Metabolomics Elucidates Dose-Dependent Molecular Beneficial Effects of Hesperidin Supplementation in Rats Fed an Obesogenic Diet

Metabolic syndrome (MetS) is a global epidemic concern. Polyphenols are proposed as good candidates for its prevention, although their mechanisms are not fully understood. The gut microbiota seems to play a key role in polyphenol beneficial effects. Here, we assessed the effects of the citrus polyphenol hesperidin combining an untargeted metabolomics approach, which has an inherent potential to elucidate the host-microbiome interplay, with extensive anthropometric and biochemical characterizations and integrating metabolomics results with our previous 16S rRNA bacterial sequencing data. The rats were fed either a standard or an obesogenic cafeteria diet (CAF) for 17 weeks. After nine weeks, rats were supplemented with vehicle; low- (H1), or high- (H2) hesperidin doses. CAF animals developed MetS features. Hesperidin supplementation in CAF rats decreased the total cholesterol, LDL-C, and free fatty acids. The highest hesperidin dose also ameliorated blood pressure, insulin sensitivity, and decreased markers of arterial stiffness and inflammation. Metabolomics revealed an improvement of the lipidomic profile, decreases in circulating amino acids, and lower excretions of inflammation- and oxidative stress-related metabolites. Bacteroidaceae increases in the CAF-H2 group paralleled higher excretions of microbial-derived metabolites. Overall, our results provide detailed insights into the molecular effects of hesperidin on MetS and suggest that it is a promising prebiotic for the treatment of MetS and related conditions.

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Faculty Opinions recommendation of High-intensity interval training beneficial effects on body mass, blood pressure, and oxidative stress in diet-induced obesity in ovariectomized mice.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726692682.793522525 ◽

2016 ◽

Author(s):

Jerome Fleg

Keyword(s):

Oxidative Stress ◽

Blood Pressure ◽

High Intensity ◽

Interval Training ◽

High Intensity Interval Training ◽

Beneficial Effects ◽

Diet Induced Obesity ◽

Ovariectomized Mice ◽

High Intensity Interval ◽

And Oxidative Stress

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Effect ofBifidobacterium lactisHN019 on inflammatory markers and oxidative stress in subjects with and without the metabolic syndrome

British Journal Of Nutrition ◽

10.1017/s0007114518001861 ◽

2018 ◽

Vol 120 (6) ◽

pp. 645-652 ◽

Cited By ~ 5

Author(s):

Luciana J. Bernini ◽

Andréa N. Colado Simão ◽

Cínthia H. B. de Souza ◽

Daniela F. Alfieri ◽

Liliane G. Segura ◽

...

Keyword(s):

Oxidative Stress ◽

Metabolic Syndrome ◽

Inflammatory Markers ◽

Healthy Subjects ◽

Antioxidant Defenses ◽

Beneficial Effects ◽

The Metabolic Syndrome ◽

Inflammatory State ◽

Baseline Values ◽

And Oxidative Stress

AbstractBeneficial effects of probiotics have been reported on body weight, lipid and carbohydrate metabolism, inflammatory state and oxidative stress in healthy subjects and in many metabolic and inflammatory diseases. The aim of this study was to evaluate the effects ofBifidobacterium lactisHN019 on inflammatory state and nitro-oxidative stress in patients with and without the metabolic syndrome (MetS). The usual diets of the thirty-three subjects were supplemented with probiotic milk for 90 d. Inflammatory markers and oxidative measurements were performed. In relation to the baseline values, subjects in both groups showed a decrease in homocysteine (P=0·02 andP=0·03, respectively), hydroperoxides (P=0·02 andP=0·01, respectively) and IL-6 levels (P=0·02). Increases in adiponectin (P=0·04) and nitric oxide metabolites (NOx,P=0·001) levels were only seen in the group with the MetS in relation to the baseline values, whereas only the individuals without the MetS had increases in total radical-trapping antioxidant parameter levels (P=0·002). In conclusion,B. lactisHN019 have several beneficial effects on inflammatory and oxidative biomarkers in healthy subjects and the MetS patients. Patients with the MetS showed a specific improvement in adiponectin and NOx levels, whereas a specific favourable effect was shown in the antioxidant defenses in healthy subjects. If the results obtained in the present study are confirmed, supplementation of fermented milk with probiotics in healthy subjects and patients with the MetS must be further discussed.

