scholarly journals Environmental Stressors on Skin Aging. Mechanistic Insights

2019 ◽  
Vol 10 ◽  
Author(s):  
Concepcion Parrado ◽  
Sivia Mercado-Saenz ◽  
Azahara Perez-Davo ◽  
Yolanda Gilaberte ◽  
Salvador Gonzalez ◽  
...  
Keyword(s):  
Skin Aging ◽  
Environmental Stressors

scholarly journals Inflammatory Molecules Associated with Ultraviolet Radiation-Mediated Skin Aging

2021 ◽  
Vol 22 (8) ◽  
pp. 3974
Author(s):  
Tuba M. Ansary ◽  
Md. Razib Hossain ◽  
Koji Kamiya ◽  
Mayumi Komine ◽  
Mamitaro Ohtsuki
Keyword(s):  
Ultraviolet Radiation ◽  
Air Pollutants ◽  
Skin Aging ◽  
Environmental Stressors ◽  
Oxygen Species ◽  
Delayed Wound Healing ◽  
Different Types ◽  
Aged Skin ◽  
Inflammatory Molecules ◽  
Complex Organ

Skin is the largest and most complex organ in the human body comprised of multiple layers with different types of cells. Different kinds of environmental stressors, for example, ultraviolet radiation (UVR), temperature, air pollutants, smoking, and diet, accelerate skin aging by stimulating inflammatory molecules. Skin aging caused by UVR is characterized by loss of elasticity, fine lines, wrinkles, reduced epidermal and dermal components, increased epidermal permeability, delayed wound healing, and approximately 90% of skin aging. These external factors can cause aging through reactive oxygen species (ROS)-mediated inflammation, as well as aged skin is a source of circulatory inflammatory molecules which accelerate skin aging and cause aging-related diseases. This review article focuses on the inflammatory pathways associated with UVR-mediated skin aging.

scholarly journals Neuroendocrine Aspects of Skin Aging

2019 ◽  
Vol 20 (11) ◽  
pp. 2798 ◽  
Author(s):  
Georgeta Bocheva ◽  
Radomir M. Slominski ◽  
Andrzej T. Slominski
Keyword(s):  
Environmental Factors ◽  
Skin Aging ◽  
Environmental Stressors ◽  
Biological Processes ◽  
Loss Of Function ◽  
Downstream Signaling ◽  
Gradual Loss ◽  
Systemic Factors ◽  
Specific Receptors ◽  
Low Toxicity

Skin aging is accompanied by a gradual loss of function, physiological integrity and the ability to cope with internal and external stressors. This is secondary to a combination of complex biological processes influenced by constitutive and environmental factors or by local and systemic pathologies. Skin aging and its phenotypic presentation are dependent on constitutive (genetic) and systemic factors. It can be accelerated by environmental stressors, such as ultraviolet radiation, pollutants and microbial insults. The skin’s functions and its abilities to cope with external stressors are regulated by the cutaneous neuroendocrine systems encompassing the regulated and coordinated production of neuropeptides, neurohormones, neurotransmitters and hormones, including steroids and secosteroids. These will induce/stimulate downstream signaling through activation of corresponding receptors. These pathways and corresponding coordinated responses to the stressors decay with age or undergo pathological malfunctions. This affects the overall skin phenotype and epidermal, dermal, hypodermal and adnexal functions. We propose that skin aging can be attenuated or its phenotypic presentation reversed by the topical use of selected factors with local neurohormonal activities targeting specific receptors or enzymes. Some of our favorite factors include melatonin and its metabolites, noncalcemic secosteroids and lumisterol derivatives, because of their low toxicity and their desirable local phenotypic effects.

Quantification of Cognitive Process Degradation While Mobile, Attributable to the Environmental Stressors Endurance, Vibration, and Noise

1998 ◽  
Author(s):  
Salvatore P. Schipani ◽  
◽  
Richard S. Bruno ◽  
Michael A. Lattin ◽  
Bobby M. King ◽  
...  
Keyword(s):  
Cognitive Process ◽  
Environmental Stressors

Apoptosis: A Role in Skin Aging?

