Antitumor Effects of Natural Compounds Derived from Allium sativum on Neuroblastoma: An Overview

Garlic (Allium sativum) has been used in alternative medicine to treat several diseases, such as cardiovascular and neurodegenerative diseases, cancer, and hepatic diseases. Several publications have highlighted other features of garlic, including its antibacterial, antioxidative, antihypertensive, and antithrombotic properties. The properties of garlic result from the combination of natural compounds that act synergistically and cause different effects. Some garlic-derived compounds have been studied for the treatment of several types of cancer; however, reports on the effects of garlic on neuroblastoma are scarce. Neuroblastoma is a prevalent childhood tumor for which the search for therapeutic alternatives to improve treatment without affecting the patients’ quality of life continues. Garlic-derived compounds hold potential for the treatment of this type of cancer. A review of articles published to date on some garlic compounds and their effect on neuroblastoma was undertaken to comprehend the possible therapeutic role of these compounds. This review aimed to analyze the impact of some garlic compounds on cells derived from neuroblastoma.

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The impact of HIV-status disclosure on quality of life and the mediational role of avoidance coping

PsycEXTRA Dataset ◽

10.1037/e546872013-285 ◽

2013 ◽

Author(s):

Calvin Fitch ◽

Gail Ironson ◽

Neil Schneiderman

Keyword(s):

Quality Of Life ◽

Hiv Status ◽

Avoidance Coping ◽

Hiv Status Disclosure ◽

Mediational Role ◽

Status Disclosure ◽

The Impact

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Strategic Role of Zakat in Multidimensional Quality of Life in Sijunjung, Indonesia

The Journal of Muamalat and Islamic Finance Research ◽

10.33102/jmifr.v15i1.101 ◽

2018 ◽

Vol 15 (1) ◽

pp. 55-72

Author(s):

Herlin Hamimi ◽

Abdul Ghafar Ismail ◽

Muhammad Hasbi Zaenal

Keyword(s):

Quality Of Life ◽

Positive Impact ◽

Wealth Distribution ◽

Absolute Poverty ◽

Before And After ◽

The Status ◽

Being There ◽

The Impact

Zakat is one of the five pillars of Islam which has a function of faith, social and economic functions. Muslims who can pay zakat are required to give at least 2.5 per cent of their wealth. The problem of poverty prevalent in disadvantaged regions because of the difficulty of access to information and communication led to a gap that is so high in wealth and resources. The instrument of zakat provides a paradigm in the achievement of equitable wealth distribution and healthy circulation. Zakat potentially offers a better life and improves the quality of human being. There is a human quality improvement not only in economic terms but also in spiritual terms such as improving religiousity. This study aims to examine the role of zakat to alleviate humanitarian issues in disadvantaged regions such as Sijunjung, one of zakat beneficiaries and impoverished areas in Indonesia. The researcher attempted a Cibest method to capture the impact of zakat beneficiaries before and after becoming a member of Zakat Community Development (ZCD) Program in material and spiritual value. The overall analysis shows that zakat has a positive impact on disadvantaged regions development and enhance the quality of life of the community. There is an improvement in the average of mustahik household incomes after becoming a member of ZCD Program. Cibest model demonstrates that material, spiritual, and absolute poverty index decreased by 10, 5, and 6 per cent. Meanwhile, the welfare index is increased by 21 per cent. These findings have significant implications for developing the quality of life in disadvantaged regions in Sijunjung. Therefore, zakat is one of the instruments to change the status of disadvantaged areas to be equivalent to other areas.

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Mutual Influence of Psoriasis and Sport

Medicina ◽

10.3390/medicina57020161 ◽

2021 ◽

Vol 57 (2) ◽

pp. 161

Author(s):

Paolo Custurone ◽

Laura Macca ◽

Lucrezia Bertino ◽

Debora Di Mauro ◽

Fabio Trimarchi ◽

...

