scholarly journals Harnessing Clinical Trial Capacity to Mitigate Zoonotic Diseases: The Role of Expert Scientists in Ethiopia

2021 ◽  
Vol 9 ◽  
Author(s):  
Senait Belay ◽  
Mirutse Giday ◽  
Tsegahun Manyazewal
Keyword(s):  
Public Health ◽  
Clinical Trials ◽  
Data Analysis ◽  
One Health ◽  
Good Governance ◽  
Addis Ababa ◽  
Zoonotic Diseases ◽  
Multidisciplinary Teams ◽  
Addis Ababa University ◽  
Depth Interviews

Background: The emergence and resurgence of zoonotic diseases have continued to be a major threat to global health and the economy. Developing countries are particularly vulnerable due to agricultural expansions and domestication of animals with humans. Scientifically sound clinical trials are important to find better ways to prevent, diagnose, and treat zoonotic diseases, while there is a lack of evidence to inform the clinical trials' capacity and practice in countries highly affected with the diseases. This study aimed to investigate expert scientists' perceptions and experiences in conducting clinical trials toward zoonotic diseases in Ethiopia.Methods: This study employed a descriptive, qualitative study design. It included major academic and research institutions in Ethiopia that had active engagements in veterinary and public health researches. It included the National Veterinary Institute, the National Animal Health Diagnostic and Investigation Center, the College of Veterinary Medicine at Addis Ababa University, the Ethiopian Public Health Institute, the Armauer Hansen Research Institute, and the College of Health Sciences at Addis Ababa University. In-depth interviews were conducted with expert scientists. Data were collected from October 2019 to April 2020. Data analysis was undertaken using open code 4.03 for qualitative data analysis.Results: Five major themes, with 18 sub-themes, emerged from the in-depth interviews. These were: challenges in the prevention, control, and treatment of zoonotic diseases; One Health approach to mitigate zoonotic diseases; personal and institutional experiences in conducting clinical trials on zoonotic diseases; barriers in conducting clinical trials toward zoonotic diseases; and strategies that promote conducting clinical trials on zoonotic diseases. Conducting clinical trials on zoonotic diseases in Ethiopia is hampered by a lack of clearly articulated ethics and regulatory frameworks, trial experts, financial resources, and good governance.Conclusion: In Ethiopia, conducting clinical trials on zoonotic diseases deserves due attention. Strengthening institutional and human resources capacity is a pre-condition to harness effective implementation of clinical trials on zoonotic diseases in the country. In Ethiopia where skilled human resource is scarce, One Health approach has the potential to form multidisciplinary teams to systematically improve clinical trials capacity and outcomes in the country.

scholarly journals Prioritization of zoonotic diseases of public health significance in Nigeria using the one-health approach

One Health ◽  
2021 ◽  
pp. 100257
Author(s):  
Chikwe Ihekweazu ◽  
Charles Akataobi Michael ◽  
Patrick M. Nguku ◽  
Ndadilnasiya Endie Waziri ◽  
Abdulrazaq Garba Habib ◽  
...  
Keyword(s):  
Public Health ◽  
One Health ◽  
Zoonotic Diseases ◽  
Public Health Significance ◽  
Health Significance ◽  
The One

A proposal to leverage high-quality veterinary diagnostic laboratory large data streams for animal health, public health, and One Health

2021 ◽  
pp. 104063872110030
Author(s):  
Craig N. Carter ◽  
Jacqueline L. Smith
Keyword(s):  
Public Health ◽  
Data Streams ◽  
One Health ◽  
Animal Health ◽  
Disease Outbreaks ◽  
Large Data ◽  
Health Impact ◽  
The United States ◽  
Zoonotic Diseases ◽  
Diagnostic Laboratory

