scholarly journals Evaluation of Long-Time Decoction-Detoxicated Hei-Shun-Pian (Processed Aconitum carmichaeli Debeaux Lateral Root With Peel) for Its Acute Toxicity and Therapeutic Effect on Mono-Iodoacetate Induced Osteoarthritis

2020 ◽  
Vol 11 ◽  
Author(s):  
Lei Zhang ◽  
Ting Li ◽  
Rongrong Wang ◽  
Jiaan Xu ◽  
Li Zhou ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Therapeutic Effect ◽  
Lateral Root ◽  
Long Time ◽  
Aconitum Carmichaeli

Circadian clock regulates metabolism and toxicity of Fuzi(lateral root of Aconitum carmichaeli Debx) in mice

Phytomedicine ◽  
2020 ◽  
Vol 67 ◽  
pp. 153161 ◽  
Author(s):  
Zemin Yang ◽  
Yanke Lin ◽  
Lu Gao ◽  
Ziyue Zhou ◽  
Shuai Wang ◽  
...  
Keyword(s):  
Circadian Clock ◽  
Lateral Root ◽  
Aconitum Carmichaeli

THE IN VIVO INVESTIGATION OF Fe3O4-NANOPARTICLES ACUTE TOXICITY IN MICE

2012 ◽  
Vol 24 (03) ◽  
pp. 229-235 ◽  
Author(s):  
Shuhua Zhao ◽  
Xinli Lin ◽  
Long Zhang ◽  
Lei Sun ◽  
Jun Li ◽  
...  
Keyword(s):  
Body Weight ◽  
Acute Toxicity ◽  
Confidence Interval ◽  
Intravenous Injection ◽  
Cardiac Tissue ◽  
Kidney Tubules ◽  
Tissue Protein ◽  
Long Time ◽  
Different Doses

To observe acute toxicity of naked Fe3O4 -nanoparticles in mice, ICR mice were selected and exposed once to naked Fe3O4 -nanoparticles by tail intravenous injection with different doses, i.e. 0, 102.4, 128, 160, 200, 250 mg/kg of body weight. 15 days later, Fe3O4 distribution and pathologic changes in main organs were investigated. By tail intravenous injection, LD50 of naked Fe3O4 -nanoparticles in mice was 163.60 mg/kg of body weight (147.58, 181.37 mg/kg of body weight, 95% confidence interval). Deaths of mice mainly caused by decompensation and twitching were observed. Immediately after injection, nanoparticles performed fast distribution in lung, liver, spleen etc, yet little were traced in brain, heart and kidney. 15 days after injection, apparent decline of nanoparticles content in lung and spleen was observed, whereas in liver the content rose. Pathologic detection indicated local particle denaturation and necrosis in the cardiac tissue. Protein cast was seen in several kidney tubules, and extravasated blood in carunculae papillaris, yet no pathologic changes were observed in other organs. LD50 of Fe3O4 nanoparticles (9 nm) by means of tail intravenous injection is 163.60 mg/kg, and they mainly distributed in liver, spleen, lung and caused denaturation and necrosis in the cardiac muscle and malfunction of kidney. Also, the process of excreting the particles takes a long time.

scholarly journals Examples of the use of music in clinical medicine

2001 ◽  
Vol XXXIII (1-2) ◽  
pp. 117-117
Author(s):  
A. Myskja ◽  
M Lindbaek
Keyword(s):  
Music Therapy ◽  
Therapeutic Effect ◽  
Clinical Studies ◽  
Therapeutic Efficacy ◽  
Clinical Medicine ◽  
Practical Medicine ◽  
The Real ◽  
Long Time

The use of music as a therapeutic effect has been used in practical medicine for a long time, but only recently have serious clinical studies been carried out on the real therapeutic efficacy of music therapy.

scholarly journals Toxicity of Cypermethrin-chlorpyrifos and Butachlor to Tadpole of Quasipaa boulengeri

2021 ◽  
Vol 293 ◽  
pp. 01012
Author(s):  
Zhang Xiaoqin ◽  
Zhao Changju ◽  
Wu Haoyang
Keyword(s):  
Regression Analysis ◽  
Acute Toxicity ◽  
Scientific Basis ◽  
The Body ◽  
Analysis Method ◽  
Subchronic Toxicity ◽  
Accumulation Effect ◽  
Frog Tadpoles ◽  
Different Types ◽  
Long Time

