scholarly journals Measuring the Impact of Nuclear Interaction in Particle Therapy and in Radio Protection in Space: the FOOT Experiment

2021 ◽  
Vol 8 ◽  
Author(s):  
Giuseppe Battistoni ◽  
Marco Toppi ◽  
Vincenzo Patera ◽  
The FOOT Collaboration
Keyword(s):  
Cross Sections ◽  
Computational Models ◽  
Bragg Peak ◽  
Charged Particles ◽  
Absorbed Dose ◽  
High Energy ◽  
Particle Therapy ◽  
Main Concern ◽  
Nuclear Fragmentation ◽  
The Impact

In Charged Particle Therapy (PT) proton or 12C beams are used to treat deep-seated solid tumors exploiting the advantageous characteristics of charged particles energy deposition in matter. For such projectiles, the maximum of the dose is released at the end of the beam range, in the Bragg peak region, where the tumour is located. However, the nuclear interactions of the beam nuclei with the patient tissues can induce the fragmentation of projectiles and/or target nuclei and needs to be carefully taken into account when planning the treatment. In proton treatments, the target fragmentation produces low energy, short range fragments along all the beam path, that deposit a non-negligible dose especially in the first crossed tissues. On the other hand, in treatments performed using 12C, or other (4He or 16O) ions of interest, the main concern is related to the production of long range fragments that can release their dose in the healthy tissues beyond the Bragg peak. Understanding nuclear fragmentation processes is of interest also for radiation protection in human space flight applications, in view of deep space missions. In particular 4He and high-energy charged particles, mainly 12C, 16O, 28Si and 56Fe, provide the main source of absorbed dose in astronauts outside the atmosphere. The nuclear fragmentation properties of the materials used to build the spacecrafts need to be known with high accuracy in order to optimise the shielding against the space radiation. The study of the impact of these processes, which is of interest both for PT and space radioprotection applications, suffers at present from the limited experimental precision achieved on the relevant nuclear cross sections that compromise the reliability of the available computational models. The FOOT (FragmentatiOn Of Target) collaboration, composed of researchers from France, Germany, Italy and Japan, designed an experiment to study these nuclear processes and measure the corresponding fragmentation cross sections. In this work we discuss the physics motivations of FOOT, describing in detail the present detector design and the expected performances, coming from the optimization studies based on accurate FLUKA MC simulations and preliminary beam test results. The measurements planned will be also presented.

Calculation of the Depth Dependence of Relative Biological Effectiveness For Clinical Proton Beams

2019 ◽  
pp. 5-10
Author(s):  
А. Белоусов ◽  
A. Belousov ◽  
Р. Бахтиозин ◽  
R. Bahtiosin ◽  
М. Колыва­нова ◽  
...  
Keyword(s):  
Bragg Peak ◽  
Relative Biological Effectiveness ◽  
Complex Function ◽  
Absorbed Dose ◽  
High Energy ◽  
Clinical Value ◽  
Proton Beams ◽  
Depth Dependence ◽  
Biological Effectiveness ◽  
The Impact

Purpose: Accurate establishing the value of relative biological effectiveness (RBE) for high energy protons is one of the main challenges of modern radiotherapy. The purpose of the study is to calculate the depth dependence of RBE for proton beams forming a spread-out Bragg peak. Material and methods: Spatial distributions of absorbed dose and dose-average linear energy transfer (LET) for 50-100 MeV (0.5 MeV energy step) monochromatic proton beams were obtained by Monte-Carlo computer simulation using Geant4 software. A linear dependence of RBE on the dose-average LET was used. Absorbed dose distributions were obtained in a water phantom for monochromatic pencil proton beams of 2.5 mm radius. The absorbed dose and the dose-average LET values were calculated in voxels with dimensions of 2×2×0.2 mm. Results: Calculations of depth dependencies of absorbed dose and dose-average LET for 50–100 MeV monochromatic proton beams were performed. Depth dependencies of RBE for these beams were established. The weighing coefficients values allowing to generate uniformspread-out Bragg peak (SOBP) were determined. Depth distribution of “RBE-weighted” dose and RBE values for SOBP were found. Conclusion: The impact of the initial beam energy step on the degree of homogeneity of the modified Bragg curve was investigated. It was shown that a step up to 1.5 MeV is acceptable for generate a smooth Bragg curve. The depth dependence of the average RBE value is a complex function, which rapidly changes especially at the far end of the SOBP. RBE may vary up to 10-30 % compared to current clinical value. The linear model of RBE-LET dependence shown in the study can be easily used in dosimetric planning systems, that may will significantly improve the quality of proton radiotherapy.