Test data generated by ~60 accredited member laboratories of the American Association of Veterinary Laboratory Diagnosticians (AAVLD) is of exceptional quality. These data are captured by 1 of 13 laboratory information management systems (LIMSs) developed specifically for veterinary diagnostic laboratories (VDLs). Beginning ~2000, the National Animal Health Laboratory Network (NAHLN) developed an electronic messaging system for LIMS to automatically send standardized data streams for 14 select agents to a national repository. This messaging enables the U.S. Department of Agriculture to track and respond to high-consequence animal disease outbreaks such as highly pathogenic avian influenza. Because of the lack of standardized data collection in the LIMSs used at VDLs, there is, to date, no means of summarizing VDL large data streams for multi-state and national animal health studies or for providing near-real-time tracking for hundreds of other important animal diseases in the United States that are detected routinely by VDLs. Further, VDLs are the only state and federal resources that can provide early detection and identification of endemic and emerging zoonotic diseases. Zoonotic diseases are estimated to be responsible for 2.5 billion cases of human illness and 2.7 million deaths worldwide every year. The economic and health impact of the SARS-CoV-2 pandemic is self-evident. We review here the history and progress of data management in VDLs and discuss ways of seizing unexplored opportunities to advance data leveraging to better serve animal health, public health, and One Health.

Knowledge Sharing among Public Health Professionals on Management of Zoonoses in Nigeria; dividends of the One Health Concept

2022 ◽  
Vol 7 (1) ◽  
pp. 0-0
Keyword(s):  
Public Health ◽  
Knowledge Sharing ◽  
Health Professionals ◽  
One Health ◽  
Qualitative Content Analysis ◽  
Professional Associations ◽  
Structured Interview ◽  
Zoonotic Diseases ◽  
Public Health Professionals ◽  
The One

Zoonotic diseases are characterized by significant morbidity and mortality in humans. In Nigeria, tragic effects of zoonotic diseases have been reported. This calls for a sustained collaboration among public health professionals to confront the ever-increasing challenges of managing zoonotic diseases. This study explores the perception of public health professionals about knowledge sharing and the absorptive capacity of health professionals in managing zoonotic diseases. Data were collected through a semi- structured interview. The analysis was done using qualitative content analysis. Findings revealed positive perception of public health professionals about knowledge sharing in managing zoonotic. Also, the study found that Public Health professionals acquire external knowledge for managing zoonotic disease through multidisciplinary networks and professional associations. The One Health initiative is one avenue where public health professionals can leverage on the strength and capacities of each other to respond competently to emerging health threats of zoonotic diseases.

scholarly journals Evolution of Public Health Prevention of Leptospirosis in a One Health Perspective: The Example of Mahasarakham Province (Thailand)

2021 ◽  
Vol 6 (3) ◽  
pp. 168
Author(s):  
Jaruwan Viroj ◽  
Claire Lajaunie ◽  
Serge Morand
Keyword(s):  
Public Health ◽  
Policy Implementation ◽  
Prevention And Control ◽  
One Health ◽  
Local Level ◽  
National Level ◽  
Control Policy ◽  
Policy Framework ◽  
And Control ◽  
Depth Interviews

Leptospirosis is an endemic disease with moderate to high incidence in Mahasarakham province, Thailand. The present study was designed to assess the policy implementation mission regarding leptospirosis prevention and control from the national level to the local administrative levels, through a One Health perspective. A qualitative study was conducted, using documentation review, individual in-depth interviews with public health officers, local government officers, livestock officers who developed policy implementation tools or have responsibilities in leptospirosis prevention and control. The results show that Thailand has progressively developed a leptospirosis prevention and control policy framework at the national level, transferring the responsibility of its implementation to the local level. The province of Mahasarakham has decided to foster cooperation in leptospirosis prevention and control at the local level. However, there are insufficient linkages between provincial, district and sub-district departments to ensure comprehensive disease prevention activities at the local level concerning leptospirosis patients and the whole population.

