scholarly journals How Wide the Divide? – Theorizing ‘Constructions’ in Generative and Usage-Based Frameworks

2021 ◽  
Vol 12 ◽  
Author(s):  
Matthew T. Carlson ◽  
Antonio Fábregas ◽  
Michael T. Putnam
Keyword(s):  
Cognitive Science ◽  
Mental Representations ◽  
Human Mind ◽  
Human Language ◽  
Structure Building ◽  
And Function

What is the nature and function of mental representations in cognitive science, and in human language in particular? How do they come into existence and interact, and how is the information attributed to them stored in and retrieved from the human mind? Some theories treat constructions as primitive entities used for structure-building, central in both production and comprehension, while other theories only admit construction-like entities as devices to map the structure into semantics or to relate them to specific morphophonological exponents. In this positional piece, we seek to elucidate areas of commonality across what have traditionally been divergent approaches to the role of constructions in language. Here we outline a robust specification of the differences in how chunks of structure containing information are treated in the two main approaches, and we seek to offer a path toward a more unified theoretical stance.

Language, Revelation and Illumination

1973 ◽  
Vol 26 (1) ◽  
pp. 1-23
Author(s):  
Erik C. Fudge
Keyword(s):  
Human Mind ◽  
Human Language ◽  
Relationship With God ◽  
The Bible

This paper1 is an attempt to sketch to sketch the role of language in man's relationship with God, especially as a means whereby God teaches men about himself. Serious doubts have been raised about the adequacy of human language for this purpose—even many of those who see no inadequacy within language itself would feel that, since the human mind is finite, no message communicated through it by an infinite God can be reliable. Some believe that a man may become genuinely aware of the reality of God, but that it is immaterial whether any linguistic propositions involved in this process (and in particular the propositions of the Bible) are true or false.

Towards a Standard Model of the Cognitive Science of Nationalism – the Calendar

2020 ◽  
Vol 20 (5) ◽  
pp. 432-457
Author(s):  
Michal Fux ◽  
Amílcar Antonio Barreto
Keyword(s):  
Cognitive Science ◽  
Memory Systems ◽  
Human Mind ◽  
National Identities ◽  
Social Forms ◽  
Political Sciences ◽  
Representation Systems ◽  
Thought Patterns ◽  
Behavioral Motivation

Abstract The Cognitive Science of Nationalistic Behavior (CSNB), presented in this paper, integrates the political sciences of nationalities as invented communities with an evolutionary cognitive analysis of social forms as products of the human mind. The framework is modeled after the Cognitive Science of Religion, where decades of cross-disciplinary work has generated standards, predictions, and data about the role of individual cognitive tendencies in shaping societies. We study the nationalistic calendar as a cultural attractor and draw on cue-based behavioral motivation and differential autobiographical memory systems to explain its appeal to the human mind. Calendrical elements are analyzed in the context of essentialist thought patterns and action representation systems. We conclude with the implications of calendrical thinking on the control of elites who aim to forge and reinforce national identities. This paper lays the groundwork for applying a similar approach to the study of other nationalistic elements.

Representational Kinds

2020 ◽  
pp. 213-241
Author(s):  
Joulia Smortchkova ◽  
Michael Murez
Keyword(s):  
Cognitive Science ◽  
Philosophy Of Mind ◽  
Natural Kinds ◽  
Mental Representations ◽  
Scientific Theories ◽  
Explanatory Role ◽  
Levels Of Explanation ◽  
Different Levels

Many debates in philosophy of mind and cognitive science focus on whether folk or scientific psychological notions pick out cognitive natural kinds. Examples include memory, emotions, and concepts. A potentially interesting type of kind is kinds of mental representations (as opposed, for example, to kinds of psychological faculties). This chapter outlines a proposal for a theory of representational kinds in cognitive science. It argues that the explanatory role of representational kinds in scientific theories, in conjunction with a mainstream approach to explanation in cognitive science, suggests that representational kinds are multilevel. This is to say that representational kinds’ properties cluster at different levels of explanation and allow for intra- and interlevel projections.