scholarly journals Insights on the impact of mitochondrial organisation on bioenergetics in high-resolution computational models of cardiac cell architecture

2018 ◽  
Author(s):  
Shouryadipta Ghosh ◽  
Kenneth Tran ◽  
Lea M. D. Delbridge ◽  
Anthony J. R. Hickey ◽  
Eric Hanssen ◽  
...  
Keyword(s):  
Cross Sections ◽  
Computational Models ◽  
Force Production ◽  
Creatine Phosphate ◽  
High Energy ◽  
Enzymatic Reactions ◽  
Force Dynamics ◽  
Significant Spatial Variation ◽  
Microscopy Data ◽  
The Impact

AbstractRecent electron microscopy data have revealed that cardiac mitochondria are not arranged in crystalline columns, but are organised with several mitochondria aggregated into columns of varying sizes often spanning the cell cross-section. This raises the question - how does the mitochondrial arrangement affect the metabolite distributions within cardiomyocytes and their impact on force dynamics? Here we employed finite element modelling of cardiac bioenergetics, using computational meshes derived from electron microscope images, to address this question. Our results indicate that heterogeneous mitochondrial distributions can lead to significant spatial variation across the cell in concentrations of inorganic phosphate, creatine (Cr) and creatine phosphate (PCr). However, our model predicts that sufficient activity of the creatine kinase (CK) system, coupled with rapid diffusion of Cr and PCr, maintains near uniform ATP and ADP ratios across the cell cross sections. This homogenous distribution of ATP and ADP should also evenly distribute force production and twitch duration with contraction. These results suggest that the PCr shuttle, and associated enzymatic reactions, act to maintain uniform force dynamics in the cell despite the heterogeneous mitochondrial organization. However, our model also predicts that under hypoxia - activity of mitochondrial CK enzyme and diffusion of high-energy phosphate compounds may be insufficient to sustain uniform ATP/ADP distribution and hence force generation.

scholarly journals Novel Organic Material Induced by Electron Beam Irradiation for Medical Application

Polymers ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 306 ◽  
Author(s):  
Adrian Barylski ◽  
Krzysztof Aniołek ◽  
Andrzej S. Swinarew ◽  
Sławomir Kaptacz ◽  
Jadwiga Gabor ◽  
...  
Keyword(s):  
Electron Beam ◽  
Electron Beam Irradiation ◽  
Absorbed Dose ◽  
Medical Application ◽  
High Energy ◽  
Polymer Chains ◽  
Degree Of Crystallinity ◽  
Beam Irradiation ◽  
The Impact ◽  
The Degree Of Crystallinity

This study analyzed the effects of irradiation of polytetrafluoroethylene (PTFE) containing 40% of bronze using an electron beam with energy of 10 MeV. Dosages from 26 to156 kGy (2.6–15.6 Mrad) were used. The impact of a high-energy electron beam on the thermal, spectrophotometric, mechanical, and tribological properties was determined, and the results were compared with those obtained for pure PTFE. Thermal properties studies showed that such irradiation caused changes in melting temperature Tm and crystallization temperature Tc, an increase in crystallization heat ∆Hc, and a large increase in crystallinity χc proportional to the absorbed dose for both polymers. The addition of bronze decreased the degree of crystallinity of PTFE by twofold. Infrared spectroscopy (FTIR) studies confirmed that the main phenomenon associated with electron beam irradiation was the photodegradation of the polymer chains for both PTFE containing bronze and pure PTFE. This had a direct effect on the increase in the degree of crystallinity observed in DSC studies. The use of a bronze additive could lead to energy dissipation over the additive particles. An increase in hardness H and Young’s modulus E was also observed. The addition of bronze and the irradiation with an electron beam improved of the operational properties of PTFE.

