scholarly journals Comparison of Antimicrobial Treatment Incidence Quantification Based on Detailed Field Data on Animal Level with the Standardized Methodology of the European Medicines Agency in Veal Calves, Switzerland, 2016–2018

Antibiotics ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 832
Author(s):  
Jens Becker ◽  
Mireille Meylan
Keyword(s):  
Field Data ◽  
Drug Application ◽  
Drug Level ◽  
Antimicrobial Treatment ◽  
European Medicines Agency ◽  
Veterinary Medicines ◽  
Defined Daily Doses ◽  
Class Level ◽  
Precise Quantification ◽  
Good Agreement

Precise quantification of antimicrobial treatment incidence (TI) is crucial for benchmarking. Two widespread methods for treatment incidence quantification were compared for agreement. Field data were obtained from 38 veal farms from 2016 to 2018 (1905 calves, 1864 treatments). Calculation of TIswiss for calves was based on detailed treatment records using pharmacokinetic values from the Swiss Veterinary Medicines Compendium. The method published by the European Medicines Agency was used to calculate TI in defined daily doses (TIDDD). For each calf and treatment, TIswiss and TIDDD were calculated on level of the antimicrobial class, drug, application route, and farm. The quotient (Q) of TIswiss and TIDDD was calculated. Divergence in results between the two methods of ≤25% was arbitrarily set as good agreement. The agreement between TIswiss and TIDDD was mostly good. On class level, good agreement was observed for treatments representing 71.5% of the TIDDD, and 74.5% of the total TIDDD on drug level. Poor agreement was mainly observed for tylosin and sulfadimidine. The agreement was better for parenteral than for oral treatments (81.6% vs. 72.3%). For practically orientated calculation on farm level, good agreement was observed (77.5% of the TIDDD). The TIDDD method showed mostly good agreement, especially for parenteral treatments.

Field Observation and Simulation of Sediment Resuspension in a Shallow Lake

1988 ◽  
Vol 20 (6-7) ◽  
pp. 263-270 ◽  
Author(s):  
K. Otsubo ◽  
K. Muraoka
Keyword(s):  
Numerical Simulation ◽  
Shallow Lake ◽  
Water Wave ◽  
Field Data ◽  
Sediment Resuspension ◽  
Field Research ◽  
Lake Kasumigaura ◽  
Bed Erosion ◽  
Current Water ◽  
Good Agreement

The dispersion and resuspension of sediments in Takahamairi Bay basin of Lake Kasumigaura were studied by means of field research and numerical simulation. The field data on wind direction and velocity, lake current, water wave, and turbidity were shown. Based on these results, we discuss how precipitated sediments were resuspended in this shallow lake. To predict the turbidity and the depth of bed erosion, a simulation model was established for this lake. The calculated turbidity showed good agreement with the field data. According to the simulated results, the turbidity reaches 200 ppm, and the bed is eroded several millimeters deep when the wind velocity exceeds 12 m/s in the lake.

Predicting Seepage of Earth Dams Using Neural Network and Genetic Algorithm

2011 ◽  
Vol 403-408 ◽  
pp. 3081-3085 ◽  
Author(s):  
Xin Ying Miao ◽  
Jin Kui Chu ◽  
Jing Qiao ◽  
Ling Han Zhang
Keyword(s):  
Neural Network ◽  
Genetic Algorithm ◽  
Field Data ◽  
Back Propagation ◽  
Earth Dam ◽  
Earth Dams ◽  
Gradient Descent Algorithm ◽  
Levenberg Marquardt ◽  
Lm Algorithm ◽  
Good Agreement

Measurements of seepage are fundamental for earth dam surveillance. However, it is difficult to establish an effective and practical dam seepage prediction model due to the nonlinearity between seepage and its influencing factors. Genetic Algorithm for Levenberg-Marquardt(GA-LM), a new neural network(NN) model has been developed for predicting the seepage of an earth dam in China using 381 databases of field data (of which 366 in 2008 were used for training and 15 in 2009 for testing). Genetic algorithm(GA) is an ecological system algorithm, which was adopted to optimize the NN structure. Levenberg-Marquardt (LM) algorithm was originally designed to serve as an intermediate optimization algorithm between the Gauss-Newton(GN) method and the gradient descent algorithm, which was used to train NN. The predicted seepage values using GA-LM model are in good agreement with the field data. It is demonstrated here that the model is capable of predicting the seepage of earth dams accurately. The performance of GA-LM has been compared with that of conventional Back-Propagation(BP) algorithm and LM algorithm with trial-and-error approach. The comparison indicates that the GA-LM model can offer stronger and better performance than conventional NNs when used as a quick interpolation and extrapolation tool.