1998 ◽  
Vol 3 (1) ◽  
pp. 28-35 ◽  
Author(s):  
Anne R Haake ◽  
Inna Roublevskaia ◽  
Molly Cooklis
Keyword(s):  
Skin Aging

scholarly journals How environmental stressors affect reproductive potential in a saltmarsh plant species Plantago maritima

2021 ◽  
Author(s):  
Magdalena Lazarus ◽  
Jacek Mazur ◽  
Katarzyna Wszałek‐Rożek ◽  
Adrian Zwolicki
Keyword(s):  
Plant Species ◽  
Reproductive Potential ◽  
Environmental Stressors

scholarly journals Anti-Aging Potential of Extracts from Washingtonia filifera Seeds

Plants ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 151
Author(s):  
Benedetta Era ◽  
Sonia Floris ◽  
Valeria Sogos ◽  
Clara Porcedda ◽  
Alessandra Piras ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Protective Effect ◽  
Pharmaceutical Preparation ◽  
Human Keratinocytes ◽  
Inhibitory Effect ◽  
Skin Aging ◽  
Stressed Cells ◽  
Collagenase Inhibition ◽  
Washingtonia Filifera ◽  
Seed Extracts

The aim of this study was to test the inhibitory effect of fruit extracts from Washingtonia filifera on skin aging-related enzymes. The pulp extracts did not exert a significant enzyme inhibition while seed extracts from W. filifera exhibit anti-elastase, anti-collagenase, and anti-tyrosinase activities. Tyrosinase was mildly inhibited while a stronger effect was observed with respect to elastase and collagenase inhibition. Alcoholic extracts provided better results than aqueous extracts. Among them, methanol extracts showed the prominent enzyme inhibitory activities being IC50 value for elastase and collagenase comparable and even better than the reference compound. The inhibition mode of the most active extracts was investigated by Lineweaver-Burk plot analysis. Seed extracts from W. filifera were also investigated for their photo-protective effect by Mansur equation and the antioxidant activity of W. filifera extract was evaluated in oxidative-stressed cells. To evaluate the safety of the extract, the effect on cell viability of human keratinocytes cells was analyzed. Methanol extract presented the best photo-protective effect and exerted an antioxidant activity in a cellular system with no cytotoxic effect. The overall results demonstrate that W. filifera extracts are promising sources of bioactive compounds that could be used in cosmetic and pharmaceutical preparation.

scholarly journals The Gene Regulatory Roles of Herbal Extracts on the Growth, Immune System, and Reproduction of Fish

Animals ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 2167
Author(s):  
Ehsan Ahmadifar ◽  
Hamideh Pourmohammadi Fallah ◽  
Morteza Yousefi ◽  
Mahmoud A. O. Dawood ◽  
Seyed Hossein Hoseinifar ◽  
...  
Keyword(s):  
Immune System ◽  
Mode Of Action ◽  
Medicinal Herbs ◽  
Environmental Stressors ◽  
Fish Diet ◽  
Sustainable Aquaculture ◽  
Herbal Supplements ◽  
Aquatic Animals ◽  
Gene Regulatory

The crucial need for safe and healthy aquatic animals obligates researchers in aquaculture to investigate alternative and beneficial additives. Medicinal herbals and their extracts are compromised with diverse effects on the performances of aquatic animals. These compounds can affect growth performance and stimulate the immune system when used in fish diet. In addition, the use of medicinal herbs and their extracts can reduce oxidative stress induced by several stressors during fish culture. Correspondingly, aquatic animals could gain increased resistance against infectious pathogens and environmental stressors. Nevertheless, the exact mode of action where these additives can affect aquatic animals’ performances is still not well documented. Understanding the mechanistic role of herbal supplements and their derivatives is a vital tool to develop further the strategies and application of these additives for feasible and sustainable aquaculture. Gene-related studies have clarified the detailed information on the herbal supplements’ mode of action when administered orally in aquafeed. Several review articles have presented the potential roles of medicinal herbs on the performances of aquatic animals. However, this review article discusses the outputs of studies conducted on aquatic animals fed dietary, medicinal herbs, focusing on the gene expression related to growth and immune performances. Furthermore, a particular focus is directed to the expected influence of herbal supplements on the reproduction of aquatic animals.

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