scholarly journals Sex, Pramipexole and Tiagabine Affect Behavioral and Hormonal Response to Traumatic Stress in a Mouse Model of PTSD

2021 ◽  
Vol 12 ◽  
Author(s):  
Natalia Malikowska-Racia ◽  
Kinga Salat ◽  
Joanna Gdula-Argasinska ◽  
Piotr Popik
Keyword(s):  
Mouse Model ◽  
Conditioned Fear ◽  
Plasma Corticosterone ◽  
Plasma Testosterone ◽  
Potential Capacity ◽  
17Β Estradiol ◽  
Plasma Hormones ◽  
Hpa Response ◽  
Prolonged Stress

Posttraumatic stress disorder (PTSD) has been associated with abnormal regulation of the hypothalamic-pituitary-adrenal gland axis (HPA). Women demonstrate a more robust HPA response and are twice as likely to develop PTSD than men. The role of sex hormones in PTSD remains unclear. We investigated whether post-trauma chronic treatment with the GABA-ergic agent tiagabine and dopamine-mimetic pramipexole affected the behavioral outcome and plasma levels of corticosterone, testosterone, or 17β-estradiol in female and male mice. These medications were investigated due to their potential capacity to restore GABA-ergic and dopaminergic deficits in PTSD. Animals were exposed to a single prolonged stress procedure (mSPS). Following 13 days treatment with tiagabine (10 mg/kg) or pramipexole (1 mg/kg) once daily, the PTSD-like phenotype was examined in the fear conditioning paradigm. Plasma hormones were measured almost immediately following the conditioned fear assessment. We report that the exposure to mSPS equally enhanced conditioned fear in both sexes. However, while males demonstrated decreased plasma corticosterone, its increase was observed in females. Trauma elevated plasma testosterone in both sexes, but it had no significant effects on 17β-estradiol. Behavioral manifestation of trauma was reduced by pramipexole in both sexes and by tiagabine in females only. While neither compound affected corticosterone in stressed animals, testosterone levels were further enhanced by tiagabine in females. This study shows sex-dependent efficacy of tiagabine but not pramipexole in a mouse model of PTSD-like symptoms and a failure of steroid hormones’ levels to predict PTSD treatment efficacy.

scholarly journals Radix Polygalae Extract Attenuates PTSD-like Symptoms in a Mouse Model of Single Prolonged Stress and Conditioned Fear Possibly by Reversing BAG1

2018 ◽  
Vol 27 (3) ◽  
pp. 200-209 ◽  
Author(s):  
Ju-Yeon Shin ◽  
Jung-Won Shin ◽  
Sang-Kyu Ha ◽  
Yoorim Kim ◽  
Kelley M. Swanberg ◽  
...  
Keyword(s):  
Mouse Model ◽  
Conditioned Fear ◽  
Single Prolonged Stress ◽  
Prolonged Stress

Conditioned fear stress combined with single-prolonged stress: A new PTSD mouse model

2012 ◽  
Vol 73 (2) ◽  
pp. 142-152 ◽  
Author(s):  
Haifeng Wang ◽  
Daiying Zuo ◽  
Bin He ◽  
Foxiao Qiao ◽  
Mingqi Zhao ◽  
...  
Keyword(s):  
Mouse Model ◽  
Conditioned Fear ◽  
Single Prolonged Stress ◽  
Conditioned Fear Stress ◽  
Prolonged Stress

ESTROGEN SYNTHESIS IN NORMAL AND HYPOGONADAL MEN: QUANTITATIVE STUDIES ON THE PRECURSOR ROLE OF TESTOSTERONE

1966 ◽  
Vol 44 (6) ◽  
pp. 971-977 ◽  
Author(s):  
B. J. Epstein ◽  
M. C. Raheja ◽  
E. Frow ◽  
W. I. Morse
Keyword(s):  
New Method ◽  
Plasma Testosterone ◽  
Quantitative Studies ◽  
Estrogen Production ◽  
Estrogen Synthesis ◽  
17Β Estradiol ◽  
Specific Activities ◽  
Normal Men