ACOUSTIC THREE-DIMENSIONAL EFFECTS AROUND THE TAIWAN STRAIT: COMPUTATIONAL RESULTS

1999 ◽  
Vol 07 (01) ◽  
pp. 15-26 ◽  
Author(s):  
CHI-FANG CHEN ◽  
JANG-JIA LIN ◽  
DING LEE
Keyword(s):  
Field Data ◽  
Bottom Topography ◽  
Three Dimensional ◽  
Propagation Model ◽  
Computational Results ◽  
Submarine Canyons ◽  
Offshore Area ◽  
Ocean Environment ◽  
The Taiwan Strait ◽  
Good Agreement

A set of experiments were performed in the offshore area off the coasts of Taiwan and three-dimensional (3-D) measurements recorded. The 3-D effect on underwater propagation due to azimuthal variation of bottom topography is studied for the offshore regions southwest of Taiwan, where submarine canyons exist. A 3-D acoustic propagation model, FOR3D, is used to detect the 3-D effect. Computational results show that the 3-D effect is more prominent along the axis of the canyon than across it. Calculations show a very good agreement with field data, which indicate that the 3-D effect exists in this realistic ocean environment.

scholarly journals Storage of prescription veterinary medicines on UK dairy farms: a cross-sectional study

2018 ◽  
Vol 184 (5) ◽  
pp. 153-153 ◽  
Author(s):  
Gwen M Rees ◽  
David C Barrett ◽  
Henry Buller ◽  
Harriet L Mills ◽  
Kristen K Reyher
Keyword(s):  
Dairy Farms ◽  
Evidence Base ◽  
Cross Sectional Study ◽  
European Medicines Agency ◽  
Cross Sectional ◽  
Veterinary Medicines ◽  
Veterinary Profession ◽  
Farmer Decision Making ◽  
The Uk ◽  
Future Work

Prescription veterinary medicine (PVM) use in the UK is an area of increasing focus for the veterinary profession. While many studies measure antimicrobial use on dairy farms, none report the quantity of antimicrobials stored on farms, nor the ways in which they are stored. The majority of PVM treatments occur in the absence of the prescribing veterinarian, yet there is an identifiable knowledge gap surrounding PVM use and farmer decision making. To provide an evidence base for future work on PVM use, data were collected from 27 dairy farms in England and Wales in Autumn 2016. The number of different PVMs stored on farms ranged from 9 to 35, with antimicrobials being the most common therapeutic group stored. Injectable antimicrobials comprised the greatest weight of active ingredient found, while intramammary antimicrobials were the most frequent unit of medicine stored. Antimicrobials classed by the European Medicines Agency as critically important to human health were present on most farms, and the presence of expired medicines and medicines not licensed for use in dairy cattle was also common. The medicine resources available to farmers are likely to influence their treatment decisions; therefore, evidence of the PVM stored on farms can help inform understanding of medicine use.

scholarly journals MEASUREMENT OF SEDIMENT SUSPENSION IN COMBINATIONS OF WAVES AND CURRENTS

1972 ◽  
Vol 1 (13) ◽  
pp. 55
Author(s):  
J. Kirkegarrd Jensen ◽  
Torben Sorenson
Keyword(s):  
Thin Layer ◽  
Concentration Profile ◽  
Field Data ◽  
Concentration Profiles ◽  
Sediment Suspension ◽  
Calculated Concentration ◽  
Waves And Currents ◽  
The Mean ◽  
Mean Concentration ◽  
Good Agreement

The paper describes a procedure for obtaining field data on the mean concentration of sediments in combination of waves and currents outside the breaker zone, as well as some results of such measurements. It is assumed that the current turbulence alone is responsible for the maintenance of the concentration profile above a thin layer close to the bottom, in which pick-up of sediments due to wave agitation takes place. This assumption gives a good agreement between field data and calculated concentration profiles.