scholarly journals High Energy Rho Meson Leptoproduction §

2014 ◽  
Vol 1 (1) ◽  
pp. 33-35
Author(s):  
Adrien Besse ◽  
Lech Szymanowski ◽  
Samuel Wallon
Keyword(s):  
Cross Sections ◽  
Scattering Amplitude ◽  
Good Description ◽  
High Energy ◽  
Energy Limit ◽  
Rho Meson ◽  
Forward Limit ◽  
Helicity Amplitudes ◽  
Impact Parameter Space ◽  
The Impact

We investigate the longitudinal and transverse polarized cross-sections of the leptoproduction of the ρ meson in the high energy limit. Our model is based on the computation of the impact factor γ*(λγ)→ ρ (λρ) using the twist expansion in the forward limit which is expressed in the impact parameter space. This treatment involves in the final stage the twist 2 and twist 3 distribution amplitudes (DAs) of the ρ meson and the dipole scattering amplitude. Taking models that exist for the DAs and for the dipole cross-section. We get a phenomenological model for the helicity amplitudes. We compare our predictions with HERA data and get a fairly good description for large enough virtualities of the photon. PACS number(s): 13.60.Le, 12.39.St, 12.38.Bx.

scholarly journals Forbidden transitions in excitation by proton impact in Li-like Al ions

2007 ◽  
Vol 25 (2) ◽  
pp. 277-282 ◽  
Author(s):  
V. Stancalie ◽  
V. Pais ◽  
M. Totolici ◽  
A. Mihailescu
Keyword(s):  
Cross Sections ◽  
Born Approximation ◽  
High Energy ◽  
Impact Excitation ◽  
Proton Impact ◽  
Collision Strength ◽  
Energy Behavior ◽  
Forbidden Transitions ◽  
Excitation Processes ◽  
The Impact

This paper presents cross-sections and collision strengths for proton-impact excitation of optically forbidden transitions in Al10+. These data, calculated in the impact-parameter formalism, covering the expected range of energies/temperature in laser-produced plasmas, are believed to represent the first such detailed treatment of this system. The cross-sections decrease with energy as E−1, while the collision strengths tend to finite limits as the energy of colliding proton becomes infinitely great. This high-energy limiting value has been evaluated combining results from the semi-classical treatment of ion-impact excitation processes and the Born approximation for high-energy behavior of the collision strength. The effective target size has been estimated from the calculated high-energy limit of the collision strength in the Born approximation.

scholarly journals Some Recent Results on High-Energy Proton Interactions

Particles ◽  
2019 ◽  
Vol 2 (1) ◽  
pp. 57-69 ◽  
Author(s):  
I. M. Dremin
Keyword(s):  
Cross Sections ◽  
Scattering Amplitude ◽  
High Energy ◽  
Unitarity Condition ◽  
Total Cross Sections ◽  
Energy Proton ◽  
Elastic Scattering Amplitude ◽  
Energy Behavior ◽  
Impact Parameter Space ◽  
The Impact

Recent experimental results about the energy behavior of the total cross sections, the share of elastic and inelastic contributions to them, the peculiar shape of the differential cross section and our guesses about the behavior of real and imaginary parts of the elastic scattering amplitude are discussed. The unitarity condition relates elastic and inelastic processes. Therefore it is used in the impact-parameter space to get some information about the shape of the interaction region of colliding protons by exploiting new experimental data. The obtained results are described.