scholarly journals Rift Valley fever and Brucella spp. in ruminants, Somalia

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Ahmed A. Hassan-Kadle ◽  
Aamir M. Osman ◽  
Mohamed A. Shair ◽  
Omar M. Abdi ◽  
Abdulkarim A. Yusuf ◽  
...  
Keyword(s):  
Public Health ◽  
Rift Valley ◽  
Rift Valley Fever ◽  
One Health ◽  
Zoonotic Diseases ◽  
Limited Data ◽  
Serological Evidence ◽  
Serum Samples ◽  
Valley Fever ◽  
Female Cattle

Abstract Background Fourteen-years after the last Rift Valley fever (RVF) virus (RVFV) outbreak, Somalia still suffers from preventable transboundary diseases. The tradition of unheated milk consumption and handling of aborted materials poses a public health risk for zoonotic diseases. Limited data are available on RVF and Brucella spp. in Somali people and their animals. Hence, this study has evaluated the occurrence of RVFV and Brucella spp. antibodies in cattle, goats and sheep sera from Afgoye and Jowhar districts of Somalia. Methods Serum samples from 609 ruminants (201 cattle, 203 goats and 205 sheep), were serologically screened for RVF by a commercial cELISA, and Brucella species by modified Rose Bengal Plate Test (mRBPT) and a commercial iELISA. Results Two out of 609 (0.3 %; 95 %CI: 0.04–1.2 %) ruminants were RVF seropositive, both were female cattle from both districts. Anti-Brucella spp. antibodies were detected in 64/609 (10.5 %; 95 %CI: 8.2–13.2 %) ruminants by mRBPT, which were 39/201 (19.4 %) cattle, 16/203 (7.9 %) goats and 9/205 (4.4 %) sheep. Cattle were 5.2 and 2.8 times more likely to be Brucella-seropositive than sheep (p = 0.000003) and goats (p = 0.001), respectively. When mRBPT-positive samples were tested by iELISA, 29/64 (45.3 %; 95 %CI: 32.8–58.3 %) ruminant sera were positive for Brucella spp. Only 23/39 (58.9 %) cattle sera and 6/16 (37.5 %) goat sera were positive to Brucella spp. by iELISA. Conclusions The present study showed the serological evidence of RVF and brucellosis in ruminants from Afgoye and Jowhar districts of Somalia. Considering the negligence of the zoonotic diseases at the human-animal interface in Somali communities, a One Health approach is needed to protect public health.

Explaining LARCs discontinuity in Ethiopia: The experience of women who access contraceptives in selected public health facilities

2020 ◽  
Author(s):  
Solomon Mekonnen Abebe ◽  
Getasew Sisay Mihretie ◽  
Daniel T Assefa ◽  
Awol Yemane Legesse ◽  
Mikyas Abera
Keyword(s):  
Public Health ◽  
Family Planning ◽  
Cultural Values ◽  
Addis Ababa ◽  
Public Health Problem ◽  
Health Facilities ◽  
Public Health Facilities ◽  
Planning Methods ◽  
Depth Interviews ◽  
Family Planning Methods

Abstract Background: Unintended pregnancy remains an important public health problem among teenagers and women in developing countries. Modern family planning methods, particularly Long Acting Reversible Contraceptives (LARCs), are highly effective in addressing the problem and its undesirable outcomes in maternal mortality. But dissatisfaction with contraceptives has contributed to their early discontinuation, but the reasons in Ethiopia are not adequately explored.Objective: This study aims to explore the main reasons of discontinuation of LARCs-use within one year of adoption in selected public health facilities in Ethiopia.Methods: Institution-based, multi-center prospective-cohort study design was used to identify the reasons of discontinuation among LARCs-users in Ethiopia. The study covered four university hospitals and health centers in Addis Ababa, Gondar, Mekelle and Jimma. The main study employed survey and in-depth interviews. But this article is based on qualitative data collected through in-depth interviews. It explored the decision-making processes involved in LARCs-discontinuation based on the experiences of 29 women aged 15-49 who did within a year of insertion. Interview data were thematically organized, coded and analyzed in light of the study objectives.Results: The study found women were sufficiently aware of the various types of contraceptives, including LARCs. Many of them experimented with different types before deciding on their choice. On LARCs, most were satisfied with its benefits while they also mentioned several reasons to discontinue its use including weight gain/loss, heavy menses, tiredness, reduced libido, desire to conceive and husbands’ disapproval. Their decisions to use or not use LARCs reflected the common cultural values about childbirth and myths on contraceptive use.Conclusions: The study found women use (or discontinue use) of contraceptives depends on their knowledge about their options, personal experience with side-effects, and the support from significant others, mainly husbands. As such, any campaign to promote family planning methods has to take into account the status of women in the Ethiopian society and cultural definition of their sexuality.

