scholarly journals Brain Arousal as Measured by EEG-Assessment Differs Between Children and Adolescents With Attention-Deficit/Hyperactivity Disorder (ADHD) and Depression

2021 ◽  
Vol 12 ◽  
Author(s):  
Christoph Berger ◽  
Alexander Dück ◽  
Felicitas Perin ◽  
Katharina Wunsch ◽  
Johannes Buchmann ◽  
...  
Keyword(s):  
Resting State ◽  
Test Performance ◽  
Adult Adhd ◽  
Standard Procedure ◽  
Small Sample ◽  
External Stimulation ◽  
Children With Adhd ◽  
Male Age ◽  
Assessment Time ◽  
Brain Arousal

Objective: Disturbed regulation of vigilance in the wake state seems to play a key role in the development of mental disorders. It is assumed that hyperactivity in adult ADHD is an attempt to increase a general low vigilance level via external stimulation in order to avoid drowsiness. For depression, the avoidance of stimulation is interpreted as a reaction to a tonic increased vigilance state. Although ADHD is assumed to start during childhood, this vigilance model has been barely tested with children diagnosed for ADHD so far.Methods: Resting-state EEG (8 min) measures from two groups of children diagnosed with either ADHD [N = 76 (16 female, 60 male), age: (mean/SD) 118/33 months] or depression [N = 94 (73 female, 21 male), age: 184/23 months] were analyzed. Using the VIGALL toolbox, EEG patterns of vigilance level, and regulation were derived and compared between both groups. In correlation analysis, the relations between vigilance measures, attentional test performance (alertness and inhibition), and mental health symptoms were analyzed.Results: Children with ADHD differed from children with most prominent depressive symptoms in brain arousal regulation and level, but EEG vigilance was not related to behavior problems and not related to the attentional test performance. Brain arousal was dependent on the age of the participant in the whole sample; younger children showed lower vigilance stages than teenagers; this effect was not present when analyzed separately for each diagnostic group. EEG assessment time and received medication had no effect on the EEG vigilance.Discussion: Although based on a small sample, this explorative research revealed that EEG vigilance level is different between children with ADHD and with depression. Moreover, even the standard procedure of the clinical routine EEG (resting state) can be used to differentiate brain arousal states between participants with ADHD and depression. Because routine EEG is not specialized to vigilance assessment, it may not be sufficiently sensitive to find vigilance–symptomatology associations. Further research should address developmental changes in EEG measurements in children and use bigger samples of participants within the same age range.

Physical Fitness and Resting EEG in Children With Attention Deficit Hyperactivity Disorder

2015 ◽  
Vol 29 (1) ◽  
pp. 26-32 ◽  
Author(s):  
Ching-Wen Huang ◽  
Chung-Ju Huang ◽  
Chiao-Ling Hung ◽  
Chia-Hao Shih ◽  
Tsung-Min Hung
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Physical Fitness ◽  
Attention Deficit ◽  
Resting State ◽  
Self Control ◽  
Children With Adhd ◽  
Hyperactivity Disorder ◽  
Higher Power ◽  
Eyes Open ◽  
The Relationship

Children with attention deficit hyperactivity disorder (ADHD) are characterized by a deviant pattern of brain oscillations during resting state, particularly elevated theta power and increased theta/alpha and theta/beta ratios that are related to cognitive functioning. Physical fitness has been found beneficial to cognitive performance in a wide age population. The purpose of the present study was to investigate the relationship between physical fitness and resting-state electroencephalographic (EEG) oscillations in children with ADHD. EEG was recorded during eyes-open resting for 28 children (23 boys and 5 girls, 8.66 ± 1.10 years) with ADHD, and a battery of physical fitness assessments including flexibility, muscular endurance, power, and agility tests were administered. The results indicated that ADHD children with higher power fitness exhibited a smaller theta/alpha ratio than those with lower power fitness. These findings suggest that power fitness may be associated with improved attentional self-control in children with ADHD.

scholarly journals Functional network topology of the right insula affects emotion dysregulation in hyperactive-impulsive attention-deficit/hyperactivity disorder