Tritiated (7α-3H) testosterone was injected intravenously into normal and hypogonadal men after which all urine was collected for 5 days. The urine was assayed for estrone, 17β-estradiol, estriol, and 3H associated with these fractions by the new method of Blair and co-workers. The specific activities of the urinary estrogen fractions from the normal men were sufficiently low to warrant the conclusion that there were other sources of estrogen production in addition to the plasma testosterone pool. It was also shown that the higher specific activities observed in this laboratory during a previous study, similar except that the Bauld method was used for the assays, were due to radiochemical impurities in the final estrogen fractions. The hypogonadal men had low urinary estrogen levels but there was no evidence of gross abnormality in the metabolism of 3H-testosterone to 3H-estrogens in this group.In two out of three instances, 1,2-3H-testosterone injection produced less 3H-labeled urinary estrogen than 7-3H-testosterone injection. This finding suggested that 3H was lost either from the C-1 or the C-2 position during the biosynthesis of estradiol from testosterone.

P2-126: THE ROLE OF APOE GENOTYPE, SEX, AND 17β-ESTRADIOL IN MEMORY CONSOLIDATION IN A MOUSE MODEL OF ALZHEIMER'S DISEASE

2006 ◽  
Vol 14 (7S_Part_13) ◽  
pp. P717-P717
Author(s):  
Lisa R. Taxier ◽  
Sarah M. Philippi ◽  
Jason York ◽  
Mary Jo LaDu ◽  
Karyn M. Frick
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Memory Consolidation ◽  
Apoe Genotype ◽  
Model Of Alzheimer’S Disease ◽  
17Β Estradiol

The role of tachykinin 1 in a mouse model of trait anxiety

2007 ◽  
Vol 40 (05) ◽  
Author(s):  
L Czibere ◽  
LA Baur-Jaronowski ◽  
P Weber ◽  
B Pütz ◽  
M Panhuysen ◽  
...  
Keyword(s):  
Mouse Model ◽  
Trait Anxiety

Age Advantages of Emotional Experience during the COVID-19 Pandemic are Robust, but Diminished Compared to Pre-pandemic Conditions

2020 ◽  
Author(s):  
Rui Sun ◽  
Disa Sauter
Keyword(s):  
Older Adults ◽  
Large Scale ◽  
Negative Emotion ◽  
Emotional Experience ◽  
Negative Emotions ◽  
Older Individuals ◽  
Selection Strategies ◽  
Scale Test ◽  
Prolonged Stress

Getting old is generally seen as unappealing, yet aging confers considerable advantages in several psychological domains (North & Fiske, 2015). In particular, older adults are better off emotionally than younger adults, with aging associated with the so-called “age advantages,” that is, more positive and less negative emotional experiences (Carstensen et al., 2011). Although the age advantages are well established, it is less clear whether they occur under conditions of prolonged stress. In a recent study, Carstensen et al (2020) demonstrated that the age advantages persist during the COVID-19 pandemic, suggesting that older adults are able to utilise cognitive and behavioural strategies to ameliorate even sustained stress. Here, we build on Carstensen and colleagues’ work with two studies. In Study 1, we provide a large-scale test of the robustness of Carstensen and colleagues’ finding that older individuals experience more positive and less negative emotions during the COVID-19 pandemic. We measured positive and negative emotions along with age information in 23,629 participants in 63 countries in April-May 2020. In Study 2, we provide a comparison of the age advantages using representative samples collected before and during the COVID-19 pandemic. We demonstrate that older people experience less negative emotion than younger people during the prolonged stress of the COVID-19 pandemic. However, the advantage of older adults was diminished during the pandemic, pointing to a likely role of older adults use of situation selection strategies (Charles, 2010).

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