scholarly journals Androgens, Endometriosis and Pain

2021 ◽  
Vol 3 ◽  
Author(s):  
Susan F. Evans ◽  
M. Louise Hull ◽  
Mark R. Hutchinson ◽  
Paul E. Rolan

The intriguing relationship between androgens, endometriosis and chronic pain continues to unfold. Determining this relationship is of crucial importance to gynecologists managing people with these conditions, as common treatments dramatically alter her hormonal profiles, with both intended and unintended consequences. Although they may be present in the same individual, there is a recognized disconnect between pain or pain-related symptoms, and the presence or extent of endometriosis lesions. Reduced androgen levels provide a potential mechanism to link the development of endometriosis lesions and the presence of chronic pain. This research paper expands the presentation of our research at the World Endometriosis Congress in 2021, subsequently published in the Journal of Pain Research which demonstrated a strong inverse relationship between androgen levels and days per month of pelvic and period pain. Here we extend and further explore the evidence for a role for androgens in the etiology and management of dysmenorrhea and pelvic pain in women, both with and without endometriosis. We explore the potential for inflammation to induce low androgen levels and consider ways in which clinicians can optimize levels of androgens when treating women with these conditions. This article prompts the question: Is it estrogens that predispose people to a life of pain, or androgens that are protective?

2016 ◽  
Vol 3 (01) ◽  
Author(s):  
Rakesh Rangwani

Despite substantial improvements over the past 23 years in many key areas of sustainable development, the world is not on track to achieve the goals as aspired to in Agenda 21, adopted in Rio de Janeiro in 1992, and reiterated in subsequent world conferences, such as the World Summit on Sustainable Development held in Johannesburg in 2002. While there have been some achievements in implementing Agenda 21, including the implementation of the chapters on “Science for Sustainable Development” and on “Promoting Education, Public Awareness and Training”, for which UNESCO was designated as the lead agency, much still remains to be done. This decade had seen the idea of a “green economy” float out of its specialist moorings in environmental economics and into the mainstream of policy discourse. It is found increasingly in the words of heads of state and finance ministers, in the text of G20 communiqués, and discussed in the context of sustainable development and poverty eradication. The research paper focused to establish a relationship between sustainable development and green economics. The research paper is descriptive and analytical in nature. The data collected from secondary sources such as report from niti aayog, IMF indicators, RBI reports, newspapers, journals. The research design was adopted to have greater accuracy and in depth analysis of the research study. The statistical tools for the analysis are also being used.


Recycling ◽  
2019 ◽  
Vol 4 (1) ◽  
pp. 3 ◽  
Author(s):  
Linda Godfrey

With changing consumption patterns, growing populations and increased urbanisation, developing countries face significant challenges with regards to waste management. Waste plastic is a particularly problematic one, with single-use plastic leaking into the environment, including the marine environment, at an unprecedented rate. Around the world, countries are taking action to minimise these impacts, including banning single-use plastics; changing petroleum-based plastics to alternative bio-benign products such as paper, glass or biodegradable plastics; and improving waste collection systems to ensure that all waste is appropriately collected and reprocessed or safely disposed. However, these “solutions” are often met with resistance, from business, government or civil society, due to the intended and unintended consequences, leaving many questioning the most appropriate solution to reducing the leakage. This paper argues that there is no one single solution to addressing the leakage of plastic into the environment, but that the solution is likely to be a combination of the three approaches, based on local considerations.


2020 ◽  
Vol 68 (3) ◽  
pp. 382-403
Author(s):  
Andreas Gelhard

AbstractHegel’s approach to ancient scepticism is often discussed only in the context of epistemological questions. But it is also of crucial importance for his practical philosophy. Hegel draws on central figures of Pyrrhonian scepticism in order to subject Kant’s antinomies – i. e., Kant’s cosmology – to a fundamental revision. He radicalises Kant’s sceptical method to “self-completing scepticism”. At the same time he gives Kant’s concept of the world a practical twist: In Hegel’s Phenomenology of Spirit, world means an inhabited sphere in which powers and counter-powers are in conflict with each other. In doing so, he opens up the tradition of negativist thinking in political philosophy, which ranges from Marx and Adorno to the current theories of radical democracy. When Hegel calls Pyrrhonian skepticism a “negative dialectic”, he thereby marks what he views as a deficit: the inferiority of Pyrrhonian skepticism to speculative philosophy. However, it is precisely the practical dimension of Hegel’s dialectic that suggests that the sceptical motives of his thinking should be given great weight. This can be seen most clearly in Hegel’s concept of Bildung, which defines emancipation processes as the reactivation of open power relations in static conditions of domination.


2000 ◽  
Vol 78 (6) ◽  
pp. 748-752 ◽  
Author(s):  
Antonella Cattaneo ◽  
Lucie Fortin

To model the distribution of aquatic mosses, we measured their cover in 33 Quebec streams. The variation in moss cover among streams was explained mostly (42%) by substratum size (percentage >25 cm in diameter). Water pH and depth also explained a significant amount of variation (9 and 10%, respectively). Within a stream, moss cover was again positively correlated to the availability of large substrata and negatively to water depth. There was a strong inverse relationship between covers of moss and of the filamentous cyanobacterium Stigonema, suggesting a competitive interaction. This study confirms previous observations that moss distribution is mainly controlled by substratum size. Chemistry explains part of the among-stream variation. Stigonema-moss competition partly accounts for the patchy distribution within a stream.Key words: aquatic mosses, Fontinalis, streams, Quebec.