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Tammo Viering ◽  
Pieter J. Hoekstra ◽  
Alexandra Philipsen ◽  
Jilly Naaijen ◽  
Andrea Dietrich ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Network Topology ◽  
Resting State ◽  
Latent Variable ◽  
Emotion Dysregulation ◽  
Adult Adhd ◽  
Brain Regions ◽  
Graph Analysis ◽  
Hyperactivity Disorder ◽  
The Right

AbstractEmotion dysregulation is common in attention-deficit/hyperactivity disorder (ADHD). It is highly prevalent in young adult ADHD and related to reduced well-being and social impairments. Neuroimaging studies reported neural activity changes in ADHD in brain regions associated with emotion processing and regulation. It is however unknown whether deficits in emotion regulation relate to changes in functional brain network topology in these regions. We used a combination of graph analysis and structural equation modelling (SEM) to analyze resting-state functional connectivity in 147 well-characterized young adults with ADHD and age-matched healthy controls from the NeuroIMAGE database. Emotion dysregulation was gauged with four scales obtained from questionnaires and operationalized through a latent variable derived from SEM. Graph analysis was applied to resting-state data and network topology measures were entered into SEM models to identify brain regions whose local network integration and connectedness differed between subjects and was associated with emotion dysregulation. The latent variable of emotion dysregulation was characterized by scales gauging emotional distress, emotional symptoms, conduct symptoms, and emotional lability. In individuals with ADHD characterized by prominent hyperactivity-impulsivity, the latent emotion dysregulation variable was related to an increased clustering and local efficiency of the right insula. Thus, in the presence of hyperactivity-impulsivity, clustered network formation of the right insula may underpin emotion dysregulation in young adult ADHD.

Altered Resting-State Frontoparietal Control Network in Children with Attention-Deficit/Hyperactivity Disorder

2015 ◽  
Vol 21 (4) ◽  
pp. 271-284 ◽  
Author(s):  
Hsiang-Yuan Lin ◽  
Wen-Yih Isaac Tseng ◽  
Meng-Chuan Lai ◽  
Kayako Matsuo ◽  
Susan Shur-Fen Gau
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Prefrontal Cortex ◽  
Functional Connectivity ◽  
Resting State ◽  
Control Network ◽  
Children With Adhd ◽  
Hyperactivity Disorder ◽  
Anterior Prefrontal Cortex ◽  
The Right ◽  
Frontoparietal Control Network

AbstractThe frontoparietal control network, anatomically and functionally interposed between the dorsal attention network and default mode network, underpins executive control functions. Individuals with attention-deficit/hyperactivity disorder (ADHD) commonly exhibit deficits in executive functions, which are mainly mediated by the frontoparietal control network. Involvement of the frontoparietal control network based on the anterior prefrontal cortex in neurobiological mechanisms of ADHD has yet to be tested. We used resting-state functional MRI and seed-based correlation analyses to investigate functional connectivity of the frontoparietal control network in a sample of 25 children with ADHD (7–14 years; mean 9.94±1.77 years; 20 males), and 25 age-, sex-, and performance IQ-matched typically developing (TD) children. All participants had limited in-scanner head motion. Spearman’s rank correlations were used to test the associations between altered patterns of functional connectivity with clinical symptoms and executive functions, measured by the Conners’ Continuous Performance Test and Spatial Span in the Cambridge Neuropsychological Test Automated Battery. Compared with TD children, children with ADHD demonstrated weaker connectivity between the right anterior prefrontal cortex (PFC) and the right ventrolateral PFC, and between the left anterior PFC and the right inferior parietal lobule. Furthermore, this aberrant connectivity of the frontoparietal control network in ADHD was associated with symptoms of impulsivity and opposition-defiance, as well as impaired response inhibition and attentional control. The findings support potential integration of the disconnection model and the executive dysfunction model for ADHD. Atypical frontoparietal control network may play a pivotal role in the pathophysiology of ADHD. (JINS, 2015, 21, 271–284)

A Reliability-Based Approach to Assess Fatigue Behaviour Based on Small Incomplete Data Sets

2008 ◽  
Vol 44-46 ◽  
pp. 871-878 ◽  
Author(s):  
Chu Yang Luo ◽  
Jun Jiang Xiong ◽  
R.A. Shenoi
Keyword(s):  
Incomplete Data ◽  
Standard Procedure ◽  
Fatigue Behaviour ◽  
Fatigue Tests ◽  
Small Sample ◽  
Data Sets ◽  
Safe Life ◽  
A New Technique ◽  
And Performance