Response of Soybean (Glycine max) Cultivars to Metribuzin in the Field and Greenhouse

1989 ◽  
Vol 3 (4) ◽  
pp. 566-572 ◽  
Author(s):  
W. W. De Weese ◽  
L. M. Wax ◽  
W. C. Carlson ◽  
J. A. Ciarletta
Keyword(s):  
Glycine Max ◽  
Correlation Coefficient ◽  
Field Data ◽  
The Other ◽  
Screening Procedure ◽  
Soybean Cultivars ◽  
Greenhouse Screening ◽  
Significant Injury ◽  
Good Agreement

Experimental objectives were to assess metribuzin tolerance of predominately privately developed soybean cultivars and to evaluate a greenhouse screening procedure. In field results in 1982, ‘Vinton 81’, ‘Northrup King 1884’ and ‘L77-1863’ soybean cultivars were extremely sensitive to metribuzin at 0.56 kg/ha, averaging 34% injury. The other 45 cultivars showed no significant injury at the 0.56 kg/ha rate, from 9 to 46% injury at 1.4 kg/ha, and 18 to 72% injury at 2.2 kg/ha. In greenhouse hydroponic studies, these same three soybean cultivars were killed, while the other 45 cultivars were injured from 15 to 82%. A good agreement of greenhouse and field data was determined, with a correlation coefficient of r = 0.82.

CALCULATION OF THE MAGNETOTELLURIC TENSOR IMPEDANCE: ANALYSIS OF BAND‐LIMITED MT SIGNAL PAIRS

Geophysics ◽  
1975 ◽  
Vol 40 (5) ◽  
pp. 790-797 ◽  
Author(s):  
Larry R. Grillot
Keyword(s):  
Field Data ◽  
Fourier Coefficients ◽  
Impedance Analysis ◽  
Impedance Tensor ◽  
Period Range ◽  
Tensor Impedance ◽  
Band Limited ◽  
Good Agreement ◽  
Least Squares Approach

A method of analyzing the tensor nature of magnetotelluric fields from short independent sections of filtered MT data is presented in which: (1) horizontal field components are filtered at chosen periods; (2) short sections which show a well defined signal over 3–4 cycles are selected from the records; (3) the polarizations of these short record sections are plotted; and (4) Fourier coefficients calculated for section pairs showing differing magnetic field polarizations are then used to calculate the elements of the impedance tensor. Results of this analysis performed on MT field data show that the use of MT signal pairs yields uniform principal resistivities for calculations using several different section pairs of the same period. These results also illustrate internal consistency of the resistivity estimates over the complete period range of the data (30–7500 sec). A brief comparison of the MT pairs calculations and results derived from a least‐squares approach at a selected period shows good agreement between the two methods. The overall results suggest that the use of independent signal pairs in the determination of the tensor impedance could complement more traditional methods in some cases.

scholarly journals Establishing defined daily doses (DDDs) for antimicrobial agents used for pigs, cattle and poultry in Japan and comparing them with European DDD values

2020 ◽  
Author(s):  
Kyoko Fujimoto ◽  
Mai Kawasaki ◽  
Reiko Abe ◽  
Takashi Yokoyama ◽  
Takeshi Haga ◽  
...  
Keyword(s):  
Antimicrobial Agents ◽  
Farm Animals ◽  
European Medicines Agency ◽  
Antimicrobial Use ◽  
Defined Daily Dose ◽  
Defined Daily Doses ◽  
Animal Medicine ◽  
European Values ◽  
The Difference ◽  
Number Of Treatment

AbstractMonitoring of antimicrobial use is essential to manage the development and selection of antimicrobial resistance. A variety of indicators has become available to monitor antimicrobial use in human and animal medicine. One of them is an indicator based on defined daily dose (DDD). By using the number of DDDs used and normalizing it by the population at risk of being treated in a defined period, one can estimate the number of treatment days with antimicrobial agents in a population. For veterinary medicine, the European Medicines Agency (EMA) has published the European values of DDD (DDDvet) for food-producing animals. In this study, we defined Japanese defined daily doses for antimicrobial agents (DDDjp) using DDD values that we previously assigned for antimicrobial products approved for use in pigs, cattle and poultry in Japan and compared them with DDDvet values. For the comparison, the quotient of Japanese and European values (QDDD) was calculated and the effect of the administration route and the number of active substances contained in the preparation was investigated. A total of 59, 51 and 27 DDDjp values were defined for 43, 32 and 25 antimicrobial agents using the data of 269, 195 and 131 products approved for use in pigs, cattle and poultry respectively. A comparison was possible for 44, 27 and 17 pairs of DDDjp and DDDvet values for antimicrobial agents used for pigs, cattle and poultry respectively. The comparison showed median QDDD value of 0.66 and 0.63 for antimicrobial agents used for pigs and cattle respectively (P<0.01), indicating that the Japanese daily doses are significantly lower than the corresponding EMA values in these species. For the antimicrobial agents used for poultry, no siginificant difference was observed between DDDjp and DDDvet values with median QDDD value of 1.17. The difference between DDDvet and DDDjp values and absence of DDDvet values for some antimicrobial agents marketed in Japan indicate that DDDjp rather than DDDvet should be used as the basis for the calculation of antimicrobial use monitoring in farm animals in Japan.

