scholarly journals Modulating OFC Activity With tDCS Alters Regret About Human Decision-Making

2021 ◽  
Vol 12 ◽  
Author(s):  
Ping Yu ◽  
Xinbo Lu ◽  
Yuyou Chen ◽  
Hang Ye ◽  
Lulu Zeng ◽  
...  
Keyword(s):  
Decision Making ◽  
Orbitofrontal Cortex ◽  
Emotional Intensity ◽  
Making Choices ◽  
Human Decision ◽  
The Mean ◽  
Post Hoc ◽  
Cathodal Stimulation ◽  
Over Time

Regret is a common emotion in daily life. Humans always regret their decision-making choices if the chosen outcome is bad. Neuroscientific studies suggest that the orbitofrontal cortex (OFC) influences feelings of regret. We used a transcranial direct current stimulation (tDCS) device to study the role of regret in participants’ decision-making by modulating the activity of the OFC. The two-wheel-of-fortune gamble task was used in our experimental design, and we asked the participants to rate their feelings of regret after the computer presented the obtained and unobtained outcomes. The experimental results revealed that the effect of stimulation type was significant, which indicated that the influence of the OFC in regret was modulated by tDCS. Furthermore, based on post hoc analyses (Bonferroni), regret was lower in those who received left anodal/right cathodal stimulation than in those who received sham stimulation, which revealed that modulating the activity of the OFC reduced the emotional intensity of regret. In addition, an inverted U-shaped curve characterized the mean ratings of regret over time.

scholarly journals Interacting roles of lateral and medial Orbitofrontal cortex in decision-making and learning : A system-level computational model

2019 ◽  
Author(s):  
Bhargav Teja Nallapu ◽  
Frédéric Alexandre
Keyword(s):  
Decision Making ◽  
Prefrontal Cortex ◽  
Computational Model ◽  
Orbitofrontal Cortex ◽  
Temporal Dynamics ◽  
System Level ◽  
Interacting Networks ◽  
Cortical Regions ◽  
Experimental Findings

AbstractIn the context of flexible and adaptive animal behavior, the orbitofrontal cortex (OFC) is found to be one of the crucial regions in the prefrontal cortex (PFC) influencing the downstream processes of decision-making and learning in the sub-cortical regions. Although OFC has been implicated to be important in a variety of related behavioral processes, the exact mechanisms are unclear, through which the OFC encodes or processes information related to decision-making and learning. Here, we propose a systems-level view of the OFC, positioning it at the nexus of sub-cortical systems and other prefrontal regions. Particularly we focus on one of the most recent implications of neuroscientific evidences regarding the OFC - possible functional dissociation between two of its sub-regions : lateral and medial. We present a system-level computational model of decision-making and learning involving the two sub-regions taking into account their individual roles as commonly implicated in neuroscientific studies. We emphasize on the role of the interactions between the sub-regions within the OFC as well as the role of other sub-cortical structures which form a network with them. We leverage well-known computational architecture of thalamo-cortical basal ganglia loops, accounting for recent experimental findings on monkeys with lateral and medial OFC lesions, performing a 3-arm bandit task. First we replicate the seemingly dissociate effects of lesions to lateral and medial OFC during decision-making as a function of value-difference of the presented options. Further we demonstrate and argue that such an effect is not necessarily due to the dissociate roles of both the subregions, but rather a result of complex temporal dynamics between the interacting networks in which they are involved.Author summaryWe first highlight the role of the Orbitofrontal Cortex (OFC) in value-based decision making and goal-directed behavior in primates. We establish the position of OFC at the intersection of cortical mechanisms and thalamo-basal ganglial circuits. In order to understand possible mechanisms through which the OFC exerts emotional control over behavior, among several other possibilities, we consider the case of dissociate roles of two of its topographical subregions - lateral and medial parts of OFC. We gather predominant roles of each of these sub-regions as suggested by numerous experimental evidences in the form of a system-level computational model that is based on existing neuronal architectures. We argue that besides possible dissociation, there could be possible interaction of these sub-regions within themselves and through other sub-cortical structures, in distinct mechanisms of choice and learning. The computational framework described accounts for experimental data and can be extended to more comprehensive detail of representations required to understand the processes of decision-making, learning and the role of OFC and subsequently the regions of prefrontal cortex in general.

