scholarly journals Registered Interventional Clinical Trials for Old Populations With Infectious Diseases on ClinicalTrials.gov: A Cross-Sectional Study

2020 ◽  
Vol 11 ◽  
Author(s):  
Lingmin Chen ◽  
Menghua Wang ◽  
Yi Yang ◽  
Jing Shen ◽  
Yonggang Zhang
Author(s):  
Md Hasanuzzaman ◽  
Md Hafizur Rahman ◽  
Md Shafiqul Islam Khan ◽  
Musammet Rasheda Begum ◽  
Farjana Alam ◽  
...  

Background: Over 200 million under-five-children born in low-income countries are at risk of not reaching their development potential and infectious diseases are the leading cause of development deficits in these regions.Methods: A cross-sectional study was conducted to investigate personal and household hygiene practices among 154 mothers and their association with the incidence of infectious diseases among 167 children aged 6 months to 59 months in Patuakhali district, Bangladesh.Results: Only 13.6% of the mothers had proper hand washing knowledge. Besides, 14% and 53.9% of the mothers washed their hands with soap and only with water respectively before feeding their child. About 68.2% of mothers prepared food on the ground and half (49.5%) of the toilet did not have a hand washing location beside it. The risk of childhood infectious disease was significantly associated with hand washing of mothers before feeding a child (OR: 2.3, 95% CI: 1.5-4.1, p<0.05) and hand washing of child before eating (OR: 3.4, 95% CI: 1.8-5.7, p<0.05).Conclusions: Hand washing agents were inadequate and compliance to hand washing was poor. Therefore, the continuous focus is needed on the mother's awareness construction to increase the compliance to hand washing practice among mothers as well as their child with soap, especially during child feeding.


2020 ◽  
Vol 16 (5) ◽  
Author(s):  
Allan B. Smith ◽  
Anita Y. Niu ◽  
Joseph Descallar ◽  
Geoff P. Delaney ◽  
Verena S. Wu ◽  
...  

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S225-S225
Author(s):  
Jolanta Piszczek ◽  
Eric Partlow ◽  
Shay-Anne Daniels ◽  
Milena Semproni ◽  
Wayne Ghesquiere

Abstract Background Moderate to severe cellulitis is a common reason for presentation to the emergency department and administration of intravenous antibiotics. Misdiagnosis of cellulitis occurs frequently as the disease can masquerade as a wide variety of noninfectious and infectious problems. There are currently no studies evaluating the impact of infectious diseases physicians on the diagnostic accuracy and management of cellulitis referred to an outpatient parenteral antibiotic clinic from the emergency department. The objective of this study was to quantify the prevalence of misdiagnosed moderate to severe cellulitis through an evaluation by an infectious diseases specialist, characterize the alternative diagnoses, and assess variables associated with misdiagnosis. Methods A prospective cross-sectional study of adults referred from emergency departments with presumed moderate to severe cellulitis to an outpatient parenteral antibiotic clinic staffed by infectious diseases specialists. Results 301 consecutive patients with presumed cellulitis were evaluated over a 6-month period. A concurring diagnosis of cellulitis was found in 170 patients (56.5%), for a misdiagnosis rate of 43.5% (131/301). Table 1 summarizes the alternative diagnoses. Infectious conditions other than cellulitis were the most common (63/301; 20.9%), with abscess being present in 23 (7.6%) of patients. Fifty-two of 301 (17.3%) of the diagnoses were noninfectious and 16/301 (5.3%) patients had a dual diagnosis where minor cellulitis was present, but secondary to another, predomintating condition. The presence of stasis dermatitis (OR 6.62, P = 0.013) and a history of physical trauma (OR 1.76, P = 0.046) were associated with a misdiagnosis. 31.9% (107/335) of antibiotic regimens prescribed by emergency physicians were inappropriate or sub-optimal compared with 7.9% (22/280) of those ordered by infectious disease doctors. Conclusion Moderate to severe cellulitis was incorrectly diagnosed in nearly half of the patients referred for intravenous antibiotics and resulted in a high rate of unstewardly antimicrobial use. Infectious diseases physicians at an outpatient antibiotic clinic improved the diagnostic accuracy and management of this complicated condition. Disclosures All authors: No reported disclosures.


2021 ◽  
Author(s):  
Fanny Velardo ◽  
Hanifa Bouziri ◽  
Lucie Adélaïde ◽  
Emma Oliosi ◽  
Maylis Layan ◽  
...  

Abstract Background: Freshwater sports can be associated with infections from pathogenic microorganisms. In French Brittany, such infections are a major concern since a leptospirosis outbreak in 2016. Objectives: We aimed to estimate the prevalence of infectious diseases related to the practice of freshwater sports and identify the factors associated with these pathologies in Brittany, France. Methods: We conducted a cross-sectional study from March 18 to May 8, 2019, among freshwater sport licensees (online study) and clubs (phone study). Licensees were 18 years old or more, and practiced at least one freshwater sport, in one of the 79 Brittany clubs. Club presidents and instructors were also surveyed. We used logistic regression models to study the association between our variables of interest and potential risk factors. Results: In total, 551 licensees (20.3% of the total number of licensees) and 38 clubs (48.1%) were surveyed. A diagnosis of leptospirosis was reported by 29 (5.3%) licensees, of which 41.3% occurred in the last five years. The most reported symptoms were skin symptoms (24.3%) and 7.1% of individuals reported at least one hospitalization in their lifetime for a disease related to freshwater sports. The occurrence of leptospirosis was negatively associated with boarding from a pontoon (OR=0.20 [0.06-0.56]), practicing for less than 4 years (OR=0.17 [0.04-0.56]) compared to more than 10 years, and the occurrence of leptospirosis was positively associated with taking a soapy shower after practice (OR=4.38 [1.90-10.51]). Eskimo roll was positively associated with the occurrence of otitis and conjunctivitis (OR=3.22 [1.82-6.03]) and skin irritations (OR=1.66 [0.99-2.84]). Conclusion: This study provides a better understanding of the proportion and factors associated with infectious diseases linked to the practice of freshwater sports in French Brittany. Complementary studies are necessary to better understand the link between these diseases and the practice of freshwater sports.


2022 ◽  
Vol 22 (1) ◽  
Author(s):  
Nethanel Asher ◽  
Ari Raphael ◽  
Ido Wolf ◽  
Sharon Pelles ◽  
Ravit Geva

Abstract Background Clinical trials are an essential source for advances in oncologic care, yet the enrollment rate is only 2-4%. Patients' reluctance to participate is an important barrier. This study evaluates patients' level of understanding and attitudes towards clinical trials. Methods This cross-sectional study was conducted in the oncology department and day care unit at the oncology division Tel Aviv Sourasky Medical Center, Israel. From January 2015 to September 2016. Two-hundred patients’ currently receiving active anti-cancer therapy at a large tertiary hospital completed an anonymous questionnaire comprised of demographic information, past experience in clinical research and basic knowledge on clinical trials. Results The majority of respondents did not meet the minimum knowledge level criteria. In those who replied they would decline to participate in a clinical trial, concern were related to potential assignment to the placebo arm, provision of informed consent and trust issues with their oncologist. Those with sufficient knowledge were significantly more interested in participating. Patients with past experience in clinical trials had a higher level of academic education, were less religious, had a better understanding of medical research and were inclined to participate in future research. Conclusions Misperceptions of clinical trials may contribute substantially to the unwillingness to participate in them.


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