Keyword(s):

Quality Of Life ◽

Physical Activity ◽

Metabolic Syndrome ◽

Mutual Influence ◽

Sport Activity ◽

Joint Involvement ◽

Indirect Benefits ◽

The Impact

The link between psoriasis and sport is a controversial issue. The topic has been poorly investigated, and nowadays there are many unsolved questions, dealing with the role of psoriasis in influencing the sporting habits of patients and, vice versa, the impact of sport activity on course, severity and extent of the disease, with particular regard to the indirect benefits on cardiovascular risk and metabolic syndrome. Moreover, the role of physical activity on patients’ quality of life and the potential limitations on physical activity due to joint involvement have not been well elucidated until now. In this narrative review we will try to provide answers to these queries.

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Coping with psychosomatic symptoms: The buffering role of psychological flexibility and impact on quality of life

Journal of Health Psychology ◽

10.1177/1359105316666657 ◽

2016 ◽

Vol 24 (2) ◽

pp. 175-187 ◽

Cited By ~ 12

Author(s):

Chrysanthi Leonidou ◽

Georgia Panayiotou ◽

Aspasia Bati ◽

Maria Karekla

Keyword(s):

Quality Of Life ◽

Negative Impact ◽

Community Sample ◽

Psychological Flexibility ◽

Avoidant Coping ◽

Screening Criteria ◽

Illness Anxiety ◽

The Impact

Individual differences in avoidant coping were hypothesized to exacerbate quality of life impairment associated with somatization and illness anxiety symptoms; psychological flexibility was expected to moderate this impairment. Individuals from a random community sample ( N = 298; 182 females), who met screening criteria for somatization and illness anxiety, reported lower quality of life and psychological flexibility and greater avoidant coping compared to controls. Psychological flexibility significantly moderated the impact of somatization and illness anxiety on quality of life domains. Findings suggest that decreasing avoidant coping through therapy may be promising in mitigating the negative impact of these symptom categories.

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Impact of Exercise/Sport on Well-being in Congenital Bleeding Disorders

Seminars in Thrombosis and Hemostasis ◽

10.1055/s-0038-1673628 ◽

2018 ◽

Vol 44 (08) ◽

pp. 796-801

Author(s):

Silvia Fasoli ◽

Giorgio Gandini ◽

Anna Giuffrida ◽

Massimo Franchini

Keyword(s):

Quality Of Life ◽

Physical Activity ◽

Well Being ◽

The Other ◽

Bleeding Disorders ◽

Coagulation Disorders ◽

Sporting Activity ◽

The Impact

AbstractPhysical activity provides many benefits in patients with congenital bleeding disorders. Patients with hemophilia are encouraged to participate in exercise and sports, especially those patients receiving prophylaxis. Several publications and guidelines have explored this issue in hemophilia patients, evaluating in particular the impact of physical activity on patients' well-being and quality of life. The other rare congenital bleeding disorders are less studied; they are heterogeneous in terms of clinical bleeding phenotype, incidence of hemarthrosis, and arthropathy. Furthermore, prophylaxis in these patients is less common than in hemophilia patients, which must be considered when choosing the type of physical and sporting activity. In this review, the authors have analyzed the literature focusing their attention on those rare coagulation disorders that may be complicated by arthropathy and the role of exercise and sports in this context.

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[P1-630]: THE IMPACT OF PAIN ON QUALITY OF LIFE AND THE MEDIATING ROLE OF ACTIVITIES OF DAILY LIVING AND DEPRESSIVE SYMPTOMS IN SEVERE DEMENTIA

Alzheimer s & Dementia ◽

10.1016/j.jalz.2017.06.646 ◽

2017 ◽

Vol 13 (7S_Part_10) ◽

pp. P540-P540

Author(s):

Hanne Marie Rostad ◽

Martine Puts ◽

Milada Cvancarova Småstuen ◽

Inger Utne ◽

Ellen Karine Grov ◽

...

Keyword(s):

Quality Of Life ◽

Depressive Symptoms ◽

Activities Of Daily Living ◽

Daily Living ◽

Severe Dementia ◽

Mediating Role ◽

The Impact

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Health-Related Quality of Life in the Aftermath of the L’Aquila Earthquake in Italy

Disaster Medicine and Public Health Preparedness ◽

10.1017/dmp.2015.91 ◽

2015 ◽

Vol 10 (1) ◽

pp. 11-15 ◽

Cited By ~ 1

Author(s):

Antonella Gigantesco ◽

Paolo D’Argenio ◽

Vincenza Cofini ◽

Cristiana Mancini ◽

Valentina Minardi

Keyword(s):