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Epicatechin improves lipid profile and oxidative stress status, but does not reduce abdominal fat or blood pressure in an obese SHR model of metabolic syndrome

Heart Lung and Circulation ◽

10.1016/j.hlc.2015.06.177 ◽

2015 ◽

Vol 24 ◽

pp. S187

Author(s):

K. Connolly ◽

D. Jackson ◽

R. Batacan ◽

A. Fenning

Keyword(s):

Oxidative Stress ◽

Blood Pressure ◽

Metabolic Syndrome ◽

Lipid Profile ◽

Abdominal Fat ◽

Oxidative Stress Status ◽

And Oxidative Stress

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Beneficial effects of argan oil on blood pressure, insulin resistance, and oxidative stress in rat

Nutrition ◽

10.1016/j.nut.2016.02.021 ◽

2016 ◽

Vol 32 (10) ◽

pp. 1132-1137 ◽

Cited By ~ 15

Author(s):

Adil El Midaoui ◽

Youssef Haddad ◽

Réjean Couture

Keyword(s):

Oxidative Stress ◽

Insulin Resistance ◽

Blood Pressure ◽

Beneficial Effects ◽

Argan Oil ◽

And Oxidative Stress

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Beneficial Effects of Multicomponent Functional Foods in Patients with Metabolic Syndrome

10.20944/preprints201811.0015.v1 ◽

2018 ◽

Author(s):

Simona Dragan ◽

Georgiana Damian ◽

Dana Velimirovici ◽

Maria Rada ◽

Delia Berceanu ◽

...

Keyword(s):

Oxidative Stress ◽

Metabolic Syndrome ◽

Plasma Lipids ◽

Grape Juice ◽

Beneficial Effects ◽

The Metabolic Syndrome ◽

Trial Testing ◽

Balsamic Vinegar ◽

Group 3 ◽

And Oxidative Stress

The ANTIATERO-ALIM study was a randomized, parallel design nutritional trial testing functional food (FF) diets against the usual diet recommended in the metabolic syndrome. Functional meals included balsamic vinegar from apples and honey and grape juice enriched with polyphenols from seeds of red grapes. 300 patients with metabolic syndrome were randomized into 4 groups: gr.1: FF + Ω-3 supplements, gr.2: FF, gr.3: Ω-3 supplements, gr.4: control. IRHOMA insulin resistance, plasma lipids and oxidative stress were assessed at inclusion and at 6 months. After 6 months there was a very significant decrease of oxidative stress in group 3, followed by a significant decrease in groups 1 and 2.

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High-intensity interval training beneficial effects on body mass, blood pressure, and oxidative stress in diet-induced obesity in ovariectomized mice

Life Sciences ◽

10.1016/j.lfs.2015.08.004 ◽

2015 ◽

Vol 139 ◽

pp. 75-82 ◽

Cited By ~ 22

Author(s):

Marcel Pimenta ◽

Isabele Bringhenti ◽

Vanessa Souza-Mello ◽

Iara Karise dos Santos Mendes ◽

Marcia B. Aguila ◽

...

Keyword(s):

Oxidative Stress ◽

Blood Pressure ◽

High Intensity ◽

Interval Training ◽

High Intensity Interval Training ◽

Beneficial Effects ◽

Diet Induced Obesity ◽

Ovariectomized Mice ◽

High Intensity Interval ◽

And Oxidative Stress

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Relationship Between C-Reactive Protein and Atherosclerotic Risk Factors and Oxidative Stress Markers Among Young Persons 10–18 Years Old

Clinical Chemistry ◽

10.1373/clinchem.2006.073668 ◽

2007 ◽

Vol 53 (3) ◽

pp. 456-464 ◽

Cited By ~ 37

Author(s):

Roya Kelishadi ◽

Mohsen Sharifi ◽

Alireza Khosravi ◽

Khosrow Adeli

Keyword(s):

Oxidative Stress ◽

Blood Pressure ◽

Metabolic Syndrome ◽

Young People ◽

Hdl Cholesterol ◽

Oxidative Stress Markers ◽

C Reactive Protein ◽

Reactive Protein ◽

Stress Markers ◽

And Oxidative Stress

AbstractBackground: This study was undertaken to determine the association of serum C-reactive protein (CRP) with generalized and abdominal obesity, body fat composition, the metabolic syndrome, and oxidative stress markers among young people.Methods: We conducted a population-based study of 512 young people, aged 10–18 years. We obtained anthropometric and blood pressure measurements. Fasting blood sugar, total cholesterol (TC), HDL-cholesterol, triglycerides, CRP, malondialdehyde (MDA), and conjugated diene (CDE) were quantified. LDL-cholesterol (LDL-C) was calculated for samples with TG ≤4.52 mmol/LResults: Mean triglycerides, waist and hip circumferences, percentage body fat, subcutaneous fat, and systolic blood pressure increased significantly with increasing body mass index (BMI). In contrast, the mean LDL and TC were higher in underweight than normal weight individuals, and then increased significantly from normal to higher BMI categories. Mean HDL cholesterol significantly decreased with increasing BMI. Overall, CRP, MDA, and CDE were significantly correlated with measures of abdominal obesity. Serum CRP, MDA, and CDE significantly increased in the upper quartiles of waist circumference. Study participants with higher CRP concentrations were more likely to have metabolic syndrome and high oxidative stress markers.Conclusion: We found a significant positive association between CRP and oxidative stress markers in healthy young people, as well as an increase in these markers in the upper quartiles of waist circumference, but not BMI. Oxidative stress and CRP may interact in the early inflammatory processes of atherosclerosis.

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