Measurement and Prediction of Sound Exposure Levels by University Wind Bands

2010 ◽  
Vol 25 (1) ◽  
pp. 29-34 ◽  
Author(s):  
Kris Chesky
Keyword(s):  
Linear Regression Analysis ◽  
Critical Role ◽  
Significant Proportion ◽  
Sound Exposure ◽  
Sound Levels ◽  
Wind Bands ◽  
Exposure Levels ◽  
The Mean ◽  
Over Time

The purpose of this study was to determine sound exposure levels generated in two college wind bands. Dosimeter data from a large sample of ensemble-based instructional activities (n = 43) was collected over time and processed to assess associations with predictor variables that may be relevant to this context, including indicators of time spend at various intensity levels, maximum and peak sound levels, degree of variability of sound levels over time, and the percentage of time playing music. The mean dose per event for the entire sample was 109.5% and ranged from 53.8% to 166.9%. Results of linear regression analysis revealed that regressors accounted for a significant proportion of the variance in dose (F = 128.42, p < 0.000) and a statistically significant and very large (96% variance accounted for) contribution to the prediction of dose. Findings implicate the critical role of the instructor and teaching pedagogy.

The views and perceptions of managers on the role of marketing research in decision making

2018 ◽  
Vol 60 (1) ◽  
pp. 67-87 ◽  
Author(s):  
Piotr Tarka
Keyword(s):  
Decision Making ◽  
Marketing Research ◽  
Decision Makers ◽  
Irrational Thinking ◽  
Analytical Thinking ◽  
Making Choices ◽  
Decision Making Processes ◽  
Specific Factors ◽  
Views And Perceptions

In this article, the author conducts an empirical diagnosis of managers’ views and perceptions in the context of use of information obtained from marketing research in decision-making processes. It is argued that decision makers who take charge of management, despite their strong declarations and beliefs about the potential and usefulness of information in decisions, in reality prefer solutions based on intuition and irrational thinking. Therefore, the objective of the conducted study is to explore mechanisms of such paradoxes. However, through empirical research, the author endeavored to find the answers associated with the specific factors that are likely to favor such an unreasonable thinking and activities undertaken by managers in decision-making processes. Based on the sample ( N = 213), which contained mainly information users, it was confirmed that managers, faced with a difficulty of information processing (e.g., due to information overloading problems and requirements of analytical thinking), or narrow cognitive capacities, limited memory, and strong reliance on personal experience, look for much simpler solutions in decision making. They preferably move toward the irrational sphere of making choices. Thus, the information, obtained from research, that is available to managers is rather neglected instead of being closely inspected (scrutinized). Moreover, the greater the surprise in information derived from marketing research (i.e., the wider is the discrepancy between the value of information provided by analysts and managers’ expectations), the greater their inclination to reject any information and much greater exposure toward irrational thinking in decision making. As a matter of fact, the problems associated with information adaptation in decisions, as well as the problems of analytical thinking, put the question mark over the entire usefulness of information and further deliberate conducting of the marketing research.

Human Medial Orbitofrontal Cortex Is Recruited During Experience of Imagined and Real Rewards

2010 ◽  
Vol 103 (5) ◽  
pp. 2506-2512 ◽  
Author(s):  
Signe Bray ◽  
Shinsuke Shimojo ◽  
John P. O'Doherty
Keyword(s):  
Decision Making ◽  
Orbitofrontal Cortex ◽  
Critical Role ◽  
Brain Regions ◽  
Mental Simulation ◽  
Human Decision ◽  
Tangible Rewards ◽  
Action Choice

Human decision-making frequently relies on mental simulation of future rewards to guide action choice. In this study, we sought to uncover brain regions engaged during reward imagery and to address whether these regions functionally overlap with regions activated by tangible rewards. We found that medial orbitofrontal cortex (mOFC) is engaged both for real and imagined rewards and is preferentially engaged for imagery with rewarding content compared with other nonrewarding imagery. These findings support a critical role for mOFC in the representation of rewarding goal states, even if hypothetical.

Neural Mechanisms of the Testosterone–Aggression Relation: The Role of Orbitofrontal Cortex

2010 ◽  
Vol 22 (10) ◽  
pp. 2357-2368 ◽  
Author(s):  
Pranjal H. Mehta ◽  
Jennifer Beer
Keyword(s):  
Decision Making ◽  
Aggressive Behavior ◽  
Orbitofrontal Cortex ◽  
Impulse Control ◽  
Ultimatum Game ◽  
Self Regulation ◽  
Neural Circuitry ◽  
Neural Mechanisms ◽  
Reduced Activity

Testosterone plays a role in aggressive behavior, but the mechanisms remain unclear. The present study tested the hypothesis that testosterone influences aggression through the OFC, a region implicated in self-regulation and impulse control. In a decision-making paradigm in which people chose between aggression and monetary reward (the ultimatum game), testosterone was associated with increased aggression following social provocation (rejecting unfair offers). The effect of testosterone on aggression was explained by reduced activity in the medial OFC. The findings suggest that testosterone increases the propensity toward aggression because of reduced activation of the neural circuitry of impulse control and self-regulation.

scholarly journals Branching and competitive hierarchies in populations of Galium aparine