scholarly journals Antimicrobial Usage Among Different Age Categories and Herd Sizes in Swiss Farrow-to-Finish Farms

2020 ◽  
Vol 7 ◽  
Author(s):  
Thomas Echtermann ◽  
Cedric Muentener ◽  
Xaver Sidler ◽  
Dolf Kuemmerlen
Keyword(s):  
Linear Regression ◽  
International Comparisons ◽  
Herd Size ◽  
Antimicrobial Treatment ◽  
Wilcoxon Test ◽  
Antimicrobial Usage ◽  
Defined Daily Doses ◽  
The Individual ◽  
Number Of Treatment ◽  
Fattening Pigs

In the Swiss pig sector, the usage of antimicrobials has been recorded, evaluated and systematically reduced on a voluntary basis since 2015. This monitoring has been carried out using various methods thereby enabling continuous national scrutiny as well as international comparisons. To gain a better understanding of the dynamics of the antimicrobial usage on Swiss farms, consumption data of farrow-to-finish farms were analyzed for (i) the within-herd relationships among different age categories and (ii) the influence of the herd size. The data were collected on 71 farms for the year 2017, encompassing the amount of active ingredients and number of defined daily doses Switzerland (nDDDch) in total, and stratified for the different age categories of piglets, weaners, fattening pigs, and sows. The differences in nDDDch per animal among the age categories were determined by a Wilcoxon test and subsequent post-hoc analysis according to Bonferroni. The within-herd relationship among the individual age categories as well as the influence of the herd size on nDDDch per animal measured as kept sows were analyzed by simple linear regression. The evaluation of the treatment days showed that 50% of the nDDDch were used in piglets, 44% for weaners, and 3% each for fattening pigs and sows. Compared to the other age categories, the examination of the number of nDDDch per animal showed a significantly higher number for sows, whereas for fattening pigs the number was significantly lower (P &lt; 0.01). The farm-based analysis using linear regression showed a relationship between antimicrobial usage in sows and piglets (P &lt; 0.001; adj. R2 = 0.19). Similarly, a significant relationship between larger herd size and increased antimicrobial usage was observed (P = 0.02; adj. R2 = 0.06). The present study provides an insight into the antimicrobial treatment dynamics of farrow-to-finish farms. In particular, the age categories piglets and sows—with their higher number of treatment days in total or per animal—are of interest regarding the potential reduction in antimicrobial usage. Likewise, larger farms with higher management requirements were found to be of particular importance for the reduction of antimicrobial usage. Monitoring programs should therefore evaluate different age categories separately to identify problems for individual farms.

scholarly journals Seroprevalence of Antibodies against Tick-Borne Pathogens in Czech Patients with Suspected Post-Treatment Lyme Disease Syndrome

2021 ◽  
Vol 9 (11) ◽  
pp. 2217
Author(s):  
Kristyna Sloupenska ◽  
Jana Dolezilkova ◽  
Barbora Koubkova ◽  
Beata Hutyrova ◽  
Mojmir Racansky ◽  
...  
Keyword(s):  
Lyme Disease ◽  
Significant Influence ◽  
Anaplasma Phagocytophilum ◽  
Wide Spectrum ◽  
Bartonella Henselae ◽  
Antimicrobial Treatment ◽  
Post Treatment ◽  
Babesia Microti ◽  
Serum Samples ◽  
Good Agreement

The hypothesized importance of coinfections in the pathogenesis of post-treatment Lyme disease syndrome (PTLDS) leads to the use of combined, ongoing antimicrobial treatment in many cases despite the absence of symptoms typical of the presence of infection with specific pathogens. Serum samples from 103 patients with suspected post-treatment Lyme disease syndrome were tested for the presence of antibodies to the major tick-borne pathogens Anaplasma phagocytophilum, Bartonella henselae/Bartonella quinatana, and Babesia microti. Although the presence of anti-Anaplasma antibodies was detected in 12.6% of the samples and anti-Bartonella antibodies in 9.7% of the samples, the presence of antibodies against both pathogens in the same samples or anti-Babesia antibodies in the selected group of patients could not be confirmed. However, we were able to detect autoantibodies, mostly antinuclear, in 11.6% of the patients studied. Our results are in good agreement with previously published studies showing the presence of a wide spectrum of autoantibodies in some patients with complicated forms of Lyme disease and post-treatment Lyme disease syndrome, but they do not reveal a significant influence of co-infections on the development of PTLDS in the studied group of patients.

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