This paper outlines a new technique to address the paucity of data in determining fatigue life and performance based on reliability concepts. Two new randomized models are presented for estimating the safe life and pS-N curve, by using the standard procedure for statistical analysis and dealing with small sample numbers of incomplete data. The confidence level formulations for the safe and p-S-N curve are also given. The concepts are then applied for the determination of the safe life and p-S-N curve. Two sets of fatigue tests for the safe life and p-S-N curve are conducted to validate the presented method, demonstrating the practical use of the proposed technique.

scholarly journals The Role of Self- and Informant-Reports on Symptoms and Impairments in the Clinical Evaluation of Adult ADHD

2021 ◽  
Vol 13 (8) ◽  
pp. 4564
Author(s):  
Nana Guo ◽  
Anselm B. M. Fuermaier ◽  
Janneke Koerts ◽  
Bernhard W. Mueller ◽  
Christian Mette ◽  
...  
Keyword(s):  
Clinical Evaluation ◽  
Test Performance ◽  
Adult Adhd ◽  
Comparison Group ◽  
Neuropsychological Test ◽  
Neuropsychological Testing ◽  
Adhd Group ◽  
Adhd Symptoms ◽  
Clinical Comparison

Little is known about which clinical features may aid the differentiation between attention deficit hyperactivity disorder (ADHD) and other clinical conditions. This study seeks to determine the role of self- and informant reports on symptoms and impairments in the clinical evaluation of adult ADHD and explore their association with objective neuropsychological test performance by examining data of 169 outpatients referred for a diagnostic evaluation of adult ADHD. Participants were assigned either to an ADHD group (ADHD, n = 73) or one of two clinical comparison groups, depending on whether they show indications (Clinical Comparison Group, CCG, n = 53) or no indications (Clinical Comparison Group—Not Diagnosed, CCG-ND, n = 43) of psychiatric disorders other than ADHD. All participants and their informants completed a set of questionnaires. Compared to the CCG-ND, the ADHD group obtained significantly higher scores on ADHD symptoms, impulsivity, cognitive deficits, and anxiety. Compared to the CCG, the ADHD group scored significantly higher on ADHD symptoms but lower on depression. Further regression analyses revealed that self- and informant reports failed to predict neuropsychological test performance. Self- and informant reported information may be distinct features and do not correspond to results of objective neuropsychological testing.

Resting-state EEG Connectivity in Young Children with ADHD

2020 ◽  
pp. 1-17
Author(s):  
Sarah Furlong ◽  
Jessica R. Cohen ◽  
Joseph Hopfinger ◽  
Jenna Snyder ◽  
Madeline M. Robertson ◽  
...  
Keyword(s):  
Young Children ◽  
Resting State ◽  
Children With Adhd ◽  
Eeg Connectivity

Maternal ADHD symptoms, child ADHD symptoms and broader child outcomes

2018 ◽  
Vol 103 (9) ◽  
pp. 841-846 ◽  
Author(s):  
Daryl Efron ◽  
Kirsten Furley ◽  
Alisha Gulenc ◽  
Emma Sciberras
Keyword(s):  
Adhd Symptom ◽  
Symptom Severity ◽  
Adult Adhd ◽  
Rating Scale ◽  
Child Outcomes ◽  
Adhd Symptoms ◽  
Children With Adhd ◽  
Maternal Report ◽  
Child Adhd ◽  
Maternal Adhd