Scanning electron microscopic study of collagen fibrillogenesis and extracellular compartmentalization in the chick embryo tendon

1986 ◽  
Vol 44 ◽  
pp. 208-209
Author(s):  
Grace C.H. Yang
Keyword(s):  
Chick Embryo ◽  
Extracellular Space ◽  
Fibroblast Cell ◽  
Collagen Fibrils ◽  
Electron Microscopic ◽  
Voltage Electron ◽  
Scanning Electron Microscopic Study ◽  
Microscopic Studies ◽  
And Function

The size and organization of collagen fibrils in the extracellular matrix is an important determinant of tissue structure and function. The synthesis and deposition of collagen involves multiple steps which begin within the cell and continue in the extracellular space. High-voltage electron microscopic studies of the chick embryo cornea and tendon suggested that the extracellular space is compartmentalized by the fibroblasts for the regulation of collagen fibril, bundle, and tissue specific macroaggregate formation. The purpose of this study is to gather direct evidence regarding the association of the fibroblast cell surface with newly formed collagen fibrils, and to define the role of the fibroblast in the control and the precise positioning of collagen fibrils, bundles, and macroaggregates during chick tendon development.

Role of the Cilia Membrane in Control of Microtubule Sliding

1980 ◽  
Vol 38 ◽  
pp. 612-615
Author(s):  
Edna S. Kaneshiro
Keyword(s):  
Control Mechanism ◽  
Beat Frequency ◽  
Surface Membrane ◽  
Ciliary Membrane ◽  
Ciliary Beating ◽  
Ciliary Reversal ◽  
Voltage Dependent ◽  
Reversal Mechanism ◽  
And Function

It is currently believed that ciliary beating results from microtubule sliding which is restricted in regions to cause bending. Cilia beat can be modified to bring about changes in beat frequency, cessation of beat and reversal in beat direction. In ciliated protozoans these modifications which determine swimming behavior have been shown to be related to intracellular (intraciliary) Ca2+ concentrations. The Ca2+ levels are in turn governed by the surface ciliary membrane which exhibits increased Ca2+ conductance (permeability) in response to depolarization. Mutants with altered behaviors have been isolated. Pawn mutants fail to exhibit reversal of the effective stroke of ciliary beat and therefore cannot swim backward. They lack the increased inward Ca2+ current in response to depolarizing stimuli. Both normal and pawn Paramecium made leaky to Ca2+ by Triton extrac¬tion of the surface membrane exhibit backward swimming only in reactivating solutions containing greater than IO-6 M Ca2+ Thus in pawns the ciliary reversal mechanism itself is left operational and only the control mechanism at the membrane is affected. The topographic location of voltage-dependent Ca2+ channels has been identified as a component of the ciliary mem¬brane since the inward Ca2+ conductance response is eliminated by deciliation and the return of the response occurs during cilia regeneration. Since the ciliary membrane has been impli¬cated in the control of Ca2+ levels in the cilium and therefore is the site of at least one kind of control of microtubule sliding, we have focused our attention on understanding the structure and function of the membrane.

POPDC proteins and cardiac function

2019 ◽  
Vol 47 (5) ◽  
pp. 1393-1404 ◽  
Author(s):  
Thomas Brand
Keyword(s):  
Potential Role ◽  
Striated Muscle ◽  
Short Review ◽  
Effector Proteins ◽  
Muscle Disease ◽  
Disease Genes ◽  
Protein Protein Interaction ◽  
Interaction Partners ◽  
And Function

Abstract The Popeye domain-containing gene family encodes a novel class of cAMP effector proteins in striated muscle tissue. In this short review, we first introduce the protein family and discuss their structure and function with an emphasis on their role in cyclic AMP signalling. Another focus of this review is the recently discovered role of POPDC genes as striated muscle disease genes, which have been associated with cardiac arrhythmia and muscular dystrophy. The pathological phenotypes observed in patients will be compared with phenotypes present in null and knockin mutations in zebrafish and mouse. A number of protein–protein interaction partners have been discovered and the potential role of POPDC proteins to control the subcellular localization and function of these interacting proteins will be discussed. Finally, we outline several areas, where research is urgently needed.

Do Writing Directions Influence How People Map Space onto Time?