scholarly journals Brazilian Spotted Fever with an Approach in Veterinary Medicine and One Health Perspective

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Sabrina Destri Emmerick Campos ◽  
Nathalie Costa da Cunha ◽  
Nádia Regina Pereira Almosny
Keyword(s):  
Public Health ◽  
One Health ◽  
Spotted Fever ◽  
Rhipicephalus Sanguineus ◽  
Holistic Approach ◽  
Zoonotic Diseases ◽  
Rickettsial Infection ◽  
Brazilian Spotted Fever ◽  
Vector Borne

There is increasing interaction between man and pathogens transmitted by arthropods, especially by ticks. It is on this background that a holistic approach stands out, for the sake of Public Health. Brazilian Spotted Fever is an endemic disease at the country’s southeast, withAmblyomma sculptumas its major contributor, followed byA. aureolatumand potentiallyRhipicephalus sanguineus. Dogs have been considered sentinels, and in some areas the disease in dogs can precede human disease. Considering the importance of this disease for human health, the serological evidence in dogs, and the transmission of ticks between dogs and their owners, this review aimed to elucidate the importance of the epidemiological investigation, the diagnosis in dogs, and the role of veterinarians in Public Health to control vector-borne zoonotic diseases. We encourage veterinarians to include this rickettsial infection in the diagnosis of febrile diseases of common occurrence in dogs.

Pedagang Kaki Lima, Profil Entrepreneurship Sejati, Pelaku Ekonomi Kerakyatan, Ciptakan Jiwa Kewirausahaan Mandiri

2019 ◽  
Vol 20 (1) ◽  
pp. 30-35
Author(s):  
Agus Prasetya
Keyword(s):  
Qualitative Research ◽  
Data Analysis ◽  
Data Display ◽  
Job Seekers ◽  
Street Vendor ◽  
Street Vendors ◽  
The Social ◽  
Collection Data ◽  
Definition Of ◽  
Depth Interviews

This article is motivated by the fact that the existence of the Street Vendor (PKL) profession is a manifestation of the difficulty of work and the lack of jobs. The scarcity of employment due to the consideration of the number of jobs with unbalanced workforce, economically this has an impact on the number of street vendors (PKL) exploding ... The purpose of being a street vendor is, as a livelihood, making a living, looking for a bite of rice for family, because of the lack of employment, this caused the number of traders to increase. The scarcity of jobs, causes informal sector migration job seekers to create an independent spirit, entrepreneurship, entrepreneurship, with capital, managed by traders who are true populist economic actors. The problems in street vendors are: (1) how to organize, regulate, empower street vendors in the cities (2) how to foster, educate street vendors, and (3) how to help, find capital for street vendors (4) ) how to describe grief as a Five-Foot Trader. This paper aims to find a solution to the problem of street vendors, so that cases of conflict, cases of disputes, clashes of street vendors with Satpol PP can be avoided. For this reason, the following solutions must be sought: (1) understanding the causes of the explosions of street vendors (2) understanding the problems of street vendors. (3) what is the solution to solving street vendors in big cities. (4) describe Street Vendors as actors of the people's economy. This article is qualitative research, the social paradigm is the definition of social, the method of retrieving observational data, in-depth interviews, documentation. Data analysis uses Interactive Miles and Huberman theory, with stages, Collection Data, Display Data, Data Reduction and Vervying or conclusions.

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