scholarly journals Production of heavy charged particles in proton-proton ultraperipheral collisions at the Large Hadron Collider: survival factor

2021 ◽  
Vol 2021 (10) ◽  
Author(s):  
S. I. Godunov ◽  
V. A. Novikov ◽  
A. N. Rozanov ◽  
M. I. Vysotsky ◽  
E. V. Zhemchugov
Keyword(s):  
Large Hadron Collider ◽  
Cross Sections ◽  
Hadron Collider ◽  
Charged Particles ◽  
High Energy ◽  
Proton Proton ◽  
Heavy Charged Particles ◽  
Survival Factors ◽  
Survival Factor

Abstract Ultraperipheral collisions of high energy protons are a source of approximately real photons colliding with each other. Photon fusion can result in production of yet unknown charged particles in very clean events. The cleanliness of such an event is due to the requirement that the protons survive during the collision. Finite sizes of the protons reduce the probability of such outcome compared to point-like particles. We calculate the survival factors and cross sections for the production of heavy charged particles at the Large Hadron Collider.

Investigating the impact of the partonic structure on the description of hadronic collisions at high energies

2020 ◽  
Vol 35 (22) ◽  
pp. 2050127
Author(s):  
M. Broilo ◽  
V. P. Gonçalves ◽  
P. V. R. G. Silva
Keyword(s):  
Cross Sections ◽  
High Energy ◽  
Distribution Functions ◽  
Parton Distribution Functions ◽  
Proton Proton ◽  
High Energies ◽  
High Energy Behavior ◽  
Energy Behavior ◽  
The Impact ◽  
Hadronic Collisions

The impact of the partonic structure on the description of the hadronic cross-sections is investigated considering a multichannel eikonal model based on the Good–Walker approach. The total, elastic and single diffractive cross-sections are estimated considering different parametrizations for the parton distribution functions and the predictions are compared with the experimental data for proton–proton [Formula: see text] and antiproton–proton [Formula: see text] collisions. We show that the description of the high-energy behavior of the hadronic cross-sections is sensitive to the partonic structure.

scholarly journals A feasibility study on the use of phantoms with statistical lung masses for determining the uncertainty in the dose absorbed by the lung from broad beams of incident photons and neutrons

2017 ◽  
Vol 58 (3) ◽  
pp. 313-328 ◽  
Author(s):  
Atiyeh Ebrahimi Khankook ◽  
Hashem Miri Hakimabad ◽  
Laleh Rafat Motavalli
Keyword(s):  
Neutron Beam ◽  
Computational Models ◽  
Anatomical Variation ◽  
Absorbed Dose ◽  
High Energy ◽  
Low Energy ◽  
Radiological Protection ◽  
Energy Photon ◽  
Organ Volume ◽  
Photon Sources

Abstract Computational models of the human body have gradually become crucial in the evaluation of doses absorbed by organs. However, individuals may differ considerably in terms of organ size and shape. In this study, the authors sought to determine the energy-dependent standard deviations due to lung size of the dose absorbed by the lung during external photon and neutron beam exposures. One hundred lungs with different masses were prepared and located in an adult male International Commission on Radiological Protection (ICRP) reference phantom. Calculations were performed using the Monte Carlo N-particle code version 5 (MCNP5). Variation in the lung mass caused great uncertainty: ~90% for low-energy broad parallel photon beams. However, for high-energy photons, the lung-absorbed dose dependency on the anatomical variation was reduced to <1%. In addition, the results obtained indicated that the discrepancy in the lung-absorbed dose varied from 0.6% to 8% for neutron beam exposure. Consequently, the relationship between absorbed dose and organ volume was found to be significant for low-energy photon sources, whereas for higher energy photon sources the organ-absorbed dose was independent of the organ volume. In the case of neutron beam exposure, the maximum discrepancy (of 8%) occurred in the energy range between 0.1 and 5 MeV.

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