The tadpole of Quasipaa boulangeri was taken as the research object in this paper. The toxic effects of cypermethrin-chlorpyrifos and butachlor on tadpole of Q.boulangeri were studied by acute toxicity experiment and subchronic toxicity experiment in order to master the toxicity of different types of pesticides on tadpole of Q.boulangeri and provide scientific basis for amphibian protection. The results of acute toxicity experiment were analyzed by the method of probability unit regression analysis. The results of the acute toxicity experiment were analyzed by means of the probability-unit regression analysis method, and the LC50 of cypermethrin-chlorpyrifos and butachlor to the 2-month-old frog tadpoles at 24h, 48h, 72h and 96h were 0.419, 0.357, 0.346L, 0.332 and 1.183, 1.108, 0.925 and 0.876(mg/L), respectively. In the subchronic toxicity experiment, we observed the accumulation effect of different concentrations of pesticides on tadpoles through the statistics of the growth and development of tadpoles exposed to the drugs for a long time. The results suggested that the body length and body weight of tadpoles increased slowly with the increase of time and concentration of pesticide in the solution during the experiment.

Development and assessment of a complete-detoxication strategy for Fuzi (lateral root of Aconitum carmichaeli) and its application in rheumatoid arthritis therapy

2013 ◽  
Vol 146 (2) ◽  
pp. 562-571 ◽  
Author(s):  
Peijian Tong ◽  
Chengliang Wu ◽  
Xiaofen Wang ◽  
Hongzhou Hu ◽  
Hongting Jin ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Lateral Root ◽  
Aconitum Carmichaeli

200kv superconducting cryo electron microscope

1987 ◽  
Vol 45 ◽  
pp. 642-643
Author(s):  
M. Iwatsuki ◽  
Y. Kokubo ◽  
Y. Harada ◽  
J. Lehman
Keyword(s):  
Electron Microscope ◽  
Structure Analysis ◽  
Organic Materials ◽  
Strong Interactions ◽  
Specimen Preparation ◽  
Great Effort ◽  
Electron Microscopic ◽  
Crystal Fields ◽  
Special Skill ◽  
Long Time

In recent years, the electron microscope has been significantly improved in resolution and we can obtain routinely atomic-level high resolution images without any special skill. With this improvement, the structure analysis of organic materials has become one of the interesting targets in the biological and polymer crystal fields.Up to now, X-ray structure analysis has been mainly used for such materials. With this method, however, great effort and a long time are required for specimen preparation because of the need for larger crystals. This method can analyze average crystal structure but is insufficient for interpreting it on the atomic or molecular level. The electron microscopic method for organic materials has not only the advantage of specimen preparation but also the capability of providing various information from extremely small specimen regions, using strong interactions between electrons and the substance. On the other hand, however, this strong interaction has a big disadvantage in high radiation damage.

A Stationary Solution of High-Energy Electron Reflection (HEER) for An Arbitrary Surface

1990 ◽  
Vol 48 (2) ◽  
pp. 374-375
Author(s):  
YIQUN MA
Keyword(s):  
Stationary Solution ◽  
High Energy ◽  
Bloch Wave ◽  
Dynamical Theory ◽  
High Energy Electron ◽  
Bulk Materials ◽  
Periodic Surface ◽  
Electron Transmission ◽  
Electron Reflection ◽  
Long Time

For a long time, the development of dynamical theory for HEER has been stagnated for several reasons. Although the Bloch wave method is powerful for the understanding of physical insights of electron diffraction, particularly electron transmission diffraction, it is not readily available for the simulation of various surface imperfection in electron reflection diffraction since it is basically a method for bulk materials and perfect surface. When the multislice method due to Cowley & Moodie is used for electron reflection, the “edge effects” stand firmly in the way of reaching a stationary solution for HEER. The multislice method due to Maksym & Beeby is valid only for an 2-D periodic surface.Now, a method for solving stationary solution of HEER for an arbitrary surface is available, which is called the Edge Patching method in Multislice-Only mode (the EPMO method). The analytical basis for this method can be attributed to two important characters of HEER: 1) 2-D dependence of the wave fields and 2) the Picard iteractionlike character of multislice calculation due to Cowley and Moodie in the Bragg case.

Sign in / Sign up

Export Citation Format

Share Document