1970 ◽  
Vol 22 (3) ◽  
pp. 478-483 ◽  
Author(s):  
C. G. Miles ◽  
N. J. Mackintosh ◽  
R. F. Westbrook

Twenty-eight pigeons were given discrimination training. Four groups were run in which for 0, 2, 4 and 9 sessions of training colour was an irrelevant cue and tone was relevant. Generalization tests were given in extinction; the training colour (C1) and another colour (C2) were presented with tone (T) and noise (N). Responding to these four stimulus combinations, TC1, TC2, NC1 and NC2, allowed the assessment of control by colour and tone. A reduction of control by colour and an increase in control by tone were found to be positively related to the amount of training with colour irrelevant. Tests showed a strong inverse relationship between control by colour and tone.


The age of European high imperialism was characterized by the movement of plants and animals on a historically unprecedented scale. The human migrants who colonized territories around the world brought a variety of other species with them, from the crops and livestock they hoped to propagate, to the parasites, invasive plants, and pests they carried unawares, producing a host of unintended consequences that reshaped landscapes around the world. While the majority of histories about the dynamics of these transfers have concentrated on the British Empire, these nine case studies--focused on the Ottoman, French, Dutch, German, and British empires--seek to advance a historical analysis that is comparative, transnational, and interdisciplinary to understand the causes, consequences, and networks of biological exchange and ecological change resulting from imperialism.


Aula Palma ◽  
2019 ◽  
pp. 211-234
Author(s):  
Carlos Alberto Pérez Garay

ResumenEl presente trabajo de investigación describe y analiza la vasta correspondencia que tuvo el escritor limeño con diversos personajes del ámbito político, económico, social y cultural del Perú y del mundo, pertenecientes a la Colección Ricardo Palma de la Biblioteca Nacional delPerú.Palabras Claves: Ricardo Palma, Correspondencia, Biblioteca Nacional AbstractThis research paper describes and analyzes the vast correspondence that the Lima writer had with various characters from the political, economic, social and cultural spheres of Peru and the world, belonging to the Ricardo Palma Collection of the National Library of Peru.Keywords: Ricardo Palma, Correspondence, National Library


2021 ◽  
Vol 9 (8) ◽  
pp. 9-24
Author(s):  
Mukhtar Ahmad Ganie ◽  
Dr. Shubhra Tripathi

Mother is a bonus bestowed upon humanity by Almighty Allah as she can claim all the calamities for her children to make them safe. The importance of mother as suggested by Prophet Mohammad (PBUH) If I (PBUH) would have been in prayer (Salat) and she (Mother) had called me, I (PBUH) would have left my prayer to listen to her first and then I would have completed my prayer. Here it shows the essence of mother, as she is the source for a man to claim the heaven. Nissim Ezekiel in one of his poems says, ‘Thank God! Scorpion picked on me and spared my children’ this shows that she can suffer the pain of poison to make safety of her children possible. African motherhood is a paradigm for mothers all over the world. These black mothers have suffered sexual abuse during the period of slavery to save their wards. They worked very hard and even sometimes murdered their children to save them from slavery and sexual assault from the rich white masters. Same thing can be seen in the novels of this study. This research paper will explore the circumstances that compelled mothers to sacrifice their wards and suffer the pangs for whole life. Importance of motherhood will be explored here.


Author(s):  
Olga Kuvaldina ◽  
Volodymyr Driukov

Analysis of Ukrainian athletes’ results at the XXXII Olympiad Games allows pointing out the factors of the weak performance of Ukrainian athletes in women's individual saber and epee competitions, as well as men's team epee competitions, despite the possibility of winning medals in these sports events according to many analysts including those of Infostrada Sports and other sports statistics experts. These, in our opinion, include an unsatisfactory level of efficiency of the process of reaching the peak of readiness for the Olympic Games; lack of psychological stability of athletes at the competitions; weak tactical preparation of some athletes. Based on the performances of athletes of the Ukrainian fencing team in Tokyo, a conclusion was made about the unsatisfactory level of athletes’ preparation for the XXXII Olympic Games. Only 20% of the national team members were able to realize their potential at the XXXII Olympic Games. The dynamics of the athletes’ results at the World Championships 2017 – 2019 indicates the need to use in the new Olympic cycle the planning, which is focused on our athletes reaching the peak of readiness for the Olympics: at first, the training should be aimed at the maximum stimulation of the growth of sportsmanship, whereas at the final stage it should be focused on its realization in the major competitions. It is shown that despite the unsuccessful performance of the Ukrainian fencing team in the Olympic Tokyo, this type of martial arts has significant potential for improving sports achievements at the XXXIII Olympic Games 2024 in Paris. It is noted that in the new Olympic cycle it is of crucial importance to identify candidates for the XXXIII Olympic Games as soon as possible and to create all the conditions for their full-fledged preparation. Thus, to ensure further winning medal places at the Olympic Games, it is necessary to improve the system of sports training in the Olympic cycle, which envisages participation in numerous competitions during the year to achieve a high level of readiness in the major competitions of triennial – the Olympic Games.


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