1998 ◽  
Vol 76 (1) ◽  
pp. 63-74
Author(s):  
Javier G Puntieri ◽  
Petr Pysek
Keyword(s):  
Height Growth ◽  
Low Density ◽  
Growth Limitation ◽  
Galium Aparine ◽  
Key Words Allometry ◽  
Annual Herb ◽  
The Mean ◽  
Competitive Hierarchies ◽  
Over Time

The role of branching on the development of size hierarchies was studied on experimental populations of the annual herb Galium aparine L. (Rubiaceae). All branches of plants growing at high and low density were severed as plants developed, and the growth of individual plants, the development of growth and size inequalities, and the mean change in the size ranking of plants over time were compared with those of populations of naturally branched plants. Size allometries were analysed for all treatments. The effect of the branch-severing treatment on growth and size inequalities was not significant for crowded populations. The position of individual plants in the ranking of weights in crowded conditions was less variable for populations of unbranched plants than for those of branched plants. Size and growth inequalities among branched plants were not significantly affected by population density. The hypothesis that branching increases the development of competitive hierarchies in G. aparine populations is not supported by the results. The role of height growth limitation in crowded conditions as a constraint to competitive hierarchy development is discussed. Key words: allometry, branching pattern, competitive hierarchy, Galium aparine, intraspecific competition.

scholarly journals Serum Neutrophil Gelatinase-Associated Lipocalin Levels In Early Detection Of Contrast-Induced Nephropathy

2016 ◽  
Vol 39 (3) ◽  
pp. 88 ◽  
Author(s):  
Murat Muratoglu ◽  
Cemil Kavalci ◽  
Elif Kilicli ◽  
Meliha Findik ◽  
Afşin Emre Kayipmaz ◽  
...  
Keyword(s):  
Early Detection ◽  
P Value ◽  
Ngal Level ◽  
Contrast Induced Nephropathy ◽  
Sodium Potassium ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
The Mean ◽  
Neutrophil Gelatinase ◽  
Over Time

Purpose: The purpose of this study was to investigate the role of serum neutrophil gelatinase-associated lipocalin (NGAL) levels in the early detection of contrast-induced nephropathy (CIN). Methods: This prospective study enrolled 74 patients undergoing abdominal tomography with contrast (1 November 2014 - 28 February 2015). Demographic properties (age and sex), symptoms and CT examination results were analysed. Sodium, potassium, urea, creatinine and NGAL levels were measured at 0th, 6th, and 72nd hours. P value < 0.05 was considered statistically significant. Results: CIN developed in 16.2% of the study patients. The mean age was significantly higher in the patients who developed CIN (p0.05). Urea levels did not differ significantly between the groups at 0th and 6th hours (p>0.05) but was significantly higher in the patients with CIN at 72nd hour (p0.05). Creatinine level was not significantly different between the groups (p>0.05) but increased significantly over time (p>0.05). There were no significant differences between the groups with respect to NGAL levels at 0th and 72nd hours (p>0.05) whereas the group with CIN had a significantly higher NGAL level at 6th hour (p

scholarly journals The role of time in human decision-making

2013 ◽  
Vol 13 (9) ◽  
pp. 305-305
Author(s):  
M. Popovic ◽  
M. Lengyel ◽  
J. Fiser
Keyword(s):  
Decision Making ◽  
Human Decision

scholarly journals The Orbitofrontal Cortex Represents Advantageous Choice in the Iowa Gambling Task

2021 ◽  
Author(s):  
Rujing Zha ◽  
Peng Li ◽  
Ying Li ◽  
Nan Li ◽  
Meijun Gao ◽  
...  
Keyword(s):  
Decision Making ◽  
Orbitofrontal Cortex ◽  
Iowa Gambling Task ◽  
Real Life ◽  
Binary Choice ◽  
Learning Tools ◽  
Gambling Task ◽  
Complex Decision Making ◽  
Complex Decision

Abstract A good-based model proposes that the orbitofrontal cortex (OFC) represents binary choice outcome, i.e., the chosen good. Previous studies have found that the OFC represents the binary choice outcome in decision-making tasks involving commodity type, cost, risk, and delay. Real-life decisions are often complex and involve uncertainty, rewards, and penalties; however, whether the OFC represents binary choice outcomes in a such decision-making situation, e.g., Iowa gambling task (IGT), remains unclear. Here, we propose that the OFC represents binary choice outcome, i.e., advantageous choice versus disadvantageous choice, in the IGT. We propose two hypotheses: first, the activity pattern in the human OFC represents an advantageous choice; and second, choice induces an OFC-related functional network. Using functional magnetic resonance imaging and advanced machine learning tools, we found that the OFC represented an advantageous choice in the IGT. The OFC representation of advantageous choice was related to decision-making performance. Choice modulated the functional connectivity between the OFC and the superior medial gyrus. In conclusion, the OFC represents an advantageous choice during the IGT. In the framework of a good-based model, the results extend the role of the OFC to complex decision-making when making a binary choice.

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