2018 ◽  
Vol 77 (4) ◽  
pp. 173-184
Author(s):  
Wenxing Yang ◽  
Ying Sun
Keyword(s):  
Mental Representations ◽  
Space Time ◽  
Horizontal Axis ◽  
Causal Role ◽  
Writing Systems ◽  
Temporal Cognition ◽  
Japanese Speakers ◽  
Psychological Experiments ◽  
Vertical Up

Abstract. The causal role of a unidirectional orthography in shaping speakers’ mental representations of time seems to be well established by many psychological experiments. However, the question of whether bidirectional writing systems in some languages can also produce such an impact on temporal cognition remains unresolved. To address this issue, the present study focused on Japanese and Taiwanese, both of which have a similar mix of texts written horizontally from left to right (HLR) and vertically from top to bottom (VTB). Two experiments were performed which recruited Japanese and Taiwanese speakers as participants. Experiment 1 used an explicit temporal arrangement design, and Experiment 2 measured implicit space-time associations in participants along the horizontal (left/right) and the vertical (up/down) axis. Converging evidence gathered from the two experiments demonstrate that neither Japanese speakers nor Taiwanese speakers aligned their vertical representations of time with the VTB writing orientation. Along the horizontal axis, only Japanese speakers encoded elapsing time into a left-to-right linear layout, which was commensurate with the HLR writing direction. Therefore, two distinct writing orientations of a language could not bring about two coexisting mental time lines. Possible theoretical implications underlying the findings are discussed.

Role of the 807 C/T Polymorphism of the α2 Gene in Platelet GP Ia Collagen Receptor Expression and Function

1999 ◽  
Vol 81 (06) ◽  
pp. 951-956 ◽  
Author(s):  
J. Corral ◽  
R. González-Conejero ◽  
J. Rivera ◽  
F. Ortuño ◽  
P. Aparicio ◽  
...  
Keyword(s):  
Venous Thrombosis ◽  
Cell Types ◽  
Receptor Expression ◽  
Case Control Studies ◽  
Platelet Surface ◽  
Vitro Analysis ◽  
And Function ◽  
In Vitro Analysis

SummaryThe variability of the platelet GP Ia/IIa density has been associated with the 807 C/T polymorphism (Phe 224) of the GP Ia gene in American Caucasian population. We have investigated the genotype and allelic frequencies of this polymorphism in Spanish Caucasians. The T allele was found in 35% of the 284 blood donors analyzed. We confirmed in 159 healthy subjects a significant association between the 807 C/T polymorphism and the platelet GP Ia density. The T allele correlated with high number of GP Ia molecules on platelet surface. In addition, we observed a similar association of this polymorphism with the expression of this protein in other blood cell types. The platelet responsiveness to collagen was determined by “in vitro” analysis of the platelet activation and aggregation response. We found no significant differences in these functional platelet parameters according to the 807 C/T genotype. Finally, results from 3 case/control studies involving 302 consecutive patients (101 with coronary heart disease, 104 with cerebrovascular disease and 97 with deep venous thrombosis) determined that the 807 C/T polymorphism of the GP Ia gene does not represent a risk factor for arterial or venous thrombosis.

Von Willebrand disease and Weibel-Palade bodies

2010 ◽  
Vol 30 (03) ◽  
pp. 150-155 ◽  
Author(s):  
J. W. Wang ◽  
J. Eikenboom
Keyword(s):  
Platelet Adhesion ◽  
Coagulation Factor ◽  
Von Willebrand Disease ◽  
Inflammatory Factors ◽  
Limited Data ◽  
Storage Organelle ◽  
And Function ◽  
Von Willebrand ◽  
Willebrand Factor

SummaryVon Willebrand factor (VWF) is a pivotal haemostatic protein mediating platelet adhesion to injured endothelium and carrying coagulation factor VIII (FVIII) in the circulation to protect it from premature clearance. Apart from the roles in haemostasis, VWF drives the formation of the endothelial cell specific Weibel-Palade bodies (WPBs), which serve as a regulated storage of VWF and other thrombotic and inflammatory factors. Defects in VWF could lead to the bleeding disorder von Willebrand disease (VWD).Extensive studies have shown that several mutations identified in VWD patients cause an intracellular retention of VWF. However, the effects of such mutations on the formation and function of its storage organelle are largely unknown. This review gives an overview on the role of VWF in WPB biogenesis and summarizes the limited data on the WPBs formed by VWD-causing mutant VWF.

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