Quality Of Life ◽

Suicide Rate ◽

L’Aquila Earthquake ◽

Health Related Quality ◽

Cross Sectional ◽

Related Quality ◽

Health Related ◽

The Impact

AbstractObjectiveA recent article reported a reduction in the suicide rate in the inhabitants of L’Aquila (Italy) in 2009, when on the night of April 6, a devastating earthquake struck the city. The potential implications of the role of resilience in the aftermath of natural disasters, together with the limitations of existing evidence on this topic, suggest a need for more research. We aimed to retrospectively investigate the impact of the L’Aquila earthquake on a standardized self-reported measure of health-related quality of life (HRQoL).MethodsHRQoL data were collected through 2 separate cross-sectional surveys conducted during 2008 and 2010, before and after the earthquake that occurred in 2009, on 2 random samples of adults living in L’Aquila.ResultsThe data seemed to suggest no decrease in the inhabitants’ HRQoL level after the disaster, which may suggest the role of resilience in supporting survivors’ HRQoL. The findings were also consistent with previous observations of a reduction in the suicide rate in the same inhabitants after the earthquake.ConclusionsAfter a natural disaster, people likely activate personal resources and protective social factors that result in better subjective outcomes. (Disaster Med Public Health Preparedness. 2016;10:11-15)

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Development of a functional assessment of side-effects to therapy (FAST) questionnaire to assess dermatology-related quality of life in patients treated with EGFR inhibitors (EGFRI): The FAST-EGFRI

Journal of Clinical Oncology ◽

10.1200/jco.2007.25.18_suppl.19532 ◽

2007 ◽

Vol 25 (18_suppl) ◽

pp. 19532-19532 ◽

Cited By ~ 3

Author(s):

L. Wagner ◽

S. E. Lai ◽

M. Aneja ◽

P. Lorusso ◽

R. Perez-Soler ◽

...

Keyword(s):

Quality Of Life ◽

Social Life ◽

Symptom Burden ◽

Physical Symptoms ◽

Self Report ◽

Antitumor Effects ◽

Related Quality ◽

The Impact ◽

Skin Pain

19532 Background: Despite their beneficial antitumor effects, 75–87% patients who undergo EGFRI therapy develop dermatological toxicities (derm tox), including rash, paronychia, hair alterations, and pruritus. The purpose of this study was to develop a patient (pts) self-report questionnaire based on pts and expert (exp) input and to identify the most significant skin tox health-related quality of life (HRQL) factors. Methods: To generate the questionnaire, 20 pts with derm tox to EGFRIs and 12 expert clinicians (>50 treated pts) were asked interview questions and rated 62 items to assess the most bothersome aspects of derm tox and the impact on pts’ skin-specific HRQL. The questionnaire included items from the Skindex-29, a validated skin disease-specific HRQL questionnaire. Items were rated from 0 (not at all important) to 3 (extremely important) (range = 0–3) based on the items’ significance to patients’ HRQL. Both groups were also asked to circle 20 of the most concerning HRQL factors. Results: Eighteen pts and 11 exp completed the questionnaire. Symptoms reported frequently by both pts and exp that affected patients’ HRQL included painful (mean score 2.29 (pts), 2.70, (exp), burning (2.41 (pts), 2.70 (exp)), itchy (2.00 (pts), 2.20 (exp) skin, pain in fingers/toes (2.00 (pts), 2.40 (exp)) increased facial hair (1.93(pts), 1.70 (exp)). Both pts and exp also frequently reported that the patient’s skin condition makes them feel depressed (1.88 (pts), 2.60 (exp)) and makes work or hobbies difficult (2.00 (pts), 2.20 (exp)). The top three most concerning HRQL factors for pts were skin pain, burning and stinging, and irritation, while exp reported depression, skin pain, and derm tox affecting pts’ social life. Conclusions: These results document the trajectory of symptom burden and derm tox HRQL in EGFRI treated pts. These findings underscore that in addition to the psychosocial discomfort, physical symptoms impact HRQL. Further studies to validate the FAST-EGFRI, so that effects on HRQL of interventions against derm tox and differences between agents can be assessed are underway. No significant financial relationships to disclose.

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