

2017 ◽

Vol 23 (3) ◽

pp. 1646-1650

Author(s):

Valeria Mateeva ◽

◽

Dimitar Tcharaktchiev ◽

Grisha Mateev ◽

◽

...

Keyword(s):

T Cell ◽

Early Diagnosis ◽

Mycosis Fungoides ◽

Cell Lymphoma ◽

T Cell Lymphoma ◽

Peripheral T Cell Lymphoma ◽

Immunohistochemical Markers

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Modern concepts of the mycosis fungoides pathogenesis

Oncohematology ◽

10.17650/1818-8346-2018-13-3-39-46 ◽

2018 ◽

Vol 13 (3) ◽

pp. 39-46

Author(s):

A. A. Vorontsova ◽

A. E. Karamova ◽

L. F. Znamenskaya

Keyword(s):

T Cell ◽

T Lymphocytes ◽

Mycosis Fungoides ◽

Cell Lymphoma ◽

Epigenetic Mechanisms ◽

Cutaneous T Cell Lymphoma ◽

Cellular Composition ◽

Review Of The Literature ◽

Lymphoproliferative Diseases

Mycosis fungoides – the most common form of cutaneous T-cell lymphoma. The pathogenesis of this disease is complex and remains unclear. The article contains a review of the literature devoted to the main mechanisms of T-lymphocytes malignant proliferation, known to date. Data on dysregulation of immune, genetic and epigenetic mechanisms, as well as the role of microenvironment cells in the proliferation of T lymphocytes, are given. Immunophenotypic characteristics and cellular composition of the infiltrate in patients with mycosis fungoides, are described depending on the stage of the disease. Prospective directions in studying molecular-biological predictors of malignant lymphoproliferative diseases development are highlighted.

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Role of microRNAs in Obesity-Related Kidney Disease

International Journal of Molecular Sciences ◽

10.3390/ijms222111416 ◽

2021 ◽

Vol 22 (21) ◽

pp. 11416

Author(s):

Maite Caus ◽

Àuria Eritja ◽

Milica Bozic

Keyword(s):

Noncoding Rna ◽

Molecular Mechanisms ◽

Regulation Of Gene Expression ◽

Significant Risk ◽

Kidney Injury ◽

Renal Diseases ◽

Rna Molecules ◽

Small Noncoding Rna ◽

Post Transcriptional Regulation

Obesity is a major global health problem and is associated with a significant risk of renal function decline. Obesity-related nephropathy, as one of the complications of obesity, is characterized by a structural and functional damage of the kidney and represents one of the important contributors to the morbidity and mortality worldwide. Despite increasing data linking hyperlipidemia and lipotoxicity to kidney injury, the apprehension of molecular mechanisms leading to a development of kidney damage is scarce. MicroRNAs (miRNAs) are endogenously produced small noncoding RNA molecules with an important function in post-transcriptional regulation of gene expression. miRNAs have been demonstrated to be important regulators of a vast array of physiological and pathological processes in many organs, kidney being one of them. In this review, we present an overview of miRNAs, focusing on their functional role in the pathogenesis of obesity-associated renal pathologies. We explain novel findings regarding miRNA-mediated signaling in obesity-related nephropathies and highlight advantages and future perspectives of the therapeutic application of miRNAs in renal diseases.

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