ObjectiveThis study investigated the associations between maternal symptoms of attention deficit hyperactivity disorder (ADHD) and child functional outcomes in a community-based sample of children with and without ADHD.Design and settingIn this cohort study, children with ADHD and healthy controls were recruited through schools in Melbourne, Australia, using a combined screening (Conners 3 ADHD Index) and case confirmation (Diagnostic Interview Schedule for Children Version IV) procedure.Patients117 children with ADHD and 149 control children were included in the analyses.Main outcome measuresMaternal ADHD symptoms (Conners Adult ADHD Rating Scale) and child outcomes (ADHD severity, quality of life (QoL), academic competence, social-emotional functioning) were measured at a mean child age of 8.9 years.ResultsMothers of children with ADHD had clinically elevated ADHD symptoms compared with mothers of control children (adjusted analysis: 18.0% vs 2.0%, P<0.001). Elevated maternal ADHD symptoms were associated with greater child ADHD symptom severity and lower QoL by maternal report for children with (severity P=0.01; QoL P=0.003) and without (severity P=0.003; QoL P=0.003) ADHD. Elevated maternal ADHD symptoms were additionally associated with increased parent-rated emotional problems, peer problems and total impairment scores in children without ADHD (all P<0.01).ConclusionsMaternal ADHD symptoms are associated with increased ADHD symptom severity and reduced QoL by maternal report in offspring with or without ADHD, and have broader negative associations with emotional and social functioning in children without ADHD. In the evaluation of the referred children, maternal ADHD symptoms should be considered and referral made to adult services where indicated.

Pharmacotherapy of ADHD in Adults

CNS Spectrums ◽  
2008 ◽  
Vol 13 (S8) ◽  
pp. 11-13 ◽  
Author(s):  
Timothy E. Wilens
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Attention Deficit ◽  
Adult Adhd ◽  
Therapeutic Options ◽  
Major Depressive ◽  
Children With Adhd ◽  
Hyperactivity Disorder

There is a complex overlap between major depressive disorder (MDD) and attention-deficit/hyperactivity disorder (ADHD). The different therapeutic options for adult ADHD mirror those used for children with ADHD. Both stimulant and nonstimulant medications are used to treat the disorder.

scholarly journals Shared alterations in resting-state brain connectivity in adults with attention-deficit/hyperactivity disorder and their unaffected first-degree relatives

2019 ◽  
pp. 1-11
Author(s):  
Valentino Antonio Pironti ◽  
Deniz Vatansever ◽  
Barbara Jacquelyn Sahakian
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Attention Deficit ◽  
Resting State ◽  
Adult Adhd ◽  
External Validation ◽  
Negative Consequences ◽  
Default Mode ◽  
Hyperactivity Disorder ◽  
First Degree Relatives ◽  
Human Connectome Project

Abstract Background Attention-deficit/hyperactivity disorder (ADHD) is a developmental condition that often persists into adulthood with extensive negative consequences on quality of life. Despite emerging evidence indicating the genetic basis of ADHD, investigations into the familial expression of latent neurocognitive traits remain limited. Methods In a group of adult ADHD probands (n = 20), their unaffected first-degree relatives (n = 20) and typically developing control participants (n = 20), we assessed endophenotypic alterations in the default mode network (DMN) connectivity during resting-state functional magnetic resonance imaging in relation to cognitive performance and clinical symptoms. In an external validation step, we also examined the dimensional nature of this neurocognitive trait in a sample of unrelated healthy young adults (n = 100) from the Human Connectome Project (HCP). Results The results illustrated reduced anti-correlations between the posterior cingulate cortex/precuneus and right middle frontal gyrus that was shared between adult ADHD probands and their first-degree relatives, but not with healthy controls. The observed connectivity alterations were linked to higher ADHD symptoms that was mediated by performance in a sustained attention task. Moreover, this brain-based neurocognitive trait dimensionally explained ADHD symptom variability in the HCP sample. Conclusions Alterations in the default mode connectivity may represent a dimensional endophenotype of ADHD, hence a significant aspect of the neuropathophysiology of this disorder. As such, brain network organisation can potentially be employed as an important neurocognitive trait to enhance statistical power of genetic studies in ADHD and as a surrogate efficacy endpoint in the development of novel pharmaceuticals.

scholarly journals Understudied and underrecognised

2004 ◽  
Vol 10 (5) ◽  
pp. 338-340 ◽  
Author(s):  
Dave Coghill
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Longitudinal Studies ◽  
Attention Deficit ◽  
Adult Adhd ◽  
Diagnostic Validity ◽  
Children With Adhd ◽  
Hyperactivity Disorder

That Zwi & York (2004) have opened the discussion on adult attention-deficit hyperactivity disorder (ADHD) is to be applauded. Their main conclusion is that the diagnostic validity of adult ADHD remains uncertain and that further study is needed. This is based on a review of the ADHD concept in childhood and the longitudinal studies that have followed children with ADHD into adulthood.

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